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2. Psychosocial Effects of COVID-19 Measures on (Pre-)Dementia Patients During Second Lockdown

Author

Bakker, Els D., primary, van Maurik, Ingrid S., additional, Mank, Arenda, additional, Zwan, Marissa D., additional, Waterink, Lisa, additional, van den Buuse, Susanne, additional, van den Broeke, Jennifer R., additional, Gillissen, Freek, additional, van de Beek, Marleen, additional, Lemstra, Evelien, additional, van den Bosch, Karlijn A., additional, van Leeuwenstijn, Mardou, additional, Bouwman, Femke H., additional, Scheltens, Philip, additional, and van der Flier, Wiesje M., additional

Published
2022
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3. Acute response to cholinergic challenge predicts long‐term response to galantamine treatment in patients with Alzheimer's disease

Author

Baakman, Anne Catrien, primary, Gavan, Carmen, additional, van Doeselaar, Lotte, additional, de Kam, Marieke, additional, Broekhuizen, Karen, additional, Bajenaru, Ovidiu, additional, Camps, Laura, additional, Swart, Eleonora L., additional, Kalisvaart, Kees, additional, Schoonenboom, Niki, additional, Lemstra, Evelien, additional, Scheltens, Philip, additional, Cohen, Adam, additional, van Gerven, Joop, additional, and Groeneveld, Geert Jan, additional

Published
2022
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4. Psychosocial effects of Corona virus measures on (pre‐)dementia patients during 2 nd lockdown

Author

Bakker, Els D, primary, Van Maurik, Ingrid S, additional, Mank, Arenda, additional, Zwan, Marissa D, additional, van den Buuse, Susanne, additional, van den Broeke, Jennifer R, additional, Gillissen, Freek, additional, van de Beek, Marleen, additional, Lemstra, Evelien, additional, van den Bosch, Karlijn A, additional, van Leeuwenstijn, Mardou, additional, Bouwman, Femke H, additional, Scheltens, Philip, additional, and van der Flier, Wiesje M, additional

Published
2021
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5. Acute response to cholinergic challenge predicts long-term response to galantamine treatment in patients with Alzheimer's Disease

Author

Baakman, Anne Catrien, primary, Gavan, Carmen, additional, Doeselaar, Lotte Van, additional, Kam, Marieke de, additional, Broekhuizen, Karen, additional, Bajenaru, Ovidiu, additional, Camps, Laura, additional, Swart, Eleonora, additional, Kalisvaart, Kees, additional, Schoonenboom, Nikki, additional, Lemstra, Evelien, additional, Scheltens, Philip, additional, Cohen, Adam, additional, Gerven, Joop Van, additional, and Groeneveld, Geert Jan, additional

Published
2021
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7. Relationship between clinical symptomatology and disease burden in dementia with Lewy bodies: An overview of the DEvELOP baseline results

Author

van de Beek, Marleen, primary, van Steenoven, Inger, additional, van der Zande, Jessica J., additional, Teunissen, Charlotte E., additional, Stam, Cornelis J., additional, Raijmakers, Pieter G.H.M., additional, Scheltens, Philip, additional, van Der Flier, Wiesje, additional, and Lemstra, Evelien, additional

Published
2020
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8. Psychosocial Effects of Corona Measures on Patients With Dementia, Mild Cognitive Impairment and Subjective Cognitive Decline

Author

van Maurik, Ingrid S., primary, Bakker, Els D., additional, van den Buuse, Susanne, additional, Gillissen, Freek, additional, van de Beek, Marleen, additional, Lemstra, Evelien, additional, Mank, Arenda, additional, van den Bosch, Karlijn A., additional, van Leeuwenstijn, Mardou, additional, Bouwman, Femke H., additional, Scheltens, Philip, additional, and van der Flier, Wiesje M., additional

Published
2020
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9. Different combinations of diagnostic tests discriminate specific subtypes of dementia

Author

Rhodius-Meester, Hanneke F.M., Bruun, Marie, Baroni, Marta, Gjerum, Le, Remes, Anne M., Urhemaa, Timo, Tolonen, Antti, Rueckert, Daniel, van Gils, Mark, Lemstra, Evelien, Barkhof, Frederik, Frederiksen, Kristian S., Waldemar, Gunhild, Scheltens, Philip, Soininen, Hilkka, Mecocci, Patrizia, Koikkalainen, Juha, Lötjönen, Jyrki, and van der Flier, Wiesje M.

Published
2018

11. DATA-DRIVEN DIAGNOSIS OF DEMENTIA DISORDERS: THE PREDICTND VALIDATION STUDY

Author

Bruun, Marie, Gjerum, Le, Frederiksen, Kristian Steen, Rhodius-Meester, Hanneke FM., Baroni, Marta, Lemstra, Evelien, Bremer, Jonne A.E., Remes, Anne, Urhemaa, Timo, Tolonen, Antti, Tong, Tong, Guerrero, Ricardo, Rueckert, Daniel, Waldemar, Gunhild, Soininen, Hilkka, van der Flier, Wiesje M., Mecocci, Patrizia, Lotjonen, Jyrki, and Hasselbalch, Steen Gregers

Published
2017
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13. P2‐349: DIFFERENT COMBINATIONS OF DIAGNOSTIC TESTS DISCRIMINATE SPECIFIC SUBTYPES OF DEMENTIA

Author

Rhodius- Meester, Hanneke FM., primary, Bruun, Marie, additional, Baroni, Marta, additional, Gjerum, Le, additional, Remes, Anne, additional, Urhemaa, Timo, additional, Tolonen, Antti, additional, Rueckert, Daniel, additional, van Gils, Mark, additional, Lemstra, Evelien, additional, Barkhof, Frederik, additional, Frederiksen, Kristian Steen, additional, Waldemar, Gunhild, additional, Scheltens, Philip, additional, Soininen, Hilkka, additional, Mecocci, Patrizia, additional, Koikkalainen, Juha, additional, Lotjonen, Jyrki, additional, Hasselbalch, Sten Gregers, additional, and Van der Flier, Wiesje M., additional

Published
2018
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14. [P1–375]: DATA‐DRIVEN DIAGNOSIS OF DEMENTIA DISORDERS: THE PREDICTND VALIDATION STUDY

Author

Bruun, Marie, primary, Gjerum, Le, additional, Frederiksen, Kristian Steen, additional, Rhodius‐Meester, Hanneke FM., additional, Baroni, Marta, additional, Lemstra, Evelien, additional, Bremer, Jonne A.E., additional, Remes, Anne, additional, Urhemaa, Timo, additional, Tolonen, Antti, additional, Tong, Tong, additional, Guerrero, Ricardo, additional, Rueckert, Daniel, additional, Waldemar, Gunhild, additional, Soininen, Hilkka, additional, van der Flier, Wiesje M., additional, Mecocci, Patrizia, additional, Lotjonen, Jyrki, additional, and Hasselbalch, Steen Gregers, additional

Published
2017
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16. DIFFERENT COMBINATIONS OF DIAGNOSTIC TESTS DISCRIMINATE SPECIFIC SUBTYPES OF DEMENTIA

Author

Rhodius- Meester, Hanneke FM., Bruun, Marie, Baroni, Marta, Gjerum, Le, Remes, Anne, Urhemaa, Timo, Tolonen, Antti, Rueckert, Daniel, van Gils, Mark, Lemstra, Evelien, Barkhof, Frederik, Frederiksen, Kristian Steen, Waldemar, Gunhild, Scheltens, Philip, Soininen, Hilkka, Mecocci, Patrizia, Koikkalainen, Juha, Lotjonen, Jyrki, Hasselbalch, Sten Gregers, and Van der Flier, Wiesje M.

Published
2018
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19. P4-163: TRAJECTORIES OF COGNITIVE DECLINE IN VARIOUS TYPES OF DEMENTIA

Author

Smits, Lieke, primary, Corien van Harten, Argonde, additional, Pijnenburg, Yolande, additional, Koedam, Esther, additional, Sistermans, Nicole, additional, Roos-Reuling, Ilona, additional, Prins, Niels, additional, Lemstra, Evelien, additional, Scheltens, Philip, additional, and van der Flier, Wiesje M., additional

Published
2014
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22. P2-094: The role of ASL-measured cerebral blood flow in the differential diagnosis of Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies

Author

Binnewijzend, Maja, primary, Kuijer, Joost, additional, Van der Flier, Wiesje, additional, Benedictus, Marije, additional, Möller, Christiane, additional, Pijnenburg, Yolande, additional, Lemstra, Evelien, additional, Prins, Niels, additional, Wattjes, Mike, additional, van Berckel, Bart, additional, Scheltens, Philip, additional, and Barkhof, Frederik, additional

Published
2013
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23. IC-P-062: The role of ASL-measured cerebral blood flow in the differential diagnosis of Alzheimer's disease, frontotemporal dementia and dementia with Lewy bodies

Author

Binnewijzend, Maja, primary, Kuijer, Joost, additional, Van der Flier, Wiesje, additional, Benedictus, Marije, additional, Möller, Christiane, additional, Pijnenburg, Yolande, additional, Lemstra, Evelien, additional, Prins, Niels, additional, Wattjes, Mike, additional, van Berckel, Bart, additional, Scheltens, Philip, additional, and Barkhof, Frederik, additional

Published
2013
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24. Psychosocial effects of Corona virus measures on (pre‐)dementia patients during 2nd lockdown.

Author

Bakker, Els D, Van Maurik, Ingrid S, Mank, Arenda, Zwan, Marissa D, van den Buuse, Susanne, van den Broeke, Jennifer R, Gillissen, Freek, van de Beek, Marleen, Lemstra, Evelien, van den Bosch, Karlijn A, van Leeuwenstijn, Mardou, Bouwman, Femke H, Scheltens, Philip, and van der Flier, Wiesje M

Abstract

Background: The COVID‐19 pandemic poses enormous social challenges, especially during lockdown. Recently, the second lockdown started in the Netherlands. We aimed to investigate and compare the psychosocial effects of corona measures during lockdown in memory clinic (pre‐)dementia patients and their caregivers. Method: During second lockdown, n=137 symptomatic patients (age=67.7±6.54, 36.5%F, MMSE = 24.4±4.7; n=82 dementia, n=55 MCI), n=244 cognitively normal (age=63.6±7.56, 38.9%F, MMSE = 28.8±1.18; SCD) and n=198 caregivers of Alzheimer Center Amsterdam completed a survey on psychosocial effects of corona. Questions related to loneliness, worries for faster cognitive decline, psychological and behavioral problems. In a subset of patients (n=169) and caregivers (n=38) we were able to compare their answers to answers on a similar survey completed during first lockdown (May 2020). Result: In total, n=17 (4.5%) patients [n=3 (2.2%) symptomatic, n=14 (5.7%) cognitively normal] and n=8 (4%) caregivers reported a positive test result for COVID‐19. Over one‐third of caregivers reported worries for faster cognitive decline [n=76 (38%)] and behavioral problems [n=70 (35%)] in patients. Feelings of loneliness were experienced by n=23 (17%) symptomatic patients, n=44 (18%) cognitively normal and n=50 (25%) caregivers. One quarter of patients [n=78 (25%)] reported more depressive feelings during lockdown [n=27 (20%) symptomatic, n=51 (21%) cognitively normal]. More feelings of fatigue were reported by n=23 (17%) symptomatic patients, n=46 (19%) cognitively normal, and n=67 (34%) caregivers. Comparing results to those obtained during the first lockdown, feelings of loneliness [Χ2=26.4, p<.001 in patients, Χ2=10.3, p<.001 in caregivers] and anxiety [Χ2=25.9, p<.001 in patients, Χ2=6.69, p=.010 in caregivers] increased. During second lockdown, less feelings of apathy [Χ2=13.0, p<.001], but more depressive feelings [Χ2=27.6, p<.001] were reported in patients compared to first lockdown. Caregivers were more worried for memory decline in patients during second lockdown [Χ2=4.09, p=.043]. Conclusion: Compared to first lockdown, feelings of loneliness, anxiety, worries for faster cognitive decline and depressive feelings increased in second lockdown. A noticeable part of (pre‐)dementia patients and caregivers report feelings of loneliness, worries for faster cognitive decline, psychological and behavioral problems in second lockdown. These psychosocial effects are more frequently reported by caregivers than patients. [ABSTRACT FROM AUTHOR]

Published
2021
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36. [Role of secondary care too small in Dutch College of General Practitioners' (NHG) practice guideline 'Dementia'].

Author

Olde Rikkert MG, Lemstra EW, and Verhey FR

Subjects
Female, Humans, Male, Dementia diagnosis, General Practice standards, General Practitioners standards, Practice Patterns, Physicians'
Abstract

The third revision of the Dutch College of General Practitioners' practice guideline 'Dementia' is a major improvement and stimulates the general practitioner by providing concrete advice on stepped care in dementia diagnostics and organizing care management in order to obtain improvement in the quality and realization of dementia care in the primary care setting. However, this practice guideline does not address more effective and efficient dementia care by collaboration between primary and secondary care as it discourages the prescription of cholinesterase inhibitors and recommends limiting further diagnostic procedures to patients in whom a treatable condition is likely. Although, this new practice guideline strengthens the central role of the general practitioner in Dutch dementia care, this role would be further reinforced if general practitioners were to adopt integrated diagnostics of dementia and relevant additional diseases burden as the starting point.

Published
2012

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