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13 results on '"Leitner, Theo"'

1. Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Author

Frank, Daria, Patnana, Pradeep Kumar, Vorwerk, Jan, Mao, Lianghao, Gopal, Lavanya Mokada, Jung, Noelle, Hennig, Thorben, Ruhnke, Leo, Frenz, Joris Maximillian, Kuppusamy, Maithreyan, Autry, Robert, Wei, Lanying, Sun, Kaiyan, Mohammed Ahmed, Helal Mohammed, Künstner, Axel, Busch, Hauke, Müller, Heiko, Hutter, Stephan, Hoermann, Gregor, Liu, Longlong, Xie, Xiaoqing, Al-Matary, Yahya, Nimmagadda, Subbaiah Chary, Cano, Fiorella Charles, Heuser, Michael, Thol, Felicitas, Göhring, Gudrun, Steinemann, Doris, Thomale, Jürgen, Leitner, Theo, Fischer, Anja, Rad, Roland, Röllig, Christoph, Altmann, Heidi, Kunadt, Desiree, Berdel, Wolfgang E., Hüve, Jana, Neumann, Felix, Klingauf, Jürgen, Calderon, Virginie, Opalka, Bertram, Dührsen, Ulrich, Rosenbauer, Frank, Dugas, Martin, Varghese, Julian, Reinhardt, Hans Christian, von Bubnoff, Nikolas, Möröy, Tarik, Lenz, Georg, Batcha, Aarif M. N., Giorgi, Marianna, Selvam, Murugan, Wang, Eunice, McWeeney, Shannon K., Tyner, Jeffrey W., Stölzel, Friedrich, Mann, Matthias, Jayavelu, Ashok Kumar, and Khandanpour, Cyrus

Published
2023
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3. Comparison of 6 cycles of isatuximab with lenalidomide, bortezomib and dexamethasone (I-VRd) versus 3 cycles of I-VRd followed by one cycle of high-dose melphalan in newly diagnosed low-risk multiple myeloma. Protocol for a multicenter, prospective, randomized, phase II clinical trial (ELIAS-Trial)

Author

Leitner, Theo, Shumilov, Evgenii, Schwitlick, Christina, Koch, Raphael, Hamm, Franziska, Högner, Marion, Bassermann, Florian, Weisel, Katja, Einsele, Hermann, Kortüm, Martin, Rasche, Leo, Görner, Martin, Wegehenkel, Kai, Knop, Stefan, Krönke, Jan, Nogai, Axel, König, Inke R., Vens, Maren, Horn, Kay, and von Bubnoff, Nikolas

Published
2024
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4. Whole-Exome Sequencing, Mutational Signature Analysis, and Outcome in Multiple Myeloma—A Pilot Study.

Author

Oelschläger, Lorenz, Künstner, Axel, Frey, Friederike, Leitner, Theo, Leypoldt, Lisa, Reimer, Niklas, Gebauer, Niklas, Bastian, Lorenz, Weisel, Katja, Sailer, Verena-Wilbeth, Röcken, Christoph, Klapper, Wolfram, Konukiewitz, Björn, Murga Penas, Eva Maria, Forster, Michael, Schub, Natalie, Ahmed, Helal M. M., Kirfel, Jutta, von Bubnoff, Nikolas Christian Cornelius, and Busch, Hauke

Abstract

The complex and heterogeneous genomic landscape of multiple myeloma (MM) and many of its clinical and prognostic implications remains to be understood. In other cancers, such as breast cancer, using whole-exome sequencing (WES) and molecular signatures in clinical practice has revolutionized classification, prognostic prediction, and patient management. However, such integration is still in its early stages in MM. In this study, we analyzed WES data from 35 MM patients to identify potential mutational signatures and driver mutations correlated with clinical and cytogenetic characteristics. Our findings confirm the complex mutational spectrum and its impact on previously described ontogenetic and epigenetic pathways. They show TYW1 as a possible new potential driver gene and find no significant associations of mutational signatures with clinical findings. Further studies are needed to strengthen the role of mutational signatures in the clinical context of patients with MM to improve patient management. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Germline variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Author

Frank, Daria, primary, Patnana, Pradeep Kumar, additional, Vorwerk, Jan, additional, Mao, Lianghao, additional, Mokada Gopal, Lavanya, additional, Jung, Noelle, additional, Hennig, Thorben, additional, Ruhnke, Leo, additional, Frenz, Joris Maximillian, additional, Kuppusamy, Maithreyan, additional, Autry, Robert J, additional, Wei, Lanying, additional, Sun, Kaiyan, additional, Ahmed, Helal, additional, Künstner, Axel, additional, Busch, Hauke, additional, Müller, Heiko, additional, Hutter, Stephan, additional, Hoermann, Gregor, additional, Liu, Longlong, additional, Xie, Xiaoqing, additional, Al-Matary, Yahya, additional, Nimmagadda, Subbaiah Chary, additional, Charles Cano, Fiorella, additional, Heuser, Michael, additional, Thol, Felicitas R., additional, Göhring, Gudrun, additional, Steinemann, Doris, additional, Thomale, Jürgen, additional, Leitner, Theo, additional, Fischer, Anja, additional, Rad, Roland, additional, Röllig, Christoph, additional, Altmann, Heidi, additional, Kunadt, Desiree, additional, Berdel, Wolfgang E., additional, Hüve, Jana, additional, Neumann, Felix, additional, Klingauf, Jürgen, additional, Calderon, Virginie, additional, Opalka, Bertram, additional, Dührsen, Ulrich, additional, Rosenbauer, Frank, additional, Dugas, Martin, additional, Varghese, Julian, additional, Reinhardt, H. Christian H., additional, von Bubnoff, Nikolas, additional, Möröy, Tarik, additional, Lenz, Georg, additional, Batcha, Aarif M.N., additional, Giorgi, Marianna, additional, Selvam, Murugan, additional, Wang, Eunice S., additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Stölzel, Friedrich, additional, Mann, Matthias, additional, Jayavelu, Ashok Kumar, additional, and Khandanpour, Cyrus, additional

Published
2023
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7. Donor‐transmitted extramedullary acute myeloid leukaemia after living donor kidney transplantation

Author

Ghandili, Susanne, primary, Kluger, Malte A., additional, Leitner, Theo, additional, Grahammer, Florian, additional, Kirchner, Lennart, additional, Modemann, Franziska, additional, Achilles, Eike‐Gert, additional, Kreipe, Hans H., additional, Klein, Janin, additional, Steinemann, Doris, additional, Wolschke, Christine, additional, Fischer, Lutz, additional, Bokemeyer, Carsten, additional, Fiedler, Walter, additional, Huber, Tobias B., additional, Alsdorf, Winfried H., additional, and Mahmud, Maida, additional

Published
2022
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8. Real-World Analysis of Teclistamab in 115 RRMM Patients from Germany

Author

Riedhammer, Christine, Bassermann, Florian, Besemer, Britta, Bewarder, Moritz, Brunner, Franziska, Carpinteiro, Alexander, Einsele, Hermann, Faltin, Josefine, Frenking, Jan, Gezer, Deniz, Goldman-Mazur, Sarah, Hanel, Mathias, Hoegner, Marion, Kortüm, K. Martin, Krönke, Jan, Kull, Miriam, Leitner, Theo, Mann, Christoph, Mecklenbrauck, Rabea, Merz, Maximilian, Morgner, Anke, Nogai, Axel, Raab, Marc S., Teipel, Raphael, Wäsch, Ralph, and Rasche, Leo

Published
2023
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