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8 results on '"Leite‐Lima, Flávia"'

4. Unveiling metabolic changes in marsupialized odontogenic keratocyst: A pilot study.

Author

Leite‐Lima, Flávia, Bastos, Victor Coutinho, Vitório, Jéssica Gardone, Duarte‐Andrade, Filipe Fideles, Pereira, Thaís dos Santos Fontes, Martins‐Chaves, Roberta Rayra, Cruz, Aline Fernanda, de Lacerda, Júlio César Tanos, Lebron, Yuri Abner Rocha, Moreira, Victor Rezende, Santos, Lucilaine Valéria de Souza, Lange, Liséte Celina, de Macedo, Adriana Nori, Diniz, Marina Gonçalves, Gomes, Carolina Cavaliéri, de Castro, Wagner Henriques, Canuto, Gisele André Baptista, and Gomez, Ricardo Santiago

Subjects
*PILOT projects, *HIGH performance liquid chromatography, *METABOLOMICS, *FORMALDEHYDE, *METABOLISM, *MASS spectrometry, *DESCRIPTIVE statistics, *ODONTOGENIC cysts, *ORAL mucosa
Abstract

Objective: We aimed to assess which metabolic pathways would be implicated in the phenotypic changes of the epithelial lining of odontogenic keratocyst after marsupialization, comparing pre‐ and post‐marsupialized lesions with adjacent oral mucosa. Materials and Methods: Eighteen formalin‐fixed and paraffin‐embedded tissues from six subjects were divided into three paired groups: odontogenic keratocyst pre‐ (n = 6) and post‐marsupialization (n = 6), and adjacent oral mucosa (n = 6). The metabolic pathways found in these groups were obtained by high‐performance liquid chromatography‐mass spectrometry‐based untargeted metabolomics performed. Results: Through putative metabolite annotation followed by pathway enrichment and predictive analysis with automated algorithms (Mummichog and Gene Set Enrichment Analysis), we found differences in many cellular processes that may be involved in inflammation, oxidative stress response, keratinocyte‐basal membrane attachment, differentiation, and proliferation functions, all relevant to odontogenic keratocyst pathobiology and the phenotype acquired after marsupialization. Conclusion: Our study was able to identify several metabolic pathways potentially involved in the metaplastic changes induced by marsupialization of odontogenic keratocysts. An improved comprehension of this process could pave the way for the development of targeted therapies. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study

Author

Bastos, Victor Coutinho, primary, Vitório, Jéssica Gardone, additional, Martins-Chaves, Roberta Rayra, additional, Leite-Lima, Flávia, additional, Lebron, Yuri Abner Rocha, additional, Moreira, Victor Rezende, additional, Duarte-Andrade, Filipe Fideles, additional, Pereira, Thaís dos Santos Fontes, additional, Santos, Lucilaine Valéria de Souza, additional, Lange, Liséte Celina, additional, Macedo, Adriana Nori de, additional, Canuto, Gisele André Baptista, additional, Gomes, Carolina Cavaliéri, additional, and Gomez, Ricardo Santiago, additional

Published
2021
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6. Unveiling metabolic changes in marsupialized odontogenic keratocyst: A pilot study

Author

Leite‐Lima, Flávia, primary, Bastos, Victor Coutinho, additional, Vitório, Jéssica Gardone, additional, Duarte‐Andrade, Filipe Fideles, additional, Pereira, Thaís dos Santos Fontes, additional, Martins‐Chaves, Roberta Rayra, additional, Cruz, Aline Fernanda, additional, de Lacerda, Júlio César Tanos, additional, Lebron, Yuri Abner Rocha, additional, Moreira, Victor Rezende, additional, Santos, Lucilaine Valéria de Souza, additional, Lange, Liséte Celina, additional, de Macedo, Adriana Nori, additional, Diniz, Marina Gonçalves, additional, Gomes, Carolina Cavaliéri, additional, de Castro, Wagner Henriques, additional, Canuto, Gisele André Baptista, additional, and Gomez, Ricardo Santiago, additional

Published
2021
Full Text
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