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Background: The information needs of low-income pregnant women are multisectoral, encompassing both pregnancy-related and non-pregnancy-related information. Barriers to receiving information for low-income pregnant women are specific and complex. This study aimed to explore the experiences of low-income Indonesian pregnant women regarding the challenges of receiving health information.Methods: A qualitative study was conducted using content analysis according to Graneheim and Lundman’s approach between January and June 2022. A total of 17 women were selected for this study using purposive sampling. In-depth interviews were done following semi-structured interview guidelines, concluding when saturation was reached. Nvivo software version March 2020 was used for organizing data and analysis.Results: Three themes emerged concerning receiving health information among low-income women, including encountering barriers to accessing information and care, access to ineffective information sources, and difficulties in applying pregnancy health information.Conclusion: This study shows that barriers to receiving information are specific to low-income pregnant women. Therefore, solution approaches must also be specific. Efforts to improve receiving health information can be achieved through developing educational materials that are easy to access and understand, improving e-health literacy, refining counseling skills among village midwives, holding culturally tailored educational programs, improving mothers’ health literacy by family and husbands, integrating counseling with a focus on critical literacy, and formulating policies to alleviate the midwife’s workload.

To systematize published laboratory methods to inactivate Mycobacterium tuberculosis (MTB) and to describe their effectiveness. We carried out a review of the scientific literature to identify the publications that reported methods for the inactivation of MTB, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. The search addressed inactivation methodologies used in Public health laboratories for the treatment of biological material and only included studies reporting the efficacy of the method. The database used were PubMed (National Library of Medicine) and LILACS (Latin American and Caribbean Literature in Health Sciences). We evaluated the quality of the studies with the JBI (Joanna Briggs Institute) Critical Instrument Appraisal Checklist. We included 14 publications meeting the established inclusion and exclusion criteria. These 14 studies actually described a total of 35 inactivation methods. Most of them combined heat treatment with some chemical or enzymatic agent, and there were very few applying a single strategy. Twenty-four (68.57%) methods demonstrated significant efficacy in inactivating MTB. The systematic review identified 35 methods of inactivation of MTB, published in 14 studies. Most of the methods combined physical treatment techniques, especially heat, with chemical and/or enzymatic treatment techniques, obtaining mostly good results in preventing the reproduction of the microorganism. PROSPERO (International Prospective Register of Ongoing Systematic Reviews) (Code CRD42024503621).

This study aims to examine the effectiveness of SiBakul Jogja, a digital platform initiated by the government in Yogyakarta Province, in supporting small businesses and fostering collaboration among various stakeholders. Through interviews and research analysis, we investigate the mechanisms through which SiBakul Jogja facilitates small business growth and innovation. The findings reveal that SiBakul Jogja serves as a comprehensive resource hub for small businesses, offering assistance in record-keeping, advisory services, and fostering partnerships for innovation. Collaboration among government entities, businesses, academics, and the media plays a crucial role in enhancing the platform's impact. Positive outcomes include job creation and improved access to financial resources. However, challenges such as digital skills shortages and internet connectivity issues persist. The novelty of this study lies in its examination of SiBakul Jogja's collaborative approach in alignment with principles of new public service, contributing to improved public service delivery and economic growth. Addressing these challenges collectively presents an opportunity to leverage SiBakul Jogja's potential to significantly boost the local economy. Through effective teamwork and organizational strategies, digital support for small businesses can be optimized, fostering economic growth and resilience. Doi: 10.28991/ESJ-2024-08-04-015 Full Text: PDF

The synthesis of Cu(II)-doped ZIF-8/Chitosan by means of the one-pot method at room temperature was successfully carried out. The synthesized materials exhibit enhanced adsorption properties for the removal of Congo red (CR) dye. The structural and morphological properties of Cu(II)-doped ZIF-8/Chitosan were characterized. Cu(II)-doped ZIF-8/Chitosan achieved the most optimal CR removal efficiency and CR adsorption capacity (153.85 mg/g) due to its higher specific surface area (522.776 m2/g) compared to ZIF-8/Chitosan (514.882 m2/g). Electrostatic attraction, hydrogen bonding, and π-π interaction are the main interactions for the higher adsorption performance. The CR adsorption process followed pseudo-second-order kinetic model and Langmuir isotherm model. The results of the thermodynamic adsorption indicated that the process of CR adsorption by Cu-doped ZIF-8/Chitosan was an endothermic reaction. The experimental results indicate that the Cu(II)-doped ZIF-8/Chitosan material has the potential to be used in wastewater treatment for the removal of anionic dyes.

A halal certificate is a legal requirement that must be fulfilled for every Micro, Small, and Medium Enterprise. Kopi Nuansa Gembira is a pure, original ground coffee business without any mixtures which still does not have halal certification. The problems faced will result in distrust and sales volumes that continue to decline if this is still ignored. This service is carried out to help Nuansa Gembira Coffee to obtain a halal certificate. The lack of understanding regarding halal products makes it necessary to provide assistance and knowledge to Kopi Nuansa Gembira. The solution offered is in the form of aid related to halal certificates and obtaining halal certificates. The stages of halal product assistance are: The preparation stage is surveying the service location to explore the problems faced by Nuansa Gembira coffee. Phase 1, the service team and the owner of Nuansa Gembira Coffee went to the Ministry of Religion office to consult regarding halal products. Stage 2 prepares all the necessary documents. 4. Sustainability Phase of issuing a halal certificate for Kopi Nuansa Gembira. The assistance results will start from January 2023, namely when the initial assistance starts from preparations for verifying problems with partners to convincing the owner of Kopi Nuansa Gembira to apply for halal certification through the halal application. The business actor then fills it out and submits it after filing and filling in the complete documents. After going through all the processes, including the verification, validation, and return processes, both by the companion and by BPJPH, on June 9, 2023, the halal certificate for Kopi Nuansa Gembira was issued.

Transnsforming cooperative values by education institutions in Indonesia would encourage their graduates become the agents of exchange of social and economic lives. Qualitatively cooperative development is still beyond expectation therefore some youths have negative cooperative image. The research purpose was to gain the impacts of cooperative education applying phenomenology method and the informants were alumni of Indonesia Institute of Cooperative Management. The results show that their involvement in cooperative due to its uniqueness, an ideal system, and benefits for members and communities. As a life catalist, cooperative enables people to gain economic benefits, develop thinking paradigm and personality, broader networkings as well. Nevertheless cooperative image is still perceived negatively such as unprosfessional management, single business unit, profit oriented, Syariah contra, and political issues. Some efforts are rebranding cooperative by changing mindset through education and training of cooperative and entrepreneurship, implementing cooperative values and principles, involving youth; hiring professional manager, encouraging members in investment, activating stakeholders; and publishing positive information.

UKM Tani Lebak is an industry that processes coconut water into nata de coco. During production, water use could be more efficient. Apart from that, there are also rejected products and production waste that pollute the environment. So, based on this, it is necessary to measure and evaluate productivity and environmental performance. This research aims to determine the value of productivity and the green productivity index (GPI) and to propose alternative improvement solutions to increase productivity and reduce environmental impacts. The method used to solve this problem is green productivity, starting with calculating material balance during production, then creating green value stream mapping and calculating GPI. The calculation results show that the productivity value moved from 1.335 to 1.336. UKM Tani Lebak can use three alternative solutions to increase productivity while reducing environmental impacts. The best alternative is to combine the neutralization and washing processes, which produces a GPI from 0.6882 to 0.927. This value shows a better ratio of productivity to environmental impact.

Objectives The aim of this study was to investigate the relationship between the number of patient comorbidities and the delays in seeking treatment for coronary heart disease (CHD). Methods This longitudinal study utilized secondary data from the Non-Communicable Disease Risk Factor (NCDRF) cohort study conducted in Bogor City. Individuals who participated in the NCDRF cohort study and were diagnosed with CHD within the 6-year study period met the inclusion criteria. Respondents who were not continuously monitored up to the 6th year were excluded. The final sample included data from respondents with CHD who participated in the NCDRF cohort study and were monitored for the full 6-year duration. The final logistic regression analysis was conducted on data collected from 812 participants. Results Among the participants with CHD, 702 out of 812 exhibited a delay in seeking treatment. The risk of a delay in seeking treatment was significantly higher among individuals without comorbidities, with an odds ratio (OR) of 3.5 (95% confidence interval [CI], 1.735–7.036; p

Background Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma focus (CBT-TF) is crucial for enhancing treatment outcomes.Objective Using an individual participant data meta-analysis (IPD-MA) design, we examined participant-level predictors of study dropout from CBT-TF interventions for PTSD.Methods A comprehensive systematic literature search was undertaken to identify randomised controlled trials comparing CBT-TF with waitlist control, treatment-as-usual or another therapy. Academic databases were screened from conception until 11 January 2021. Eligible interventions were required to be individual and in-person delivered. Participants were considered dropouts if they did not complete the post-treatment assessment.Findings The systematic literature search identified 81 eligible studies (n=3330). Data were pooled from 25 available CBT-TF studies comprising 823 participants. Overall, 221 (27%) of the 823 dropped out. Of 581 civilians, 133 (23%) dropped out, as did 75 (42%) of 178 military personnel/veterans. Bivariate and multivariate analyses indicated that military personnel/veterans (RR 2.37) had a significantly greater risk of dropout than civilians. Furthermore, the chance of dropping out significantly decreased with advancing age (continuous; RR 0.98).Conclusions These findings underscore the risk of premature termination from CBT-TF among younger adults and military veterans/personnel.Clinical implication Understanding predictors can inform the development of retention strategies tailored to at-risk subgroups, enhance engagement, improve adherence and yield better treatment outcomes.

Remaja adalah harapan bangsa dan sasaran pembangunan kesehatan yang harus diperhatikan status kesehatanya, salah satunya adalah kesehatan reproduksi. Salah satu permasalahan pada remaja adalah anemia yang banyak dialami oleh remaja putri. Remaja putri lebih beresiko mengalami anemia dikarenakan mengalami menstruasi setiap bulan. Tujuan penelitian ini adalah untuk mengetahui sumber informasi dan pengetahuan remaja putri tentang anemia kelas IX di MTSN 9 Wates Kabupaten Kediri. Desain penelitian ini menggunakan desain deskriptif dengan pendekatan cross sectional. Populasi penelitian adalah semua remaja putri kelas IX di MTSN 9 Wates Kabupaten Kediri. Dengan Teknik sampling sistematik random sampling didapatkan sampel 58 responden. Variabel Penelitian ini adalah sumber informasi dan pengetahuan remaja putri tentang anemia kelas IX di MTSN 9 Wates Kabupaten Kediri. Instrumen yang digunakan adalah kuesioner. Pengolahan data dengan editing, coding, scoring, dan tabulating. Analisa data dengan persentase. Hasil penelitian meunjukan Sumber Informasi tentang Anemia didapatkan sebagian besar dari 1 sumber informasi 34 responden (58,6%), dan pengetahuan remaja putri tentang anemia Sebagian besar pengetahuan kurang 27 responden (46,5%). Pengetahuan responden kurang meskipun sudah mendapatkan informasi tentang anemia, maka pertimbangkan untuk meninjau ulang efektivitas media dan metode penyampaian, serta menyesuaikan konten agar lebih relevan dan mudah dipahami. Selain itu, lakukan intervensi pendidikan berkelanjutan, libatkan responden secara aktif, dan kaji faktor sosio-kultural yang mungkin memengaruhi penerimaan informasi.

Low-Density Polyethylene (LDPE) is one of the most popular and commonly used petroleum-derived thermoplastics for packaging. The large production of LDPE has an environmental impact. Reducing production can be done by recycling LDPE (r-LDPE) and adding organic fibres as a filler that is easily decomposed. Cattle farming solid waste as a fibre source was mixed with r-LDPE with coupling agent maleic anhydride (MA). Before use, the cow manure was processed through a bleaching and hemicellulose removal process, which resulted in Cow Manure Fiber (CMF). The CMF was analyzed using FTIR spectroscopy and microscopic fibre dimension analysis. The FTIR results showed peaks at wavenumbers 3538 and 1056 cm-1, representing the -OH, -C-O and -CH functional groups from the cellulose structure. The resulting composites were tested for physical properties, including elastic modulus, yield stress, and elongation. Pure LDPE material was also used for comparison. The best physical properties of the composites were obtained by composites with 95% r-LDPE, 5% CMF, and 2% MA.

This research aims to analyze the determinants that have effects on Audit Opinion Statements by independent auditors, namely: Auditor Education, Professionalism and Auditor Switching. This research is categorized as quantitative research with data collection methods using questionnaires for 60 independent auditors who work in eight Public Accounting Firms in Jakarta, Indonesia. Data was processed using Smart PLS version 3.00 to prove the hypothesis. The quality indicators of the questionnaire have passed the validity and reliability tests. The t-test results reveal that Auditor Education, Professionalism, and Auditor Switching partially have a positive and significant effect on Audit Opinion. The effect of Professionalism on Audit Opinion shows the lowest positive influence between the effect of Auditor Education and Auditor Switching on Audit Opinion. The main findings of this research reveal the lack of contribution of auditor professionalism in providing Audit Opinion Statements.

ABSTRACT Coffee is processed with a variety of processes such as natural (dry), fullywash (wet), and honey processes. The type of coffee processing influences the characteristics of the coffee produced. The aim of this research is to analyze the physicochemical characteristics of the Sigarar Utang variety of arabica coffee based on different processing methods (fullywash, honey and natural process). The research design used a one-factor Completely Randomized Design (CRD). The research results showed that the type of coffee processing method had a significant effect on water content, coffee essence content, sucrose content, total dissolved solids (TDS), total titratable acidity (TTA), pH, total phenols and antioxidant activity of coffee brewing, but had no significant effect on ash content. The test results for water content, ash content and coffee essence content are in accordance with the Indonesian National Standard (SNI) for coffee powder. Coffee with honey processing has high values ​​for water content, sucrose content, and TDS, while coffee with fullywash processing has the highest acidity, total phenols and antioxidant activity. Keywords: Arabica coffee, Arabica sigarar utang, Fullywash, Honey, Natural process

The problem that is often faced by the banking world in general is the problem of problematic credit. The same thing happened to Bank BRI. The consequences of these problematic loans can increase the NPL level which will impact the bank's health if not handled quickly and appropriately. So in this case the bank uses credit restructuring by referring to the Loan At Risk (LAR) financial ratio as a restructuring strategy. The same thing happened to Bank BRI, where the factor that led to the implementation of the restructuring policy was because in 2019 the Covid-19 pandemic occurred which resulted in many customers being affected and unable to repay their credit on time. The consequences of these problematic loans can increase the NPL level which will impact the bank's health if not handled quickly and appropriately. So in this case the bank uses credit restructuring as a strategy to reduce non-performing loans. This type of research is qualitative descriptive analysis. Research data was collected using interviews, observation, documentation, and questionnaires. The benefits of research can be used to develop knowledge in the field of financial institutions, especially regarding the implementation of restructuring strategies in overcoming Loan At Risk (LAR). From the implementation of credit restructuring carried out by BRI Bank, it can be concluded that the implementation of credit restructuring as a strategy for reducing problem loans has been carried out effectively in accordance with the procedures and policies that have been determined by the bank's internal and banking regulations. This effectiveness can be proven by the decreasing percentage of LAR levels every year.

Highlights: 1. This study investigated the etiology of paralytic strabismus, a condition that requires further research to prevent its incidence, particularly in adults. 2. The findings of this study provided valuable insight into the primary etiology of paralytic strabismus and its underlying factors. Abstract Paralytic strabismus is the most common cause of adult-onset strabismus. It can result from paralysis of the third, fourth, or sixth cranial nerves, either separately or in combination, which are responsible for innervating the ocular motor muscles. Paralysis of these cranial nerves occurs due to congenital disorders, neoplasms, trauma, intracranial processes, idiopathic diseases, and other causes. This study aimed to determine the etiology of paralytic strabismus incidence at the Department of Ophthalmology of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, between 2017 and 2022. This study employed a retrospective methodology and utilized total sampling. The medical records of patients diagnosed with paralytic strabismus were used to collect secondary data. Out of the total of 282 cases, the most common condition was combined ocular motor cranial nerve palsy, which accounted for 102 (36.2%) cases. The main factors contributing to this condition were neoplasms (37.2%), intracranial processes (25.5%), trauma (25.5%), other causes (8.8%), idiopathic diseases (2%), and congenital disorders (1%). The incidence of third cranial nerve palsy and sixth cranial nerve palsy was equally prevalent, each accounting for 86 (30.5%) cases. Meanwhile, fourth cranial nerve palsy was the least frequent with just eight (2.8%) cases. This study concluded that the most frequent etiology of paralytic strabismus was combined ocular motor nerve paralysis, which primarily results from neoplasms.

Sustainability competencies can be developed through Education for Sustainable Development (ESD) whose implementation will be helped by appropriate teaching materials. The purpose of this study is to determine the perceptions and initial knowledge of students, conditions, and difficulties experienced, as well as the form of teaching materials that can facilitate students to achieve competence in biotechnology courses. This descriptive quantitative research was conducted on 30 students who had taken biotechnology courses at the Department of Biology, Universitas Negeri Malang purposively. Data collection using survey techniques and review of Semester Learning Plan documents. The survey results were analyzed descriptively using percentages. The results showed that 83.3% of students ranked biotechnology in the field of biorefinery as the most difficult material to understand in biotechnology, 83.3% of students thought that textbooks were teaching materials that were considered to make it easier to understand biotechnology material, and the main problem felt by 53.3% of students while undergoing biotechnology courses was difficulty in accessing appropriate teaching materials. In addition, the low number of students (13.3%) who apply the knowledge they have obtained during college to support sustainability in the community around their place of residence. So, it can be concluded that ESD-oriented textbooks with material content of fermentation technology applications in the biorefinery field need to be developed.

Abstract Background Alcohol consumption is prevalent among students, with a common tendency to overestimate peers' alcohol use, contributing to increased consumption. This misperception is evident among Flemish students. This study aimed to develop and assess a Social Norms Approach (SNA) intervention targeting Flemish students to correct misperceptions and subsequently reduce alcohol use. Methods The 'Alcoholfacts' social media campaign was implemented using a quasi-experimental design from November 2022 to March 2023. A process evaluation followed Medical Research Council guidance, and intervention effects were evaluated using baseline and post-intervention surveys. Multiple linear regression with a Difference-in-Difference approach was performed for outcome assessment, using an intention-to-treat approach. Results The process evaluation showed that 36.3% of the intervention group had seen the campaign and that most of the exposed students found the campaign credible (73.3%). However, 54.8% of the exposed students did not find the campaign appealing. Results of the outcome assessment indicated that students of the intervention group at endline estimated students’ alcohol consumption significantly lower (bootstrapped p = 0.013; B = -1.93, bootstrapped CI = -3.620 to -0.565) compared to students of the control group. However, no significant intervention effect on student’s alcohol consumption was found (bootstrapped p = 0.741; B = -0.32, bootstrapped CI = -2.101 to 1.534). Conclusions The study supports the efficacy of an SNA campaign in correcting misperceptions but did not yield an immediate reduction in alcohol consumption. Future research should involve the target group in campaign material development to enhance attractiveness and impact.

Abstract Background Women are counseled preconceptionally about the potential risks of rAML progression and chance of complications during and due to pregnancy. However, a systematic search investigating the evidence on which this advice is based does not exist. The aim of this systematic review is to determine the effect of pregnancy on renal angiomyolipoma (rAML) size and risk of haemorrhage in patients with tuberous sclerosis complex (TSC). Methods We searched PubMed, EMBASE, Medline and ClinicalTrials.gov using terms for “renal angiomyolipoma” and “pregnancy”. English-language articles published between January 1st 2000, and December 31st 2020 of which full-text was available were included. The initial search resulted in 176 articles. After the screening process we included 45 case reports and 1 retrospective study. For the retrospective study we assessed the risk of bias using the Newcastle–Ottawa Scale. We included articles about renal AML and pregnancy with and without an established diagnosis of TSC. From these articles we recorded the rAML sizes and rAML complications. Results Seven case reports, from a total of 45 case reports, provided follow-up data on renal AML size (these were all cases of renal AML without a known diagnosis of TSC). Of these cases, renal AML size decreased in one patient, was stable in one patient, increased in three patients and fluctuated in two others. Renal AML size of women who suffered a haemorrhage were significantly larger (12.1 ± 4.6 cm) than rAMLs of women who did not suffer a haemorrhage (8.3 ± 3.2 cm). Data from the retrospective study showed no difference in renal complications between the women with and without a history of pregnancy. Haemorrhage occurred in 30% of the women with a history of pregnancy (n = 20) and in 11% in the patients without a history of pregnancy (n = 2), however this retrospective study had methodological limitations. Conclusion The effect of pregnancy on renal AML size and complications in patients with TSC is unclear. More research is needed to determine the risk of pregnancy on TSC-associated kidney disease in TSC patient.

Background: Delirium is an acute attention disorder that often occurs in elderly patients. The serotoninergic pathway is the main neurotransmitter pathway involved in the development of delirium. Serotonin, known as 5-hydroxythyramine (5-HT), affects mood, aggressiveness, cognition, depression, pressure, and stress in the brain environment. This may lead to the formation of hypoactive, hyperactive, or mixed delirium processes. This study utilized laboratory data with the aim of investigating whether serotonin levels have a correlation with severity score and delirium type in elderly individuals who experience delirium during hospitalization. Methods: This study was conducted in the field of geriatrics at Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, Indonesia, from April 2022 to October 2023. The sample was gathered consecutively, consisting of 62 hospitalized geriatric patients who suffered from delirium and were willing to participate by signing an informed consent. We excluded post-surgical patients and psychoactive drug users. The data were collected using the Memorial Delirium Assessment Scale (MDAS), the Confusion Assessment Method (CAM), and a serum serotonin test. This study used bivariate analysis, the Kruskal-Wallis test, and Spearman’s correlation (p

Background: Childhood stunting poses serious long-term risks to cognitive development, education, and adult productivity. While research has explored stunting’s causes and effects, there is a lack of focus on maternal knowledge of nutrition-focused nurturing care for stunted children. This gap limits the ability to design effective interventions that target improved caregiving practices. Objective: This study aimed to assess maternal knowledge of nutrition-focused nurturing care and explore associated factors, including child gender, maternal age, education, income, and prior exposure to nurturing care information, among mothers of stunted children aged 6-23 months in Indonesia. Methods: A cross-sectional study was conducted with 73 mothers in Kulon Progo, Yogyakarta. Data were collected from February to March 2024 using a validated self-assessment questionnaire covering four domains: responsive caregiving, early learning opportunities, safety and security, and supportive caregiver well-being. Statistical analyses, including t-tests and one-way ANOVA, were performed. Results: Overall maternal knowledge of nurturing care was high, with a mean score of 25.15 (SD = 4.72). Factors significantly associated with higher knowledge included having male children (p = 0.017), being aged 30-34 years (p = 0.035), possessing higher education levels (p = 0.002), and prior exposure to nurturing care information (p

Background: Between 2002 and 2011, the incidence of severe primary postpartum hemorrhage (PPH) in Dutch women with von Willebrand disease (VWD) and hemophilia carriers (HCs) was 8% vs 4.5% in the general population. Objectives: To determine the contemporary incidence of severe primary PPH in women with VWD and HCs. Methods: All women with VWD or HCs who delivered between 2012 and 2017 were selected from all 6 Dutch hemophilia treatment centers. Data on patient and disease characteristics, peripartum hematologic and obstetric management, and outcomes were retrospectively collected. Incidence of severe primary (≥1000 mL of blood loss ≤24 hours after childbirth) and primary (≥500 mL within ≤24 hours after childbirth) PPH was compared with the (1) previous cohort and (2) general Dutch population and between (3) women with VWD and HCs with third-trimester coagulation activity levels

Introduction Type II endoleaks (T2ELs) following endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) can lead to aneurysm growth, compromising the stent graft seal and risking rupture. Preventing these endoleaks during EVAR involves filling the AAA sac around the stent graft to exclude the aneurysm and block any arteries causing the endoleak. This study investigates the feasibility and safety of using AneuFix, a biocompatible injectable polymer developed by TripleMed (Geleen, the Netherlands), for aneurysmal sac filling during EVAR in high-risk T2EL patients.Methods and analysis A feasibility, single-arm, single-centre clinical trial will initially include five patients with infrarenal AAA, eligible for EVAR, and at high risk for T2EL based on the number of patent lumbar arteries and the cross-sectional area of the aortic lumen at the level of the inferior mesenteric artery. Postevaluation by the Data Safety and Monitoring Board, the study cohort will extend to 25 patients. During EVAR and after stent graft deployment, the aneurysm sac is filled with AneuFix polymer using a filling sheath positioned parallel to the contralateral limb with the tip inside the aneurysm sac. Primary outcome is technical success (successful AAA sac filling). The secondary outcomes include clinical success at 6 and 12 months (occurrence of T2ELs and AAA growth assessed with CT angiography), intraoperative and perioperative complications, all endoleaks, adverse events, re-interventions, aneurysm rupture and patient survival.Ethics and dissemination This trial was approved by the Dutch Authorities (Central Committee on Research Involving Human Subjects, IGJ), Amsterdam University Medical Centre Ethical Commission, and adheres to the Declaration of Helsinki and European Medical Device Regulation. Results will be shared at (inter)national conferences and in peer-reviewed journals.Trial registration number NCT04307992.

Purpose — The objective of this research is to assess the tourism potential of Plalangan Village for developing it as a tourism destination, specifically focusing on sustainable agro-edutourism. Method — This study utilized a qualitative approach with qualitative descriptive methods. Data collection involved the use of observation, focus group discussions (FGDs), and in-depth interviews with key figures. Additionally, literature studies conducted online and literature reviews were undertaken. Visual evidence in the form of documentation was employed to enhance the credibility of the research findings. Result — The research results indicate that Plalangan Village possesses tourism potential, with various attractions such as natural sites like Plalangan Hill and the Twin Dams, cultural sites like Can Macanan Kadduk, and man-made attractions like fish farming and the cracker industry. Additionally, the village has potential areas for a people's market and open green spaces. In light of this potential, a tourism map of Plalangan Village has been created, showcasing the various attractions, as well as the suggested flow of tourist visits, one-day tour packages, and a visualization of the appealing camping grounds on Plalangan Hill. These findings strongly suggest that Plalangan Village has the potential to be developed as a tourism village, with a sustainable agro-edutourism concept. Novelty — This study focused on specific regional agro-edutourism potentials and their development strategies, aiming to enhance local welfare and community prosperity through tailored approaches.

Background: Amidst the COVID-19 pandemic, the proliferation of fake news and an infodemic has highlighted the necessity to enhance health literacy, particularly among school-aged children in the concrete operational phase of cognitive development. However, current health literacy studies predominantly focus on the adult population and overlook COVID-19 prevention protocols. Objective: This study aimed to evaluate the effectiveness of COVID-19 prevention education utilizing interactive comic and animated videos on the health literacy of school-aged children in Sleman Regency, Yogyakarta, Indonesia. Methods: The study employed a quasi-experimental research design with pretest-posttest nonequivalent control groups conducted from July to November 2021. Non-random sampling was utilized to select elementary schools and students, resulting in seventy-eight respondents. Health literacy was assessed using the modified 22-item Indonesian version of the Health Literacy Scale of COVID-19. Data analysis employed the Wilcoxon test. Results: Significant improvements in children’s health literacy were evident within the intervention group from pretest to posttest (p = 0.046, p

Early childhood educators are among those professionals susceptible to excessive job-related stressors. This study explores the relationship between religiosity, mindfulness, and occupational well-being and analyzes mindfulness's role as a mediator between religiosity and occupational well-being. Employing a quantitative correlational method, the study's population comprised 177 teachers from Aashiya Kindergarten in Sidoarjo. The Krejcie Morgan table with a 5% error margin determined a sample size of 118 teachers. The sampling technique used in data collection is accidental sampling techniques, using Google Forms to collect the data. Research instruments for religiosity, mindfulness, and occupational well-being were adapted, translated from previous studies, and validated for reliability. Data analysis used mediation analysis with path analysis technique, using JASP software. Findings indicated partial mediation, revealing that mindfulness mediates the relationship between religiosity and occupational well-being. Results imply that when accompanied by mindfulness, teachers' religiosity level can have a significant positive impact on early childhood teachers. This research can also be reference to future for well-being research in the context of occupation among teacher.

This study explores the variables of workload, level of audit fees and audit risk on audit quality by testing the three research hypotheses using SPSS with multiple linear regression methods. The study was conducted at a Public Accounting Firm in East Java, Indonesia, with a population of 48 officially registered auditors. A questionnaire instrument was used to collect research data, containing questions/statements related to research variables tested for validity and reliability. The collected data were analyzed using multiple linear regression methods. The research results show that workload variables, audit fees, and risk levels significantly positively affect audit quality. The main research contribution of this study is aimed at practitioners and authorities or associations that, in the preparation and implementation of audit standards, must consider the auditor's internal and external factors and the client's real condition. The association needs to bridge the mistakes of the auditor or KAP when dealing with different client conditions. In addition, based on the results of this study, it is necessary to consider work overload and working time for auditors because they affect audit quality.

This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important. This might help treating physicians in making the right decisions on how to intervene and improve metabolism for the benefit of patients, and to understand why and how metabolism responds in their specific cases. We will specifically address the interplay between GH, IGF-1, and insulin in type 1 and 2 diabetes mellitus, liver cirrhosis, and acromegaly as examples in which this knowledge is truly necessary.

Objective: To determine the risk factors of mortality among hospitalized COVID-19 patients. Methods: This retrospective study used hospitalization records collected by the Indonesia Health Social Security Administrator Agency (Badan Penyelenggara Jaminan Sosial Kesehatan-BPJS Kesehatan). A total of 38277 eligible patients with confirmed COVID-19 were analyzed. The dependent variable of the study was the discharge status (death or recovery) of COVID-19. Independent variables were history of morbidity and disease-related occurrence, type of room health facilities, length of stay and demographic variables (sex, age). The analyses use bivariate and multivariate logistic regression to determine the dominating variable associated with all these variables. Results: Of the 38277 inpatients with PCR-confirmed COVID-19, 31051 (81.1%) were discharged and 7226 (18.9%) died. Risk of death was positively associated with older age (aOR 5.74, 95% CI 4.20-7.87 for 19-64 years old; aOR 13.75, 95% CI 9.99-18.92 for 65 years above), male sex (aOR 1.13, 95% CI 1.07-1.19), treated in ICU without ventilator (aOR 5.84, 95% CI 5.41-6.30) and had comorbid respiratory diseases (aOR 5.39, 95% CI 4.93-5.90), but negatively associated with hospital stay of 15 days or longer (aOR 0.39, 95% CI 0.36-0.43). Conclusions: COVID-19 related death during hospitalization was associated with duration and type of treatment, and existing medical condition among the inpatient individuals during COVID-19 pandemic in DKI Jakarta. The findings of the study suggest importance of appropriate and timely medical intervention and care.