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502 results on '"Lell M"'

2. Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity: the randomized controlled FORMOsA-sarcopenic obesity study

Author

Wittmann K, Sieber C, von Stengel S, Kohl M, Freiberger E, Jakob F, Lell M, Engelke K, and Kemmler W

Subjects
Sarcopenic Obesity, Whole-Body Electromyostimulation, Cardiometabolic Risk, Metabolic Syndrome, Community-Dwelling, Older Woman, Geriatrics, RC952-954.6
Abstract

Katharina Wittmann,1 Cornel Sieber,2 Simon von Stengel,1 Matthias Kohl,3 Ellen Freiberger,2 Franz Jakob,4 Michael Lell,5 Klaus Engelke,1 Wolfgang Kemmler1 1Institute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, 2Institute for Biomedicine of Aging, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, 3Faculty of Medical and Life Sciences, University of Furtwangen, 4Musculoskeletal Research Center, University of Würzburg, Würzburg, 5Department of Radiology and Nuclear Medicine, Klinikum Nürnberg, Paracelsus Medizinische Privatuniversität, Nürnberg, Germany Background: Sarcopenic obesity (SO) is characterized by a combination of low muscle and high fat mass with an additive negative effect of both conditions on cardiometabolic risk. The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on the metabolic syndrome (MetS) in community-dwelling women aged ≥70 years with SO. Methods: The study was conducted in an ambulatory university setting. Seventy-five community-dwelling women aged ≥70 years with SO living in Northern Bavaria, Germany, were randomly allocated to either 6 months of WB-EMS application with (WB-EMS&P) or without (WB-EMS) dietary supplementation (150 kcal/day, 56% protein) or a non-training control group (CG). WB-EMS included one session of 20 min (85 Hz, 350 µs, 4 s of strain–4 s of rest) per week with moderate-to-high intensity. The primary study endpoint was the MetS Z-score with the components waist circumference (WC), mean arterial pressure (MAP), triglycerides, fasting plasma glucose, and high-density lipoprotein cholesterol (HDL-C); secondary study endpoints were changes in these determining variables. Results: MetS Z-score decreased in both groups; however, changes compared with the CG were significant (P=0.001) in the WB-EMS&P group only. On analyzing the components of the MetS, significant positive effects for both WB-EMS groups (P≤0.038) were identified for MAP, while the WB-EMS group significantly differed for WC (P=0.036), and the WB-EMS&P group significantly differed for HDL-C (P=0.006) from the CG. No significant differences were observed between the WB-EMS groups. Conclusion: The study clearly confirms the favorable effect of WB-EMS application on the MetS in community-dwelling women aged ≥70 years with SO. However, protein-enriched supplements did not increase effects of WB-EMS alone. In summary, we considered this novel technology an effective and safe method to prevent cardiometabolic risk factors and diseases in older women unable or unwilling to exercise conventionally. Keywords: sarcopenia, obesity, whole-body electromyostimulation, cardiovascular, metabolic risk, metabolic syndrome, community-dwelling, older people

Published
2016

3. Sportwissenschaft

Author

Kemmler W, Tutor M, Lell M, Scharf M, Fraunberger L, and von Stengel S

Subjects
Sports medicine, RC1200-1245
Published
2014
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7. Larynx

Author

Greess, H., Lell, M., Kösling, Sabrina, editor, and Bootz, Friedrich, editor

Published
2015
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10. Onkologische Diagnostik

Author

Lukas, P., Sweeney, R., Felber, S., Lell, M., Bautz, W., Frede, T., Nömayr, A., Trieb, T. R., Judmaier, W., Wannenmacher, Michael, editor, Wenz, Frederik, editor, and Debus, Jürgen, editor

Published
2013
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14. Onkologische Diagnostik

Author

Lukas, P., Sweeney, R., Felber, S., Lell, M., Bautz, W., Frede, T., Nömayr, A., Trieb, T. R., Judmaier, W., Wannenmacher, M., editor, Debus, J., editor, and Wenz, F., editor

Published
2006
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20. Multislice CT in the Diagnosis of Pancreatic Tumors

Author

Baum, U., Lell, M., Nömayr, A., Brunner, T., Wenkel, E., Greess, H., Dobritz, M., Bautz, W. A., Baert, A. L., editor, Sartor, K., editor, Reiser, Maximilian F., editor, Takahashi, Mutsumasa, editor, Modic, Michael, editor, and Bruening, Roland, editor

Published
2001
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47. Testing of alignment parameters for ancient samples: evaluating and optimizing mapping parameters for ancient samples using the TAPAS tool

Author

Taron, U, Lell, M, Barlow, A, and Paijmans, J

Subjects
lcsh:Genetics, paleogenomics, lcsh:QH426-470, palaeogenomics, short-read mapping, ancient DNA, alignment sensitivity/specificity
Abstract

High-throughput sequence data retrieved from ancient or other degraded samples has led to unprecedented insights into the evolutionary history of many species, but the analysis of such sequences also poses specific computational challenges. The most commonly used approach involves mapping sequence reads to a reference genome. However, this process becomes increasingly challenging with an elevated genetic distance between target and reference or with the presence of contaminant sequences with high sequence similarity to the target species. The evaluation and testing of mapping efficiency and stringency are thus paramount for the reliable identification and analysis of ancient sequences. In this paper, we present ‘TAPAS’, (Testing of Alignment Parameters for Ancient Samples), a computational tool that enables the systematic testing of mapping tools for ancient data by simulating sequence data reflecting the properties of an ancient dataset and performing test runs using the mapping software and parameter settings of interest. We showcase TAPAS by using it to assess and improve mapping strategy for a degraded sample from a banded linsang (Prionodon linsang), for which no closely related reference is currently available. This enables a 1.8-fold increase of the number of mapped reads without sacrificing mapping specificity. The increase of mapped reads effectively reduces the need for additional sequencing, thus making more economical use of time, resources, and sample material.

Published
2018

49. Die Computertomographie bei der Bildgebung von Kindern mit kongenitalen Herzvitien

Author

Glaser-Gallion, N., Stinn, B., Alkadhi, H., Lell, M., Goo, H.W., Paul, J. -F, Wildermuth, S., Leschka, S., Glaser-Gallion, N., Stinn, B., Alkadhi, H., Lell, M., Goo, H.W., Paul, J. -F, Wildermuth, S., and Leschka, S.

Abstract

Zusammenfassung: Kongenitale Herzfehler sind die häufigsten kongenitalen Fehlbildungen. Echokardiographie und Katheterangiographie gelten allgemein als Goldstandard zur Abklärung angeborener Herzerkrankungen. Die Magnetresonanztomographie ist aufgrund ihrer Fähigkeit, Herzvitien morphologisch und funktionell zu charakterisieren, als ein wichtiges ergänzendes Verfahren anzusehen. Durch mehr und mehr dosissparende Untersuchungsprotokolle der neuesten Gerätegenerationen und eine gleichzeitig bessere zeitliche und räumliche Auflösung findet die Computertomographie zunehmend Eingang in die Abklärung kongenitaler Herzfehler. In der präoperativen Planung und der postoperativen Kontrolle erlaubt sie eine übersichtliche Darstellung komplexer Fehlbildung nicht nur des Herzens, sondern auch der pulmonalvenösen und -arteriellen Zirkulation sowie des systemischen Kreislaufs. Dieser Beitrag gibt eine Übersicht über die technischen Aspekte der kardialen CT und die Anpassung des Untersuchungsprotokolls an die zu erwartende Pathologie und das Alter des Kindes. Zudem werden die Möglichkeiten und Limitationen der unterschiedlichen dosissparenden Protokolle erläutert

Published
2018

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