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4 results on '"Lena Meier"'

1. Divergent and Compensatory Effects of BMP2 and BMP4 on the VSMC Phenotype and BMP4’s Role in Thoracic Aortic Aneurysm Development

Author

Daniel Klessinger, Argen Mamazhakypov, Sophie Glaeser, Ramona Emig, Remi Peyronnet, Lena Meier, Kora Proelss, Katia Marenne, Christian Smolka, Sebastian Grundmann, Franziska Pankratz, Philipp R. Esser, Martin Moser, Qian Zhou, and Jennifer S. Esser

Subjects
BMP, BMP-2, BMP-4, TAA, VSMC, aortic aneurysm development, Cytology, QH573-671
Abstract

Vascular smooth muscle cells (VSMCs) play a key role in aortic aneurysm formation. Bone morphogenetic proteins (BMPs) have been implicated as important regulators of VSMC phenotype, and dysregulation of the BMP pathway has been shown to be associated with vascular diseases. The aim of this study was to investigate for the first time the effects of BMP-4 on the VSMC phenotype and to understand its role in the development of thoracic aortic aneurysms (TAAs). Using the angiotensin II (AngII) osmotic pump model in mice, aortas from mice with VSMC-specific BMP-4 deficiency showed changes similar to AngII-infused aortas, characterised by a loss of contractile markers, increased fibrosis, and activation of matrix metalloproteinase 9. When BMP-4 deficiency was combined with AngII infusion, there was a significantly higher rate of apoptosis and aortic dilatation. In vitro, VSMCs with mRNA silencing of BMP-4 displayed a dedifferentiated phenotype with activated canonical BMP signalling. In contrast, BMP-2-deficient VSMCs exhibited the opposite phenotype. The compensatory regulation between BMP-2 and BMP-4, with BMP-4 promoting the contractile phenotype, appeared to be independent of the canonical signalling pathway. Taken together, these results demonstrate the impact of VSMC-specific BMP-4 deficiency on TAA development.

Published
2024
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3. BMPER Improves Vascular Remodeling and the Contractile Vascular SMC Phenotype

Author

Franziska Pankratz, Aziza Maksudova, Roman Goesele, Lena Meier, Kora Proelss, Katia Marenne, Ann-Kathrin Thut, Gerhard Sengle, Annkatrin Correns, Jeanina Begelspacher, Deniz Alkis, Patrick M. Siegel, Christian Smolka, Sebastian Grundmann, Martin Moser, Qian Zhou, and Jennifer S. Esser

Subjects
vSMCs, Organic Chemistry, vascular disease, General Medicine, neointima, Catalysis, Computer Science Applications, Inorganic Chemistry, restenosis, growth factors/cytokines, Physical and Theoretical Chemistry, BMPER, Molecular Biology, Spectroscopy, remodeling
Abstract

Dedifferentiated vascular smooth muscle cells (vSMCs) play an essential role in neointima formation, and we now aim to investigate the role of the bone morphogenetic protein (BMP) modulator BMPER (BMP endothelial cell precursor-derived regulator) in neointima formation. To assess BMPER expression in arterial restenosis, we used a mouse carotid ligation model with perivascular cuff placement. Overall BMPER expression after vessel injury was increased; however, expression in the tunica media was decreased compared to untreated control. Consistently, BMPER expression was decreased in proliferative, dedifferentiated vSMC in vitro. C57BL/6_Bmper+/− mice displayed increased neointima formation 21 days after carotid ligation and enhanced expression of Col3A1, MMP2, and MMP9. Silencing of BMPER increased the proliferation and migration capacity of primary vSMCs, as well as reduced contractibility and expression of contractile markers, whereas stimulation with recombinant BMPER protein had the opposite effect. Mechanistically, we showed that BMPER binds insulin-like growth factor-binding protein 4 (IGFBP4), resulting in the modulation of IGF signaling. Furthermore, perivascular application of recombinant BMPER protein prevented neointima formation and ECM deposition in C57BL/6N mice after carotid ligation. Our data demonstrate that BMPER stimulation causes a contractile vSMC phenotype and suggest that BMPER has the potential for a future therapeutic agent in occlusive cardiovascular diseases.

Published
2023
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4. Niederlagen und Kriegsfolgen – 'Vae Victis' oder 'Vae Victoribus'? Vom Alten Orient bis ins Europäische Mittelalter

Author

Lena Meier, Oliver Stoll, Lena Meier, and Oliver Stoll

Subjects
Middle Ages, Civilization, Medieval
Abstract

Wie geht man mit militärischen Niederlagen um? Und welche Folgen haben Kriege auf kurze und mittlere Sicht für die kriegführenden Gesellschaften? Die (kultur-)historischen und interdisziplinären Beiträge in diesem Band spannen den Bogen vom Alten Orient und der Klassischen Antike bis ins Europäische Mittelalter und von Mesopotamien über Griechenland, Rom und Ägypten bis nach Mitteleuropa. Die Ergebnisse, zu denen die Autoren gelangen, illustrieren die erschreckende Aktualität des Themas: Kriege und deren Folgen, mithin die Veränderungen durch den Krieg, sind Universalien der Geschichte.

Published
2016

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