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5 results on '"Lekadir, K. (Karim)"'

1. Cardiometabolic risk estimation using exposome data and machine learning

Author

Atehortúa, A. (Angélica), Gkontra, P. (Polyxeni), Camacho, M. (Marina), Diaz, O. (Oliver), Bulgheroni, M. (Maria), Simonetti, V. (Valentina), Chadeau-Hyam, M. (Marc), Felix, J. F. (Janine F.), Sebert, S. (Sylvain), Lekadir, K. (Karim), Atehortúa, A. (Angélica), Gkontra, P. (Polyxeni), Camacho, M. (Marina), Diaz, O. (Oliver), Bulgheroni, M. (Maria), Simonetti, V. (Valentina), Chadeau-Hyam, M. (Marc), Felix, J. F. (Janine F.), Sebert, S. (Sylvain), and Lekadir, K. (Karim)

Abstract

Background: The human exposome encompasses all exposures that individuals encounter throughout their lifetime. It is now widely acknowledged that health outcomes are influenced not only by genetic factors but also by the interactions between these factors and various exposures. Consequently, the exposome has emerged as a significant contributor to the overall risk of developing major diseases, such as cardiovascular disease (CVD) and diabetes. Therefore, personalized early risk assessment based on exposome attributes might be a promising tool for identifying high-risk individuals and improving disease prevention. Objective: Develop and evaluate a novel and fair machine learning (ML) model for CVD and type 2 diabetes (T2D) risk prediction based on a set of readily available exposome factors. We evaluated our model using internal and external validation groups from a multi-center cohort. To be considered fair, the model was required to demonstrate consistent performance across different sub-groups of the cohort. Methods: From the UK Biobank, we identified 5,348 and 1,534 participants who within 13 years from the baseline visit were diagnosed with CVD and T2D, respectively. An equal number of participants who did not develop these pathologies were randomly selected as the control group. 109 readily available exposure variables from six different categories (physical measures, environmental, lifestyle, mental health events, sociodemographics, and early-life factors) from the participant’s baseline visit were considered. We adopted the XGBoost ensemble model to predict individuals at risk of developing the diseases. The model’s performance was compared to that of an integrative ML model which is based on a set of biological, clinical, physical, and sociodemographic variables, and, additionally for CVD, to the Framingham risk score. Moreover, we assessed the proposed model for potential bias related to sex, ethnicity, and age. Lastly, we interpreted the model’s r

Published
2023

2. LongITools:dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author

Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), Sebert, S. (Sylvain), Ronkainen, J. (Justiina), Nedelec, R. (Rozenn), Atehortua, A. (Angelica), Balkhiyarova, Z. (Zhanna), Cascarano, A. (Anna), Elhakeem, A. (Ahmed), van Enckevort, E. (Esther), Soares, A. G. (Ana Goncalves), Haakma, S. (Sido), Halonen, M. (Miia), Heil, K. F. (Katharina F.), Heiskala, A. (Anni), Hyde, E. (Eleanor), Jacquemin, B. (Benedicte), Keikkala, E. (Elina), Kerckhoffs, J. (Jules), Klavus, A. (Anton), Kopinska, J. A. (Joanna A.), Lepeule, J. (Johanna), Marazzi, F. (Francesca), Motoc, I. (Irina), Näätänen, M. (Mari), Ribbenstedt, A. (Anton), Rundblad, A. (Amanda), Savolainen, O. (Otto), Simonetti, V. (Valentina), Eadie, N. d. (Nina de Toro), Tzala, E. (Evangelia), Ulrich, A. (Anna), Wright, T. (Thomas), Zarei, I. (Iman), d'Amico, E. (Enrico), Belotti, F. (Federico), Brunius, C. (Carl), Castleton, C. (Christopher), Charles, M.-A. (Marie-Aline), Gaillard, R. (Romy), Hanhineva, K. (Kati), Hoek, G. (Gerard), Holven, K. B. (Kirsten B.), Jaddoe, V. W. (Vincent W. V.), Kaakinen, M. A. (Marika A.), Kajantie, E. (Eero), Kavousi, M. (Maryam), Lakka, T. (Timo), Matthews, J. (Jason), Mortari, A. P. (Andrea Piano), Vääräsmäki, M. (Marja), Voortman, T. (Trudy), Webster, C. (Claire), Zins, M. (Marie), Atella, V. (Vincenzo), Bulgheroni, M. (Maria), Chadeau-Hyam, M. (Marc), Conti, G. (Gabriella), Evans, J. (Jayne), Felix, J. F. (Janine F.), Heude, B. (Barbara), Järvelin, M.-R. (Marjo-Riitta), Kolehmainen, M. (Marjukka), Landberg, R. (Rikard), Lekadir, K. (Karim), Parusso, S. (Stefano), Prokopenko, I. (Inga), de Rooij, S. R. (Susanne R.), Roseboom, T. (Tessa), Swertz, M. (Morris), Timpson, N. (Nicholas), Ulven, S. M. (Stine M.), Vermeulen, R. (Roel), Juola, T. (Teija), and Sebert, S. (Sylvain)

Abstract

The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our ”modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate change, and aging. Evidence suggests that these changes are related to each other, although the social and biological mechanisms as well as their interactions have yet to be uncovered. LongITools, as one of the 9 projects included in the European Human Exposome Network, will tackle this environmental health equation linking multidimensional environmental exposures to the occurrence of cardiovascular and metabolic noncommunicable diseases.

Published
2022

3. An agenda-setting paper on data sharing platforms:euCanSHare workshop

Author

Devriendt, T. (Thijs), Ammann, C. (Clemens), Asselberghs, F. W. (Folkert W.), Bernier, A. (Alexander), Costas, R. (Rodrigo), Friedrich, M. G. (Matthias G.), Gelpi, J. L. (Josep L.), Järvelin, M.-R. (Marjo-Riitta), Kuulasmaa, K. (Kari), Lekadir, K. (Karim), Mayrhofer, M. T. (Michaela Th.), Papez, V. (Vaclav), Pasterkamp, G. (Gerard), Petersen, S. E. (Steffen E.), Schmidt, C. O. (Carsten Oliver), Schulz-Menger, J. (Jeanette), Söderberg, S. (Stefan), Shabani, M. (Mahsa), Veronesi, G. (Giovanni), Viezzer, D. S. (Darian Steven), and Borry, P. (Pascal)

Subjects
science policy, data infrastructure, incentives, data sharing, open science
Abstract

Various data sharing platforms are being developed to enhance the sharing of cohort data by addressing the fragmented state of data storage and access systems. However, policy challenges in several domains remain unresolved. The euCanSHare workshop was organized to identify and discuss these challenges and to set the future research agenda. Concerns over the multiplicity and long-term sustainability of platforms, lack of resources, access of commercial parties to medical data, credit and recognition mechanisms in academia and the organization of data access committees are outlined. Within these areas, solutions need to be devised to ensure an optimal functioning of platforms.

Published
2021

4. Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project

Author

Mariani, N. (Nicole), Borsini, A. (Alessandra), Cecil, C.A.M. (Charlotte), Felix, J.F. (Janine), Sebert, S. (Sylvain), Cattaneo, A. (Annamaria), Walton, E. (Esther), Milaneschi, Y. (Yuri), Cochrane, G. (Guy), Amid, C. (Clara), Rajan, J. (Jeena), Giacobbe, J. (Juliette), Sanz, Y. (Yolanda), Agustí, A. (Ana), Sorg, T. (Tania), Hérault, Y. (Yann), Miettunen, J. (Jouko), Parmar, P. (Priyanka), Cattane, N. (Nadia), Jaddoe, V. (Vincent), Lötjönen, J. (Jyrki), Buisan, C. (Carme), González Ballester, M.A. (Miguel A.), Piella, G. (Gemma), Gelpi, J.L. (Josep L.), Lamers, F., Penninx, B.W.J.H. (Brenda), Tiemeier, H.W. (Henning), von Tottleben, M. (Malte), Thiel, R. (Rainer), Heil, K.F. (Katharina F.), Järvelin, M.-R. (Marjo-Riitta), Pariante, C. (Carmine), Mansuy, I.M. (Isabelle M.), Lekadir, K. (Karim), Mariani, N. (Nicole), Borsini, A. (Alessandra), Cecil, C.A.M. (Charlotte), Felix, J.F. (Janine), Sebert, S. (Sylvain), Cattaneo, A. (Annamaria), Walton, E. (Esther), Milaneschi, Y. (Yuri), Cochrane, G. (Guy), Amid, C. (Clara), Rajan, J. (Jeena), Giacobbe, J. (Juliette), Sanz, Y. (Yolanda), Agustí, A. (Ana), Sorg, T. (Tania), Hérault, Y. (Yann), Miettunen, J. (Jouko), Parmar, P. (Priyanka), Cattane, N. (Nadia), Jaddoe, V. (Vincent), Lötjönen, J. (Jyrki), Buisan, C. (Carme), González Ballester, M.A. (Miguel A.), Piella, G. (Gemma), Gelpi, J.L. (Josep L.), Lamers, F., Penninx, B.W.J.H. (Brenda), Tiemeier, H.W. (Henning), von Tottleben, M. (Malte), Thiel, R. (Rainer), Heil, K.F. (Katharina F.), Järvelin, M.-R. (Marjo-Riitta), Pariante, C. (Carmine), Mansuy, I.M. (Isabelle M.), and Lekadir, K. (Karim)

Abstract

Introduction Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards the shared risk of these diseases and the development of coordinated preventive and therapeutic interventions. Methods and analysis This paper describes the study protocol for EarlyCause, a large-scale and inter-disciplinary research project funded by the European Union’s Horizon 2020 research and innovation programme. The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shapes an individual’s physical and mental health in adulthood. The study will research in detail how ELS converts into biological signals embedded simultaneously or sequentially in the brain, the cardiovascular and metabolic systems. The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. Life-course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. These strategies will help better manage the impact of multi-morbidity on human health and the associated risk.

Published
2021
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5. Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity:the EarlyCause project

Author

Mariani, N. (Nicole), Borsini, A. (Alessandra), Cecil, C. A. (Charlotte A. M.), Felix, J. F. (Janine F.), Sebert, S. (Sylvain), Cattaneo, A. (Annamaria), Walton, E. (Esther), Milaneschi, Y. (Yuri), Cochrane, G. (Guy), Amid, C. (Clara), Rajan, J. (Jeena), Giacobbe, J. (Juliette), Sanz, Y. (Yolanda), Agusti, A. (Ana), Sorg, T. (Tania), Herault, Y. (Yann), Miettunen, J. (Jouko), Parmar, P. (Priyanka), Cattane, N. (Nadia), Jaddoe, V. (Vincent), Lotjonen, J. (Jyrki), Buisan, C. (Carme), Gonzalez Ballester, M. A. (Miguel A.), Piella, G. (Gemma), Gelpi, J. L. (Josep L.), Lamers, F. (Femke), Penninx, B. W. (Brenda W. J. H.), Tiemeier, H. (Henning), von Tottleben, M. (Malte), Thiel, R. (Rainer), Heil, K. F. (Katharina F.), Jarvelin, M.-R. (Marjo-Riitta), Pariante, C. (Carmine), Mansuy, I. M. (Isabelle M.), Lekadir, K. (Karim), Mariani, N. (Nicole), Borsini, A. (Alessandra), Cecil, C. A. (Charlotte A. M.), Felix, J. F. (Janine F.), Sebert, S. (Sylvain), Cattaneo, A. (Annamaria), Walton, E. (Esther), Milaneschi, Y. (Yuri), Cochrane, G. (Guy), Amid, C. (Clara), Rajan, J. (Jeena), Giacobbe, J. (Juliette), Sanz, Y. (Yolanda), Agusti, A. (Ana), Sorg, T. (Tania), Herault, Y. (Yann), Miettunen, J. (Jouko), Parmar, P. (Priyanka), Cattane, N. (Nadia), Jaddoe, V. (Vincent), Lotjonen, J. (Jyrki), Buisan, C. (Carme), Gonzalez Ballester, M. A. (Miguel A.), Piella, G. (Gemma), Gelpi, J. L. (Josep L.), Lamers, F. (Femke), Penninx, B. W. (Brenda W. J. H.), Tiemeier, H. (Henning), von Tottleben, M. (Malte), Thiel, R. (Rainer), Heil, K. F. (Katharina F.), Jarvelin, M.-R. (Marjo-Riitta), Pariante, C. (Carmine), Mansuy, I. M. (Isabelle M.), and Lekadir, K. (Karim)

Abstract

Introduction: Depression, cardiovascular diseases and diabetes are among the major non-communicable diseases, leading to significant disability and mortality worldwide. These diseases may share environmental and genetic determinants associated with multimorbid patterns. Stressful early-life events are among the primary factors associated with the development of mental and physical diseases. However, possible causative mechanisms linking early life stress (ELS) with psycho-cardio-metabolic (PCM) multi-morbidity are not well understood. This prevents a full understanding of causal pathways towards the shared risk of these diseases and the development of coordinated preventive and therapeutic interventions. Methods and analysis: This paper describes the study protocol for EarlyCause, a large-scale and inter-disciplinary research project funded by the European Union’s Horizon 2020 research and innovation programme. The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shapes an individual’s physical and mental health in adulthood. The study will research in detail how ELS converts into biological signals embedded simultaneously or sequentially in the brain, the cardiovascular and metabolic systems. The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. Life-course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. These strategies will help better manage the impact of multi-morbidity on human health and the associated risk.

Published
2021

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