21 results on '"Lembach H"'
Search Results
2. Anatomical Liver Resections for Intrahepatic Cholangiocarcinoma: Perioperative Results and Survival. Multicenter Study in Two University Hospitals in Latin America
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Ochoa, G., primary, Cuneo, N., additional, Rebolledo, P., additional, Achurra, P., additional, Mandiola, C., additional, Orellana, O., additional, Lembach, H., additional, Castillo, J., additional, Martinez, J., additional, Diaz, J.C., additional, Briceño, E., additional, Jarufe, N., additional, Dib, M., additional, and Saure, A., additional
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- 2022
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3. P-26 PORTAL VENOUS THROMBOSIS IN TRANSPLANTED CIRRHOTIC PATIENTS AT THE “HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE”
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Henríquez Auba, V.N., Ramirez, F., Fabres, M., Abarca, P., Astrosa, B., Vera, D., Diaz, J.C., Castillo, J., Lembach, H., Sauré, A., Cattaneo, M., Poniachik, J., and Urzua, A.
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- 2021
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4. Severe Sepsis Mimicking Primary Nonfunction Following Liver Transplantation: Normothermic Machine Perfusion Is a Potential Environment for Bacterial Overgrowth and Transmission From Donor to Recipient. A Case Report
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Hann, A., primary, Lembach, H., additional, Dassanayake, B., additional, Carvalheiro, A., additional, McKay, S., additional, Rajoriya, N., additional, Armstrong, M.J., additional, Bartlett, D., additional, David, M., additional, and Perera, M.T.P.R., additional
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- 2020
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5. [Cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma in cirrhotic patients].
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Salinas M, Simian D, Carreño L, Cattaneo M, Urzúa Á, Sauré A, Lembach H, Castillo J, Díaz JC, and Poniachik J
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- Female, Humans, Middle Aged, Male, Liver Cirrhosis complications, Bile Ducts, Intrahepatic pathology, Retrospective Studies, Liver Neoplasms diagnosis, Carcinoma, Hepatocellular etiology, Cholangiocarcinoma complications, Cholangiocarcinoma diagnosis, Cholangiocarcinoma pathology, Bile Duct Neoplasms complications, Bile Duct Neoplasms diagnosis
- Abstract
Background: Cholangiocarcinoma (CCA) is a primary hepatic tumor, frequently found in patients with liver cirrhosis and biliary tract diseases. Its varieties include isolated CCA or "combined hepatocellular-cholangiocarcinoma" (cHCC-CCA). The latter is uncommon, with poorly defined diagnostic criteria and natural history., Aim: To characterize patients with cirrhosis with a pathological diagnosis of CCA and cHCC-CCA., Material and Methods: Forty-nine liver biopsies with a pathological diagnosis of CCA were reviewed. The clinical records of patients were reviewed to fetch demographic variables, etiology of cirrhosis and clinical presentation., Results: Eight of the 49 patients had cirrhosis (16% of CCA biopsies reviewed). Their median age was 64 (27-71) years and five were females. Four patients had CCA, three patients cHCC-CCA and one had a bifocal tumor. Patients in the CCA group were more commonly symptomatic. Alpha-fetoprotein and CA 19-9 levels were elevated in one of eight and four of six patients, respectively. Within 12 months from diagnosis, five of eight patients died., Conclusions: In most of these cases, the diagnosis of cHCC-CCA and CCA was made in the liver explant study without previous imaging diagnosis. This reinforces the usefulness of the histological study, in specific cases, prior to liver transplantation and emphasizes the importance of systematic explant exploration in these cases.
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- 2022
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6. Reduced Immune Response to Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Cohort of Immunocompromised Patients in Chile.
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Balcells ME, Le Corre N, Durán J, Ceballos ME, Vizcaya C, Mondaca S, Dib M, Rabagliati R, Sarmiento M, Burgos PI, Espinoza M, Ferrés M, Martinez-Valdebenito C, Ruiz-Tagle C, Ortiz C, Ross P, Budnik S, Solari S, Vizcaya MLÁ, Lembach H, Berrios-Rojas R, Melo-González F, Ríos M, Kalergis AM, Bueno SM, and Nervi B
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- Antibodies, Neutralizing, Antibodies, Viral, COVID-19 Vaccines, Chile epidemiology, Humans, Immunity, Immunocompromised Host, Prospective Studies, SARS-CoV-2, Vaccines, Inactivated, COVID-19 prevention & control, Rheumatic Diseases, Viral Vaccines
- Abstract
Background: Inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been widely implemented in low- and middle-income countries. However, immunogenicity in immunocompromised patients has not been established. Herein, we aimed to evaluate immune response to CoronaVac vaccine in these patients., Methods: This prospective cohort study included 193 participants with 5 different immunocompromising conditions and 67 controls, receiving 2 doses of CoronaVac 8-12 weeks before enrollment. The study was conducted between May and August 2021, at Red de Salud UC-CHRISTUS, Santiago, Chile. Neutralizing antibody (NAb) positivity, total anti-SARS-CoV-2 immunoglobulin G antibody (TAb) concentrations, and T-cell responses were determined., Results: NAb positivity and median neutralizing activity were 83.1% and 51.2% for the control group versus 20.6% and 5.7% (both P < .001) in the solid organ transplant group, 41.5% and 19.2% (both P < .0001) in the autoimmune rheumatic diseases group, 43.3% (P < .001) and 21.4% (P<.01 or P = .001) in the cancer with solid tumors group, 45.5% and 28.7% (both P < .001) in the human immunodeficiency virus (HIV) infection group, 64.3% and 56.6% (both differences not significant) in the hematopoietic stem cell transplant group, respectively. TAb seropositivity was also lower for the solid organ transplant (20.6%; P < .0001), rheumatic diseases (61%; P < .001), and HIV groups (70.9%; P = .003), compared with the control group (92.3%). On the other hand, the number of interferon γ spot-forming T cells specific for SARS-CoV-2 tended to be lower in all immunocompromising conditions but did not differ significantly between groups., Conclusions: Diverse immunocompromising conditions markedly reduce the humoral response to CoronaVac vaccine. These findings suggest that a boosting vaccination strategy should be considered in these vulnerable patients., Clinical Trials Registration: NCT04888793., (© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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- 2022
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7. Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours.
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Hann A, Lembach H, Nutu A, Mergental H, Isaac JL, Isaac JR, Oo YH, Armstrong MJ, Rajoriya N, Afford S, Bartlett D, Mirza DF, Hartog H, and Perera MTPR
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- Brain Death, Humans, Lactic Acid, Liver surgery, Living Donors, Organ Preservation, Perfusion adverse effects, Liver Transplantation adverse effects
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- 2022
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8. Health-related quality of life, uncertainty and coping strategies in solid organ transplant recipients during shielding for the COVID-19 pandemic.
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McKay SC, Lembach H, Hann A, Okoth K, Anderton J, Nirantharakumar K, Magill L, Torlinska B, Armstrong M, Mascaro J, Inston N, Pinkney T, Ranasinghe A, Borrows R, Ferguson J, Isaac J, Calvert M, Perera MTPR, and Hartog H
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- Adaptation, Psychological, Adult, Cross-Sectional Studies, Humans, Pandemics, Quality of Life, SARS-CoV-2, Transplant Recipients, Uncertainty, COVID-19, Organ Transplantation
- Abstract
Strict isolation of vulnerable individuals has been a strategy implemented by authorities to protect people from COVID-19. Our objective was to investigate health-related quality of life (HRQoL), uncertainty and coping behaviours in solid organ transplant (SOT) recipients during the COVID-19 pandemic. A cross-sectional survey of adult SOT recipients undergoing follow-up at our institution was performed. Perceived health status, uncertainty and coping strategies were assessed using the EQ-5D-5L, Short-form Mishel Uncertainty in Illness Scale (SF-MUIS) and Brief Cope, respectively. Interactions with COVID-19 risk perception, access to health care, demographic and clinical variables were assessed. The survey was completed by 826 of 3839 (21.5%) invited participants. Overall, low levels of uncertainty in illness were reported, and acceptance was the major coping strategy (92%). Coping by acceptance, feeling protected, self-perceived susceptibility to COVID-19 were associated with lower levels of uncertainty. Health status index scores were significantly lower for those with mental health illness, compromised access to health care, a perceived high risk of severe COVID-19 infection and higher levels of uncertainty. A history of mental health illness, risk perceptions, restricted healthcare access, uncertainty and coping strategies was associated with poorer HRQoL in SOT recipients during strict isolation. These findings may allow identification of strategies to improve HRQoL in SOT recipients during the pandemic., (© 2021 Steunstichting ESOT. Published by John Wiley & Sons Ltd.)
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- 2021
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9. Hepatocyte necrosis on liver allograft biopsy: Normothermic machine perfusion is the ideal platform for using these grafts in high-risk recipients.
- Author
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Hann A, Lembach H, Alzoubi M, McKay SC, Hartog H, Neil DAH, Mirza DF, and Perera MTPR
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- Allografts, Biopsy, Hepatocytes, Humans, Necrosis, Perfusion, Liver, Organ Preservation
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- 2021
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10. Assessment and Transplantation of Orphan Donor Livers: A Back-to-Base Approach to Normothermic Machine Perfusion.
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Hann A, Lembach H, Hartog H, and P R Perera MT
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- Humans, Living Donors, Organ Preservation, Perfusion, Liver Transplantation
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- 2021
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11. Controversies regarding shielding and susceptibility to COVID-19 disease in liver transplant recipients in the United Kingdom.
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John Hann A, Lembach H, McKay SC, Perrin M, Isaac J, Oo YH, Mutimer D, Mirza DF, Hartog H, and Perera T
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- Humans, Risk Factors, SARS-CoV-2, Transplant Recipients, United Kingdom, COVID-19, Cross Infection, Liver Transplantation, Middle East Respiratory Syndrome Coronavirus
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- 2020
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12. Ex Situ Arterial Reconstruction During Normothermic Perfusion of the Liver.
- Author
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Nasralla D, Lembach H, Mergental H, Mirza D, Friend P, Muiesan P, and Perera M
- Abstract
Background: Aberrant hepatic arterial anatomy may be seen in up to 30% of liver grafts, and reconstruction prolongs the cold ischemic time or the arterialization times. If normothermic machine preservation (NMP) is used to preserve liver grafts, the presence of aberrant arterial anatomy poses a challenge. Dual arterial cannulation is a temporary solution to enable effective perfusion, until optimal circumstances are met for arterial reconstruction, without compromising ischemia time. To date the technical and logistical feasibility of arterial reconstruction ex situ and during NMP has not been reported., Methods: Series of 5 cases from the Consortium for Organ Preservation in Europe randomized controlled trial in which grafts with arterial anatomic variations were reconstructed while organs were perfused on NMP., Results: One donor after cardiac death and 4 donor after brain death livers with arterial anatomical variations reconstructed while on NMP were included. All patients survived transplantation, spending 1-7 d in intensive care unit and discharged home after 5-15 d. None of the cases developed early allograft dysfunction or any early technical complications. At follow-up, there were no late hepatic artery thrombosis, stenosis, or any other vascular-related complication. Four of 5 patients underwent magnetic resonance cholangiopancreatography at 6 mo with no evidence of ischemic cholangiopathy., Conclusions: The case series described above suggests that ex vivo arterial reconstruction surgery on liver grafts while on board the NMP device is feasible, safe, and effective., Competing Interests: P.F. is cofounder, Chief Medical Officer, and consultant to OrganOX Limited and also holds shares in the company. D.M. holds minor shares in OrganOX Limited. The other authors declare no conflicts of interest., (Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.)
- Published
- 2020
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13. Resuming liver transplantation amid the COVID-19 pandemic.
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Lembach H, Hann A, McKay SC, Hartog H, Vasanth S, El-Dalil P, Murphy N, Snelson K, Patel JK, Isaac JL, Armstrong MJ, Ferguson J, Holt A, Bennett D, Sharp I, Cockwell P, Mirza DF, Isaac JR, and Perera MTPR
- Subjects
- Betacoronavirus, COVID-19, Clinical Protocols, Hospital Administration, Humans, Immunocompromised Host, SARS-CoV-2, United Kingdom, Coronavirus Infections epidemiology, Delivery of Health Care, Liver Transplantation, Pandemics, Pneumonia, Viral epidemiology
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- 2020
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14. [Surgical complications in cirrhotic patients. Analysis of 102 cases].
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Gajardo AI, Poniachik R, Freundlich A, Vera DB, Chesta C, Rappoport J, Díaz JC, Saure A, Castillo J, Lembach H, González K, Navea C, and Poniachik J
- Subjects
- Aged, Chile epidemiology, Elective Surgical Procedures, Female, Humans, Liver Cirrhosis complications, Liver Cirrhosis surgery, Male, Middle Aged, Severity of Illness Index, End Stage Liver Disease
- Abstract
Background: Cirrhotic patients have an increased surgical risk due to potential intra and postoperative complications., Aim: To describe the clinical characteristics and surgical complications of cirrhotic patients undergoing surgery in a Chilean university hospital., Patients and Methods: Review of medical records of 102 cirrhotic patients aged 60 ± 11 years (52% males) who underwent elective or urgency surgery at an university hospital between 2010 and 2016. General, pre-surgical, and post-surgical complications were recorded., Results: The main etiologies of cirrhosis were non-alcoholic steatohepatitis (31%), and alcoholic cirrhosis (28%). Child-Pugh scores were A, B and C in 50, 28 and 22% of cases respectively. Median MELD (Model for End-stage Liver Disease) score was 11 (interquartile range: 10-15). The surgical procedure was elective in 71% of cases, with predominance of abdominal surgery (86%). The American Society of Anesthesiologists (ASA) score was three or more in 52% of patients. The frequency of any adverse outcome was 62%. The frequency increased along with the severity of cirrhosis and when surgery was urgent. The most common complications were acute renal failure (24%), increased ascites (23%) and encephalopathy (22%). Admission to intensive care unit occurred on 26% of patients, with six hospital deaths., Conclusions: In these patients, surgical complications were common, although with low mortality.
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- 2019
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15. Reversibility of Acquired Hepatocerebral Degeneration After Liver Transplantation.
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Arenas A, Urzúa Á, Poniachik J, Carlos Diaz J, Castillo J, Saure A, Lembach H, Cancino A, Ibarra J, Besa C, Wolff R, Arrese M, and Benítez C
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- Adult, End Stage Liver Disease complications, Female, Hepatolenticular Degeneration etiology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Treatment Outcome, End Stage Liver Disease surgery, Hepatolenticular Degeneration diagnosis, Liver Transplantation
- Published
- 2018
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16. [Recommendations for the management of pancreatic cancer type adenocarcinoma: A consensus statement reached during the 2015 Latin American Symposium on Gastroenterological Oncology].
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Caglevic C, Gallardo J, de la Torre M, Mahave M, Müller B, Solé S, Moscoso Y, De La Fuente H, Roa JC, Hoefler S, Butte JM, González M P, O'Connor JM, Torres J, Pérez Encalada V, Alarcón Cano D, Ubillos L, Rolfo C, Lingua A, Díaz Romero C, Padilla Rosciano A, Cuartero V, Calderillo Ruiz G, Schwartsmann G, Kon Jara X, Andrade G A, Mas López L, Barajas O, Carballido M, Lembach H, Morillas G L, Roca E, Lobatón J, Montenegro B P, Yepes A, and Marsiglia H
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- Antimetabolites, Antineoplastic therapeutic use, Chemoradiotherapy, Consensus Development Conferences as Topic, Deoxycytidine analogs & derivatives, Deoxycytidine therapeutic use, Humans, Latin America, Gemcitabine, Adenocarcinoma therapy, Disease Management, Pancreatic Neoplasms therapy, Practice Guidelines as Topic
- Abstract
Pancreatic cancer is a malignancy of great impact in developed countries and is having an increasing impact in Latin America. Incidence and mortality rates are similar for this cancer. This is an important reason to offer to the patients the best treatments available. During the Latin American Symposium of Gastroenterology Oncology (SLAGO) held in Viña del Mar, Chile, in April 2015, a multidisciplinary group of specialists in the field met to discuss about this disease. The main conclusions of this meeting, where practitioners from most of Latin American countries participated, are listed in this consensus that seek to serve as a guide for better decision making for patients with pancreatic cancer in Latin America.
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- 2016
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17. [Skin manifestations in adults with a liver allograft].
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Daza F, Poniachik J, Zemelman V, Ibarra J, Espinoza M, Castillo J, Cardemil G, Díaz JC, Saure A, Lembach H, and Calderón P
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- Adult, Aged, Chile epidemiology, Cyclosporine adverse effects, Female, Humans, Hypertrichosis chemically induced, Immunosuppression Therapy adverse effects, Liver Cirrhosis complications, Male, Middle Aged, Prevalence, Waiting Lists, Dermatomycoses epidemiology, Liver Transplantation adverse effects, Skin Diseases, Viral epidemiology
- Abstract
Background: Skin manifestations after liver transplantation are increasing due to long term immunosuppressive therapy along with an increase in patient survival. Several studies have reported dermatologic complications following renal transplant, but few have studied dermatologic problems after liver transplantation., Aims: To describe the different types of cutaneous lesions encountered in adults receiving a liver allograft. To evaluate the frequency of cutaneous manifestations of patients in the liver transplant waiting list., Material and Methods: Eighty patients submitted to a liver transplant and 70 patients in the liver transplant waiting list were evaluated with a complete dermatological physical examination., Results: Sixty one percent of patients with a liver allograft had at least one skin manifestation. Of these, 34% had superficial fungal infections, 31% had viral infections, 20% had cutaneous side effects due to immunosuppressive treatment, 10% had malignant lesions, 2% had bacterial infections and one patient had a graft versus host disease. Only 28% of patients in the liver transplant waiting list had dermatologic problems, and the vast majority were lesions linked to liver cirrhosis., Conclusions: Cutaneous infections were the most common skin problems in liver transplant patients. Although neoplastic lesions are the most commonly mentioned lesions in the literature, only a 10% of our liver transplant patients presented these type of lesions.
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- 2015
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18. [Spontaneous clearance of hepatitis C virus after liver transplantation: Report of two cases].
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Urzúa Á, Poniachik J, Díaz JC, Castillo J, Saure A, Lembach H, Ibarra J, and Venegas M
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- Hepatitis C, Chronic, Humans, Immunosuppression Therapy methods, Male, Middle Aged, Time Factors, Hepatitis C surgery, Hepatitis C virology, Liver Transplantation, Remission, Spontaneous
- Abstract
The spontaneous clearance of hepatitis C virus infection is rare, especially after liver transplantation, condition in which recurrence is almost universal. We report two cases in which clearance of the virus was achieved after liver transplantation. We reviewed the literature and described possible mechanisms explaining this phenomenon, with emphasis on therapeutic implications.
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- 2015
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19. Type 2 diabetes mellitus in patients with mild obesity: preliminary results of surgical treatment.
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Lanzarini E, Csendes A, Gutierrez L, Cuevas P, Lembach H, Molina JC, Musleh M, Braghetto I, Papapietro K, Araya V, Lahsen R, Olguin P, Riffo A, Diaz E, Montt D, and Marín L
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- Blood Glucose metabolism, Body Mass Index, Diabetes Mellitus, Type 2 physiopathology, Female, Follow-Up Studies, Glycated Hemoglobin metabolism, Humans, Male, Middle Aged, Obesity blood, Obesity physiopathology, Prospective Studies, Remission Induction, Treatment Outcome, Weight Loss, Diabetes Mellitus, Type 2 blood, Gastric Bypass methods, Obesity surgery
- Abstract
In the last years, type 2 diabetes mellitus (T2DM) and obesity have become a serious public health problem, behaving as epidemic diseases. There is great interest in exploring different options for the treatment of T2DM in nonmorbidly obese patients. The purpose of this study is to report parameters of glycemic control in patients with T2DM and mild obesity who underwent laparoscopic Roux-en-Y gastric bypass (RYGBP). This prospective clinical trial includes patients with T2DM with a body mass index (BMI) between 30 and 35 kg/m(2) who underwent laparoscopic RYGBP from July 2008 through October 2010. Thirty-one patients were included in the study, 15 men and 16 women, with an average age of 48.7 ± 8.6 years. The average time since onset of T2DM was 5.8 years. The average postoperative follow-up was 30.4 months. The average preoperative blood glucose and glycosylated hemoglobin were 152 ± 70 mg/dl and 7.7 ± 2.1 %, respectively. All of them were using oral hypoglycemic agents, and four patients were insulin dependent. Only one patient had a postoperative complication (hemoperitoneum). At 36 months follow-up, the average BMI decreased to 24.7 kg/m(2), all patients (31) showed improvement in their glycemic control, and 29 of them (93.6 %) met the criteria for remission of T2DM in the last control. Laparoscopic RYGBP is a safe and effective procedure that improves glycemic control in patients with T2DM and mild obesity at midterm follow-up.
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- 2013
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20. Evolution of type 2 diabetes mellitus in non morbid obese gastrectomized patients with Roux en-Y reconstruction: retrospective study.
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Lanzarini E, Csendes A, Lembach H, Molina J, Gutiérrez L, and Silva J
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- Adult, Aged, Anastomosis, Roux-en-Y, Body Mass Index, Comorbidity, Female, Humans, Male, Middle Aged, Postoperative Period, Remission Induction methods, Retrospective Studies, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 therapy, Gastrectomy methods, Stomach Neoplasms epidemiology, Stomach Neoplasms surgery
- Abstract
Objective: Bariatric surgery in morbidly obese patients with type 2 diabetes results systematically in adequate glycemic control, normalization of insulinemia, and a decrease in glycosylated hemoglobin, effects that appear early after surgery in nearly 80 to 90% of them. Possible reasons that have been discussed are a decrease in caloric consumption, weight loss, and hormonal changes at the gastrointestinal level, which could have a positive effect on glucose metabolism. Various authors have proposed the possibility of passing on this indication to diabetic patients who are overweight or are mildly obese. The purpose of this retrospective investigation was to determine the effect of total or subtotal gastrectomy with Roux-en-Y reconstruction on the metabolic control of patients with type 2 diabetes with a body mass index (BMI) < 35, operated on for reasons other than obesity., Methods: From January 1999 to December 2007, a total of 23 diabetic patients who underwent total or subtotal gastrectomy with a gastrojejunal or esphagojejunal anastomosis with Roux-en-Y reconstruction of 60 to 70 cm length were included in this investigation., Results: The group consisted of 23 patients (14 men, 9 women, average age 62.9 +/- 7.9 years, average BMI 29.1 +/- 5.1). The principal reason for gastrectomy in these patients was gastric cancer in 19 patients (82.6%). The surgical procedure was total gastrectomy in 17 cases (73.9%) and subtotal gastrectomy in 6 cases (26.1%). Postoperative follow-up was 22 months. Before surgery the mean blood glucose level was 151.4 mg/dl. Late after surgery, 15 patients (65.2%) had a fasting blood glucose <126 mg/dl and are not using medication (remission), 7 (30.4%) patients have better metabolic control with a normal blood glucose but are still taking medication (improvement), and just 1 (4.3%) patient has an altered blood glucose and uses insulin (no change)., Conclusions: Gastrectomy and short Roux-en-Y limb reconstruction in type 2 diabetes patients with BMI < 35, with the patients submitted to surgery mainly for gastric cancer, correlates with remission of diabetes in 65% and improvement in 30.4%.
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- 2010
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21. [Gastrointestinal stromal tumors. Review of 15 patients].
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Braghetto I, Parada FJ, Cardemil G, Csendes A, Fernández E, Korn O, Ramírez M, Carreño L, Smok G, Molina JC, and Lembach H
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- Abdominal Pain etiology, Aged, Aged, 80 and over, Antigens, CD34 analysis, Biopsy, Endoscopy, Gastrointestinal, Female, Gastrectomy, Gastrointestinal Hemorrhage etiology, Humans, Male, Middle Aged, Proto-Oncogene Proteins c-kit analysis, Retrospective Studies, Gastrointestinal Stromal Tumors complications, Gastrointestinal Stromal Tumors pathology, Gastrointestinal Stromal Tumors surgery
- Abstract
Background: Gastrointestinal stromal tumors (GIST) are the most common mesenchymatous tumors of the digestive tract. The pathological diagnosis is based on microscopy and immunohistochemistiy., Aim: To review the experience of our surgical unit in patients with GIST MATERIAL AND METHODS: Review of medical records of 15 patients (aged 66+/-13 years, 11 women), with a pathological diagnosis of GIST, treated between 1999 and 2005., Results: The main presenting symptoms were melena in 40%, hematemesis in 20%, abdominal pain in 60% and anemia in 13%. In only one patient, the tumor appeared as an incidentaloma. All patients underwent upper gastrointestinal endoscopy A CAT scan was done in 87%, a barium swallow in 60% and a digestive endosonography in 20%. Thirteen tumors were located in the stomach and two in the small bowel. Mean tumor diameter was 5.3+/-1.7 cm. Surgical management was a tumor resection in 40%, a partial gastrectomy in 27%, a total gastrectomy in 20% and an intestinal excision in the rest. Mean hospital stay was 6.9+/-4.2 days. No postoperative complications were recorded., Conclusions: The main clinical presentation of GIST in this retrospective series was an upper gastrointestinal bleeding. Surgical treatment was devoid of complications.
- Published
- 2007
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