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3. POS0517 GREATER USE OF ASSISTED REPRODUCTIVE TECHNIQUES BUT COMPARABLE OBSTETRIC MORBIDITY IN A POPULATION OF WOMEN WITH SPONDYLOARTHRITIS: A MATCHED COMPARATIVE ANALYSIS OF THE GR2 PROSPECTIVE COHORT AND THE FRENCH NATIONAL PERINATAL SURVEYS

Author

Hamroun, S., primary, Martin de Frémont, G., additional, Costedoat-Chalumeau, N., additional, Couderc, M., additional, Flipo, R. M., additional, Sellam, J., additional, Richez, C., additional, Belkhir, R., additional, Gossec, L., additional, Marotte, H., additional, Dernis, E., additional, Frazier-Mironer, A., additional, Gervais, E., additional, Lukas, C., additional, Devauchelle-Pensec, V., additional, Dunogeant, L., additional, Deroux, A., additional, Le Guern, V., additional, Guettrot Imbert, G., additional, Lelong, N., additional, Le Ray, C., additional, Seror, R., additional, and Moltó, A., additional

Published
2024
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6. Surrisque de prématurité chez les nouveau-nés de femmes atteintes de polyarthrite rhumatoïde : analyse comparative appariée de la cohorte prospective GR2-RIC et des enquêtes nationales périnatales françaises

Author

Hamroun, S., primary, Martin de Frémont, G., additional, Costedoat-Chalumeau, N., additional, Couderc, M., additional, Flipo, R.M., additional, Gossec, L., additional, Richez, C., additional, Belkhir, R., additional, Frazier, A., additional, Devauchelle Pensec, V., additional, Marotte, H., additional, Sellam, J., additional, Elisabeth, G., additional, Alban, D., additional, Lukas, C., additional, Dernis, E., additional, Chatelus, E., additional, Le Gern, V., additional, Guettrot-Imbert, G., additional, Lelong, N., additional, Le Ray, C., additional, Seror, R., additional, and Molto, A., additional

Published
2023
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7. Un recours supérieur à la PMA mais une morbidité obstétricale comparable dans une population de femmes atteintes de spondylarthrite: analyse comparative appariée de la cohorte prospective GR2-RIC et des Enquête Nationales Périnatales françaises

Author

Hamroun, S., primary, Martin de Frémont, G., additional, Costedoat-Chalumeau, N., additional, Couderc, M., additional, Flipo, R.M., additional, Sellam, J., additional, Richez, C., additional, Belkhir, R., additional, Gossec, L., additional, Marotte, H., additional, Dernis, E., additional, Frazier, A., additional, Elisabeth, G., additional, Lukas, C., additional, Devauchelle Pensec, V., additional, Dunogeant, L., additional, Alban, D., additional, Le Gern, V., additional, Guettrot-Imbert, G., additional, Lelong, N., additional, Le Ray, C., additional, Seror, R., additional, and Molto, A., additional

Published
2023
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8. Prevalence and risk of Down syndrome in monozygotic and dizygotic multiple pregnancies in Europe: implications for prenatal screening

Author

Boyle, B, Morris, JK, McConkey, R, Garne, E, Loane, M, Addor, MC, Gatt, M, Haeusler, M, Latos-Bielenska, A, Lelong, N, McDonnell, R, Mullaney, C, O’Mahony, M, and Dolk, H

Subjects
Intellectual and Developmental Disabilities (IDD), Prevention, Genetics, Conditions Affecting the Embryonic and Fetal Periods, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Brain Disorders, Clinical Research, Down Syndrome, Reproductive health and childbirth, Congenital, Good Health and Well Being, Adult, Europe, Female, Humans, Maternal Age, Middle Aged, Pregnancy, Pregnancy Outcome, Pregnancy, Multiple, Prenatal Diagnosis, Prevalence, Risk, Risk Assessment, Twins, Dizygotic, Twins, Monozygotic, Young Adult, Concordance, Down syndrome, monozygotic and dizygotic pregnancies, multiple births, pregnancy outcomes, twins, Medical and Health Sciences, Obstetrics & Reproductive Medicine
Abstract

ObjectiveTo determine risk of Down syndrome (DS) in multiple relative to singleton pregnancies, and compare prenatal diagnosis rates and pregnancy outcome.DesignPopulation-based prevalence study based on EUROCAT congenital anomaly registries.SettingEight European countries.Population14.8 million births 1990-2009; 2.89% multiple births.MethodsDS cases included livebirths, fetal deaths from 20 weeks, and terminations of pregnancy for fetal anomaly (TOPFA). Zygosity is inferred from like/unlike sex for birth denominators, and from concordance for DS cases.Main outcome measuresRelative risk (RR) of DS per fetus/baby from multiple versus singleton pregnancies and per pregnancy in monozygotic/dizygotic versus singleton pregnancies. Proportion of prenatally diagnosed and pregnancy outcome.Statistical analysisPoisson and logistic regression stratified for maternal age, country and time.ResultsOverall, the adjusted (adj) RR of DS for fetus/babies from multiple versus singleton pregnancies was 0.58 (95% CI 0.53-0.62), similar for all maternal ages except for mothers over 44, for whom it was considerably lower. In 8.7% of twin pairs affected by DS, both co-twins were diagnosed with the condition. The adjRR of DS for monozygotic versus singleton pregnancies was 0.34 (95% CI 0.25-0.44) and for dizygotic versus singleton pregnancies 1.34 (95% CI 1.23-1.46). DS fetuses from multiple births were less likely to be prenatally diagnosed than singletons (adjOR 0.62 [95% CI 0.50-0.78]) and following diagnosis less likely to be TOPFA (adjOR 0.40 [95% CI 0.27-0.59]).ConclusionsThe risk of DS per fetus/baby is lower in multiple than singleton pregnancies. These estimates can be used for genetic counselling and prenatal screening.

Published
2014

15. To which extent social withdrawal at the age of 1 year is associated with IQ at 5–6 years old? Results of the EDEN mother–child cohort

Author

Guedeney, Antoine, Doukhan, Sarah, Forhan, Anne, Heude, Barbara, Peyre, Hugo, Annesi-Maesano, I., Bernard, J. Y., Botton, J., Charles, M. A., Dargent-Molina, P., de Lauzon-Guillain, B., Ducimetière, P., de Agostini, M., Foliguet, B., Forhan, A., Fritel, X., Germa, A., Goua, V., Hankard, R., Heude, B., Kaminski, M., Larroque, B., Lelong, N., Lepeule, J., Magnin, G., Marchand, L., Nabet, C., Pierre, F., Slama, R., Saurel-Cubizolles, M. J., Schweitzer, M., Thiebaugeorges, O., and On behalf of the EDEN Mother–Child Cohort Study Group

Published
2017
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23. Linking a European cohort of children born with congenital anomalies to vital statistics and mortality records: A EUROlinkCAT study

Author

Loane, M., primary, Given, J. E., additional, Tan, J., additional, Reid, A., additional, Akhmedzhanova, D., additional, Astolfi, G., additional, Barišić, I., additional, Bertille, N., additional, Bonet, L. B., additional, Carbonell, C. C., additional, Carollo, O. Mokoroa, additional, Coi, A., additional, Densem, J., additional, Draper, E., additional, Garne, E., additional, Gatt, M., additional, Glinianaia, S. V., additional, Heino, A., additional, Hond, E. Den, additional, Jordan, S., additional, Khoshnood, B., additional, Kiuru-Kuhlefelt, S., additional, Klungsøyr, K., additional, Lelong, N., additional, Lutke, L. R., additional, Neville, A. J., additional, Ostapchuk, L., additional, Puccini, A., additional, Rissmann, A., additional, Santoro, M., additional, Scanlon, I., additional, Thys, G., additional, Tucker, D., additional, Urhoj, S. K., additional, de Walle, H. E. K., additional, Wellesley, D., additional, Zurriaga, O., additional, and Morris, J. K., additional

Published
2021
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24. Linking a European cohort of children born with congenital anomalies to vital statistics and mortality records:A EUROlinkCAT study

Author

Loane, M., Given, J. E., Tan, J., Reid, A., Akhmedzhanova, D., Astolfi, G., Barišić, I., Bertille, N., Bonet, L. B., Carbonell, C. C., Carollo, O. Mokoroa, Coi, A., Densem, J., Draper, E., Gatt, M., Glinianaia, S. V., Heino, A., Hond, E. Den, Jordan, S., Khoshnood, B., Kiuru-Kuhlefelt, S., Klungsøyr, K., Lelong, N., Lutke, L. R., Neville, A. J., Ostapchuk, L., Puccini, A., Rissmann, A., Santoro, M., Scanlon, I., Thys, G., Tucker, D., Urhoj, S. K., De Walle, H. E.K., Wellesley, D., Zurriaga, O., Morris, J. K., Loane, M., Given, J. E., Tan, J., Reid, A., Akhmedzhanova, D., Astolfi, G., Barišić, I., Bertille, N., Bonet, L. B., Carbonell, C. C., Carollo, O. Mokoroa, Coi, A., Densem, J., Draper, E., Gatt, M., Glinianaia, S. V., Heino, A., Hond, E. Den, Jordan, S., Khoshnood, B., Kiuru-Kuhlefelt, S., Klungsøyr, K., Lelong, N., Lutke, L. R., Neville, A. J., Ostapchuk, L., Puccini, A., Rissmann, A., Santoro, M., Scanlon, I., Thys, G., Tucker, D., Urhoj, S. K., De Walle, H. E.K., Wellesley, D., Zurriaga, O., and Morris, J. K.

Abstract

EUROCAT is a European network of population-based congenital anomaly (CA) registries. Twenty-one registries agreed to participate in the EUROlinkCAT study to determine if reliable information on the survival of children born with a major CA between 1995 and 2014 can be obtained through linkage to national vital statistics or mortality records. Live birth children with a CA could be linked using personal identifiers to either their national vital statistics (including birth records, death records, hospital records) or to mortality records only, depending on the data available within each region. In total, 18 of 21 registries with data on 192,862 children born with congenital anomalies participated in the study. One registry was unable to get ethical approval to participate and linkage was not possible for two registries due to local reasons. Eleven registries linked to vital statistics and seven registries linked to mortality records only; one of the latter only had identification numbers for 78% of cases, hence it was excluded from further analysis. For registries linking to vital statistics: six linked over 95% of their cases for all years and five were unable to link at least 85% of all live born CA children in the earlier years of the study. No estimate of linkage success could be calculated for registries linking to mortality records. Irrespective of linkage method, deaths that occurred during the first week of life were over three times less likely to be linked compared to deaths occurring after the first week of life. Linkage to vital statistics can provide accurate estimates of survival of children with CAs in some European countries. Bias arises when linkage is not successful, as early neonatal deaths were less likely to be linked. Linkage to mortality records only cannot be recommended, as linkage quality, and hence bias, cannot be assessed.

Published
2021

27. Anorectal malformations and pregnancy-related disorders: a registry-based case–control study in 17 European regions

Author

Wijers, C HW, van Rooij, I ALM, Bakker, M K, Marcelis, C LM, Addor, M C, Barisic, I, Béres, J, Bianca, S, Bianchi, F, Calzolari, E, Greenlees, R, Lelong, N, Latos-Bielenska, A, Dias, C M, McDonnell, R, Mullaney, C, Nelen, V, OʼMahony, M, Queisser-Luft, A, Rankin, J, Zymak-Zakutnia, N, de Blaauw, I, Roeleveld, N, and de Walle, H EK

Published
2013
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28. Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984–2007

Author

Boyle, B, McConkey, R, Garne, E, Loane, M, Addor, M C, Bakker, M K, Boyd, P A, Gatt, M, Greenlees, R, Haeusler, M, Klungsyr, K, Latos-Bielenska, A, Lelong, N, McDonnell, R, Métneki, J, Mullaney, C, Nelen, V, OʼMahony, M, Pierini, A, Rankin, J, Rissmann, A, Tucker, D, Wellesley, D, and Dolk, H

Published
2013
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34. Trisomy 13 and 18—Prevalence and mortality—A multi‐registry population based analysis

Author

Goel, N, Morris, JK, Tucker, D, de Walle, HEK, Bakker, MK, Kancherla, V, Marengo, L, Canfield, MA, Kallen, K, Lelong, N, Camelo, JL, Stallings, EB, Jones, AM, Nance, A, Huynh, M-P, Martínez-Fernández, M-L, Sipek, A, Pierini, A, Nembhard, WN, Goetz, D, Rissmann, A, Groisman, B, Luna-Muñoz, L, Szabova, E, Lapchenko, S, Zarante, I, Hurtado-Villa, P, Martinez, LE, Tagliabue, G, Landau, D, Gatt, M, Dastgiri, S, and Morgan, M

Abstract

The aim of the study is to determine the prevalence, outcomes, and survival (among live births [LB]), in pregnancies diagnosed with trisomy 13 (T13) and 18 (T18), by congenital anomaly register and region. Twenty‐four population‐ and hospital‐based birth defects surveillance registers from 18 countries, contributed data on T13 and T18 between 1974 and 2014 using a common data‐reporting protocol. The mean total birth prevalence (i.e., LB, stillbirths, and elective termination of pregnancy for fetal anomalies [ETOPFA]) in the registers with ETOPFA (n = 15) for T13 was 1.68 (95% CI 1.3–2.06), and for T18 was 4.08 (95% CI 3.01–5.15), per 10,000 births. The prevalence varied among the various registers. The mean prevalence among LB in all registers for T13 was 0.55 (95%CI 0.38–0.72), and for T18 was 1.07 (95% CI 0.77–1.38), per 10,000 births. The median mortality in the first week of life was 48% for T13 and 42% for T18, across all registers, half of which occurred on the first day of life. Across 16 registers with complete 1‐year follow‐up, mortality in first year of life was 87% for T13 and 88% for T18. This study provides an international perspective on prevalence and mortality of T13 and T18. Overall outcomes and survival among LB were poor with about half of live born infants not surviving first week of life; nevertheless about 10% survived the first year of life. Prevalence and outcomes varied by country and termination policies. The study highlights the variation in screening, data collection, and reporting practices for these conditions.

Published
2019

35. Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

Author

Yong, Chu Yan, primary, Reynaud, Eve, additional, Forhan, Anne, additional, Dargent-Molina, Patricia, additional, Heude, Barbara, additional, Charles, Marie-Aline, additional, Plancoulaine, Sabine, additional, Annesi-Maesano, I., additional, Bernard, J.Y., additional, Botton, J., additional, Charles, M.A., additional, Dargent-Molina, P., additional, de Lauzon-Guillain, B., additional, Ducimetière, P., additional, de Agostini, M., additional, Foliguet, B., additional, Forhan, A., additional, Fritel, X., additional, Germa, A., additional, Goua, V., additional, Hankard, R., additional, Heude, B., additional, Kaminski, M., additional, Larroque, B., additional, Lelong, N., additional, Lepeule, J., additional, Magnin, G., additional, Marchand, L., additional, Nabet, C., additional, Pierre, F., additional, Slama, R., additional, Saurel-Cubizolles, M.J., additional, Schweitzer, M., additional, and Thiebaugeorges, O., additional

Published
2019
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36. Early oral exposure to house dust mite allergen through breast milk: A potential risk factor for allergic sensitization and respiratory allergies in children

Author

Annesi-Maesano, I., Bernard, J.Y., Botton, J., Charles, M.A., Dargent-Molina, P., de Lauzon-Guillain, B., Ducimetière, P., de Agostini, M., Foliguet, B., Forhan, A., Fritel, X., Germa, A., Goua, V., Hankard, R., Heude, B., Kaminski, M., Larroque, B., Lelong, N., Lepeule, J., Magnin, G., Pierre, F., Marchand, L., Nabet, C., Slama, R., Saurel-Cubizolles, M.J., Schweitzer, M., Thiebaugeorges, O., Baïz, Nour, Macchiaverni, Patricia, Tulic, Meri K., Rekima, Akila, Annesi-Maesano, Isabella, and Verhasselt, Valérie

Published
2017
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37. The changing epidemiology of Ebstein's anomaly and its relationship with maternal mental health conditions: a European registry-based study

Author

Boyle B, Garne E, Loane M, Addor MC, Arriola L, Cavero-Carbonell C, Gatt M, Lelong N, Lynch C, Nelen V, Neville AJ, O'Mahony M, Pierini A, Rissmann A, Tucker D, Zymak-Zakutnia N, and Dolk H

Subjects
Ebstein's anomaly, antidepressants, prevalence, psycholeptics, mental illness
Abstract

Objectives: The aim of this study was to describe the epidemiology of Ebstein's anomaly in Europe and its association with maternal health and medication exposure during pregnancy. Design: We carried out a descriptive epidemiological analysis of population-based data. Setting: We included data from 15 European Surveillance of Congenital Anomalies Congenital Anomaly Registries in 12 European countries, with a population of 5.6 million births during 1982-2011. Participants: Cases included live births, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly. Main outcome measures: We estimated total prevalence per 10,000 births. Odds ratios for exposure to maternal illnesses/medications in the first trimester of pregnancy were calculated by comparing Ebstein's anomaly cases with cardiac and non-cardiac malformed controls, excluding cases with genetic syndromes and adjusting for time period and country. Results: In total, 264 Ebstein's anomaly cases were recorded; 81% were live births, 2% of which were diagnosed after the 1st year of life; 54% of cases with Ebstein's anomaly or a co-existing congenital anomaly were prenatally diagnosed. Total prevalence rose over time from 0.29 (95% confidence interval (CI) 0.20-0.41) to 0.48 (95% CI 0.40-0.57) (p < 0.01). In all, nine cases were exposed to maternal mental health conditions/medications (adjusted odds ratio (adjOR) 2.64, 95% CI 1.33-5.21) compared with cardiac controls. Cases were more likely to be exposed to maternal beta-thalassemia (adjOR 10.5, 95% CI 3.13-35.3, n = 3) and haemorrhage in early pregnancy (adjOR 1.77, 95% CI 0.93-3.38, n = 11) compared with cardiac controls. Conclusions: The increasing prevalence of Ebstein's anomaly may be related to better and earlier diagnosis. Our data suggest that Ebstein's anomaly is associated with maternal mental health problems generally rather than lithium or benzodiazepines specifically; therefore, changing or stopping medications may not be preventative. We found new associations requiring confirmation.

Published
2017

38. Developing a knowledge base to support the annotation of ultrasound images of ectopic pregnancy

Author

Dhombres, F., Maurice, P., Friszer, S., Guilbaud, L., Lelong, N., Khoshnood, B., Jean Charlet, Perrot, N., Jauniaux, E., Jurkovic, D., Jm Jouannic, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Echographie [Paris], Centre d’Imagerie Médicale Pyramides [Paris], Department of Obstetrics and Gynaecology [UCL - London, UK], University College of London [London] (UCL)-Institute for Women's Health [London, UK], Department of Obstetrics and Gynaecology [UCLH - London, UK], Gynaecology Diagnostic and Outpatient Treatment Unit [UCLH - London, UK], University College London Hospitals (UCLH)-University College London Hospitals (UCLH), The development of the web-application was founded by the SATT-Lutech for the Pierre and Marie Curie University, Paris, France., Charlet, Jean, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé ( LIMICS ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris 13 ( UP13 ), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique ( CRESS - U1153 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ), University College of London [London] ( UCL ) -Institute for Women's Health [London, UK], University College London Hospitals ( UCLH ) -University College London Hospitals ( UCLH ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), and BMC, BMC

Subjects
[ SDV ] Life Sciences [q-bio], Ectopic pregnancy, Research, [SDV]Life Sciences [q-bio], Application ontology, Pregnancy, Ectopic, [SDV] Life Sciences [q-bio], Knowledge base, Biological Ontologies, Pregnancy, Data Mining, Humans, Female, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Ultrasonography, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]
Abstract

International audience; AbstractBackgroundEctopic pregnancy is a frequent early complication of pregnancy associated with significant rates of morbidly and mortality. The positive diagnosis of this condition is established through transvaginal ultrasound scanning. The timing of diagnosis depends on the operator expertise in identifying the signs of ectopic pregnancy, which varies dramatically among medical staff with heterogeneous training. Developing decision support systems in this context is expected to improve the identification of these signs and subsequently improve the quality of care. In this article, we present a new knowledge base for ectopic pregnancy, and we demonstrate its use on the annotation of clinical images.ResultsThe knowledge base is supported by an application ontology, which provides the taxonomy, the vocabulary and definitions for 24 types and 81 signs of ectopic pregnancy, 484 anatomical structures and 32 technical elements for image acquisition. The knowledge base provides a sign-centric model of the domain, with the relations of signs to ectopic pregnancy types, anatomical structures and the technical elements. The evaluation of the ontology and knowledge base demonstrated a positive feedback from a panel of 17 medical users. Leveraging these semantic resources, we developed an application for the annotation of ultrasound images. Using this application, 6 operators achieved a precision of 0.83 for the identification of signs in 208 ultrasound images corresponding to 35 clinical cases of ectopic pregnancy.ConclusionsWe developed a new ectopic pregnancy knowledge base for the annotation of ultrasound images. The use of this knowledge base for the annotation of ultrasound images of ectopic pregnancy showed promising results from the perspective of clinical decision support system development. Other gynecological disorders and fetal anomalies may benefit from our approach.

Published
2016

40. Postpartum psychological distress associated with anal incontinence in the EDEN mother-child cohort.

Author

Fritel, X, Gachon, B, Saurel‐Cubizolles, MJ, Annesi‐Maesano, I, Bernard, JY, Botton, J, Charles, MA, Dargent‐Molina, P, de Lauzon‐Guillain, B, Ducimetière, P, de Agostini, M, Foliguet, B, Forhan, A, Germa, A, Goua, V, Hankard, R, Heude, B, Kaminski, M, Larroque, B, and Lelong, N

Subjects
PSYCHOLOGICAL distress, POSTPARTUM depression, HOSPITAL wards, MENTAL health, WOMEN'S hospitals, PRENATAL depression
Abstract

Objective: To estimate the prevalence of flatus-only and faecal incontinence, to describe their risk factors and to analyse the association between anal incontinence and psychological distress over the first year postpartum.Design: Cohort study from pregnancy to 12 months postpartum.Setting: Two university hospital maternity wards in France.Population: A total of 2002 pregnant women were recruited between 2003 and 2006. Data on anal incontinence were available for the 1632 women who comprise the sample for analysis.Methods: Women were enrolled during pregnancy. A postal questionnaire was sent at 4 and 12 months postpartum.Main Outcome Measures: Anal (flatus-only and faecal) incontinence was assessed at 4 months postpartum. Mental health was assessed at 4 and 12 months postpartum by the Edinburgh Postpartum Depression Scale (EPDS) and use of antidepressant drugs as well as by self-rated mental health.Results: At 4 months postpartum, the prevalence for flatus-only incontinence was 14.4% and for faecal incontinence 1.7%; multivariate analysis, restricted to women reporting no anal incontinence before the index pregnancy, showed that continuing breastfeeding at 4 months was related to a higher risk of de novo postpartum anal incontinence (OR = 2.23). Women who reported anal incontinence at 4 months were more frequently depressed (EPDS ≥10 or antidepressant use) at 12 months postpartum: 36.0% of those with faecal incontinence were depressed, 23.3% of those with flatus-only incontinence and only 14.8% of the continent women.Conclusion: Postnatal faecal incontinence was rare but associated with poorer maternal mental health. Postnatal screening should be encouraged, and psychological support offered.Tweetable Abstract: Postnatal faecal incontinence was associated with depression; postnatal screening should be encouraged and psychological support offered. [ABSTRACT FROM AUTHOR]

Published
2020
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42. Night sleep duration trajectories and associated factors among preschool children from the EDEN cohort

Author

Plancoulaine, Sabine, primary, Reynaud, Eve, additional, Forhan, Anne, additional, Lioret, Sandrine, additional, Heude, Barbara, additional, Charles, Marie-Aline, additional, Annesi-Maesano, I., additional, Bernard, J.Y., additional, Botton, J., additional, Charles, M.A., additional, Dargent-Molina, P., additional, de Lauzon-Guillain, B., additional, Ducimetière, P., additional, de Agostini, M., additional, Foliguet, B., additional, Forhan, A., additional, Fritel, X., additional, Germa, A., additional, Goua, V., additional, Hankard, R., additional, Heude, B., additional, Kaminski, M., additional, Larroque, B., additional, Lelong, N., additional, Lepeule, J., additional, Magnin, G., additional, Marchand, L., additional, Nabet, C., additional, Pierre, F., additional, Slama, R., additional, Saurel-Cubizolles, M.J., additional, Schweitzer, M., additional, and Thiebaugeorges, O., additional

Published
2018
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43. Night-waking and behavior in preschoolers: a developmental trajectory approach

Author

Reynaud, Eve, primary, Forhan, Anne, additional, Heude, Barbara, additional, Charles, Marie-Aline, additional, Plancoulaine, Sabine, additional, Annesi-Maesano, I., additional, Bernard, J.Y., additional, Botton, J., additional, Charles, M.A., additional, Dargent-Molina, P., additional, de Lauzon-Guillain, B., additional, Ducimetière, P., additional, de Agostini, M., additional, Foliguet, B., additional, Forhan, A., additional, Fritel, X., additional, Germa, A., additional, Goua, V., additional, Hankard, R., additional, Heude, B., additional, Kaminski, M., additional, Larroque, B., additional, Lelong, N., additional, Lepeule, J., additional, Magnin, G., additional, Marchand, L., additional, Nabet, C., additional, Pierre, F., additional, Slama, R., additional, Saurel-Cubizolles, M.J., additional, Schweitzer, M., additional, and Thiebaugeorgeson, O., additional

Published
2018
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44. Early oral exposure to house dust mite allergen through breast milk: A potential risk factor for allergic sensitization and respiratory allergies in children

Author

Baïz, Nour, primary, Macchiaverni, Patricia, additional, Tulic, Meri K., additional, Rekima, Akila, additional, Annesi-Maesano, Isabella, additional, Verhasselt, Valérie, additional, Annesi-Maesano, I., additional, Bernard, J.Y., additional, Botton, J., additional, Charles, M.A., additional, Dargent-Molina, P., additional, de Lauzon-Guillain, B., additional, Ducimetière, P., additional, de Agostini, M., additional, Foliguet, B., additional, Forhan, A., additional, Fritel, X., additional, Germa, A., additional, Goua, V., additional, Hankard, R., additional, Heude, B., additional, Kaminski, M., additional, Larroque, B., additional, Lelong, N., additional, Lepeule, J., additional, Magnin, G., additional, Pierre, F., additional, Marchand, L., additional, Nabet, C., additional, Slama, R., additional, Saurel-Cubizolles, M.J., additional, Schweitzer, M., additional, and Thiebaugeorges, O., additional

Published
2017
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45. Prenatal natural history of congenital pulmonary malformations: MALFPULM population-based cohort study.

Author

Delacourt, C., Bertille, N., Salomon, L. J., Benachi, A., Henry, E., Massardier, J., Mottet, N., Rosenblatt, J., Sartor, A., Thong‐Vanh, C., Valat‐Rigot, A. S., Winer, N., Lelong, N., Khoshnood, B., Alanio, E., Bory, J.‐P., Aquilue, L. N., Choupeaux, L., Hauw, C., and Banaszkiewicz, N.

Subjects
HUMAN abnormalities, NATURAL history, COHORT analysis, DIAGNOSTIC ultrasonic imaging, GESTATIONAL age, DIAGNOSIS of fetal diseases, FETAL ultrasonic imaging, LONGITUDINAL method, PRENATAL care, PROGNOSIS, RESEARCH funding, LUNG abnormalities
Abstract

Objectives: To assess prenatal changes in the volume of congenital pulmonary malformations (CPM) and examine whether these changes differ in lesions that appear cystic on ultrasound compared with hyperechoic lesions, and to study the relationship between CPM volume and risk of fetal compression.Methods: We conducted a nationally representative, multicenter, prospective cohort study, which included 579 ultrasound examinations in 176 pregnant women with a diagnosis of fetal CPM, between March 2015 and November 2016. Several ultrasound examinations were performed between diagnosis and delivery, including measurement of CPM volume. We modeled changes in CPM volume ratio (CVR) as a function of gestational age, overall and for cystic/mixed vs hyperechoic malformations, and examined the association between CVR and signs of compression during pregnancy.Results: When modeling CVR changes over time, there was a statistically significant decrease in CVR with increasing gestational age (P < 0.001), but the pattern of change differed according to CPM phenotype at first ultrasound examination: cystic/mixed CPM were characterized by a monotonic decrease in CVR with increasing gestational age (P = 0.002), whereas hyperechoic CPM showed an initial increase in CVR up to 27 weeks of gestation, followed by a decrease thereafter (P < 0.001). Peak CVR values were predicted as early as 21-22 weeks for cystic/mixed CPMs compared with 25-26 weeks for hyperechoic malformations. Regardless of CPM phenotype, fetuses that showed no sign of compression at any point had substantially lower CVR at first CVR measurement, and the CVR remained relatively constant thereafter. Among the subpopulation of fetuses with no sign of compression at first CVR measurement, the odds of a subsequent compression was 7-fold higher (adjusted odds ratio, 7.0; 95% CI, 1.6-29.9) if initial CVR was > 0.4 vs CVR ≤ 0.4 cm2 .Conclusions: Predicted changes in CVR during pregnancy differ between cystic and hyperechoic malformations. This may be the result of different pathophysiological mechanisms or differences in the timing of occurrence of these different types of CPM. CVR measured at the initial diagnostic ultrasound examination was strongly associated with the odds of subsequent compression. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Prevalence and Risk of Down Syndrome in Monozygotic and Dizygotic Multiple Pregnancies in Europe

Author

Boyle, B., primary, Morris, J.K., additional, McConkey, R., additional, Garne, E., additional, Loane, M., additional, Addor, M.C., additional, Gatt, M., additional, Haeusler, M., additional, Latos-Bielensk, A., additional, Lelong, N., additional, McDonnell, R., additional, Mullaney, C., additional, O’Mahony, M., additional, and Dolk, H., additional

Published
2014
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48. Anorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regions

Author

Wijers, C.H.W., Rooij, I.A.L.M. van, Bakker, M.K., Marcelis, C.L.M., Addor, M.C., Barisic, I., Beres, J., Bianca, S., Bianchi, F., Calzolari, E., Greenlees, R., Lelong, N., Latos-Bielenska, A., Dias, C.M., McDonnell, R., Mullaney, C., Nelen, V., O'Mahony, M., Queisser-Luft, A., Rankin, J., Zymak-Zakutnia, N., Blaauw, I. de, Roeleveld, N., Walle, H.E. de, Wijers, C.H.W., Rooij, I.A.L.M. van, Bakker, M.K., Marcelis, C.L.M., Addor, M.C., Barisic, I., Beres, J., Bianca, S., Bianchi, F., Calzolari, E., Greenlees, R., Lelong, N., Latos-Bielenska, A., Dias, C.M., McDonnell, R., Mullaney, C., Nelen, V., O'Mahony, M., Queisser-Luft, A., Rankin, J., Zymak-Zakutnia, N., Blaauw, I. de, Roeleveld, N., and Walle, H.E. de

Abstract

Item does not contain fulltext, OBJECTIVE: To identify pregnancy-related risk factors for different manifestations of congenital anorectal malformations (ARMs). DESIGN: A population-based case-control study. SETTING: Seventeen EUROCAT (European Surveillance of Congenital Anomalies) registries, 1980-2008. POPULATION: The study population consisted of 1417 cases with ARM, including 648 cases of isolated ARM, 601 cases of ARM with additional congenital anomalies, and 168 cases of ARM-VACTERL (vertebral, anal, cardiac, tracheo-esophageal, renal, and limb defects), along with 13 371 controls with recognised syndromes or chromosomal abnormalities. METHODS: Multiple logistic regression analyses were used to calculate adjusted odds ratios (ORs) for potential risk factors for ARM, such as fertility treatment, multiple pregnancy, primiparity, maternal illnesses during pregnancy, and pregnancy-related complications. MAIN OUTCOME MEASURES: Adjusted ORs for pregnancy-related risk factors for ARM. RESULTS: The ARM cases were more likely to be firstborn than the controls (OR 1.6, 95% CI 1.4-1.8). Fertility treatment and being one of twins or triplets seemed to increase the risk of ARM in cases with additional congenital anomalies or VACTERL (ORs ranging from 1.6 to 2.5). Maternal fever during pregnancy and pre-eclampsia were only associated with ARM when additional congenital anomalies were present (OR 3.9, 95% CI 1.3-11.6; OR 3.4, 95% CI 1.6-7.1, respectively), whereas maternal epilepsy during pregnancy resulted in a five-fold elevated risk of all manifestations of ARM (OR 5.1, 95% CI 1.7-15.6). CONCLUSIONS: This large European study identified maternal epilepsy, fertility treatment, multiple pregnancy, primiparity, pre-eclampsia, and maternal fever during pregnancy as potential risk factors primarily for complex manifestations of ARM with additional congenital anomalies and VACTERL.

Published
2013

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