Search

Your search keyword '"Leitch, Harry"' showing total 149 results
Start Over Author "Leitch, Harry"
149 results on '"Leitch, Harry"'

2. Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation

Author

Bernkopf, Marie, Abdullah, Ummi B., Bush, Stephen J., Wood, Katherine A., Ghaffari, Sahar, Giannoulatou, Eleni, Koelling, Nils, Maher, Geoffrey J., Thibaut, Loïc M., Williams, Jonathan, Blair, Edward M., Kelly, Fiona Blanco, Bloss, Angela, Burkitt-Wright, Emma, Canham, Natalie, Deng, Alexander T., Dixit, Abhijit, Eason, Jacqueline, Elmslie, Frances, Gardham, Alice, Hay, Eleanor, Holder, Muriel, Homfray, Tessa, Hurst, Jane A., Johnson, Diana, Jones, Wendy D., Kini, Usha, Kivuva, Emma, Kumar, Ajith, Lees, Melissa M., Leitch, Harry G., Morton, Jenny E. V., Németh, Andrea H., Ramachandrappa, Shwetha, Saunders, Katherine, Shears, Deborah J., Side, Lucy, Splitt, Miranda, Stewart, Alison, Stewart, Helen, Suri, Mohnish, Clouston, Penny, Davies, Robert W., Wilkie, Andrew O. M., and Goriely, Anne

Published
2023
Full Text
View/download PDF

3. The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans

Author

Wyrwoll, Margot J., Gaasbeek, Channah M., Golubickaite, Ieva, Stakaitis, Rytis, Oud, Manon S., Nagirnaja, Liina, Dion, Camille, Sindi, Emad B., Leitch, Harry G., Jayasena, Channa N., Sironen, Anu, Dicke, Ann-Kristin, Rotte, Nadja, Stallmeyer, Birgit, Kliesch, Sabine, Grangeiro, Carlos H.P., Araujo, Thaís F., Lasko, Paul, D’Hauwers, Kathleen, Smits, Roos M., Ramos, Liliana, Xavier, Miguel J., Conrad, Don F., Almstrup, Kristian, Veltman, Joris A., Tüttelmann, Frank, and van der Heijden, Godfried W.

Published
2022
Full Text
View/download PDF

5. Primordial germ cell DNA demethylation and development require DNA translesion synthesis

Author

Hubrecht Institute with UMC, Shah, Pranay, Hill, Ross, Dion, Camille, Clark, Stephen J., Abakir, Abdulkadir, Willems, Jeroen, Arends, Mark J., Garaycoechea, Juan I., Leitch, Harry G., Reik, Wolf, Crossan, Gerry P., Hubrecht Institute with UMC, Shah, Pranay, Hill, Ross, Dion, Camille, Clark, Stephen J., Abakir, Abdulkadir, Willems, Jeroen, Arends, Mark J., Garaycoechea, Juan I., Leitch, Harry G., Reik, Wolf, and Crossan, Gerry P.

Published
2024

8. Enhanced cannabis timeline followback (EC‐TLFB): Comprehensive assessment of cannabis use including standard THC units and validation through biological measures

Author

Petrilli, Kat, primary, Lawn, Will, additional, Lees, Rachel, additional, Mokrysz, Claire, additional, Borissova, Anya, additional, Ofori, Shelan, additional, Trinci, Katie, additional, dos Santos, Renato, additional, Leitch, Harry, additional, Soni, Shilpa, additional, Hines, Lindsey A., additional, Lorenzetti, Valentina, additional, Curran, H. Valerie, additional, and Freeman, Tom P., additional

Published
2023
Full Text
View/download PDF

9. Enhanced cannabis timeline followback (EC‐TLFB): Comprehensive assessment of cannabis use including standard THC units and validation through biological measures.

Author

Petrilli, Kat, Lawn, Will, Lees, Rachel, Mokrysz, Claire, Borissova, Anya, Ofori, Shelan, Trinci, Katie, dos Santos, Renato, Leitch, Harry, Soni, Shilpa, Hines, Lindsey A., Lorenzetti, Valentina, Curran, H. Valerie, and Freeman, Tom P.

Subjects
CANNABIS (Genus), CROSS-sectional method, DESCRIPTIVE statistics, LONGITUDINAL method
Abstract

Aims: The aims of this study were to present an enhanced cannabis timeline followback (EC‐TLFB) enabling comprehensive assessment of cannabis use measures, including standard tetrahydrocannabinol (THC) units, and to validate these against objectively indexed urinary 11‐nor‐9‐carboxy‐tetrahydrocannabinol (THC‐COOH) concentrations. Design: We used cross‐sectional baseline data from the 'CannTeen' observational longitudinal study. Setting: The study was conducted in London, UK. Participants: A total of 147 participants who used cannabis regularly took part in the study (n = 71 female, n = 76 male; mean age = 21.90, standard deviation = 5.32). Measurements The EC‐TLFB was used to calculate frequency of cannabis use, method of administration, including co‐administration with tobacco, amount of cannabis used (measured with unaided self‐report and also using pictorial aided self‐report) and type of cannabis product (flower, hash) which was used to estimate THC concentration (both from published data on THC concentration of products and analysis of cannabis samples donated by participants in this study). We calculated total weekly standard THC units (i.e. 5 mg THC for all cannabis products and methods of administration) using the EC‐TLFB. The outcome variable for validation of past week EC‐TLFB assessments was creatinine‐normalized carboxy‐tetrahydrocannabinol (THC‐COOH) in urine. Findings All measures of cannabis exposure included in this analysis were positively correlated with levels of THC‐COOH in urine (r = 0.41–0.52). Standard THC units, calculated with average concentrations of THC in cannabis in the UK and unaided self‐report measures of amount of cannabis used in grams showed the strongest correlation with THC‐COOH in urine (r = 0.52, 95% bias‐corrected and accelerated = 0.26–0.70). Conclusions: The enhanced cannabis timeline followback (EC‐TLFB) can provide a valid assessment of a comprehensive set of cannabis use measures including standard tetrahydrocannabinol units as well as and traditional TLFB assessments (e.g. frequency of use and grams of cannabis use). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Contributors

Author

Aranda, Sergi, primary, Arcidiacono, Orazio Angelo, additional, Artus, Jerome, additional, Bártová, Eva, additional, Battle, Stephanie L., additional, Bavli, Danny, additional, Biran, Alva, additional, Branco, Miguel R., additional, Bressan, Raul Bardini, additional, Caporale, Nicolò, additional, Di Croce, Luciano, additional, Dion, Camille, additional, Gonzalez, Inma, additional, Hawkins, R. David, additional, Kozulin, Chen, additional, Krejčí, Jana, additional, Legartová, Soňa, additional, Leitch, Harry G., additional, Lopez-Tobon, Alejandro, additional, Mermoud, Jacqueline E., additional, Meshorer, Eran, additional, Navarro, Pablo, additional, Owens, Nick D.L., additional, Platania, Angeliki, additional, Pollard, Steven M., additional, Poot, Raymond A., additional, Ram, Oren, additional, Schlesinger, Sharon, additional, Sexton, Tom, additional, Stixova, Lenka, additional, Testa, Giuseppe, additional, and Trattaro, Sebastiano, additional

Published
2020
Full Text
View/download PDF

14. Expanding the allelic spectrum of ELOVL4‐related autosomal recessive neuro‐ichthyosis

Author

Alabdulrazzaq, Fatima, primary, Alanzi, Talal, additional, Al‐Balool, Haya H., additional, Gardham, Alice, additional, Wakeling, Emma, additional, Leitch, Harry G., additional, AlSayed, Moeenaldeen, additional, Abdulrahim, Maha, additional, Aladwani, Abdulaziz, additional, Romito, Antonio, additional, Kampe, Kapil, additional, Ferdinandusse, Sacha, additional, Aboelanine, Ashraf H., additional, Abdullah, Amira, additional, Alwadani, Amal, additional, Bastaki, Laila, additional, Vaz, Frédéric M., additional, Bertoli‐Avella, Aida M., additional, and Marafi, Dana, additional

Published
2023
Full Text
View/download PDF

17. The PREGCARE study: Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation

Author

Bernkopf, Marie, primary, Abdullah, Ummi B., additional, Bush, Stephen J., additional, Wood, Katherine, additional, Ghaffari, Sahar, additional, Giannoulatou, Eleni, additional, Koelling, Nils, additional, Maher, Geoffrey J., additional, Thibault, Loïc M., additional, Williams, Jonathan, additional, Blair, Edward M., additional, Kelly, Fiona Blanco, additional, Bloss, Angela, additional, Burkitt-Wright, Emma, additional, Canham, Natalie, additional, Deng, Alexander T., additional, Dixit, Abhijit, additional, Eason, Jacqueline, additional, Elmslie, Frances, additional, Gardham, Alice, additional, Hay, Eleanor, additional, Holder, Muriel, additional, Homfray, Tessa, additional, Hurst, Jane A., additional, Johnson, Diana, additional, Jones, Wendy D., additional, Kini, Usha, additional, Kivuva, Emma, additional, Kumar, Ajith, additional, Lees, Melissa M., additional, Leitch, Harry G., additional, Morton, Jenny E. V., additional, Németh, Andrea H., additional, Ramachandrappa, Shwetha, additional, Saunders, Katherine, additional, Shears, Deborah J., additional, Side, Lucy, additional, Splitt, Miranda, additional, Stewart, Alison, additional, Stewart, Helen, additional, Suri, Mohnish, additional, Clouston, Penny, additional, Davies, Robert W., additional, Wilkie, Andrew O. M., additional, and Goriely, Anne, additional

Published
2022
Full Text
View/download PDF

18. The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans

Author

Wyrwoll, Margot J, Gaasbeek, Channah M, Golubickaite, Ieva, Stakaitis, Rytis, Oud, Manon S, Nagirnaja, Liina, Dion, Camille, Sindi, Emad B, Leitch, Harry G, Jayasena, Channa N, Sironen, Anu, Dicke, Ann-Kristin, Rotte, Nadja, Stallmeyer, Birgit, Kliesch, Sabine, Grangeiro, Carlos H P, Araujo, Thaís F, Lasko, Paul, D'Hauwers, Kathleen, Smits, Roos M, Ramos, Liliana, Xavier, Miguel J, Conrad, Don F, Almstrup, Kristian, Veltman, Joris A, Tüttelmann, Frank, van der Heijden, Godfried W, Wyrwoll, Margot J, Gaasbeek, Channah M, Golubickaite, Ieva, Stakaitis, Rytis, Oud, Manon S, Nagirnaja, Liina, Dion, Camille, Sindi, Emad B, Leitch, Harry G, Jayasena, Channa N, Sironen, Anu, Dicke, Ann-Kristin, Rotte, Nadja, Stallmeyer, Birgit, Kliesch, Sabine, Grangeiro, Carlos H P, Araujo, Thaís F, Lasko, Paul, D'Hauwers, Kathleen, Smits, Roos M, Ramos, Liliana, Xavier, Miguel J, Conrad, Don F, Almstrup, Kristian, Veltman, Joris A, Tüttelmann, Frank, and van der Heijden, Godfried W

Abstract

Infertility affects around 7% of the male population and can be due to severe spermatogenic failure (SPGF), resulting in no or very few sperm in the ejaculate. We initially identified a homozygous frameshift variant in FKBP6 in a man with extreme oligozoospermia. Subsequently, we screened a total of 2,699 men with SPGF and detected rare bi-allelic loss-of-function variants in FKBP6 in five additional persons. All six individuals had no or extremely few sperm in the ejaculate, which were not suitable for medically assisted reproduction. Evaluation of testicular tissue revealed an arrest at the stage of round spermatids. Lack of FKBP6 expression in the testis was confirmed by RT-qPCR and immunofluorescence staining. In mice, Fkbp6 is essential for spermatogenesis and has been described as being involved in piRNA biogenesis and formation of the synaptonemal complex (SC). We did not detect FKBP6 as part of the SC in normal human spermatocytes, but small RNA sequencing revealed that loss of FKBP6 severely impacted piRNA levels, supporting a role for FKBP6 in piRNA biogenesis in humans. In contrast to findings in piRNA-pathway mouse models, we did not detect an increase in LINE-1 expression in men with pathogenic FKBP6 variants. Based on our findings, FKBP6 reaches a "strong" level of evidence for being associated with male infertility according to the ClinGen criteria, making it directly applicable for clinical diagnostics. This will improve patient care by providing a causal diagnosis and will help to predict chances for successful surgical sperm retrieval.

Published
2022

19. Hallmarks of pluripotency

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Xi, Ruibin, Fujiwara, Yuko, Benvenisty, Nissim, Deng, Hongkui, Hochedlinger, Konrad, Jaenisch, Rudolf, Lee, Soohyun, Leitch, Harry G., Lensch, M. William, Lujan, Ernesto, Pei, Duanqing, Rossant, Janet, Wernig, Marius, Park, Peter J., and Daley, George Q.

Published
2015
Full Text
View/download PDF

23. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Author

Hill, Peter W. S., Leitch, Harry G., Requena, Cristina E., Sun, Zhiyi, Amouroux, Rachel, Roman-Trufero, Monica, Borkowska, Malgorzata, Terragni, Jolyon, Vaisvila, Romualdas, Linnett, Sarah, Bagci, Hakan, Dharmalingham, Gopuraja, Haberle, Vanja, Lenhard, Boris, Zheng, Yu, Pradhan, Sriharsa, and Hajkova, Petra

Subjects
Epigenetic inheritance -- Research, Cell differentiation -- Research, Nuclear reprogramming -- Genetic aspects, Cytological research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Peter W. S. Hill [1, 2]; Harry G. Leitch [1, 2]; Cristina E. Requena [1, 2]; Zhiyi Sun [3]; Rachel Amouroux [1, 2]; Monica Roman-Trufero [1, 2]; Malgorzata Borkowska [...]

Published
2018
Full Text
View/download PDF

26. Defined conditions for propagation and manipulation of mouse embryonic stem cells

Author

Mulas, Carla, Kalkan, Tüzer, Von Meyenn, Ferdinand, Leitch, Harry G, Nichols, Jennifer, Smith, Austin, Mulas, Carla [0000-0002-9492-6482], von Meyenn, Ferdinand [0000-0001-9920-3075], Leitch, Harry G [0000-0002-3486-8962], Nichols, Jennifer [0000-0002-8650-1388], Smith, Austin [0000-0002-3029-4682], and Apollo - University of Cambridge Repository

Subjects
GERM-CELLS, Pluripotency, Embryonic stem cells, Cell Culture Techniques, INHIBITION, Differentiation, Self-renewal, DEMETHYLATION, Mice, Animals, Humans, RNA, Small Interfering, NAIVE PLURIPOTENCY, 11 Medical and Health Sciences, Neurons, Science & Technology, Cell Cycle, Correction, Cell Differentiation, Mouse Embryonic Stem Cells, IN-VITRO, 06 Biological Sciences, Embryo, Mammalian, Stem Cells and Regeneration, Coculture Techniques, Culture Media, Mice, Inbred C57BL, GENOME, DERIVATION, Karyotyping, GROUND-STATE, CRISPR-Cas Systems, Life Sciences & Biomedicine, Signal Transduction, Developmental Biology
Abstract

The power of mouse embryonic stem (ES) cells to colonise the developing embryo has revolutionised mammalian developmental genetics and stem cell research. This power is vulnerable, however, to the cell culture environment, deficiencies in which can lead to cellular heterogeneity, adaptive phenotypes, epigenetic aberrations and genetic abnormalities. Here, we provide detailed methodologies for derivation, propagation, genetic modification and primary differentiation of ES cells in 2i or 2i+LIF media without serum or undefined serum substitutes. Implemented diligently, these procedures minimise variability and deviation, thereby improving the efficiency, reproducibility and biological validity of ES cell experimentation., Development, 146, ISSN:0950-1991, ISSN:1477-9129

Published
2019

28. Esrrb Complementation Rescues Development of Nanog-Null Germ Cells

Author

Zhang, Man, Leitch, Harry G, Tang, Walfred WC, Festuccia, Nicola, Hall-Ponsele, Elisa, Nichols, Jennifer, Surani, M Azim, Smith, Austin, Chambers, Ian, Tang, Walfred [0000-0002-5803-1681], Nichols, Jennifer [0000-0002-8650-1388], Surani, Azim [0000-0002-8640-4318], Smith, Austin [0000-0002-3029-4682], and Apollo - University of Cambridge Repository

Subjects
competence, MOUSE EMBRYOS, PLURIPOTENCY, Article, EPIBLAST, CULTURE, DNA DEMETHYLATION, Mice, transcription factors, Animals, primordial germ cells, NETWORK, PGCLCs, SPECIFICATION, lcsh:QH301-705.5, reproductive and urinary physiology, Science & Technology, urogenital system, naive pluripotency, Cell Differentiation, Cell Biology, Nanog Homeobox Protein, SELF-RENEWAL, Germ Cells, Receptors, Estrogen, lcsh:Biology (General), embryonic structures, biological phenomena, cell phenomena, and immunity, EMBRYONIC STEM-CELLS, Life Sciences & Biomedicine
Abstract

Summary The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extends to the germline is unknown. Here, we show that germline deletion of Nanog reduces PGC numbers 5-fold at midgestation. Despite this quantitative depletion, Nanog-null PGCs can complete germline development in contrast to previous findings. PGC-like cell (PGCLC) differentiation of Nanog-null ESCs is also impaired, with Nanog-null PGCLCs showing decreased proliferation and increased apoptosis. However, induced expression of Esrrb restores PGCLC numbers as efficiently as Nanog. These effects are recapitulated in vivo: knockin of Esrrb to Nanog restores PGC numbers to wild-type levels and results in fertile adult mice. These findings demonstrate that Esrrb can replace Nanog function in germ cells., Graphical Abstract, Highlights • Germline deletion of Nanog reduces PGC numbers but does not abolish PGC development • Without Nanog, PGCLCs form ineffectively with less proliferation and more apoptosis • The Nanog target gene Esrrb can rescue PGCLC differentiation of Nanog−/− ESCs • Knockin of Esrrb at the Nanog locus restores PGC development efficiency, Although transcription factors functional in naive pluripotent cells are also expressed in primordial germ cells (PGCs), their PGC role remains unclear. Here, Zhang et al. show that, without Nanog, PGCs form ineffectively but that normal PGC development can be restored by induced expression of the NANOG target gene Esrrb.

Published
2018

30. Reconstitution of the oocyte transcriptional network with transcription factors

Author

Hamazaki, Nobuhiko, primary, Kyogoku, Hirohisa, additional, Araki, Hiromitsu, additional, Miura, Fumihito, additional, Horikawa, Chisako, additional, Hamada, Norio, additional, Shimamoto, So, additional, Hikabe, Orie, additional, Nakashima, Kinichi, additional, Kitajima, Tomoya S., additional, Ito, Takashi, additional, Leitch, Harry G., additional, and Hayashi, Katsuhiko, additional

Published
2020
Full Text
View/download PDF

35. Signalling pathways drive heterogeneity of ground state pluripotency

Author

McEwen, Kirsten R., primary, Linnett, Sarah, additional, Leitch, Harry G., additional, Srivastava, Prashant, additional, Al-Zouabi, Lara, additional, Huang, Tien-Chi, additional, Rotival, Maxime, additional, Sardini, Alessandro, additional, Chan, Thalia E., additional, Filippi, Sarah, additional, Stumpf, Michael P.H., additional, Petretto, Enrico, additional, and Hajkova, Petra, additional

Published
2018
Full Text
View/download PDF

37. Erratum: Corrigendum: Hallmarks of pluripotency

Author

De Los Angeles, Alejandro, primary, Ferrari, Francesco, additional, Xi, Ruibin, additional, Fujiwara, Yuko, additional, Benvenisty, Nissim, additional, Deng, Hongkui, additional, Hochedlinger, Konrad, additional, Jaenisch, Rudolf, additional, Lee, Soohyun, additional, Leitch, Harry G., additional, Lensch, M. William, additional, Lujan, Ernesto, additional, Pei, Duanqing, additional, Rossant, Janet, additional, Wernig, Marius, additional, Park, Peter J., additional, and Daley, George Q., additional

Published
2015
Full Text
View/download PDF

38. Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.

Author

Man Zhang, Leitch, Harry G., Tang, Walfred W. C., Festuccia, Nicola, Hall-Ponsele, Elisa, Nichols, Jennifer, Surani, M. Azim, Smith, Austin, and Chambers, Ian

Abstract

The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extends to the germline is unknown. Here, we show that germline deletion of Nanog reduces PGC numbers 5-fold at midgestation. Despite this quantitative depletion, Nanog-null PGCs can complete germline development in contrast to previous findings. PGC-like cell (PGCLC) differentiation of Nanog-null ESCs is also impaired, with Nanog-null PGCLCs showing decreased proliferation and increased apoptosis. However, induced expression of Esrrb restores PGCLC numbers as efficiently as Nanog. These effects are recapitulated in vivo: knockin of Esrrb to Nanog restores PGC numbers to wild-type levels and results in fertile adult mice. These findings demonstrate that Esrrb can replace Nanog function in germ cells. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

40. Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

Author

Le Bin, Gloryn Chia, primary, Muñoz-Descalzo, Silvia, additional, Kurowski, Agata, additional, Leitch, Harry, additional, Lou, Xinghua, additional, Mansfield, William, additional, Etienne-Dumeau, Charles, additional, Grabole, Nils, additional, Mulas, Carla, additional, Niwa, Hitoshi, additional, Hadjantonakis, Anna-Katerina, additional, and Nichols, Jennifer, additional

Published
2014
Full Text
View/download PDF

42. Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion

Author

Massachusetts Institute of Technology. Department of Biology, Jaenisch, Rudolf, Piccolo, Francesco M., Bagci, Hakan, Brown, Karen E., Landeira, David, Soza-Ried, Jorge, Feytout, Amelie, Mooijman, Dylan, Hajkova, Petra, Leitch, Harry G., Tada, Takashi, Kriaucionis, Skirmantas, Dawlaty, Meelad M., Merkenschlager, Matthias, Fisher, Amanda G., Massachusetts Institute of Technology. Department of Biology, Jaenisch, Rudolf, Piccolo, Francesco M., Bagci, Hakan, Brown, Karen E., Landeira, David, Soza-Ried, Jorge, Feytout, Amelie, Mooijman, Dylan, Hajkova, Petra, Leitch, Harry G., Tada, Takashi, Kriaucionis, Skirmantas, Dawlaty, Meelad M., Merkenschlager, Matthias, and Fisher, Amanda G.

Abstract

Genomic imprinting directs the allele-specific marking and expression of loci according to their parental origin. Differential DNA methylation at imprinted control regions (ICRs) is established in gametes and, although largely preserved through development, can be experimentally reset by fusing somatic cells with embryonic germ cell (EGC) lines. Here, we show that the Ten-Eleven Translocation proteins Tet1 and Tet2 participate in the efficient erasure of imprints in this model system. The fusion of B cells with EGCs initiates pluripotent reprogramming, in which rapid re-expression of Oct4 is accompanied by an accumulation of 5-hydroxymethylcytosine (5hmC) at several ICRs. Tet2 was required for the efficient reprogramming capacity of EGCs, whereas Tet1 was necessary to induce 5-methylcytosine oxidation specifically at ICRs. These data show that the Tet1 and Tet2 proteins have discrete roles in cell-fusion-mediated pluripotent reprogramming and imprint erasure in somatic cells.

Published
2013

45. Rebuilding Pluripotency from Primordial Germ Cells

Author

Leitch, Harry G., primary, Nichols, Jennifer, additional, Humphreys, Peter, additional, Mulas, Carla, additional, Martello, Graziano, additional, Lee, Caroline, additional, Jones, Ken, additional, Surani, M. Azim, additional, and Smith, Austin, additional

Published
2013
Full Text
View/download PDF

47. Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion

Author

Piccolo, Francesco M., primary, Bagci, Hakan, additional, Brown, Karen E., additional, Landeira, David, additional, Soza-Ried, Jorge, additional, Feytout, Amelie, additional, Mooijman, Dylan, additional, Hajkova, Petra, additional, Leitch, Harry G., additional, Tada, Takashi, additional, Kriaucionis, Skirmantas, additional, Dawlaty, Meelad M., additional, Jaenisch, Rudolf, additional, Merkenschlager, Matthias, additional, and Fisher, Amanda G., additional

Published
2013
Full Text
View/download PDF

48. Naive pluripotency is associated with global DNA hypomethylation

Author

Leitch, Harry G, primary, McEwen, Kirsten R, additional, Turp, Aleksandra, additional, Encheva, Vesela, additional, Carroll, Tom, additional, Grabole, Nils, additional, Mansfield, William, additional, Nashun, Buhe, additional, Knezovich, Jaysen G, additional, Smith, Austin, additional, Surani, M Azim, additional, and Hajkova, Petra, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results