Search

Your search keyword '"Lemper, Marie"' showing total 15 results
Start Over Author "Lemper, Marie"
15 results on '"Lemper, Marie"'

3. Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Author

Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W, Pan, Fong C, Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A, Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher VE, Van de Casteele, Mark, German, Michael S, Bouwens, Luc, and Heimberg, Harry

Subjects
Biochemistry and Cell Biology, Biological Sciences
Abstract

This article has been retracted; see accompanying Retraction Note, which can be accessed via a link at the top of the paper.

Published
2020

6. Sources of beta cells inside the pancreas

Author

De Groef, Sofie, Staels, Willem, Van Gassen, Naomi, Lemper, Marie, Yuchi, Yixing, Sojoodi, Mozhdeh, Bussche, Leen, Heremans, Yves, Leuckx, Gunter, De Leu, Nico, Van de Casteele, Mark, Baeyens, Luc, and Heimberg, Harry

Published
2016
Full Text
View/download PDF

7. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Author

Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W, Pan, Fong C, Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A, Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher V E, Van de Casteele, Mark, German, Michael S, Bouwens, Luc, and Heimberg, Harry

Published
2014
Full Text
View/download PDF

8. Baby Care Products

Author

Lemper, Marie, primary, De Paepe, Kristien, additional, Rogiers, Vera, additional, and Adam, Ralf, additional

Published
2009
Full Text
View/download PDF

9. Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

Author

Ovacik, Ayse Meric, primary, Li, Ji, additional, Lemper, Marie, additional, Danilenko, Dimitry, additional, Stagg, Nicola, additional, Mathieu, Mary, additional, Ellerman, Diego, additional, Gupta, Vinita, additional, Kalia, Navdeep, additional, Nguy, Trung, additional, Plaks, Vicki, additional, David Johnson, Clarissa, additional, Wang, Weiru, additional, Brumm, Jochen, additional, Fine, Bernard, additional, Junttila, Teemu, additional, Lin, Kedan, additional, Carter, Paul J., additional, Prabhu, Saileta, additional, Spiess, Christoph, additional, and Kamath, Amrita V., additional

Published
2018
Full Text
View/download PDF

11. Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.

Author

Ovacik, Ayse Meric, Li, Ji, Lemper, Marie, Danilenko, Dimitry, Stagg, Nicola, Mathieu, Mary, Ellerman, Diego, Gupta, Vinita, Kalia, Navdeep, Nguy, Trung, Plaks, Vicki, David Johnson, Clarissa, Wang, Weiru, Brumm, Jochen, Fine, Bernard, Junttila, Teemu, Lin, Kedan, Carter, Paul J., Prabhu, Saileta, and Spiess, Christoph

Published
2019
Full Text
View/download PDF

12. Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitroand in vivoproperties

Author

Ovacik, Ayse Meric, Li, Ji, Lemper, Marie, Danilenko, Dimitry, Stagg, Nicola, Mathieu, Mary, Ellerman, Diego, Gupta, Vinita, Kalia, Navdeep, Nguy, Trung, Plaks, Vicki, David Johnson, Clarissa, Wang, Weiru, Brumm, Jochen, Fine, Bernard, Junttila, Teemu, Lin, Kedan, Carter, Paul J., Prabhu, Saileta, Spiess, Christoph, and Kamath, Amrita V.

Abstract

ABSTRACTBispecific antibody production using single host cells has been a new advancement in the antibody engineering field. We previously showed comparable in vitrobiological activity and in vivomouse pharmacokinetics (PK) for two novel single cell variants (v10 and v11) and one traditional dual cell in vitro-assembled anti-human epidermal growth factor receptor 2/CD3 T-cell dependent bispecific (TDB) antibodies. Here, we extended our previous work to assess single cell-produced bispecific variants of a novel TDB against FcRH5, a B-cell lineage marker expressed on multiple myeloma (MM) tumor cells. An in vitro-assembled anti- FcRH5/CD3 TDB antibody was previously developed as a potential treatment option for MM. Two bispecific antibody variants (designs v10 and v11) for manufacturing anti-FcRH5/CD3 TDB in single cells were compared to in vitro-assembled TDB in a dual-cell process to understand whether differences in antibody design and production led to any major differences in their in vitrobiological activity, in vivomouse PK, and PK/pharmacodynamics (PD) or immunogenicity in cynomolgus monkeys (cynos). The binding, in vitropotencies, in vitropharmacological activities and in vivo PK in mice and cynos of these single cell TDBs were comparable to those of the in vitro-assembled TDB. In addition, the single cell and in vitro-assembled TDBs exhibited robust PD activity and comparable immunogenicity in cynos. Overall, these studies demonstrate that single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitroand in vivoproperties, and support further development of single-cell production method for anti-FcRH5/CD3 TDBs and other single-cell bispecifics.

Published
2019
Full Text
View/download PDF

13. Baby Care Products. In: André O. Barel, Marc Paye and Howard I. Maibach (Eds). Handbook of Cosmetic Science and Technology

Author

Lemper, Marie, Barel, André O., Paye, Marc, Maibach, Howard I., and Toxicology, Dermato-cosmetology and Pharmacognosy

Subjects
safety evaluation, risk assessment, baby care, integumentary system, full-term baby, newborn skin, cosmetic products, skin cleansing, protecting cosmetics, sun protecti, baby skin problems, diaper rash, miliaria, acne ne
Abstract

A great variety of baby skin and hair care products are brought to the market. Those products claim to be specially developed for the delicate baby skin and therefore specific requirements should be considered when developing products for the care of babies. In order to understand whether babies need different skin and hair care cosmetics than adults, it seems necessary to explain some anatomical and physiological differences of the skin and annexes between both groups. A further distinction can be made between the skin of full-term and premature babies, but in this chapter only the former group is considered. Cleansing and protective baby cosmetics are available and in the EU they are based on exposure-based risk assessment as well for the individual ingredients as for the finished products. Finally, some common baby skin problems and the applicability of cosmetic products in impaired skin conditions are discussed.

Published
2009

14. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Author

Baeyens, Luc, primary, Lemper, Marie, additional, Leuckx, Gunter, additional, De Groef, Sofie, additional, Bonfanti, Paola, additional, Stangé, Geert, additional, Shemer, Ruth, additional, Nord, Christoffer, additional, Scheel, David W, additional, Pan, Fong C, additional, Ahlgren, Ulf, additional, Gu, Guoqiang, additional, Stoffers, Doris A, additional, Dor, Yuval, additional, Ferrer, Jorge, additional, Gradwohl, Gerard, additional, Wright, Christopher V E, additional, Van de Casteele, Mark, additional, German, Michael S, additional, Bouwens, Luc, additional, and Heimberg, Harry, additional

Published
2013
Full Text
View/download PDF

15. Sources of beta cells inside the pancreas.

Author

Groef, Sofie, Staels, Willem, Gassen, Naomi, Lemper, Marie, Yuchi, Yixing, Sojoodi, Mozhdeh, Bussche, Leen, Heremans, Yves, Leuckx, Gunter, Leu, Nico, Casteele, Mark, Baeyens, Luc, and Heimberg, Harry

Abstract

The generation of beta(-like) cells to compensate for their absolute or relative shortage in type 1 and type 2 diabetes is an obvious therapeutic strategy. Patients first received grafts of donor islet cells over 25 years ago, but this procedure has not become routine in clinical practice because of a donor cell shortage and (auto)immune problems. Transplantation of differentiated embryonic and induced pluripotent stem cells may overcome some but not all the current limitations. Reprogramming exocrine cells towards functional beta(-like) cells would offer an alternative abundant and autologous source of beta(-like) cells. This review focuses on work by our research group towards achieving such a source of cells. It summarises a presentation given at the 'Can we make a better beta cell?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Amin Ardestani and Kathrin Maedler, DOI: , and by Heiko Lickert and colleagues, DOI: ) and a commentary by the Session Chair, Shanta Persaud (DOI: ). [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results