Search

Your search keyword '"Leitzmann, M. F."' showing total 134 results
Start Over Author "Leitzmann, M. F."
134 results on '"Leitzmann, M. F."'

11. Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites

Author

Schlecht, I., Gronwald, Wolfram, Behrens, G., Baumeister, S. E., Hertel, J., Hochrein, J., Zacharias, Helena, Fischer, B., Oefner, Peter J., and Leitzmann, M. F.

Subjects
B Vitamins, Male, Physiology, 610 Medizin, lcsh:Medicine, Urine, Biochemistry, Body Mass Index, Glucose Metabolism, Metabolites, Medicine and Health Sciences, lcsh:Science, metabolism [Subcutaneous Fat], ddc:610, blood [Biomarkers], Organic Compounds, Vitamins, Middle Aged, Body Fluids, Chemistry, Physiological Parameters, Adipose Tissue, Physical Sciences, Metabolome, Carbohydrate Metabolism, Female, Anatomy, Research Article, metabolism [Intra-Abdominal Fat], Adult, Subcutaneous Fat, Cholines, Intra-Abdominal Fat, urine [Obesity], Metabolomics, Humans, Obesity, BODY-MASS INDEX, INSULIN-RESISTANCE, NMR-SPECTROSCOPY, SYSTEMS EPIDEMIOLOGY, HEALTHY-ADULTS, RISK-FACTORS, OBESITY, PROFILES, CHOLINE, MICE, Body Weight, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, blood [Obesity], Metabolism, Biological Tissue, lcsh:Q, Biomarkers, urine [Biomarkers]
Abstract

Obesity is a complex multifactorial phenotype that influences several metabolic pathways. Yet, few studies have examined the relations of different body fat compartments to urinary and serum metabolites. Anthropometric phenotypes (visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), the ratio between VAT and SAT (VSR), body mass index (BMI), waist circumference (WC)) and urinary and serum metabolite concentrations measured by nuclear magnetic resonance spectroscopy were measured in a population-based sample of 228 healthy adults. Multivariable linear and logistic regression models, corrected for multiple testing using the false discovery rate, were used to associate anthropometric phenotypes with metabolites. We adjusted for potential confounding variables: age, sex, smoking, physical activity, menopausal status, estimated glomerular filtration rate (eGFR), urinary glucose, and fasting status. In a fully adjusted logistic regression model dichotomized for the absence or presence of quantifiable metabolite amounts, VAT, BMI and WC were inversely related to urinary choline (beta = -0.18, p = 2.73*10(-3)), glycolic acid (beta = -0.20, 0.02), and guanidinoacetic acid (beta = -0.12, p = 0.04), and positively related to ethanolamine (beta = 0.18, p = 0.02) and dimethylamine (beta = 0.32, p = 0.02). BMI and WC were additionally inversely related to urinary glutamine and lactic acid. Moreover, WC was inversely associated with the detection of serine. VAT, but none of the other anthropometric parameters, was related to serum essential amino acids, such as valine, isoleucine, and phenylalanine among men. Compared to other adiposity measures, VAT demonstrated the strongest and most significant relations to urinary and serum metabolites. The distinct relations of VAT, SAT, VSR, BMI, and WC to metabolites emphasize the importance of accurately differentiating between body fat compartments when evaluating the potential role of metabolic regulation in the development of obesity-related diseases, such as insulin resistance, type 2 diabetes, and cardiovascular disease.

Published
2017
Full Text
View/download PDF

14. Physical activity in relation to risk of prostate cancer: a systematic review and meta-analysis.

Author

Benke, I N, Leitzmann, M F, Behrens, G, and Schmid, D

Subjects
*PROSTATE cancer, *PHYSICAL activity, *CANCER risk factors, *MEDLINE, *RANDOM effects model
Abstract

Background: Prostate cancer (PCa) is one of the most common cancers among men, yet little is known about its modifiable risk and protective factors. This study aims to quantitatively summarize observational studies relating physical activity (PA) to PCa incidence and mortality. Materials and methods: Published articles pertaining to PA and PCa incidence and mortality were retrieved in July 2017 using the Medline and EMBASE databases. The literature review yielded 48 cohort studies and 24 case-control studies with a total of 151 748 PCa cases. The mean age of the study participants at baseline was 61 years. Results: In random-effects models, comparing the highest versus the lowest level of overall PA showed a summary relative risk (RR) estimate for total PCa incidence close to the null [RR¼0.99, 95% confidence interval (CI)¼0.94-1.04]. The corresponding RRs for advanced and non-advanced PCa were 0.92 (95% CI¼0.80-1.06) and 0.95 (95% CI¼0.85-1.07), respectively. We noted a statistically significant inverse association between long-term occupational activity and total PCa (RR¼0.83, 95% CI¼0.71-0.98, n studies¼13), although that finding became statistically non-significant when individual studies were removed from the analysis. When evaluated by cancer subtype, an inverse association with long-term occupational activity was noted for nonadvanced/ non-aggressive PCa (RR¼0.51, 95% CI¼0.37-0.71, n studies¼2) and regular recreational activity was inversely related to advanced/aggressive PCa (RR¼0.75, 95% CI¼0.60-0.95, n studies¼2), although these observations are based on a low number of studies. Moreover, PA after diagnosis was related to reduced risk of PCa mortality among survivors of PCa (summary RR based on four studies¼0.69, 95% CI¼0.55-0.85). Conclusions: Whether PA protects against PCa remains elusive. Further investigation taking into account the complex clinical and pathologic nature of PCa is needed to clarify the PA and PCa incidence relation. Moreover, future studies are needed to confirm whether PA after diagnosis reduces risk of PCa mortality. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

21. Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO Study

Author

Shebl, F M, primary, Sakoda, L C, additional, Black, A, additional, Koshiol, J, additional, Andriole, G L, additional, Grubb, R, additional, Church, T R, additional, Chia, D, additional, Zhou, C, additional, Chu, L W, additional, Huang, W-Y, additional, Peters, U, additional, Kirsh, V A, additional, Chatterjee, N, additional, Leitzmann, M F, additional, Hayes, R B, additional, and Hsing, A W, additional

Published
2012
Full Text
View/download PDF

24. A prospective study of intake of fish and marine fatty acids and prostate cancer

Author

Augustsson, Katarina, Michaud, D S, Rimm, E B, Leitzmann, M F, Stampfer, M J, Willett, W C, Giovannucci, E, Augustsson, Katarina, Michaud, D S, Rimm, E B, Leitzmann, M F, Stampfer, M J, Willett, W C, and Giovannucci, E

Abstract

Experimental studies suggest that marine fatty acids have an antitumor effect on prostate tumor cells. The aim of this study was to investigate whether high consumption of fish and marine fatty acids reduces the risk of prostate cancer in humans. We followed 47,882 men participating in the Health Professionals Follow-up Study. Dietary intake was assessed in 1986, 1990, and 1994, using a validated food frequency questionnaire. During 12 years of follow-up, 2,482 cases of prostate cancer were diagnosed, of which 617 were diagnosed as advanced prostate cancer including 278 metastatic prostate cancers. Eating fish more than three times per week was associated with a reduced risk of prostate cancer, and the strongest association was for metastatic cancer (multivariate relative risk, 0.56; 95% confidence interval, 0.37-0.86, compared with infrequent consumption, i.e., less than twice per month). Intake of marine fatty acids from food showed a similar but weaker association. Each additional daily intake of 0.5 g of marine fatty acid from food was associated with a 24% decreased risk of metastatic cancer. We found that men with high consumption of fish had a lower risk of prostate cancer, especially for metastatic cancer. Marine fatty acids may account for part of the effect, but other factors in fish may also play a role.

Published
2003

36. Waist Circumference and Mortality

Author

Koster, A., primary, Leitzmann, M. F., additional, Schatzkin, A., additional, Mouw, T., additional, Adams, K. F., additional, van Eijk, J. Th. M., additional, Hollenbeck, A. R., additional, and Harris, T. B., additional

Published
2008
Full Text
View/download PDF

37. Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China

Author

Chang, S.-C., primary, Rashid, A., additional, Gao, Y.-T., additional, Andreotti, G., additional, Shen, M.-C., additional, Wang, B.-S., additional, Han, T.-Q., additional, Zhang, B.-H., additional, Sakoda, L. C., additional, Leitzmann, M. F., additional, Chen, B. E., additional, Rosenberg, P. S., additional, Chen, J., additional, Chanock, S. J., additional, and Hsing, A. W., additional

Published
2008
Full Text
View/download PDF

39. Fruits, Vegetables, and Colon Cancer Risk in a Pooled Analysis of 14 Cohort Studies

Author

Koushik, A., primary, Hunter, D. J., additional, Spiegelman, D., additional, Beeson, W. L., additional, van den Brandt, P. A., additional, Buring, J. E., additional, Calle, E. E., additional, Cho, E., additional, Fraser, G. E., additional, Freudenheim, J. L., additional, Fuchs, C. S., additional, Giovannucci, E. L., additional, Goldbohm, R. A., additional, Harnack, L., additional, Jacobs, D. R., additional, Kato, I., additional, Krogh, V., additional, Larsson, S. C., additional, Leitzmann, M. F., additional, Marshall, J. R., additional, McCullough, M. L., additional, Miller, A. B., additional, Pietinen, P., additional, Rohan, T. E., additional, Schatzkin, A., additional, Sieri, S., additional, Virtanen, M. J., additional, Wolk, A., additional, Zeleniuch-Jacquotte, A., additional, Zhang, S. M., additional, and Smith-Warner, S. A., additional

Published
2007
Full Text
View/download PDF

43. Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies

Author

Lee, J. E., primary, Hunter, D. J., additional, Spiegelman, D., additional, Adami, H.-O., additional, Albanes, D., additional, Bernstein, L., additional, van den Brandt, P. A., additional, Buring, J. E., additional, Cho, E., additional, Folsom, A. R., additional, Freudenheim, J. L., additional, Giovannucci, E., additional, Graham, S., additional, Horn-Ross, P. L., additional, Leitzmann, M. F., additional, McCullough, M. L., additional, Miller, A. B., additional, Parker, A. S., additional, Rodriguez, C., additional, Rohan, T. E., additional, Schatzkin, A., additional, Schouten, L. J., additional, Virtanen, M., additional, Willett, W. C., additional, Wolk, A., additional, Zhang, S. M., additional, and Smith-Warner, S. A., additional

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results