1,538 results on '"Leist, Marcel"'
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2. Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment
3. Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
4. Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis
5. Novel Proline Transporter Inhibitor (LQFM215) Presents Antipsychotic Effect in Ketamine Model of Schizophrenia
6. Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
7. Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
8. Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells
9. Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease
10. Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
11. Modeling ferroptosis in human dopaminergic neurons: Pitfalls and opportunities for neurodegeneration research
12. Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells
13. G × E interactions as a basis for toxicological uncertainty
14. The sensitivity of the zebrafish embryo coiling assay for the detection of neurotoxicity by compounds with diverse modes of action
15. Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
16. Deconvoluting gene and environment interactions to develop an “epigenetic score meter” of disease
17. Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration
18. Risk assessment of parabens in a transcriptomics-based in vitro test
19. Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models
20. Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid
21. New approach methodologies in human regulatory toxicology – Not if, but how and when!
22. Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)
23. Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
24. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery
25. Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung
26. Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis
27. A framework for chemical safety assessment incorporating new approach methodologies within REACH
28. p53 regulates expression of nuclear envelope components in cancer cells
29. Leveraging Biomarkers and Translational Medicine for Preclinical Safety - Lessons for Advancing the Validation of Alternatives to Animal Testing.
30. Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
31. Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
32. Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes
33. PathwayNexus: a tool for interactive metabolic data analysis
34. New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
35. Application of the 3Rs principles in the development of pharmaceutical generics
36. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
37. Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons
38. New approach methods to assess developmental and adult neurotoxicity for regulatory use : a PARC work package 5 project
39. Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing
40. A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling
41. Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway
42. Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
43. Comparing in vitro human liver models to in vivo human liver using RNA-Seq
44. Human neuronal signaling and communication assays to assess functional neurotoxicity
45. Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors
46. Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air–liquid interface model
47. Handling deviating control values in concentration-response curves
48. Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience
49. Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants
50. Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals
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