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27 results on '"Leiva, Tyler"'

1. Biomarkers of necrotizing enterocolitis in the era of machine learning and omics.

Author

Leiva, Tyler, Lueschow, Shiloh, Burge, Kathryn, Devette, Christa, Chaaban, Hala, and McElroy, Steven

Subjects
Infant, Infant, Newborn, Humans, Infant, Premature, Enterocolitis, Necrotizing, Artificial Intelligence, Biomarkers, Infant, Newborn, Diseases, Machine Learning
Abstract

Necrotizing enterocolitis (NEC) continues to be a major cause of morbidity and mortality in preterm infants. Despite decades of research in NEC, no reliable biomarkers can accurately diagnose NEC or predict patient prognosis. The recent emergence of multi-omics could potentially shift NEC biomarker discovery, particularly when evaluated using systems biology techniques. Furthermore, the use of machine learning and artificial intelligence in analyzing this big data could enable novel interpretations of NEC subtypes, disease progression, and potential therapeutic targets, allowing for integration with personalized medicine approaches. In this review, we evaluate studies using omics technologies and machine learning in the diagnosis of NEC. Future implications and challenges inherent to the field are also discussed.

Published
2023

5. Despite Recovery from Necrotizing Enterocolitis Infants Retain a Hyperinflammatory Response to Injury

Author

Snyder,Katherine, Calkins,Chase, Golubkova,Alena, Leiva,Tyler, Schlegel,Camille, Hunter,Catherine, Snyder,Katherine, Calkins,Chase, Golubkova,Alena, Leiva,Tyler, Schlegel,Camille, and Hunter,Catherine

Abstract

Katherine B Snyder,1,2 Chase L Calkins,3 Alena Golubkova,1,2 Tyler Leiva,1,2 Camille Schlegel,1 Catherine J Hunter1,2 1Division of Pediatric Surgery, Oklahoma City, OK, 73104, USA; 2Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; 3College of Medicine, The University of Oklahoma College of Medicine, Oklahoma City, OK, 73104, USACorrespondence: Catherine J Hunter, Department of Pediatric Surgery, Oklahoma Children’s Hospital, 1200 Everett Drive, ET NP 2320, Oklahoma City, OK, 73104, USA, Email catherine-hunter@ouhsc.eduBackground: Necrotizing enterocolitis (NEC) is the leading gastrointestinal cause of death of premature neonates. NEC is associated with prematurity, a hyperinflammatory response, and dysregulation of intestinal barrier function. We hypothesize that patients with NEC will have, and continue to have after recovery, an increased hyperinflammatory intestinal response compared to those patients without NEC.Methods: Neonates with NEC, those that have recovered from NEC, and those without NEC undergoing intestinal resections had specimens collected and snap frozen or generated into enteroids. The enteroids were treated with 100ug/mL lipopolysaccharide (LPS) and subjected to 24 hr of hypoxia together, then compared with untreated controls. Expression of Tumor Necrosis Factor (TNF-α) and interleukin 8 (IL-8) were evaluated via RT-qPCR and ELISA to measure inflammatory response. ANOVA determined statistical significance (p< 0.05).Results: There was no difference in inflammatory markers in recovered NEC tissue compared to non-NEC tissue on RTqPCR (p=0.701 TNF-α and 0.861 IL-8). However, recovered NEC enteroids demonstrate elevated levels of inflammatory markers after treatment compared to non-NEC enteroids after treatment on RTqPCR (p=0.0485 TNF-α, p=0.0057 IL-8) and ELISA (p=0.0354 TNF-α, p=0.0011 IL-8). Recovered NEC enteroids that underwent treatment demonstrated increased inflammatory markers c

Published
2024

27. A Review of the Diagnosis and Treatment of Necrotizing Enterocolitis.

Author

Cai X, Liebe HL, Golubkova A, Leiva T, and Hunter CJ

Subjects
Infant, Newborn, Humans, Biomarkers, Enterocolitis, Necrotizing diagnosis, Enterocolitis, Necrotizing therapy, Infant, Newborn, Diseases, Infant, Premature, Diseases diagnosis, Infant, Premature, Diseases therapy
Abstract

Necrotizing enterocolitis (NEC) is a devastating disease that primarily affects the gastrointestinal tract of premature neonates. The diagnosis and treatment of NEC remain challenging. New biomarkers and potential treatments for NEC have emerged in recent years, leading to the potential of earlier therapeutic intervention and improved outcomes. This paper aims to provide a review of the most recent diagnostic indicators and therapeutics of NEC along with a brief overview of future directions of research into this disease., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
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