Search

Your search keyword '"Lejoncour, A."' showing total 13 results
Start Over Author "Lejoncour, A."
13 results on '"Lejoncour, A."'

1. Behçet's disease uveitis

Author

Joubert, M., Desbois, A.-C., Domont, F., Ghembaza, A., Lejoncour, A., Mirouse, A., Maalouf, G., Leclercq, M., Touhami, S., Cacoub, P., Bodaghi, B., and Saadoun, D.

Published
2023
Full Text
View/download PDF

2. Specific Follicular Helper T Cell Signature in Takayasu Arteritis

Author

A.C. Desbois, Boris Bienvenu, Nicolas Dérian, Valentin Quiniou, M Rosenzwag, David Klatzmann, P Bruneval, Maxime Samson, David Saadoun, H. Vallet, Anna Maciejewski-Duval, Cloé Comarmond, Pierre Fouret, Damien Sène, Jacques Pouchot, Fabien Koskas, P. Régnier, G. Darrasse-Jèze, A Lejoncour, Marlène Garrido, and Patrice Cacoub

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, Receptors, CXCR5, 0301 basic medicine, T Follicular Helper Cells, Receptors, Antigen, T-Cell, alpha-beta, Antigens, CD19, Giant Cell Arteritis, Programmed Cell Death 1 Receptor, Immunology, C-C chemokine receptor type 6, CXCR3, CD19, Immunophenotyping, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Nitriles, Humans, Janus Kinase Inhibitors, Immunology and Allergy, Aorta, Aged, Cell Proliferation, Aged, 80 and over, 030203 arthritis & rheumatology, CD20, B-Lymphocytes, biology, Gene Expression Profiling, T-cell receptor, Middle Aged, Antigens, CD20, Takayasu Arteritis, CCL20, Pyrimidines, Tertiary Lymphoid Structures, 030104 developmental biology, Immunoglobulin G, biology.protein, Pyrazoles, Female, Antibody, Transcriptome, Immunologic Memory
Abstract

OBJECTIVE Our aim was to compare transcriptome and phenotype profiles of CD4+ T cells and CD19+ B cells in patients with Takayasu arteritis (TAK), patients with giant cell arteritis (GCA), and healthy donors. METHODS Gene expression analyses, flow cytometry immunophenotyping, T cell receptor (TCR) gene sequencing, and functional assessments of cells from peripheral blood and arterial lesions from TAK patients, GCA patients, and healthy donors were performed. RESULTS Among the most significantly dysregulated genes in CD4+ T cells of TAK patients compared to GCA patients (n = 720 genes) and in CD4+ T cells of TAK patients compared to healthy donors (n = 1,447 genes), we identified a follicular helper T (Tfh) cell signature, which included CXCR5, CCR6, and CCL20 genes, that was transcriptionally up-regulated in TAK patients. Phenotypically, there was an increase in CD4+CXCR5+CCR6+CXCR3- Tfh17 cells in TAK patients that was associated with a significant enrichment of CD19+ B cell activation. Functionally, Tfh cells helped B cells to proliferate, differentiate into memory cells, and secrete IgG antibodies. Maturation of B cells was inhibited by JAK inhibitors. Locally, in areas of arterial inflammation, we found a higher proportion of tertiary lymphoid structures comprised CD4+, CXCR5+, programmed death 1+, and CD20+ cells in TAK patients compared to GCA patients. CD4+CXCR5+ T cells in the aortas of TAK patients had an oligoclonal α/β TCR repertoire. CONCLUSION We established the presence of a specific Tfh cell signature in both circulating and aorta-infiltrating CD4+ T cells from TAK patients. The cooperation of Tfh cells and B cells might be critical in the occurrence of vascular inflammation in patients with TAK.

Published
2021

3. Specific Follicular Helper T Cell Signature in Takayasu Arteritis

Author

Desbois, A. C., primary, Régnier, P., additional, Quiniou, V., additional, Lejoncour, A., additional, Maciejewski‐Duval, A., additional, Comarmond, C., additional, Vallet, H., additional, Rosenzwag, M., additional, Darrasse‐Jèze, G., additional, Derian, N., additional, Pouchot, J., additional, Samson, M., additional, Bienvenu, B., additional, Fouret, P., additional, Koskas, F., additional, Garrido, M., additional, Sène, D., additional, Bruneval, P., additional, Cacoub, P., additional, Klatzmann, D., additional, and Saadoun, D., additional

Published
2021
Full Text
View/download PDF

4. The vasoactive peptide urotensin II as a new chemokine exhibits migration/adhesion mesenchymal properties accompanying angiogenesis during glioma development

Author

Castel, Hélène, Guichet, Pierre-Olivier, Lecointre, Céline, Lejoncour, Vadim, Joubert Jane, Eileen, Perzo, Nicolas, Leduc, Richard, Prézeau, Laurent, Laquerrière, Annie, Morin, Fabrice, Gandolfo, Pierrick, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Sherbrooke (UdeS), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), and Histopathology Laboratory, Rouen University Hospital

Subjects
[SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

5. The vasoactive peptide urotensinII: A chemokine exhibiting migration/adhesion properties in glioma

Author

Castel, H, Lecointre, C, LeJoncour, V, guichet, po, joubert, je, Perzo, N, Desrues, L, Modzelewski, R, Vera, P, Bohn, P, Morin, F, Gandolfo, P, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Service de médecine nucléaire [Rouen], and CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

6. Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis

Author

Benoît Joseph, Vadim Lejoncour, Marie-Thérèse Schouft, François Liger, Céline Lecointre, Laurent Meijer, Gildas Lyvinec, Marie Jarry, Pierrick Gandolfo, Hélène Castel, Nadège Loaëc, Céline Malleval, Jérôme Honnorat, Laurence Desrues, Usr3151, Hal, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuroendocrinologie cellulaire et moléculaire, Synthèse de Molécules d'Intérêt Thérapeutique (SMITh), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Phophorylation de protéines et Pathologies Humaines (P3H), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff [Roscoff] (SBR), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, Cell cycle checkpoint, Angiogenesis, Blotting, Western, Mice, Nude, Apoptosis, Immunoenzyme Techniques, Mice, 03 medical and health sciences, 0302 clinical medicine, Cyclin-dependent kinase, Glioma, Human Umbilical Vein Endothelial Cells, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Phosphorylation, Rats, Wistar, Cells, Cultured, Cell Proliferation, 030304 developmental biology, Neurons, 0303 health sciences, Neovascularization, Pathologic, biology, Kinase, Cell growth, Cell Cycle, Cell cycle, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Xenograft Model Antitumor Assays, Cyclin-Dependent Kinases, Rats, 3. Good health, Endothelial stem cell, Pyrimidines, Oncology, 030220 oncology & carcinogenesis, Basic and Translational Investigations, biology.protein, Cancer research, Neurology (clinical)
Abstract

International audience; Glioblastomas are the most frequent and most aggressive primary brain tumors in adults. The median overall survival is limited to a few months despite surgery, radiotherapy, and chemotherapy. It is now clearly established that hyperactivity of cyclin-dependent kinases (CDKs) is one of the processes underlying hyperproliferation and tumoral growth. The marine natural products meridianins and variolins, characterized as CDK inhibitors, display a kinase-inhibitory activity associated with cytotoxic effects. In order to improve selectivity and efficiency of these CDK inhibitors, a series of hybrid compounds called meriolins have been synthesized. The potential antitumoral activity of meriolins was investigated in vitro on glioma cell lines (SW1088 and U87), native neural cells, and a human endothelial cell line (HUV-EC-C). The impact of intraperitoneal or intratumoral administrations of meriolin 15 was evaluated in vivo on 2 different nude mice-xenografted glioma models. Meriolins 3, 5, and 15 exhibited antiproliferative properties with nanomolar IC50 and induced cell-cycle arrest and CDK inhibition associated with apoptotic events in human glioma cell lines. These meriolins blocked the proliferation rate of HUV-EC-C through cell cycle arrest and apoptosis. In vivo, meriolin 15 provoked a robust reduction in tumor volume in spite of toxicity for highest doses, associated with inhibition of cell division, activation of caspase 3, reduction of CD133 cells, and modifications of the vascular architecture. Meriolins, and meriolin 15 in particular, exhibit antiproliferative and proapoptotic activities on both glioma and intratumoral endothelial cells, constituting key promising therapeutic lead compounds for the treatment of glioblastoma.

Published
2014

7. The neuropeptide urotensin II as a new chemokine in glioma development activating biased migration/adhesion pathway

Author

Lecointre, Céline, Lejoncour, Vadim, Jarry, Marie, Desrues, Laurence, Schouft, Marie-Thérèse, Morin, Fabrice, Olivier, Langlois, Proust, François, Compère, Vincent, Gandolfo, Pierrick, Castel, Hélène, Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurochirurgie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service Anesthésie et soins intensifs [CHU Rouen], Normandie Université (NU)-Normandie Université (NU), CASTEL, Hélène, Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), and Service de neurochirurgie [CHU Rouen]

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

8. Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis

Author

Jarry, M., primary, Lecointre, C., additional, Malleval, C., additional, Desrues, L., additional, Schouft, M.-T., additional, Lejoncour, V., additional, Liger, F., additional, Lyvinec, G., additional, Joseph, B., additional, Loaec, N., additional, Meijer, L., additional, Honnorat, J., additional, Gandolfo, P., additional, and Castel, H., additional

Published
2014
Full Text
View/download PDF

11. 1167 POSTER Comparison of the Impact of the Targeted Therapy Everolimus (Afinitor®) and the Chemotherapy 5-FU on Cognitive Functions and Cerebral Plasticity in an Animal Model

Author

M.C. Tonon, Pierrick Gandolfo, Martine Dubois, N. Lapinte, V Lejoncour, Florence Joly, Hélène Castel, P. Hilber, and V. Roy

Subjects
Oncology, Cancer Research, Chemotherapy, medicine.medical_specialty, Everolimus, business.industry, medicine.medical_treatment, Cognition, Cerebral plasticity, Pharmacology, Targeted therapy, Animal model, Internal medicine, Medicine, business, medicine.drug
Published
2011

13. The vasoactive peptide urotensin II: a new chemokine exhibiting migration/adhesion properties in glioma

Author

Hélène Castel, Céline Lecointre, Vadim Lejoncour, Pierre-Olivier Guichet, Jane Eilen Joubert, Nicolas Perzo, Laurence Desrues, Romain Modzelewski, Pierre Vera, Pierre Bohn, Fabrice Morin, Pierrick Gandolfo, CASTEL, Hélène, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Sherbrooke (UdeS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), and Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie)

Subjects
TheoryofComputation_MISCELLANEOUS, [SDV] Life Sciences [q-bio], [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV]Life Sciences [q-bio], ComputingMilieux_COMPUTERSANDEDUCATION, [SDV.CAN]Life Sciences [q-bio]/Cancer, GeneralLiterature_MISCELLANEOUS, ComputingMilieux_MISCELLANEOUS
Abstract

Invited lecture; International audience

Catalog

Books, media, physical & digital resources
See catalog results