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1. Criteria for melanocytic lesions in LC‐OCT.

Author

Perez‐Anker, J., Soglia, S., Lenoir, C., Albero, R., Alos, L., García, A., Alejo, B., Cinotti, E., Orte Cano, C., Habougit, C., Dorado Cortes, Ch., Pellegrino, L., Tognetti, L., Castillo, P., Rubegni, P., Suppa, M., Perrot, J. L., del Marmol, V., Puig, S., and Malvehy, J.

Subjects
OPTICAL coherence tomography, DENDRITIC cells, LOGISTIC regression analysis, DIAGNOSTIC imaging, DERMOSCOPY
Abstract

Background: Line‐field confocal optical coherence tomography (LC‐OCT) is an emerging diagnostic tool with imaging depth reaching ~400 μm and a novel three‐dimensional (3D) cube providing cellular resolution. As far as we are aware, there are only a limited number of papers that have reported diagnostic criteria for melanocytic lesions using this technique, and none of them have been multicentric. Objectives: Our aim was to establish the diagnostic criteria for melanocytic lesions using LC‐OCT and identify the most significant architectural and cytologic features associated with malignancy. Methods: A retrospective evaluation of 80 consecutive melanocytic lesions from a prospective multicentric data set spanning three European centres was conducted. We excluded facial, acral and mucosal lesions from the study. Dermoscopic and LC‐OCT images were evaluated by a consensus of four observers. Multivariate logistic regression with backward elimination was employed. Results: The main melanoma diagnostic criteria include detecting >10 pagetoid cells in 3D acquisition, irregular 3D epidermal architecture, disrupted dermoepidermal junction (DEJ) and clefting. Significant risk factors were irregular 3D epidermal architecture, >10 pagetoid cells, dendritic cells at DEJ without underlying inflammation. Novel malignancy criteria in vertical view were DEJ disruption and clefting around atypical melanocyte nests. Exclusive melanoma features were epidermal nests, epidermal consumption, dense dermal nests with atypia. Protective features in the absence of any malignancy indicators were DEJ ring pattern, cobblestone, elongated rete ridges (vertical), well‐defined DEJ and wave pattern (vertical). Conclusions: A series of diagnostic criteria for the identification of melanocytic lesions with LC‐OCT have been established. Validation of these criteria in clinical practice through future studies is essential to further establish their utility. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Understanding the anatomy of dermoscopy of melanocytic skin tumours: Correlation in vivo with line‐field optical coherence tomography.

Author

Soglia, S., Pérez‐Anker, J., Albero, R., Alós, L., Berot, V., Castillo, P., Cinotti, E., Del Marmol, V., Fakih, A., García, A., Lenoir, C., Monnier, J., Perrot, J. L., Puig, S., Rubegni, P., Skowron, F., Suppa, M., Tognetti, L., Venturini, M., and Malvehy, J.

Subjects
OPTICAL coherence tomography, RETINAL imaging, DERMOSCOPY, CONFOCAL microscopy, ANATOMY, PANCREATIC cysts
Abstract

Background: Early melanoma detection is the main factor affecting prognosis and survival. For that reason, non‐invasive technologies have been developed to provide a more accurate diagnosis. Recently, line‐field confocal optical coherence tomography (LC‐OCT) was developed to provide an in vivo, imaging device, with deep penetration and cellular resolution in three dimensions. Combining the advantages of conventional OCT and reflectance confocal microscopy, this tool seems to be particularly suitable for melanocytic lesions. Objectives: The objective of this study was to identify and describe the correlation between specific dermoscopic criteria and LC‐OCT features in three dimensions associated with melanocytic lesions. Methods: Dermoscopic and LC‐OCT images of 126 melanocytic lesions were acquired in three different centres. The following dermoscopic criteria have been considered: reticular pattern, dots and globules, structureless areas, blue‐whitish veil, regression structures, negative network, homogeneous pattern, streaks and blotches. Results: 69 (55%) benign and 57 (45%) malignant lesions were analysed. A regular reticular pattern was found associated in the 75% of the cases with the presence of elongated rete ridges with pigmented cells along the basal layer, while atypical reticular pattern showed an irregular organization of rete ridges with melanocytic hyperplasia, broadened and fused ridges and elongated nests. Both typical and atypical dots and globules were found associated with melanocytic nests in the dermis or at the dermoepidermal junction (DEJ), as well as with keratin cysts/pseudocysts. Grey globules corresponded to the presence of melanin‐containing dermal inflammatory cells (melanophages) within the papillae. Structureless brown/black areas correlated with alterations of the DEJ. We observed the same DEJ alterations, but with the presence of dermal melanophages, in 36% of the cases of blue/white/grey structureless areas. A description of each LC‐OCT/dermoscopy correlation was made. Conclusions: LC‐OCT permitted for the first time to perform an in vivo, 3D correlation between dermoscopic criteria and pathological‐like features of melanocytic lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Diagnostic criteria for melanocytic lesions in LC-OCT

Author

Pérez-Anker, M.J., primary, Soglia, S., additional, Lenoir, C., additional, Albero, R., additional, Alos, L., additional, Cinotti, E., additional, Pellegrino, L., additional, Tognetti, L., additional, Rubegni, P., additional, Suppa, M., additional, Perrot, J.L., additional, del Marmol, V., additional, Puig, S., additional, and Malvehy, J., additional

Published
2024
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6. Assessment of facial pigmented lesions using Line-field Confocal Optical Coherence Tomography and its correlation with Reflectance Confocal Microscopy and histopathology

Author

Lenoir, C., primary, Suppa, M., additional, Soglia, S., additional, Puig, S., additional, Tognetti, L., additional, Cinotti, E., additional, Orte Cano, C., additional, Diet, G., additional, Rubegni, P., additional, Perrot, J.-L., additional, del Marmol, V., additional, Malvehy, J., additional, and Pérez-Anker, J., additional

Published
2024
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7. Understanding the anatomy of dermoscopy of melanocytic skin tumours: Correlation in vivo with line‐field optical coherence tomography

Author

Soglia, S., primary, Pérez‐Anker, J., additional, Albero, R., additional, Alós, L., additional, Berot, V., additional, Castillo, P., additional, Cinotti, E., additional, Del Marmol, V., additional, Fakih, A., additional, García, A., additional, Lenoir, C., additional, Monnier, J., additional, Perrot, J. L., additional, Puig, S., additional, Rubegni, P., additional, Skowron, F., additional, Suppa, M., additional, Tognetti, L., additional, Venturini, M., additional, and Malvehy, J., additional

Published
2023
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8. Les lymphomes compliquant la maladie de Sjögren sont associés à une accumulation de variations génétiques germinales sur des voies favorisant l’hyper-activation lymphocytaire B

Author

Nocturne, G., primary, Jabot-Hanin, F., additional, Gottenberg, J.E., additional, Hachulla, E., additional, Le Gern, V., additional, Lenoir, C., additional, Larroche, C., additional, Olivier, V., additional, Saraux, A., additional, Latour, S., additional, and Mariette, X., additional

Published
2023
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11. Optimal design and optimal control of structures undergoing finite rotations and elastic deformations

Author

Ibrahimbegovic, A., Knopf-Lenoir, C., Kucerova, A., and Villon, P.

Subjects
Computer Science - Neural and Evolutionary Computing, Computer Science - Computational Engineering, Finance, and Science, G.1.6, G.1.8
Abstract

In this work we deal with the optimal design and optimal control of structures undergoing large rotations. In other words, we show how to find the corresponding initial configuration and the corresponding set of multiple load parameters in order to recover a desired deformed configuration or some desirable features of the deformed configuration as specified more precisely by the objective or cost function. The model problem chosen to illustrate the proposed optimal design and optimal control methodologies is the one of geometrically exact beam. First, we present a non-standard formulation of the optimal design and optimal control problems, relying on the method of Lagrange multipliers in order to make the mechanics state variables independent from either design or control variables and thus provide the most general basis for developing the best possible solution procedure. Two different solution procedures are then explored, one based on the diffuse approximation of response function and gradient method and the other one based on genetic algorithm. A number of numerical examples are given in order to illustrate both the advantages and potential drawbacks of each of the presented procedures., Comment: 35 pages, 11 figures

Published
2009
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17. Line-field confocal optical coherence tomography in melanocytic and non-melanocytic skin tumors

Author

Suppa, M., Palmisano, Gerardo, Tognetti, L., Lenoir, C., Cappilli, Simone, Fontaine, M., Orte Cano, C., Diet, G., Perez-Anker, J., Schuh, S., Di Stefani, Alessandro, Lacarrubba, F., Puig, S., Malvehy, J., Rubegni, P., Welzel, J., Perrot, J. -L., Peris, Ketty, Cinotti, E., Del Marmol, V., Palmisano G., Cappilli S., Di Stefani A., Peris K. (ORCID:0000-0002-5237-0463), Suppa, M., Palmisano, Gerardo, Tognetti, L., Lenoir, C., Cappilli, Simone, Fontaine, M., Orte Cano, C., Diet, G., Perez-Anker, J., Schuh, S., Di Stefani, Alessandro, Lacarrubba, F., Puig, S., Malvehy, J., Rubegni, P., Welzel, J., Perrot, J. -L., Peris, Ketty, Cinotti, E., Del Marmol, V., Palmisano G., Cappilli S., Di Stefani A., and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

INTRODUCTION: Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced, non-invasive skin imaging technique combining the technical advantages of reflectance confocal microscopy and conventional OCT in terms of isotropic resolution and in-tissue penetration. Several studies have been published so far about the use of LC-OCT in melanocytic and non-melanocytic skin tumors. The aim of this review was to summarize the currently available data on the use of LC-OCT for benign and malignant melanocytic and non-melanocytic skin tumors. EVIDENCE ACQUISITION: We searched scientific databases for any literature published up to 30th April 2023 and concerning the use of LC-OCT for melanocytic and non-melanocytic skin tumors. Identified papers were evaluated, and relevant information was extracted. EVIDENCE SYNTHESIS: A total of 29 studies were found including original articles, short reports, and letters to the Editor: 6 applied to melanocytic skin tumors, 22 to non-melanocytic skin tumors and 1 to both. The use of LC-OCT increased the diagnostic accuracy for melanocytic and non-melanocytic skin lesions. The highest diagnostic performance was found for basal cell carcinoma (BCC), but significant improvements in the diagnostic accuracy were also detected for the differentiation of actinic keratosis (AK) from squamous cell carcinoma (SCC) and of melanoma from nevi. The LC-OCT features of other skin tumors were also described and successfully correlated with histopathology. CONCLUSIONS: LC-OCT proved to increase the diagnostic accuracy for melanocytic and non-melanocytic skin lesions, thanks to the combination of high resolution/penetration, 3D reconstructions, and integrated dermoscopy. Although BCC seems the most suitable tumors for LC-OCT examination, the device is extremely performant for the differentiation of AK from SCC and the discrimination of melanoma from nevi as well. Additional studies on diagnostic performance and new investigations about the

Published
2023

18. Line‐field confocal optical coherence tomography: A new in vivo assessment tool for cutaneous mycosis fungoides.

Author

Soglia, S., Pérez‐Anker, J., Ghini, I., Lenoir, C., Maione, V., Sala, R., Tonon, F., Suppa, M., Calzavara‐Pinton, P. G., Malvehy, J., and Venturini, M.

Subjects
OPTICAL coherence tomography, MYCOSIS fungoides, SEZARY syndrome, CUTANEOUS T-cell lymphoma
Abstract

This article discusses the use of line-field confocal optical coherence tomography (LC-OCT) as a new tool for assessing cutaneous mycosis fungoides (MF), the most common variant of cutaneous T-cell lymphoma. The early diagnosis of MF is challenging and often results in a therapeutic delay. LC-OCT allows for the visualization of various features of MF, such as epidermal architectural disarray, atypical lymphocytes, and dermal changes. The study demonstrates that LC-OCT has a high correlation with histology and can provide valuable information for the diagnosis and follow-up of MF. [Extracted from the article]

Published
2024
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19. P929: IXAZOMIB AND DARATUMUMAB WITHOUT DEXAMETHASONE (I-DARA) IN ELDERLY FRAIL RELAPSING MYELOMA (RRMM) PATIENTS: RESULTS OF THE PHASE 2 STUDY IFM 2018-02 OF THE INTERGROUPE FRANCOPHONE DU MYELOME (IFM).

Author

Macro, M., primary, Touzeau, C., additional, Mariette, C., additional, Manier, S., additional, Brechignac, S., additional, Vincent, L., additional, Hebraud, B., additional, Decaux, O., additional, Schulmann, S., additional, Lenoir, C., additional, Godmer, P., additional, Farge, A., additional, Peyro Saint Paul, L., additional, Parienti, J.-J., additional, and Leleu, X., additional

Published
2022
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21. Line-field confocal optical coherence tomography of basosquamous carcinoma: a case series with histopathological correlation

Author

Cappilli, Simone, Cinotti, E., Lenoir, C., Tognetti, L., Perez-Anker, J., Rubegni, P., Puig, S., Malvehy, J., Perrot, J. L., del Marmol, V., Peris, Ketty, Suppa, M., Cappilli S., Peris K. (ORCID:0000-0002-5237-0463), Cappilli, Simone, Cinotti, E., Lenoir, C., Tognetti, L., Perez-Anker, J., Rubegni, P., Puig, S., Malvehy, J., Perrot, J. L., del Marmol, V., Peris, Ketty, Suppa, M., Cappilli S., and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

Background: Basosquamous carcinoma (BSC) is a rare and potentially aggressive cutaneous neoplasm combining histopathological features of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Line-field confocal optical coherence tomography (LC-OCT) is a new, non-invasive imaging technique featuring excellent resolution and penetration. To date, studies about the use of LC-OCT in the BCC and SCC fields are available, but similar investigations are lacking in the BSC field. Objective: The goal of the present study was to identify/describe LC-OCT criteria of BSC. Methods: Consecutively enrolled BSCs were imaged with dermoscopy and LC-OCT prior to surgical excision. Dermoscopic and LC-OCT images were evaluated, and histopathological slides were reviewed. Results: Six BSCs from six patients [four (66.7%) males and two (33.3%) females; mean age 76.5 (62–96) years] were included. Identified LC-OCT criteria for BSC included BCC-associated (dermal lobules with millefeuille pattern, dilated vessels, bright cells within the epidermis, bright cells within lobules, stromal stretching, stromal brightness) and SCC-associated features (acanthosis, hyperkeratosis, disarranged epidermal architecture, broad strands, elastosis and glomerular vessels). Interruption of the dermal–epidermal junction and ulceration represented overlapping criteria. Conclusion: Line-field confocal-OCT is a new promising technique that may support the non-invasive recognition of BSC through the simultaneous detection of BCC-associated and SCC-associated features. We hypothesize that the use of LC-OCT might be helpful not only in the diagnostic setting but also in the follow-up surveillance for an early identification of recurrences. Further larger studies are needed to prove this hypothesis.

Published
2022

26. WR15 Six-port Interferometric Set-up for Millimeter-wave Characterization in Harsh Environments

Author

Alsaleh, N, Pomorski, D, Sebbache, M, Lenoir, C, Haddadi, K, and Université de Lille

Subjects
millimeter-waves, [SPI]Engineering Sciences [physics], Six-Port, free-space, demodulator IQ, radar
Abstract

International audience; Continuous wave (CW) millimeter-wave radars have gained the interest from industry for accurate distance measurement. In particular, six-port radar (SPR) architecture presents advantages such as high resolution combined with lowpower consumption and low-cost implementation. A WR15 waveguide six-port interferometer is designed and realized for accurate phase measurement in the millimeter-wave regime for harsh environment conditions. This latter is combined with dedicated calibration algorithms to provide measurements performance in terms of sensitivity and accuracy. Experimental results are exemplary shown with mean phase error 2.2 degrees at the test frequency 60 GHz.

Published
2021

28. Line‐field confocal optical coherence tomography for actinic keratosis and squamous cell carcinoma: a descriptive study

Author

Cinotti, E., primary, Tognetti, L., additional, Cartocci, A., additional, Lamberti, A., additional, Gherbassi, S., additional, Orte Cano, C., additional, Lenoir, C., additional, Dejonckheere, G., additional, Diet, G., additional, Fontaine, M., additional, Miyamoto, M., additional, Perez‐Anker, J., additional, Solmi, V., additional, Malvehy, J., additional, del Marmol, V., additional, Perrot, J. L., additional, Rubegni, P., additional, and Suppa, M., additional

Published
2021
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29. Line‐field confocal optical coherence tomography of actinic keratosis: a case series

Author

Lenoir, C., primary, Cinotti, E., additional, Tognetti, L., additional, Orte Cano, C., additional, Diet, G., additional, Miyamoto, M., additional, Rocq, L., additional, Trépant, A.‐L., additional, Perez‐Anker, J., additional, Puig, S., additional, Malvehy, J., additional, Rubegni, P., additional, Perrot, J.‐L., additional, Marmol, V., additional, and Suppa, M., additional

Published
2021
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31. Diagnostic yield of next-generation sequencing in very early-onset inflammatory bowel diseases

Author

Charbit-Henrion, F., Parlato, M., Hanein, S., Duclaux-Loras, R., Nowak, J., Begue, B., Rakotobe, S., Bruneau, J., Fourrage, C., Alibeu, O., Rieux-Laucat, F., Levy, E., Stolzenberg, M.C., Mazerolles, F., Latour, S., Lenoir, C., Fischer, A., Picard, C., Aloi, M., Dias, J.A., Hariz, M. ben, Bourrier, A., Breuer, C., Breton, A., Bronsky, J., Buderus, S., Cananzi, M., Coopman, S., Cremilleux, C., Dabadie, A., Dumant-Forest, C., Gurkan, O.E., Fabre, A., Diaz, M.G., Gonzalez-Lama, Y., Goulet, O., Guariso, G., Gurcan, N., Homan, M., Hugot, J.P., Jeziorski, E., Karanika, E., Lachaux, A., Lewindon, P., Lima, R., Magro, F., Major, J., Malamut, G., Mas, E., Mattyus, I., Mearin, L.M., Melek, J., Navas-Lopez, V.M., Paerregaard, A., Pelatan, C., Pigneur, B., Pais, I.P., Rebeuh, J., Romano, C., Siala, N., Strisciuglio, C., Tempia-Caliera, M., Tounian, P., Turner, D., Urbonas, V., Willot, S., Ruemmele, F.M., and Cerf-Bensussan, N.

Published
2021

34. Line‐field confocal optical coherence tomography of sebaceous hyperplasia: a case series

Author

Lenoir, C., primary, Diet, G., additional, Cinotti, E., additional, Tognetti, L., additional, Orte Cano, C., additional, Rocq, L., additional, Trépant, A.‐L., additional, Monnier, J., additional, Perez‐Anker, J., additional, Rubegni, P., additional, Puig, S., additional, Malvehy, J., additional, Perrot, J.‐L., additional, Marmol, V., additional, and Suppa, M., additional

Published
2021
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36. Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains

Author

Vidal M., W.Q. Liu, Lenoir, C., Salzmann, J., Gresh, N., and Garbay, C.

Subjects
Amino acids -- Research, Biological sciences, Chemistry
Abstract

The design made by combining N-alkyl amino acid incorporation in a proline rich sequence with subsequent dimerization of the peptoid sequence based on structural data and molecular modeling is presented. The data suggests that compounds capable to recognize with both enhanced affinity and selectivity Grb2 SH3 domains can be tailored by dimerization.

Published
2004

41. Improving the treatment and remission of major depression in homeless people with severe mental illness: the multicentric French Housing First (FHF) program. French Housing First Study Group Running title: Major depression in homeless people with severe mental disorders

Author

Fond, Guillaume, Boyer, L., Boucekine, M., Girard, V., Loubière, S., Lenoir, C., Auquier, P., Tinland, A., Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), 2011 Programme Hospitalier de Recherche Clinique National and the French Ministry of Health (Direction Générale de la Santé), and Assistance Publique-Hôpitaux de Marseille (AP-HM)

Subjects
Mania, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Schizophrenia, Bipolar disorders, Homelessness, Antidepressant, Violence, Alcohol
Abstract

International audience; ObjectiveThe aim of this study was to investigate the factors associated with violent behavior in a large multicenter sample of Homeless Schizophrenia (SZ) and Bipolar Disorder (BD) (HSB) subjects.MethodsThis multicenter study was conducted in 4 French cities: Lille, Marseille, Paris and Toulouse. Violent behavior was defined by at least one episode of verbal or physical violence in the last 6 months.ResultsOverall, 675 HSB patients, mean aged 38 years and 82.5% men were included, 458 SZ (68.4%) and 212 BD (31.6%). During the 6 months before evaluation, 213 (34.3%) committed at least one physical or verbal violence. In multivariate analysis, violence has been associated with younger age (aOR = 0.96[0.94–0.99], p = .001), number of nights in the street (aOR = 1.01[1.01–1.01]), BD diagnosis (aOR = 1.63[1.01–2.65], p = .04), higher current illness severity (CGI score) (aOR = 1.32[1.07–1.64], p = .01), higher rates of current manic episode (aOR = 2.24[1.32–3.81], p = .002), current alcohol use disorder (aOR = 2.05 [1.33–3.15], p = .001), antisocial personality disorder (aOR = 2.51[1.55–4.07], p

Published
2019

44. Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre Study

Author

Charbit-Henrion, F., Parlato, M., Hanein, S., Duclaux-Loras, R., Nowak, J., Begue, B., Rakotobe, S., Bruneau, J., Fourrage, C., Alibeu, O., Rieux-Laucat, F., Levy, E., Stolzenberg, M.C., Mazerolles, F., Latour, S., Lenoir, C., Fischer, A., Picard, C., Aloi, M., Dias, J.A., Hariz, M. ben, Bourrier, A., Breuer, C., Breton, A., Bronski, J., Buderus, S., Cananzi, M., Coopman, S., Cremilleux, C., Dabadie, A., Dumant-Forest, C., Gurkan, O.E., Fabre, A., Diaz, M.G., Gonzalez-Lama, Y., Goulet, O., Guariso, G., Gurcan, N., Homan, M., Hugot, J.P., Jeziorski, E., Karanika, E., Lachaux, A., Lewindon, P., Lima, R., Magro, F., Major, J., Malamut, G., Mas, E., Mattyus, I., Mearin, L.M., Melek, J., Navas-Lopez, V.M., Paerregaard, A., Pelatan, C., Pigneur, B., Pais, I.P., Rebeuh, J., Romano, C., Siala, N., Strisciuglio, C., Tempia-Caliera, M., Tounian, P., Turner, D., Urbonas, V., Willot, S., Ruemmele, F.M., and Cerf-Bensussan, N.

Subjects
paediatrics, VEO-IBD, TNGS, Genetics and molecular epidemiology, monogenic disorders
Published
2018

45. Comparison of time under tension, repetition maximum and electromyographic activity in bench press exercise in different speeds execution

Author

Werneck Salarolli, Lenoir C., primary, Bedin Barros, Raphael M., additional, da Silva, Jurandir B., additional, da Silva Carvalho, Igor L., additional, de Souza Vale, Rodrigo G., additional, de Alkmim Moreira Nunes, Rodolfo, additional, Brandão Pinto de Castro, Juliana, additional, and Pinheiro Lima, Vicente, additional

Published
2018
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