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4. Reassuring pregnancy outcomes in women with mild COL4A3-5–related disease (Alport syndrome) and genetic type of disease can aid personalized counseling

Author

Gosselink, Margriet E., Snoek, Rozemarijn, Cerkauskaite-Kerpauskiene, Agne, van Bakel, Sophie P.J., Vollenberg, Renee, Groen, Henk, Cerkauskiene, Rimante, Miglinas, Marius, Attini, Rossella, Tory, Kálmán, Claes, Kathleen J., van Calsteren, Kristel, Servais, Aude, de Jong, Margriet F.C., Gillion, Valentine, Vogt, Liffert, Mastrangelo, Antonio, Furlano, Monica, Torra, Roser, Bramham, Kate, Wiles, Kate, Ralston, Elizabeth R., Hall, Matthew, Liu, Lisa, Hladunewich, Michelle A., Lely, A. Titia, and van Eerde, Albertien M.

Published
2024
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5. Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women

Author

Sarma, AMY A., PANIAGUA, SAMANTHA M., LAU, EMILY S., WANG, DONGYU, LIU, ELIZABETH E., LARSON, MARTIN G., HAMBURG, NAOMI M., MITCHELL, GARY F., KIZER, JORGE, PSATY, BRUCE M., ALLEN, NORRINA B., LELY, A. TITIA, GANSEVOORT, RONALD T., ROSENBERG, EMILY, MUKAMAL, KENNETH, BENJAMIN, EMELIA J., VASAN, RAMACHANDRAN S., CHENG, SUSAN, LEVY, DANIEL, BOER, RUDOLF A. DE, GOTTDIENER, JOHN S., SHAH, SANJIV J., and HO, JENNIFER E.

Published
2023
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10. Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis

Author

MS Verloskunde, Sociale pediatrie onderzoek 2, Child Health, Circulatory Health, Infection & Immunity, Arts-assistenten Kinderen, Van De Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, Terstappen, Fieke, MS Verloskunde, Sociale pediatrie onderzoek 2, Child Health, Circulatory Health, Infection & Immunity, Arts-assistenten Kinderen, Van De Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, and Terstappen, Fieke

Published
2024

11. Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis

Author

CDL Nanomedicine, Genetica, MS Verloskunde, Child Health, Circulatory Health, Onderzoek, van Kammen, Caren M, Taal, Seija E L, Wever, Kimberley E, Granger, Joey P, Lely, A Titia, Terstappen, Fieke, CDL Nanomedicine, Genetica, MS Verloskunde, Child Health, Circulatory Health, Onderzoek, van Kammen, Caren M, Taal, Seija E L, Wever, Kimberley E, Granger, Joey P, Lely, A Titia, and Terstappen, Fieke

Published
2024

12. Understanding changes in echocardiographic parameters at different ages following fetal growth restriction:a systematic review and meta-analysis

Author

van de Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, Terstappen, Fieke, van de Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C.A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, and Terstappen, Fieke

Abstract

Fetal growth restriction (FGR) increases cardiovascular risk by cardiac remodeling and programming. This systematic review and meta-analysis across species examines the use of echocardiography in FGR offspring at different ages. PubMed and Embase.com were searched for animal and human studies reporting on echocardiographic parameters in placental insufficiency- induced FGR offspring. We included six animal and 49 human studies. Although unable to perform a meta-analysis of animal studies because of insufficient number of studies per individual outcome, all studies showed left ventricular dysfunction. Our meta-analyses of human studies revealed a reduced left ventricular mass, interventricular septum thickness, mitral annular peak velocity, and mitral lateral early diastolic velocity at neonatal age. No echocardiographic differences during childhood were observed, although the small age range and number of studies limited these analyses. Only two studies at adult age were performed. Meta-regression on other influential factors was not possible due to underreporting. The few studies on myocardial strain analysis showed small changes in global longitudinal strain in FGR offspring. The quality of the human studies was considered low and the risk of bias in animal studies was mostly unclear. Echocardiography may offer a noninvasive tool to detect early signs of cardiovascular predisposition following FGR. Clinical implementation yet faces multiple challenges including identification of the most optimal timing and the exact relation to long-term cardiovascular function in which echocardiography alone might be limited to reflect a child's vascular status. Future research should focus on myocardial strain analysis and the combination of other (non)imaging techniques for an improved risk estimation.

Published
2024

13. Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis.

Author

Kammen, Caren M. van, Taal, Seija E. L., Wever, Kimberley E., Granger, Joey P., Lely, A. Titia, and Terstappen, Fieke

Subjects
FETAL growth retardation, PREECLAMPSIA, PHENOTYPIC plasticity, PERFUSION, BLOOD pressure
Abstract

The reduced uterine perfusion pressure (RUPP) model is frequently used to study preeclampsia and fetal growth restriction. An improved understanding of influential factors might improve reproducibility and reduce animal use considering the variability in RUPP phenotype. We performed a systematic review and meta-analysis by searching Medline and Embase (until 28 March, 2023) for RUPP studies in murine. Primary outcomes included maternal blood pressure (BP) or proteinuria, fetal weight or crown-rump length, fetal reabsorptions, or antiangiogenic factors. We aimed to identify influential factors by meta-regression analysis. We included 155 studies. Our meta-analysis showed that the RUPP procedure results in significantly higher BP (MD = 24.1 mmHg; [22.6; 25.7]; n = 148), proteinuria (SMD = 2.3; [0.9; 3.8]; n = 28), fetal reabsorptions (MD = 50.4%; [45.5; 55.2]; n = 42), circulating soluble FMS-like tyrosine kinase-1 (sFlt-1) (SMD = 2.6; [1.7; 3.4]; n = 34), and lower fetal weight (MD = −0.4 g; [−0.47; −0.34]; n = 113. The heterogeneity (variability between studies) in primary outcomes appeared ≥90%. Our meta-regression identified influential factors in the method and time point of BP measurement, randomization in fetal weight, and type of control group in sFlt-1. The RUPP is a robust model considering the evident differences in maternal and fetal outcomes. The high heterogeneity reflects the observed variability in phenotype. Because of underreporting, we observed reporting bias and a high risk of bias. We recommend standardizing study design by optimal time point and method chosen for readout measures to limit the variability. This contributes to improved reproducibility and thereby eventually improves the translational value of the RUPP model. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Data mining information from electronic health records produced high yield and accuracy for current smoking status

Author

van Solinge, Wouter, Hoefer, Imo, Haitjema, Saskia, de Groot, Mark, Blasse, Enja, Asselbergs, Folkert W., Nathoe, Hendrik M., de Borst, Gert-Jan, Bots, Michiel L., Geerlings, Mirjam I., Emmelot, Marielle H., de Jong, Pim A., Leiner, Tim, Lely, A. Titia, van der Kaaij, Niels P., Kappelle, L. Jaap, Ruigrok, Ynte M., Verhaar, Marianne C., Visseren, Frank L.J., Westerink, Jan, Groenhof, T. Katrien J., Koers, Laurien R., and Grobbee, Diederick E.

Published
2020
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16. Cardiovascular Sequels During and After Preeclampsia

Author

Paauw, Nina D., Lely, A. Titia, COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, REZAEI, NIMA, Series Editor, Kerkhof, Peter L. M., editor, and Miller, Virginia M., editor

Published
2018
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19. Understanding changes in echocardiographic parameters at different ages following fetal growth restriction: a systematic review and meta-analysis.

Author

van de Meent, Mette, Nijholt, Kirsten T., Joemmanbaks, Shary C. A., Kooiman, Judith, Schipper, Henk S., Wever, Kimberley E., Lely, A. Titia, and Terstappen, Fieke

Subjects
FETAL growth retardation, GESTATIONAL age, GLOBAL longitudinal strain, ECHOCARDIOGRAPHY, VENTRICULAR septum
Abstract

Fetal growth restriction (FGR) increases cardiovascular risk by cardiac remodeling and programming. This systematic review and meta-analysis across species examines the use of echocardiography in FGR offspring at different ages. PubMed and Embase.com were searched for animal and human studies reporting on echocardiographic parameters in placental insufficiency-induced FGR offspring. We included six animal and 49 human studies. Although unable to perform a meta-analysis of animal studies because of insufficient number of studies per individual outcome, all studies showed left ventricular dysfunction. Our meta-analyses of human studies revealed a reduced left ventricular mass, interventricular septum thickness, mitral annular peak velocity, and mitral lateral early diastolic velocity at neonatal age. No echocardiographic differences during childhood were observed, although the small age range and number of studies limited these analyses. Only two studies at adult age were performed. Meta-regression on other influential factors was not possible due to underreporting. The few studies on myocardial strain analysis showed small changes in global longitudinal strain in FGR offspring. The quality of the human studies was considered low and the risk of bias in animal studies was mostly unclear. Echocardiography may offer a noninvasive tool to detect early signs of cardiovascular predisposition following FGR. Clinical implementation yet faces multiple challenges including identification of the most optimal timing and the exact relation to long-term cardiovascular function in which echocardiography alone might be limited to reflect a child's vascular status. Future research should focus on myocardial strain analysis and the combination of other (non)imaging techniques for an improved risk estimation. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Low-Density Lipoprotein Cholesterol Target Attainment in Patients With Established Cardiovascular Disease: Analysis of Routine Care Data

Author

Groenhof, T Katrien J, Kofink, Daniel, Bots, Michiel L, Nathoe, Hendrik M, Hoefer, Imo E, Van Solinge, Wouter W, Lely, A Titia, Asselbergs, Folkert W, and Haitjema, Saskia

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundDirect feedback on quality of care is one of the key features of a learning health care system (LHS), enabling health care professionals to improve upon the routine clinical care of their patients during practice. ObjectiveThis study aimed to evaluate the potential of routine care data extracted from electronic health records (EHRs) in order to obtain reliable information on low-density lipoprotein cholesterol (LDL-c) management in cardiovascular disease (CVD) patients referred to a tertiary care center. MethodsWe extracted all LDL-c measurements from the EHRs of patients with a history of CVD referred to the University Medical Center Utrecht. We assessed LDL-c target attainment at the time of referral and per year. In patients with multiple measurements, we analyzed LDL-c trajectories, truncated at 6 follow-up measurements. Lastly, we performed a logistic regression analysis to investigate factors associated with improvement of LDL-c at the next measurement. ResultsBetween February 2003 and December 2017, 250,749 LDL-c measurements were taken from 95,795 patients, of whom 23,932 had a history of CVD. At the time of referral, 51% of patients had not reached their LDL-c target. A large proportion of patients (55%) had no follow-up LDL-c measurements. Most of the patients with repeated measurements showed no change in LDL-c levels over time: the transition probability to remain in the same category was up to 0.84. Sequence clustering analysis showed more women (odds ratio 1.18, 95% CI 1.07-1.10) in the cluster with both most measurements off target and the most LDL-c measurements furthest from the target. Timing of drug prescription was difficult to determine from our data, limiting the interpretation of results regarding medication management. ConclusionsRoutine care data can be used to provide feedback on quality of care, such as LDL-c target attainment. These routine care data show high off-target prevalence and little change in LDL-c over time. Registrations of diagnosis; follow-up trajectory, including primary and secondary care; and medication use need to be improved in order to enhance usability of the EHR system for adequate feedback.

Published
2020
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23. Prenatal Sildenafil and Fetal-placental Programming in Human Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Gene Expression Analysis

Author

Terstappen, Fieke, primary, Plösch, Torsten, additional, Calis, Jorg J.A., additional, Ganzevoort, Wessel, additional, Pels, Anouk, additional, Paauw, Nina D., additional, Gordijn, Sanne J., additional, van Rijn, Bas B., additional, Mokry, Michal, additional, and Lely, A. Titia, additional

Published
2023
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26. Long-Term Kidney and Maternal Outcomes After Pregnancy in Living Kidney Donors

Author

van Buren, Marleen C., primary, Meinderts, Jildau R., additional, Oudmaijer, Christiaan A. J., additional, de Jong, Margriet F. C., additional, Groen, Henk, additional, Royaards, Tessa, additional, Maasdam, Louise, additional, Tielen, Mirjam, additional, Reinders, Marlies E. J., additional, Lely, A. Titia, additional, and van de Wetering, Jacqueline, additional

Published
2023
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28. Long-Term Kidney and Maternal Outcomes After Pregnancy in Living Kidney Donors

Author

van Buren, Marleen C., Meinderts, Jildau R., Oudmaijer, Christiaan A.J., de Jong, Margriet F.C., Groen, Henk, Royaards, Tessa, Maasdam, Louise, Tielen, Mirjam, Reinders, Marlies E.J., Lely, A. Titia, van de Wetering, Jacqueline, van Buren, Marleen C., Meinderts, Jildau R., Oudmaijer, Christiaan A.J., de Jong, Margriet F.C., Groen, Henk, Royaards, Tessa, Maasdam, Louise, Tielen, Mirjam, Reinders, Marlies E.J., Lely, A. Titia, and van de Wetering, Jacqueline

Abstract

For counseling it is important to know if pregnancy after Living Kidney Donation (LKD) affects long-term outcomes of the mono-kidney and the mother. Therefore, we performed a retrospective multicenter study in women ≤45 years who donated their kidney between 1981 and 2017. Data was collected via questionnaires and medical records. eGFR of women with post-LKD pregnancies were compared to women with pre-LKD pregnancies or nulliparous. eGFR before and after pregnancy were compared in women with post-LKD pregnancies. Pregnancy outcomes post-LKD were compared with pre-LKD pregnancy outcomes. 234 women (499 pregnancies) were included, of which 20 with pre- and post-LKD pregnancies (68) and 26 with only post-LKD pregnancies (59). Multilevel analysis demonstrated that eGFR was not different between women with and without post-LKD pregnancies (p = 0.23). Furthermore, eGFR was not different before and after post-LKD pregnancy (p = 0.13). More hypertensive disorders of pregnancy (HDP) occurred in post-LKD pregnancies (p = 0.002). Adverse fetal outcomes did not differ. We conclude that, despite a higher incidence of HDP, eGFR was not affected by post-LKD pregnancy. In line with previous studies, we found an increased risk for HDP after LKD without affecting fetal outcome. Therefore, a pregnancy wish alone should not be a reason to exclude women for LKD.

Published
2023

29. Counselling on Conceiving:Attitudes and Factors Influencing Advice of Professionals in Transplantation

Author

van Buren, Marleen C., Gosselink, Margriet, Massey, Emma K., van de Wetering, Jacqueline, Lely, A. Titia, van Buren, Marleen C., Gosselink, Margriet, Massey, Emma K., van de Wetering, Jacqueline, and Lely, A. Titia

Abstract

Pregnancy after kidney transplantation (KT) conveys risks of adverse pregnancy outcomes (APO). Little is known about performance of pre-pregnancy counselling after KT. This study investigated perceptions of risk, attitudes towards pregnancy and factors influencing advice given at pre-pregnancy counselling after KT. A web-based vignette survey was conducted among nephrologists and gynaecologists between March 2020 and March 2021, consisting of five vignettes containing known risk factors for APO and general questions on pre-pregnancy counselling after KT. Per vignette, attitudes towards pregnancy and estimation of outcomes were examined. In total 52 nephrologists and 25 gynaecologists participated, 56% from university hospitals. One third had no experience with pregnancy after KT. All gave positive pregnancy advice in the vignette with ideal circumstances (V1), versus 83% in V2 (proteinuria), 81% in V3 (hypertension), 71% in V4 (eGFR 40 ml/min/1.73 m2). Only 2% was positive in V5 (worst-case scenario). Chance of preeclampsia was underestimated by 89% in V1. 63% and 98% overestimated risk for graft loss in V4 and V5. Professionals often incorrectly estimated risk of APO after KT. As experience with pregnancy after KT was limited among professionals, patients should be referred to specialised centres for multidisciplinary pre-pregnancy counselling to build experience and increase consistency in given advice.

Published
2023

30. OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE):study protocol of a multicentre, retrospective cohort study

Author

van de Meent, Mette, Kleuskens, Dianne G., Ganzevoort, Wessel, Gordijn, Sanne J., Kooi, Elisabeth M.W., Onland, Wes, van Rijn, Bas B., Duvekot, Johannes J., Kornelisse, René F., Al-Nasiry, Salwan, Jellema, Reint K., Knol, H. Marieke, Manten, Gwendolyn T.R., Mulder-de Tollenaer, Susanne M., Derks, Jan B., Groenendaal, Floris, Bekker, Mireille N., Schuit, Ewoud, Lely, A. Titia, Kooiman, Judith, van de Meent, Mette, Kleuskens, Dianne G., Ganzevoort, Wessel, Gordijn, Sanne J., Kooi, Elisabeth M.W., Onland, Wes, van Rijn, Bas B., Duvekot, Johannes J., Kornelisse, René F., Al-Nasiry, Salwan, Jellema, Reint K., Knol, H. Marieke, Manten, Gwendolyn T.R., Mulder-de Tollenaer, Susanne M., Derks, Jan B., Groenendaal, Floris, Bekker, Mireille N., Schuit, Ewoud, Lely, A. Titia, and Kooiman, Judith

Abstract

Introduction Early-onset fetal growth restriction (FGR) requires timely, often preterm, delivery to prevent fetal hypoxia causing stillbirth or neurologic impairment. Antenatal corticosteroids (CCS) administration reduces neonatal morbidity and mortality following preterm birth, most effectively when administered within 1 week preceding delivery. Optimal timing of CCS administration is challenging in early-onset FGR, as the exact onset and course of fetal hypoxia are unpredictable. International guidelines do not provide a directive on this topic. In the Netherlands, two timing strategies are commonly practiced: administration of CCS when the umbilical artery shows (A) a pulsatility index above the 95th h centile and (B) absent or reversed end-diastolic velocity (a more progressed disease state). This study aims to (1) use practice variation to compare CCS timing strategies in early-onset FGR on fetal and neonatal outcomes and (2) develop a dynamic tool to predict the time interval in days until delivery, as a novel timing strategy for antenatal CCS in early-onset FGR. Methods and analysis A multicentre, retrospective cohort study will be performed including pregnancies complicated by early-onset FGR in six tertiary hospitals in the Netherlands in the period between 2012 and 2021 (estimated sample size n=1800). Main exclusion criteria are multiple pregnancies and fetal congenital or genetic abnormalities. Routinely collected data will be extracted from medical charts. Primary outcome for the comparison of the two CCS timing strategies is a composite of perinatal, neonatal and in-hospital mortality. Secondary outcomes include the COSGROVE core outcome set for FGR. A multivariable, mixed-effects model will be used to compare timing strategies on study outcomes. Primary outcome for the dynamic prediction tool is € days until birth'. Ethics and dissemination The need for ethical approval was waived by the Ethics Committee (University Medical Center Utrecht). Results

Published
2023

31. Long-Term Kidney and Maternal Outcomes After Pregnancy in Living Kidney Donors

Author

MS Verloskunde, Child Health, Circulatory Health, van Buren, Marleen C., Meinderts, Jildau R., Oudmaijer, Christiaan A.J., de Jong, Margriet F.C., Groen, Henk, Royaards, Tessa, Maasdam, Louise, Tielen, Mirjam, Reinders, Marlies E.J., Lely, A. Titia, van de Wetering, Jacqueline, MS Verloskunde, Child Health, Circulatory Health, van Buren, Marleen C., Meinderts, Jildau R., Oudmaijer, Christiaan A.J., de Jong, Margriet F.C., Groen, Henk, Royaards, Tessa, Maasdam, Louise, Tielen, Mirjam, Reinders, Marlies E.J., Lely, A. Titia, and van de Wetering, Jacqueline

Published
2023

33. Counselling on Conceiving: Attitudes and Factors Influencing Advice of Professionals in Transplantation

Author

Genetica Groep Van Tintelen, MS Verloskunde, Child Health, Circulatory Health, van Buren, Marleen C., Gosselink, Margriet, Massey, Emma K., van de Wetering, Jacqueline, Lely, A. Titia, Genetica Groep Van Tintelen, MS Verloskunde, Child Health, Circulatory Health, van Buren, Marleen C., Gosselink, Margriet, Massey, Emma K., van de Wetering, Jacqueline, and Lely, A. Titia

Published
2023

34. Statins in pre-eclampsia or fetal growth restriction: A systematic review and meta-analysis on maternal blood pressure and fetal growth across species

Author

MS Verloskunde, Onderzoek, Child Health, Circulatory Health, Meijerink, Lotte, Wever, Kim E., Terstappen, Fieke, Ganzevoort, Wessel, Lely, A. Titia, Depmann, Martine, MS Verloskunde, Onderzoek, Child Health, Circulatory Health, Meijerink, Lotte, Wever, Kim E., Terstappen, Fieke, Ganzevoort, Wessel, Lely, A. Titia, and Depmann, Martine

Published
2023

35. Cohort profile: the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) Study-an ongoing prospective cohort study of patients at high cardiovascular risk in the Netherlands

Author

Interne Geneeskunde Vasculaire, Cardiologie, Team Medisch, Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, MS Interne Geneeskunde, MS Geriatrie, Brain, Researchgr. Systems Radiology, Cancer, Infection & Immunity, CTC, Neurologen, MS Verloskunde, Child Health, Cardiovasculaire Epi Team 3, Epi Methoden Team 3, Nefro Vasculaire Geneeskunde, Castelijns, Maria C., Helmink, Marga A.G., Hageman, Steven H.J., Asselbergs, Folkert W., De Borst, Gert J., Bots, Michiel L., Cramer, Maarten J., Dorresteijn, Jannick A.N., Emmelot-Vonk, Marielle H., Geerlings, Mirjam I., De Jong, Pim A., Van Der Kaaij, Niels P., Kappelle, L. Jaap, Lely, A. Titia, Van Der Meer, Manon G., Mol, Barend M., Nathoe, Hendrik M., Onland-Moret, N. Charlotte, Van Petersen, Rutger B., Ruigrok, Ynte M., Van Smeden, Maarten, Teraa, Martin, Vandersteen, Angela, Verhaar, Marianne C., Westerink, Jan, Visseren, Frank L.J., Interne Geneeskunde Vasculaire, Cardiologie, Team Medisch, Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, MS Interne Geneeskunde, MS Geriatrie, Brain, Researchgr. Systems Radiology, Cancer, Infection & Immunity, CTC, Neurologen, MS Verloskunde, Child Health, Cardiovasculaire Epi Team 3, Epi Methoden Team 3, Nefro Vasculaire Geneeskunde, Castelijns, Maria C., Helmink, Marga A.G., Hageman, Steven H.J., Asselbergs, Folkert W., De Borst, Gert J., Bots, Michiel L., Cramer, Maarten J., Dorresteijn, Jannick A.N., Emmelot-Vonk, Marielle H., Geerlings, Mirjam I., De Jong, Pim A., Van Der Kaaij, Niels P., Kappelle, L. Jaap, Lely, A. Titia, Van Der Meer, Manon G., Mol, Barend M., Nathoe, Hendrik M., Onland-Moret, N. Charlotte, Van Petersen, Rutger B., Ruigrok, Ynte M., Van Smeden, Maarten, Teraa, Martin, Vandersteen, Angela, Verhaar, Marianne C., Westerink, Jan, and Visseren, Frank L.J.

Published
2023

36. OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE): study protocol of a multicentre, retrospective cohort study

Author

MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Circulatory Health, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Arts-assistenten DV&B, van de Meent, Mette, Kleuskens, Dianne G, Ganzevoort, Wessel, Gordijn, Sanne J, Kooi, Elisabeth M W, Onland, Wes, van Rijn, Bas B, Duvekot, Johannes J, Kornelisse, René F, Al-Nasiry, Salwan, Jellema, Reint K, Knol, H Marieke, Manten, Gwendolyn T R, Mulder-de Tollenaer, Susanne M, Derks, Jan B, Groenendaal, Floris, Bekker, Mireille N, Schuit, Ewoud, Lely, A Titia, Kooiman, Judith, MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Child Health, Regenerative Medicine and Stem Cells, Circulatory Health, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Arts-assistenten DV&B, van de Meent, Mette, Kleuskens, Dianne G, Ganzevoort, Wessel, Gordijn, Sanne J, Kooi, Elisabeth M W, Onland, Wes, van Rijn, Bas B, Duvekot, Johannes J, Kornelisse, René F, Al-Nasiry, Salwan, Jellema, Reint K, Knol, H Marieke, Manten, Gwendolyn T R, Mulder-de Tollenaer, Susanne M, Derks, Jan B, Groenendaal, Floris, Bekker, Mireille N, Schuit, Ewoud, Lely, A Titia, and Kooiman, Judith

Published
2023

40. OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE): study protocol of a multicentre, retrospective cohort study

Author

van de Meent, Mette, primary, Kleuskens, Dianne G., additional, Ganzevoort, Wessel, additional, Gordijn, Sanne J., additional, Kooi, Elisabeth M. W., additional, Onland, Wes, additional, van Rijn, Bas B., additional, Duvekot, Johannes J., additional, Kornelisse, René F., additional, Al-Nasiry, Salwan, additional, Jellema, Reint K., additional, Knol, H. Marieke, additional, Manten, Gwendolyn T. R., additional, Mulder-de Tollenaer, Susanne M., additional, Derks, Jan B., additional, Groenendaal, Floris, additional, Bekker, Mireille N., additional, Schuit, Ewoud, additional, Lely, A. Titia, additional, and Kooiman, Judith, additional

Published
2023
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41. Cohort profile: the Utrecht Cardiovascular Cohort–Second Manifestations of Arterial Disease (UCC-SMART) Study–an ongoing prospective cohort study of patients at high cardiovascular risk in the Netherlands

Author

Castelijns, Maria C, primary, Helmink, Marga A G, additional, Hageman, Steven H J, additional, Asselbergs, Folkert W, additional, de Borst, Gert J, additional, Bots, Michiel L, additional, Cramer, Maarten J, additional, Dorresteijn, Jannick A N, additional, Emmelot-Vonk, Marielle H, additional, Geerlings, Mirjam I, additional, de Jong, Pim A, additional, van der Kaaij, Niels P, additional, Kappelle, L Jaap, additional, Lely, A Titia, additional, van der Meer, Manon G, additional, Mol, Barend M, additional, Nathoe, Hendrik M, additional, Onland-Moret, N Charlotte, additional, van Petersen, Rutger B, additional, Ruigrok, Ynte M, additional, van Smeden, Maarten, additional, Teraa, Martin, additional, Vandersteen, Angela, additional, Verhaar, Marianne C, additional, Westerink, Jan, additional, and Visseren, Frank L J, additional

Published
2023
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45. Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

Author

van der Hout-van der Jagt, M. Beatrijs, Verweij, E.J.T., Andriessen, Peter, de Boode, Willem P., Bos, Arend F., Delbressine, Frank L.M., Eggink, Alex J., Erwich, Jan Jaap H.M., Feijs, Loe M.G., Groenendaal, Floris, Kramer, Boris W.W., Lely, A. Titia, Loop, Rachel F.A.M., Neukamp, Franziska, Onland, Wes, Oudijk, Martijn A., te Pas, Arjan B., Reiss, Irwin K.M., Schoberer, Mark, Scholten, Ralph R., Spaanderman, Marc E.A., van der Ven, Myrthe, Vermeulen, Marijn J., van de Vosse, Frans N., Oei, S. Guid, van der Hout-van der Jagt, M. Beatrijs, Verweij, E.J.T., Andriessen, Peter, de Boode, Willem P., Bos, Arend F., Delbressine, Frank L.M., Eggink, Alex J., Erwich, Jan Jaap H.M., Feijs, Loe M.G., Groenendaal, Floris, Kramer, Boris W.W., Lely, A. Titia, Loop, Rachel F.A.M., Neukamp, Franziska, Onland, Wes, Oudijk, Martijn A., te Pas, Arjan B., Reiss, Irwin K.M., Schoberer, Mark, Scholten, Ralph R., Spaanderman, Marc E.A., van der Ven, Myrthe, Vermeulen, Marijn J., van de Vosse, Frans N., and Oei, S. Guid

Abstract

Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-ethical and legal aspects, its application area, and the corresponding design implications. This paper represents the consensus opinion of a group of healthcare professionals, designers, ethicists, researchers and patient representatives, who have expertise in tertiary obstetric and neonatal care, bio-ethics, experimental perinatal animal models for physiologic research, biomedical modeling, monitoring, and design. The aim of this paper is to provide a framework for research and development of PLS technology. These requirements are considering the possible respective user perspectives, with the aim to co-create a PLS system that facilitates physiological growth and development for extremely preterm born infants.

Published
2022

46. Effect of Pregnancy on eGFR after Kidney Transplantation:A National Cohort Study

Author

Van Buren, Marleen C., Gosselink, Margriet, Groen, Henk, Van Hamersvelt, Henk, De Jong, Margriet, De Borst, Martin H., Zietse, Robert, Van De Wetering, Jacqueline, Lely, A. Titia, Van Buren, Marleen C., Gosselink, Margriet, Groen, Henk, Van Hamersvelt, Henk, De Jong, Margriet, De Borst, Martin H., Zietse, Robert, Van De Wetering, Jacqueline, and Lely, A. Titia

Abstract

Background. The effect of pregnancy on the course of estimated glomerular filtration rate (eGFR) is unknown in kidney transplant recipients (KTRs). Methods. We conducted a nationwide multicenter cohort study in KTRs with pregnancy (>20 wk) after kidney transplantation (KT). Annual eGFRs after KT until death or graft loss and additional eGFRs before each pregnancy were collected according to protocol. Changes in eGFR slope before and after each pregnancy were analyzed by generalized estimating equations multilevel analysis adjusted for transplant vintage. Results. We included 3194 eGFR measurements before and after pregnancy in 109 (55%) KTRs with 1, 78 (40%) with 2, and 10 (5%) with 3 pregnancies after KT. Median follow-up after first delivery post-KT was 14 y (interquartile range, 18 y). Adjusted mean eGFR prepregnancy was 59 mL/min/1.73 m2(SEM [standard error of the mean] 1.72; 95% confidence interval [CI], 56-63), after the first pregnancy 56 mL/min/1.73 m2(SEM 1.70; 95% CI, 53-60), after the second pregnancy 56 mL/min/1.73 m2(SEM 2.19; 95% CI, 51-60), and after the third pregnancy 55 mL/min/1.73 m2(SEM 8.63; 95% CI, 38-72). Overall eGFR slope after the first, second, and third pregnancies was not significantly worse than prepregnancy (P = 0.28). However, adjusted mean eGFR after the first pregnancy was 2.8 mL/min/1.73 m2(P = 0.08) lower than prepregnancy. Conclusions. The first pregnancy has a small, but insignificant, effect on eGFR slope in KTRs. Midterm hyperfiltration, a marker for renal reserve capacity, was associated with better eGFR and death-censored graft survival. In this KTR cohort with long-term follow-up, no significant effect of pregnancy on kidney function was detected.

Published
2022

48. Erratum: Maternal and Perinatal Outcome in Women with Systemic Lupus Erythematosus: A Retrospective Bicenter Cohort Study(Journal of Immunology Research (2017) 2017 (8245879) DOI: 10.1155/2017/8245879)

Author

Unit Opleiding Aios, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Verloskunde, Child Health, Circulatory Health, Kroese, Sylvia J., Abheiden, Carolien N.H., Blomjous, Birgit S., Van Laar, Jacob M., Derksen, Ronald W.H.M., Bultink, Irene E.M., Voskuyl, Alexandre E., Lely, A. Titia, De Boer, Marjon A., De Vries, Johanna I.P., Fritsch-Stork, Ruth D.E., Unit Opleiding Aios, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Verloskunde, Child Health, Circulatory Health, Kroese, Sylvia J., Abheiden, Carolien N.H., Blomjous, Birgit S., Van Laar, Jacob M., Derksen, Ronald W.H.M., Bultink, Irene E.M., Voskuyl, Alexandre E., Lely, A. Titia, De Boer, Marjon A., De Vries, Johanna I.P., and Fritsch-Stork, Ruth D.E.

Published
2022

49. A nationwide Dutch cohort study shows relatively good pregnancy outcomes after kidney transplantation and finds risk factors for adverse outcomes

Author

Genetica Groep Van Tintelen, MS Verloskunde, Child Health, Circulatory Health, Gosselink, Margriet E, van Buren, Marleen C, Kooiman, Judith, Groen, Henk, Ganzevoort, Wessel, van Hamersvelt, Henk W, van der Heijden, Olivier W H, van de Wetering, Jacqueline, Lely, A Titia, Genetica Groep Van Tintelen, MS Verloskunde, Child Health, Circulatory Health, Gosselink, Margriet E, van Buren, Marleen C, Kooiman, Judith, Groen, Henk, Ganzevoort, Wessel, van Hamersvelt, Henk W, van der Heijden, Olivier W H, van de Wetering, Jacqueline, and Lely, A Titia

Published
2022

50. Menstrual problems in chronic immune thrombocytopenia: A monthly challenge - a cohort study and review

Author

Poli Van Creveldkliniek Medisch, Child Health, MS VPG/Gynaecologie, MS Verloskunde, Circulatory Health, Infection & Immunity, van Dijk, Wobke E M, Punt, Marieke C, van Galen, Karin P M, van Leeuwen, Jeanette, Lely, A Titia, Schutgens, Roger E G, Poli Van Creveldkliniek Medisch, Child Health, MS VPG/Gynaecologie, MS Verloskunde, Circulatory Health, Infection & Immunity, van Dijk, Wobke E M, Punt, Marieke C, van Galen, Karin P M, van Leeuwen, Jeanette, Lely, A Titia, and Schutgens, Roger E G

Published
2022

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