2,826 results on '"Leipsic Jonathon A"'
Search Results
2. Progression of non-obstructive coronary plaque: a practical CCTA-based risk score from the PARADIGM registry
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Pontone, Gianluca, Rossi, Alexia, Baggiano, Andrea, Andreini, Daniele, Conte, Edoardo, Fusini, Laura, Gebhard, Chaterine, Rabbat, Mark G., Guaricci, Andrea, Guglielmo, Marco, Muscogiuri, Giuseppe, Mushtaq, Saima, Al-Mallah, Mouaz H., Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Hadamitzky, Martin, Kim, Yong Jin, Lee, Byoung Kwon, Lee, Sang-Eun, Maffei, Erica, Marques, Hugo, Samady, Habib, Shin, Sanghoon, Sung, Ji Min, van Rosendael, Alexander, Virmani, Renu, Bax, Jeroen J., Leipsic, Jonathon A., Lin, Fay Y., Min, James K., Narula, Jagat, Shaw, Leslee J., and Chang, Hyuk-Jae
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- 2024
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3. Sex and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography.
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van Rosendael, Sophie, Bax, A, Lin, Fay, Achenbach, Stephan, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy, Chinnaiyan, Kavitha, Chow, Benjamin, Cury, Ricardo, DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Kim, Yong-Jin, Leipsic, Jonathon, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Pontone, Gianluca, Raff, Gilbert, Rubinshtein, Ronen, Villines, Todd, Chang, Hyuk-Jae, Berman, Daniel, Min, James, Bax, Jeroen, Shaw, Leslee, van Rosendael, Alexander, and Budoff, Matthew
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coronary artery disease ,coronary computed tomography angiography (CCTA) ,prognosis ,sex differences ,Humans ,Male ,Female ,Child ,Plaque ,Atherosclerotic ,Coronary Stenosis ,Coronary Angiography ,Coronary Artery Disease ,Tomography ,X-Ray Computed ,Prognosis ,Computed Tomography Angiography ,Age Factors ,Predictive Value of Tests - Abstract
AIMS: The totality of atherosclerotic plaque derived from coronary computed tomography angiography (CCTA) emerges as a comprehensive measure to assess the intensity of medical treatment that patients need. This study examines the differences in age onset and prognostic significance of atherosclerotic plaque burden between sexes. METHODS AND RESULTS: From a large multi-center CCTA registry the Leiden CCTA score was calculated in 24 950 individuals. A total of 11 678 women (58.5 ± 12.4 years) and 13 272 men (55.6 ± 12.5 years) were followed for 3.7 years for major adverse cardiovascular events (MACE) (death or myocardial infarction). The age where the median risk score was above zero was 12 years higher in women vs. men (64-68 years vs. 52-56 years, respectively, P < 0.001). The Leiden CCTA risk score was independently associated with MACE: score 6-20: HR 2.29 (1.69-3.10); score > 20: HR 6.71 (4.36-10.32) in women, and score 6-20: HR 1.64 (1.29-2.08); score > 20: HR 2.38 (1.73-3.29) in men. The risk was significantly higher for women within the highest score group (adjusted P-interaction = 0.003). In pre-menopausal women, the risk score was equally predictive and comparable with men. In post-menopausal women, the prognostic value was higher for women [score 6-20: HR 2.21 (1.57-3.11); score > 20: HR 6.11 (3.84-9.70) in women; score 6-20: HR 1.57 (1.19-2.09); score > 20: HR 2.25 (1.58-3.22) in men], with a significant interaction for the highest risk group (adjusted P-interaction = 0.004). CONCLUSION: Women developed coronary atherosclerosis approximately 12 years later than men. Post-menopausal women within the highest atherosclerotic burden group were at significantly higher risk for MACE than their male counterparts, which may have implications for the medical treatment intensity.
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- 2023
4. Transcatheter Aortic Valve Replacement
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Sewnarain, Kavishka, Ally, Zain, Leipsic, Jonathon A., Kelsey, Anita M., editor, Vemulapalli, Sreek, editor, and Sadeghpour, Anita, editor
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- 2024
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5. Murray law-based quantitative flow ratio to assess left main bifurcation stenosis: selecting the angiographic projection matters
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Kotoku, Nozomi, Ninomiya, Kai, Ding, Daixin, O’Leary, Neil, Tobe, Akihiro, Miyashita, Kotaro, Masuda, Shinichiro, Kageyama, Shigetaka, Garg, Scot, Leipsic, Jonathon A., Mushtaq, Saima, Andreini, Daniele, Tanaka, Kaoru, de Mey, Johan, Wijns, William, Tu, Shengxian, Piazza, Nicolo, Onuma, Yoshinobu, and Serruys, Patrick W.
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- 2024
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6. Computed tomographic angiography in coronary artery disease.
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Serruys, Patrick, Kotoku, Nozomi, Nørgaard, Bjarne, Garg, Scot, Nieman, Koen, Dweck, Marc, Bax, Jeroen, Knuuti, Juhani, Narula, Jagat, Perera, Divaka, Taylor, Charles, Leipsic, Jonathon, Nicol, Edward, Piazza, Nicolo, Schultz, Carl, Kitagawa, Kakuya, Bruyne, Bernard, Collet, Carlos, Tanaka, Kaoru, Mushtaq, Saima, Belmonte, Marta, Dudek, Darius, Zlahoda-Huzior, Adriana, Tu, Shengxian, Wijns, William, Sharif, Faisal, Mey, Johan, Andreini, Daniele, Onuma, Yoshinobu, and Budoff, Matthew
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Humans ,Coronary Artery Disease ,Fractional Flow Reserve ,Myocardial ,Coronary Angiography ,Predictive Value of Tests ,Tomography ,X-Ray Computed ,Computed Tomography Angiography ,Plaque ,Atherosclerotic ,Coronary Vessels ,Coronary Stenosis - Abstract
Coronary computed tomographic angiography (CCTA) is becoming the first-line investigation for establishing the presence of coronary artery disease and, with fractional flow reserve (FFRCT), its haemodynamic significance. In patients without significant epicardial obstruction, its role is either to rule out atherosclerosis or to detect subclinical plaque that should be monitored for plaque progression/regression following prevention therapy and provide risk classification. Ischaemic non-obstructive coronary arteries are also expected to be assessed by non-invasive imaging, including CCTA. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining the disease complexity, vessel size, lesion length and tissue composition of the atherosclerotic plaque, as well as the best fluoroscopic viewing angle; it may also help in selecting adjunctive percutaneous devices (e.g., rotational atherectomy) and in determining the best landing zone for stents or bypass grafts.
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- 2023
7. Risk factors based vessel‐specific prediction for stages of coronary artery disease using Bayesian quantile regression machine learning method: Results from the PARADIGM registry
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Park, Hyung‐Bok, Lee, Jina, Hong, Yongtaek, Byungchang, So, Kim, Wonse, Lee, Byoung K, Lin, Fay Y, Hadamitzky, Martin, Kim, Yong‐Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, de A. Gonçalves, Pedro, Leipsic, Jonathon A, Shin, Sanghoon, Choi, Jung H, Virmani, Renu, Samady, Habib, Chinnaiyan, Kavitha, Stone, Peter H, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Min, James K, Kook, Woong, and Chang, Hyuk‐Jae
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Prevention ,Cardiovascular ,Heart Disease ,Humans ,Angina Pectoris ,Bayes Theorem ,Coronary Angiography ,Coronary Artery Disease ,Coronary Vessels ,Machine Learning ,Registries ,Risk Factors ,cardiovascular risk factors ,coronary artery disease ,machine learning ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
Background and hypothesisThe recently introduced Bayesian quantile regression (BQR) machine-learning method enables comprehensive analyzing the relationship among complex clinical variables. We analyzed the relationship between multiple cardiovascular (CV) risk factors and different stages of coronary artery disease (CAD) using the BQR model in a vessel-specific manner.MethodsFrom the data of 1,463 patients obtained from the PARADIGM (NCT02803411) registry, we analyzed the lumen diameter stenosis (DS) of the three vessels: left anterior descending (LAD), left circumflex (LCx), and right coronary artery (RCA). Two models for predicting DS and DS changes were developed. Baseline CV risk factors, symptoms, and laboratory test results were used as the inputs. The conditional 10%, 25%, 50%, 75%, and 90% quantile functions of the maximum DS and DS change of the three vessels were estimated using the BQR model.ResultsThe 90th percentiles of the DS of the three vessels and their maximum DS change were 41%-50% and 5.6%-7.3%, respectively. Typical anginal symptoms were associated with the highest quantile (90%) of DS in the LAD; diabetes with higher quantiles (75% and 90%) of DS in the LCx; dyslipidemia with the highest quantile (90%) of DS in the RCA; and shortness of breath showed some association with the LCx and RCA. Interestingly, High-density lipoprotein cholesterol showed a dynamic association along DS change in the per-patient analysis.ConclusionsThis study demonstrates the clinical utility of the BQR model for evaluating the comprehensive relationship between risk factors and baseline-grade CAD and its progression.
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- 2023
8. Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future.
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Ahmad, Yousif, Madhavan, Mahesh, Baron, Suzanne, Forrest, John, Borger, Michael, Leipsic, Jonathon, Cavalcante, João, Wang, Dee, McCarthy, Patrick, Szerlip, Molly, Kapadia, Samir, Makkar, Raj, Mack, Michael, Leon, Martin, and Cohen, David
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Clinical research ,Clinical trials ,Severe aortic stenosis ,Transcatheter aortic valve replacement - Abstract
Bicuspid aortic valve disease (BAVD) is present in up to half of all patients referred for surgical aortic valve replacement (SAVR) yet was an exclusion criterion for all randomized controlled trials (RCTs) comparing transcatheter aortic valve replacement (TAVR) to SAVR. Nonetheless, approximately 10% of patients currently treated with TAVR have BAVD and available observational data for performing TAVR in these patients are limited by selection bias. Many in the cardiovascular community have advocated for RCTs in this population, but none have been performed. The Heart Valve Collaboratory (HVC) is a multidisciplinary community of stakeholders with the aim of creating significant advances in valvular heart disease by stimulating clinical research, engaging in educational activities, and advancing regulatory science. In December 2020, the HVC hosted a Global Multidisciplinary workshop involving over 100 international experts in the field. Following this 2-day symposium, working groups with varied expertise were convened to discuss BAVD, including the need for and design of RCTs. This review, conducted under the auspices of the HVC, summarizes available data and knowledge gaps regarding procedural therapy for BAVD, outlining specific challenges for trials in this population. We also propose several potential studies that could be performed and discuss respective strengths and weaknesses of each approach. Finally, we present a roadmap for future directions in clinical research in TAVR for BAVD with an emphasis both on RCTs and also prospective registries focused on disease phenotyping to develop parameters and risk scores that could ultimately be applied to patients to inform clinical decision-making.
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- 2023
9. Ischemia With Nonobstructive Coronary Arteries: Insights From the ISCHEMIA Trial.
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Min, James, Hague, Cameron, Berman, Daniel, Chaitman, Bernard, Picard, Michael, Hayes, Sean, Scherrer-Crosbie, Marielle, Kwong, Raymond, Lopes, Renato, Senior, Roxy, Dwivedi, Sudhanshu, Miller, Todd, Chow, Benjamin, de Silva, Ramesh, Stone, Gregg, Boden, William, Bangalore, Sripal, OBrien, Sean, Hochman, Judith, Maron, David, Reynolds, Harmony, Diaz, Ariel, Cyr, Derek, Shaw, Leslee, Mancini, G, Leipsic, Jonathon, and Budoff, Matthew
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coronary CT angiography ,ischemia ,ischemia with nonobstructive coronary arteries ,stress testing ,Female ,Humans ,Male ,Atherosclerosis ,Coronary Angiography ,Coronary Artery Disease ,Coronary Vessels ,Ischemia ,Myocardial Ischemia ,Predictive Value of Tests - Abstract
BACKGROUND: Ischemia with nonobstructive coronary arteries (INOCA) is common clinically, particularly among women, but its prevalence among patients with at least moderate ischemia and the relationship between ischemia severity and non-obstructive atherosclerosis severity are unknown. OBJECTIVES: The authors investigated predictors of INOCA in enrolled, nonrandomized participants in ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches), sex differences, and the relationship between ischemia and atherosclerosis in patients with INOCA. METHODS: Core laboratories independently reviewed screening noninvasive stress test results (nuclear imaging, echocardiography, magnetic resonance imaging or nonimaging exercise tolerance testing), and coronary computed tomography angiography (CCTA), blinded to results of the screening test. INOCA was defined as all stenoses
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- 2023
10. TAVR in TAVR: Where Are We in 2023 for Management of Failed TAVR Valves?
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Meier, David, Tzimas, Georgios, Akodad, Mariama, Fournier, Stephane, Leipsic, Jonathon A., Blanke, Philipp, Wood, David A., Sellers, Stephanie L., Webb, John G., and Sathananthan, Janarthanan
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- 2023
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11. CAD-RADS™ 2.0 – 2022 Coronary Artery Disease – Reporting and Data System An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Cardiology (ACC), the American College of Radiology (ACR) and the North America Society of Cardiovascular Imaging (NASCI)
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Cury, Ricardo C, Leipsic, Jonathon, Abbara, Suhny, Achenbach, Stephan, Berman, Daniel, Bittencourt, Marcio, Budoff, Matthew, Chinnaiyan, Kavitha, Choi, Andrew D, Ghoshhajra, Brian, Jacobs, Jill, Koweek, Lynne, Lesser, John, Maroules, Christopher, Rubin, Geoffrey D, Rybicki, Frank J, Shaw, Leslee J, Williams, Michelle C, Williamson, Eric, White, Charles S, Villines, Todd C, and Blankstein, Ron
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Biomedical and Clinical Sciences ,Engineering ,Biomedical Engineering ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Biomedical Imaging ,Cardiovascular ,Atherosclerosis ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Coronary Artery Disease ,Coronary CTA ,CAD-RADS ,Reporting and Data System ,Stenosis Severity ,Report Standardization Termi-nology ,Plaque Burden ,Ischemia ,Report Standardization Terminology - Abstract
Coronary Artery Disease Reporting and Data System (CAD-RADS) was created to standardize reporting system for patients undergoing coronary CT angiography (CCTA) and to guide possible next steps in patient management. The goal of this updated 2022 CAD-RADS 2.0 is to improve the initial reporting system for CCTA by considering new technical developments in Cardiac CT, including data from recent clinical trials and new clinical guidelines. The updated CAD-RADS classification will follow an established framework of stenosis, plaque burden, and modifiers, which will include assessment of lesion-specific ischemia using CT fractional-flow-reserve (CT-FFR) or myocardial CT perfusion (CTP), when performed. Similar to the method used in the original CAD-RADS version, the determinant for stenosis severity classification will be the most severe coronary artery luminal stenosis on a per-patient basis, ranging from CAD-RADS 0 (zero) for absence of any plaque or stenosis to CAD-RADS 5 indicating the presence of at least one totally occluded coronary artery. Given the increasing data supporting the prognostic relevance of coronary plaque burden, this document will provide various methods to estimate and report total plaque burden. The addition of P1 to P4 descriptors are used to denote increasing categories of plaque burden. The main goal of CAD-RADS, which should always be interpreted together with the impression found in the report, remains to facilitate communication of test results with referring physicians along with suggestions for subsequent patient management. In addition, CAD-RADS will continue to provide a framework of standardization that may benefit education, research, peer-review, artificial intelligence development, clinical trial design, population health and quality assurance with the ultimate goal of improving patient care. Keywords: Coronary Artery Disease, Coronary CTA, CAD-RADS, Reporting and Data System, Stenosis Severity, Report Standardization Terminology, Plaque Burden, Ischemia Supplemental material is available for this article. This article is published synchronously in Radiology: Cardiothoracic Imaging, Journal of Cardiovascular Computed Tomography, JACC: Cardiovascular Imaging, Journal of the American College of Radiology, and International Journal for Cardiovascular Imaging. © 2022 Society of Cardiovascular Computed Tomography. Published by RSNA with permission.
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- 2022
12. Prognostic significance of plaque location in non-obstructive coronary artery disease: from the CONFIRM registry.
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Han, Donghee, Chen, Billy, Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Filippo, Maffei, Erica, Callister, Tracy Q, Chinnaiyan, Kavitha, Chow, Benjamin JW, DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Villines, Todd C, Kim, Yong Jin, Leipsic, Jonathon, Feuchtner, Gudrun, Cury, Ricardo C, Pontone, Gianluca, Andreini, Daniele, Marques, Hugo, Rubinshtein, Ronen, Chang, Hyuk Jae, Lin, Fay Y, Shaw, Leslee J, Min, James K, and Berman, Daniel S
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Heart Disease - Coronary Heart Disease ,Prevention ,Clinical Research ,Heart Disease ,Atherosclerosis ,Biomedical Imaging ,Cardiovascular ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Artery Disease ,Humans ,Plaque ,Atherosclerotic ,Predictive Value of Tests ,Prognosis ,Registries ,Risk Assessment ,Risk Factors ,coronary artery disease ,non-obstructive ,plaque location ,prognosis ,computed tomography ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
AimObstructive coronary artery disease (CAD) in proximal coronary segments is associated with a poor prognosis. However, the relative importance of plaque location regarding the risk for major adverse cardiovascular events (MACE) in patients with non-obstructive CAD has not been well defined.Methods and resultsFrom the Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter (CONFIRM) registry, 4644 patients without obstructive CAD were included in this study. The degree of stenosis was classified as 0 (no) and 1-49% (non-obstructive). Proximal involvement was defined as any plaque present in the left main or the proximal segment of the left anterior descending artery, left circumflex artery, and right coronary artery. Extensive CAD was defined as segment involvement score of >4. During a median follow-up of 5.2 years (interquartile range 4.1-6.0), 340 (7.3%) MACE occurred. Within the non-obstructive CAD group (n = 2065), proximal involvement was observed in 1767 (85.6%) cases. When compared to non-obstructive CAD patients without proximal involvement, those with proximal involvement had an increased MACE risk (log-rank P = 0.033). Multivariate Cox analysis showed when compared to patients with no CAD, proximal non-obstructive CAD was associated with increased MACE risk [hazard ratio (HR) 1.90, 95% confidence interval (CI) 1.47-2.45, P < 0.001] after adjusting for extensive CAD and conventional cardiovascular risk factors; however, non-proximal non-obstructive CAD did not increase MACE risk (HR 1.26, 95% CI 0.79-2.01, P = 0.339).ConclusionsIndependent of plaque extent, proximal coronary involvement was associated with increased MACE risk in patients with non-obstructive CAD. The plaque location information by coronary computed tomography angiography may provide additional risk prediction over CAD extent in patients with non-obstructive CAD.
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- 2022
13. Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease.
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Won, Ki-Bum, Park, Hyung-Bok, Heo, Ran, Lee, Byoung Kwon, Lin, Fay Y, Hadamitzky, Martin, Kim, Yong-Jin, Sung, Ji Min, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, Gonçalves, Pedro de Araújo, Leipsic, Jonathon A, Lee, Sang-Eun, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Chinnaiyan, Kavitha, Berman, Daniel S, Narula, Jagat, Bax, Jeroen J, Min, James K, and Chang, Hyuk-Jae
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Humans ,Cardiovascular Diseases ,Disease Progression ,Polyvinyl Chloride ,Coronary Angiography ,Risk Factors ,Blood Pressure ,Female ,Male ,Coronary Artery Disease ,Plaque ,Atherosclerotic ,Computed Tomography Angiography ,atherosclerosis ,coronary artery disease ,coronary computed tomography angiography ,systolic blood pressure ,Aging ,Clinical Research ,Cardiovascular ,Heart Disease ,Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
BackgroundAtherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain ) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease.HypothesisNormal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease.MethodsWe analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP
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- 2022
14. Completeness of revascularization by FFRCT in stable angina: Association to adverse cardiovascular outcomes
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Madsen, Kristian Tækker, Nørgaard, Bjarne Linde, Øvrehus, Kristian Altern, Jensen, Jesper Møller, Parner, Erik, Grove, Erik Lerkevang, Mortensen, Martin B., Iraqi, Nadia, Fairbairn, Timothy A., Nieman, Koen, Patel, Manesh R., Rogers, Campbell, Mullen, Sarah, Mickley, Hans, Thomsen, Kristian Korsgaard, Bøtker, Hans Erik, Leipsic, Jonathon, and Rønnow Sand, Niels Peter
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- 2024
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15. Standards for quantitative assessments by coronary computed tomography angiography (CCTA): An expert consensus document of the society of cardiovascular computed tomography (SCCT)
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Nieman, Koen, García-García, Hector M., Hideo-Kajita, Alexandre, Collet, Carlos, Dey, Damini, Pugliese, Francesca, Weissman, Gaby, Tijssen, Jan G.P., Leipsic, Jonathon, Opolski, Maksymilian P., Ferencik, Maros, Lu, Michael T., Williams, Michelle C., Bruining, Nico, Blanco, Pablo Javier, Maurovich-Horvat, Pal, and Achenbach, Stephan
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- 2024
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16. Artificial Intelligence–Enabled Quantitative Coronary Plaque and Hemodynamic Analysis for Predicting Acute Coronary Syndrome
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Koo, Bon-Kwon, Yang, Seokhun, Jung, Jae Wook, Zhang, Jinlong, Lee, Keehwan, Hwang, Doyeon, Lee, Kyu-Sun, Doh, Joon-Hyung, Nam, Chang-Wook, Kim, Tae Hyun, Shin, Eun-Seok, Chun, Eun Ju, Choi, Su-Yeon, Kim, Hyun Kuk, Hong, Young Joon, Park, Hun-Jun, Kim, Song-Yi, Husic, Mirza, Lambrechtsen, Jess, Jensen, Jesper M., Nørgaard, Bjarne L., Andreini, Daniele, Maurovich-Horvat, Pal, Merkely, Bela, Penicka, Martin, de Bruyne, Bernard, Ihdayhid, Abdul, Ko, Brian, Tzimas, Georgios, Leipsic, Jonathon, Sanz, Javier, Rabbat, Mark G., Katchi, Farhan, Shah, Moneal, Tanaka, Nobuhiro, Nakazato, Ryo, Asano, Taku, Terashima, Mitsuyasu, Takashima, Hiroaki, Amano, Tetsuya, Sobue, Yoshihiro, Matsuo, Hitoshi, Otake, Hiromasa, Kubo, Takashi, Takahata, Masahiro, Akasaka, Takashi, Kido, Teruhito, Mochizuki, Teruhito, Yokoi, Hiroyoshi, Okonogi, Taichi, Kawasaki, Tomohiro, Nakao, Koichi, Sakamoto, Tomohiro, Yonetsu, Taishi, Kakuta, Tsunekazu, Yamauchi, Yohei, Bax, Jeroen J., Shaw, Leslee J., Stone, Peter H., and Narula, Jagat
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- 2024
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17. Cardiac computed tomography post-transcatheter aortic valve replacement
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He, Albert, Wilkins, Ben, Lan, Nick S.R., Othman, Farrah, Sehly, Amro, Bhat, Vikas, Jaltotage, Biyanka, Dwivedi, Girish, Leipsic, Jonathon, and Ihdayhid, Abdul Rahman
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- 2024
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18. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation
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Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, and Lewthwaite, Hayley
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- 2024
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19. Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels
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Won, Ki-Bum, Lee, Byoung Kwon, Heo, Ran, Park, Hyung-Bok, Lin, Fay Y, Hadamitzky, Martin, Kim, Yong-Jin, Sung, Ji Min, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Leipsic, Jonathon A, Lee, Sang-Eun, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Chinnaiyan, Kavitha, Berman, Daniel S, Narula, Jagat, Bax, Jeroen J, Min, James K, and Chang, Hyuk-Jae
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Clinical Research ,Cardiovascular ,Hematology ,Atherosclerosis ,Heart Disease - Coronary Heart Disease ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,CCTA ,coronary computed tomographic angiography ,CV ,cardiovascular ,PVC ,plaque volume changes ,atherosclerosis ,coronary computed tomography angiography ,hemoglobin ,Δ hemoglobin ,hemoglobin level changes - Abstract
BackgroundDespite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited.ObjectivesThe authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA).MethodsA total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period.ResultsBaseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = -0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = -2.401; P = 0.004).ConclusionsSerial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels. (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411).
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- 2022
20. Bypass Grafting and Native Coronary Artery Disease Activity
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Kwiecinski, Jacek, Tzolos, Evangelos, Fletcher, Alexander J, Nash, Jennifer, Meah, Mohammed N, Cadet, Sebastien, Adamson, Philip D, Grodecki, Kajetan, Joshi, Nikhil, Williams, Michelle C, van Beek, Edwin JR, Lai, Chi, Tavares, Adriana AS, MacAskill, Mark G, Dey, Damini, Baker, Andrew H, Leipsic, Jonathon, Berman, Daniel S, Sellers, Stephanie L, Newby, David E, Dweck, Marc R, and Slomka, Piotr J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Cardiovascular ,Heart Disease ,Clinical Research ,Aged ,Calcinosis ,Calcium ,Coronary Angiography ,Coronary Artery Disease ,Disease Progression ,Female ,Humans ,Male ,Middle Aged ,Plaque ,Atherosclerotic ,Predictive Value of Tests ,Sodium Fluoride ,F-18-NaF ,CABG ,coronary artery bypass graft ,coronary artery disease ,PET/CT ,(18)F-NaF ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThe aim of this study was to describe the potential of 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) to identify graft vasculopathy and to investigate the influence of coronary artery bypass graft (CABG) surgery on native coronary artery disease activity and progression.BackgroundAs well as developing graft vasculopathy, CABGs have been proposed to accelerate native coronary atherosclerosis.MethodsPatients with established coronary artery disease underwent baseline 18F-NaF PET, coronary artery calcium scoring, coronary computed tomographic angiography, and 1-year repeat coronary artery calcium scoring. Whole-vessel coronary microcalcification activity (CMA) on 18F-NaF PET and change in calcium scores were quantified in patients with and without CABG surgery.ResultsAmong 293 participants (mean age 65 ± 9 years, 84% men), 48 (16%) underwent CABG surgery 2.7 years [IQR: 1.4-10.4 years] previously. Although all arterial and the majority (120 of 128 [94%]) of vein grafts showed no 18F-NaF uptake, 8 saphenous vein grafts in 7 subjects had detectable CMA. Bypassed native coronary arteries had 3 times higher CMA values (2.1 [IQR: 0.4-7.5] vs 0.6 [IQR: 0-2.7]; P < 0.001) and greater progression of 1-year calcium scores (118 Agatston unit [IQR: 48-194 Agatston unit] vs 69 [IQR: 21-142 Agatston unit]; P = 0.01) compared with patients who had not undergone CABG, an effect confined largely to native coronary plaques proximal to the graft anastomosis. In sensitivity analysis, bypassed native coronary arteries had higher CMA (2.0 [IQR: 0.4-7.5] vs 0.8 [IQR: 0.3-3.2]; P < 0.001) and faster disease progression (24% [IQR: 16%-43%] vs 8% [IQR: 0%-24%]; P = 0.002) than matched patients (n = 48) with comparable burdens of coronary artery disease and cardiovascular comorbidities in the absence of bypass grafting.ConclusionsNative coronary arteries that have been bypassed demonstrate increased disease activity and more rapid disease progression than nonbypassed arteries, an observation that appears independent of baseline atherosclerotic plaque burden. Microcalcification activity is not a dominant feature of graft vasculopathy.
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- 2022
21. Aspirin and Statin Therapy for Nonobstructive Coronary Artery Disease: Five-year Outcomes from the CONFIRM Registry
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Indraratna, Praveen, Naoum, Christopher, Ben Zekry, Sagit, Gransar, Heidi, Blanke, Philipp, Sellers, Stephanie, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Maffei, Erica, Marques, Hugo, Gonçalves, Pedro de Araújo, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Villines, Todd C, Lin, Fay Y, Shaw, Leslee J, Narula, Jagat, Bax, Jeroen J, and Leipsic, Jonathon A
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Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Clinical Trials and Supportive Activities ,Atherosclerosis ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Aspirin ,CT Angiography ,Coronary Artery Disease ,Nonobstructive Coronary Artery Disease ,Statin - Abstract
PurposeIn this cohort study, 5-year data from the Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry (ie, CONFIRM) were examined to identify associations of baseline aspirin and statin use with mortality, major adverse cardiovascular events (MACE), and myocardial infarction (MI) in individuals without substantial (≥50%) stenosis.Materials and methodsIn this prospective cohort study, all participants in the registry underwent coronary CT angiography and were classified as having no detectable coronary plaque or having nonobstructive coronary artery disease (CAD) (1%-49% stenosis). Participants with obstructive (≥50%) stenosis were excluded from analysis. The study commenced in June 2003 and was completed in March 2016. All unadjusted and risk-adjusted analyses utilized the Cox proportional hazard model with hospital sites modeled using shared frailty.ResultsA total of 6386 participants with no detectable plaque or with nonobstructive CAD were included (mean age, 56.0 years ± 13.3 [SD], 52% men). The mean follow-up period was 5.66 years ± 1.10. Nonobstructive CAD (n = 2815, 44% of all participants included in the study) was associated with a greater risk of all-cause mortality (10.6% [298 of 2815] vs 4.8% [170 of 3571], P < .001) compared to those without CAD (n = 3571, 56%). Baseline aspirin and statin use was documented for 1415 and 1429 participants, respectively, with nonobstructive CAD, and for 1560 and 1565 participants without detectable plaque, respectively. In individuals with nonobstructive CAD, baseline aspirin use was not associated with a reduction in MACE (10.9% [102 of 936] vs 14.7% [52 of 355], P = .06), all-cause mortality (9.6% [95 of 991] vs 10.9% [46 of 424], P = .468), or MI (4.4% [41 of 936] vs 6.2% [22 of 355], P = .18). On multivariate risk-adjusted analysis, baseline statin use was associated with a lower rate of MACE (hazard ratio, 0.59; 95% CI: 0.40, 0.87; P = .007). Neither therapy improved clinical outcomes for participants with no detectable plaque.ConclusionIn participants with nonobstructive CAD, baseline use of statins, but not of aspirin, was associated with improved clinical outcomes. Neither therapy was associated with benefit in participants without plaque.Keywords: Aspirin, Statin, Coronary Artery Disease, CT Angiography, Nonobstructive Coronary Artery DiseaseClinical trial registration no. NCT01443637 Supplemental material is available for this article. © RSNA, 2022See also the commentary by Canan and Navar in this issue.
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- 2022
22. Patient-Prosthesis Mismatch After Surgical Aortic Valve Replacement: Analysis of the PARTNER Trials
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Thourani, Vinod H., Abbas, Amr E., Ternacle, Julien, Hahn, Rebecca T., Makkar, Raj, Kodali, Susheel K., George, Isaac, Kapadia, Samir, Svensson, Lars G., Szeto, Wilson Y., Herrmann, Howard C., Ailawadi, Gorav, Leipsic, Jonathon, Blanke, Philipp, Webb, John, Jaber, Wael A., Russo, Mark, Malaisrie, S. Chris, Yadav, Pradeep, Clavel, Marie-Annick, Khalique, Omar K., Weissman, Neil J., Douglas, Pamela, Bax, Jeroen, Dahou, Abdellaziz, Xu, Ke, Bapat, Vinayak, Alu, Maria C., Leon, Martin B., Mack, Michael J., and Pibarot, Philippe
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- 2024
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23. Long-term prognostic implications of CT angiography-derived fractional flow reserve: Results from the DISCOVER-FLOW study
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Yang, Seokhun, Chung, Jaewook, Lesina, Krista, Doh, Joon-Hyung, Jegere, Sanda, Erglis, Andrejs, Leipsic, Jonathon A., Fearon, William F., Narula, Jagat, and Koo, Bon-Kwon
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- 2024
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24. Coronary computed tomography angiography derived fractional flow reserve and risk of recurrent angina: A 3-year follow-up study
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Madsen, Kristian Tækker, Nørgaard, Bjarne Linde, Øvrehus, Kristian Altern, Jensen, Jesper Møller, Parner, Erik, Grove, Erik Lerkevang, Mortensen, Martin B., Fairbairn, Timothy A., Nieman, Koen, Patel, Manesh R., Rogers, Campbell, Mullen, Sarah, Mickley, Hans, Thomsen, Kristian Korsgaard, Bøtker, Hans Erik, Leipsic, Jonathon, and Sand, Niels Peter Rønnow
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- 2024
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25. Colchicine and plaque: A focus on atherosclerosis imaging
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Aldana-Bitar, Jairo, Golub, Ilana S., Moore, Jeff, Krishnan, Srikanth, Verghese, Dhiran, Manubolu, Venkat S., Benzing, Travis, Ichikawa, Keshi, Hamal, Sajad, Kianoush, Sina, Anderson, Lauren R., Ramirez, Noah R., Leipsic, Jonathon A., Karlsberg, Ronald P., and Budoff, Matthew J.
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- 2024
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26. Prediction of the development of new coronary atherosclerotic plaques with radiomics
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Lee, Sang-Eun, Hong, Youngtaek, Hong, Jongsoo, Jung, Juyeong, Sung, Ji Min, Andreini, Daniele, Al-Mallah, Mouaz H., Budoff, Matthew J., Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, Gottlieb, Ilan, Hadamitzky, Martin, Kim, Yong Jin, Lee, Byoung Kwon, Leipsic, Jonathon A., Maffei, Erica, Marques, Hugo, Gonçalves, Pedro de Araújo, Pontone, Gianluca, Shin, Sanghoon, Stone, Peter H., Samady, Habib, Virmani, Renu, Narula, Jagat, Shaw, Leslee J., Bax, Jeroen J., Lin, Fay Y., Min, James K., and Chang, Hyuk-Jae
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- 2024
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27. Comprehensive Myocardial Assessment by Computed Tomography: Impact on Short-Term Outcomes After Transcatheter Aortic Valve Replacement
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Koike, Hideki, Fukui, Miho, Treibel, Thomas, Stanberry, Larissa I., Cheng, Victor Y., Enriquez-Sarano, Maurice, Schmidt, Stephanie, Schelbert, Erik B., Wang, Cheng, Okada, Atsushi, Phichaphop, Asa, Sorajja, Paul, Bapat, Vinayak N., Leipsic, Jonathon, Lesser, John R., and Cavalcante, João L.
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- 2024
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28. Associations between dyspnoea, coronary atherosclerosis, and cardiovascular outcomes: results from the long-term follow-up CONFIRM registry.
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van Rosendael, Alexander R, Bax, A Maxim, van den Hoogen, Inge J, Smit, Jeff M, Al'Aref, Subhi J, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon A, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Villines, Todd C, Gransar, Heidi, Lu, Yao, Peña, Jessica M, Lin, Fay Y, Shaw, Leslee J, Narula, Jagat, Min, James K, and Bax, Jeroen J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Atherosclerosis ,Cardiovascular ,Clinical Research ,Biomedical Imaging ,Heart Disease ,Heart Disease - Coronary Heart Disease ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Aged ,Coronary Angiography ,Coronary Artery Disease ,Dyspnea ,Follow-Up Studies ,Humans ,Male ,Middle Aged ,Predictive Value of Tests ,Prognosis ,Prospective Studies ,Registries ,Risk Factors ,coronary artery disease ,coronary computed tomography angiography ,dyspnoea ,prognosis ,Cardiovascular medicine and haematology - Abstract
AimsThe relationship between dyspnoea, coronary artery disease (CAD), and major cardiovascular events (MACE) is poorly understood. This study evaluated (i) the association of dyspnoea with the severity of anatomical CAD by coronary computed tomography angiography (CCTA) and (ii) to which extent CAD explains MACE in patients with dyspnoea.Methods and resultsFrom the international COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 4425 patients (750 with dyspnoea) with suspected but without known CAD were included and prospectively followed for ≥5 years. First, the association of dyspnoea with CAD severity was assessed using logistic regression analysis. Second, the prognostic value of dyspnoea for MACE (myocardial infarction and death), and specifically, the interaction between dyspnoea and CAD severity was investigated using Cox proportional-hazard analysis. Mean patient age was 60.3 ± 11.9 years, 63% of patients were male and 592 MACE events occurred during a median follow-up duration of 5.4 (IQR 5.1-6.0) years. On uni- and multivariable analysis (adjusting for age, sex, body mass index, chest pain typicality, and risk factors), dyspnoea was associated with two- and three-vessel/left main (LM) obstructive CAD. The presence of dyspnoea increased the risk for MACE [hazard ratio (HR) 1.57, 95% confidence interval (CI): 1.29-1.90], which was modified after adjusting for clinical predictors and CAD severity (HR 1.26, 95% CI: 1.02-1.55). Conversely, when stratified by CAD severity, dyspnoea did not provide incremental prognostic value in one-, two-, or three-vessel/LM obstructive CAD, but dyspnoea did provide incremental prognostic value in non-obstructive CAD.ConclusionIn patients with suspected CAD, dyspnoea was independently associated with severe obstructive CAD on CCTA. The severity of obstructive CAD explained the elevated MACE rates in patients presenting with dyspnoea, but in patients with non-obstructive CAD, dyspnoea portended additional risk.
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- 2022
29. Glycemic control is independently associated with rapid progression of coronary atherosclerosis in the absence of a baseline coronary plaque burden: a retrospective case–control study from the PARADIGM registry
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Won, Ki-Bum, Lee, Byoung Kwon, Lin, Fay Y, Hadamitzky, Martin, Kim, Yong-Jin, Sung, Ji Min, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Leipsic, Jonathon A, Lee, Sang-Eun, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Chinnaiyan, Kavitha, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Min, James K, and Chang, Hyuk-Jae
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Biomedical and Clinical Sciences ,Clinical Sciences ,Aging ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Cardiovascular ,Heart Disease ,Biomedical Imaging ,Clinical Research ,Prevention ,Humans ,Male ,Middle Aged ,Aged ,Female ,Plaque ,Atherosclerotic ,Coronary Artery Disease ,Retrospective Studies ,Coronary Angiography ,Case-Control Studies ,Glycemic Control ,Glycated Hemoglobin ,Prospective Studies ,Disease Progression ,Computed Tomography Angiography ,Coronary Vessels ,Registries ,Predictive Value of Tests ,Hemoglobin A1c ,Coronary artery disease ,Progression ,Coronary computed tomography angiography ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
The baseline coronary plaque burden is the most important factor for rapid plaque progression (RPP) in the coronary artery. However, data on the independent predictors of RPP in the absence of a baseline coronary plaque burden are limited. Thus, this study aimed to investigate the predictors for RPP in patients without coronary plaques on baseline coronary computed tomography angiography (CCTA) images. A total of 402 patients (mean age: 57.6 ± 10.0 years, 49.3% men) without coronary plaques at baseline who underwent serial coronary CCTA were identified from the Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging (PARADIGM) registry and included in this retrospective study. RPP was defined as an annual change of ≥ 1.0%/year in the percentage atheroma volume (PAV). During a median inter-scan period of 3.6 years (interquartile range: 2.7-5.0 years), newly developed coronary plaques and RPP were observed in 35.6% and 4.2% of the patients, respectively. The baseline traditional risk factors, i.e., advanced age (≥ 60 years), male sex, hypertension, diabetes mellitus, hyperlipidemia, obesity, and current smoking status, were not significantly associated with the risk of RPP. Multivariate linear regression analysis showed that the serum hemoglobin A1c level (per 1% increase) measured at follow-up CCTA was independently associated with the annual change in the PAV (β: 0.098, 95% confidence interval [CI]: 0.048-0.149; P
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- 2022
30. Feasibility and Utility of Anatomical and Physiological Evaluation of Coronary Disease With Cardiac CT in Severe Aortic Stenosis (FUTURE-AS Registry): Rationale and Design
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Khoo, John King, Sellers, Stephanie, Fairbairn, Timothy, Polsani, Venkateshwar, Liu, Shizhen, Yong, Gerald, Shetty, Sharad, Corrigan, Frank, Ko, Brian, Vucic, Esad, Fitzgibbons, Timothy P., Kakouros, Nikolaos, Blanke, Philipp, Sathananthan, Janarthanan, Webb, John, Wood, David, Leipsic, Jonathon, and Ihdayhid, Abdul Rahman
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- 2024
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31. Age- and Sex-Specific Nomographic CT Quantitative Plaque Data From a Large International Cohort
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Tzimas, Georgios, Gulsin, Gaurav S., Everett, Russell J., Akodad, Mariama, Meier, David, Sewnarain, Kavishka, Ally, Zain, Alnamasy, Rawan, Ng, Nicholas, Mullen, Sarah, Rotzinger, David, Sathananthan, Janarthanan, Sellers, Stephanie L., Blanke, Philipp, and Leipsic, Jonathon A.
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- 2024
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32. Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT)
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Williams, Michelle C., Weir-McCall, Jonathan R., Baldassarre, Lauren A., De Cecco, Carlo N., Choi, Andrew D., Dey, Damini, Dweck, Marc R., Isgum, Ivana, Kolossvary, Márton, Leipsic, Jonathon, Lin, Andrew, Lu, Michael T., Motwani, Manish, Nieman, Koen, Shaw, Leslee, van Assen, Marly, and Nicol, Edward
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- 2024
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33. The Canadian Cardiovascular Society Classification of Acute Atherothrombotic Myocardial Infarction Based on Stages of Tissue Injury Severity: An Expert Consensus Statement
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Kumar, Andreas, Connelly, Kim, Vora, Keyur, Bainey, Kevin R., Howarth, Andrew, Leipsic, Jonathon, Betteridge-LeBlanc, Suzanne, Prato, Frank S., Leong-Poi, Howard, Main, Anthony, Atoui, Rony, Saw, Jacqueline, Larose, Eric, Graham, Michelle M., Ruel, Marc, and Dharmakumar, Rohan
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- 2024
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34. Derivation and validation of a novel functional FFRCT score incorporating the burden of coronary stenosis severity and flow impairment to predict clinical events
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Gabara, Lavinia, Hinton, Jonathan, Kira, Mohamed, Saunders, Alec, Shambrook, James, Abbas, Ausami, Leipsic, Jonathon A., Rogers, Campbell, Mullen, Sarah, Ng, Nicholas, Wilding, Sam, Douglas, Pamela S., Patel, Manesh, Fairbairn, Timothy A., Hlatky, Mark A., and Curzen, Nick
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- 2024
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35. Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry
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Dundas, James, Leipsic, Jonathon, Fairbairn, Timothy, Ng, Nicholas, Sussman, Vida, Guez, Ilana, Rosenblatt, Rachael, Hurwitz Koweek, Lynne M., Douglas, Pamela S., Rabbat, Mark, Pontone, Gianluca, Chinnaiyan, Kavitha, de Bruyne, Bernard, Bax, Jeroen J., Amano, Tetsuya, Nieman, Koen, Rogers, Campbell, Kitabata, Hironori, Sand, Niels P.R., Kawasaki, Tomohiro, Mullen, Sarah, Huey, Whitney, Matsuo, Hitoshi, Patel, Manesh R., Norgaard, Bjarne L., Ahmadi, Amir, and Tzimas, Georgios
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- 2024
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36. Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data.
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Yoon, Yeonyee E, Baskaran, Lohendran, Lee, Benjamin C, Pandey, Mohit Kumar, Goebel, Benjamin, Lee, Sang-Eun, Sung, Ji Min, Andreini, Daniele, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, Gottlieb, Ilan, Hadamitzky, Martin, Kim, Yong Jin, Lee, Byoung Kwon, Leipsic, Jonathon A, Maffei, Erica, Marques, Hugo, de Araújo Gonçalves, Pedro, Pontone, Gianluca, Shin, Sanghoon, Narula, Jagat, Bax, Jeroen J, Lin, Fay Yu-Huei, Shaw, Leslee, and Chang, Hyuk-Jae
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Heart Disease - Coronary Heart Disease ,Cardiovascular ,Heart Disease ,Biomedical Imaging ,Aging ,Atherosclerosis ,2.1 Biological and endogenous factors - Abstract
Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national registry of consecutive patients who underwent serial coronary computed tomography angiography (median inter-scan duration, 3.3 years). K-means clustering applied to the percent volume of each plaque component and identified 4 clusters of patients with distinct plaque composition. Cluster 1 (n = 52), which comprised mainly fibro-fatty plaque with a significant necrotic core (median, 55.7% and 16.0% of the total plaque volume, respectively), showed the least total plaque volume (PV) progression (+ 23.3 mm3), with necrotic core and fibro-fatty PV regression (- 5.7 mm3 and - 5.6 mm3, respectively). Cluster 2 (n = 219), which contained largely fibro-fatty (39.2%) and fibrous plaque (46.8%), showed fibro-fatty PV regression (- 2.4 mm3). Cluster 3 (n = 376), which comprised mostly fibrous (62.7%) and calcified plaque (23.6%), showed increasingly prominent calcified PV progression (+ 21.4 mm3). Cluster 4 (n = 300), which comprised mostly calcified plaque (58.7%), demonstrated the greatest total PV increase (+ 50.7mm3), predominantly increasing in calcified PV (+ 35.9 mm3). Multivariable analysis showed higher risk for plaque progression in Clusters 3 and 4, and higher risk for adverse cardiac events in Clusters 2, 3, and 4 compared to that in Cluster 1. Unsupervised clustering algorithms may uniquely characterize patient phenotypes with varied atherosclerotic plaque profiles, yielding distinct patterns of progressive disease and outcome.
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- 2021
37. Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis
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Hwang, Doyeon, Kim, Haneol J, Lee, Seung-Pyo, Lim, Seonhee, Koo, Bon-Kwon, Kim, Yong-Jin, Kook, Woong, Andreini, Daniele, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Conte, Edoardo, Marques, Hugo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Hadamitzky, Martin, Leipsic, Jonathon A, Maffei, Erica, Pontone, Gianluca, Raff, Gilbert L, Shin, Sanghoon, Lee, Byoung Kwon, Chun, Eun Ju, Sung, Ji Min, Lee, Sang-Eun, Berman, Daniel S, Lin, Fay Y, Virmani, Renu, Samady, Habib, Stone, Peter H, Narula, Jagat, Bax, Jeroen J, Shaw, Leslee J, Min, James K, and Chang, Hyuk-Jae
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Atherosclerosis ,Cardiovascular ,Heart Disease ,Biomedical Imaging ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Coronary Artery Disease ,Data Analysis ,Exercise ,Humans ,Predictive Value of Tests ,coronary computed tomography angiography ,coronary plaque ,topological data analysis ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThis study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA).BackgroundCoronary CTA can noninvasively assess coronary plaques quantitatively.MethodsPatients who underwent 2 coronary CTAs at a minimum of 24 months' interval were analyzed (n = 1,264). A similarity Mapper network of patients was built by topological data analysis (TDA) based on the whole-heart quantitative coronary plaque analysis on coronary CTA to identify distinct patient groups and their association with outcome.ResultsThree distinct patient groups were identified by TDA, and the patient similarity network by TDA showed a closed loop, demonstrating a continuous trend of coronary plaque progression. Group A had the least coronary plaque amount (median 12.4 mm3 [interquartile range (IQR): 0.0 to 39.6 mm3]) in the entire coronary tree. Group B had a moderate coronary plaque amount (31.7 mm3 [IQR: 0.0 to 127.4 mm3]) with relative enrichment of fibrofatty and necrotic core (32.6% [IQR: 16.7% to 46.2%] and 2.7% [IQR: 0.1% to 6.9%] of the total plaque, respectively) components. Group C had the largest coronary plaque amount (187.0 mm3 [IQR: 96.7 to 306.4 mm3]) and was enriched for dense calcium component (46.8% [IQR: 32.0% to 63.7%] of the total plaque). At follow-up, total plaque volume, fibrous, and dense calcium volumes increased in all groups, but the proportion of fibrofatty component decreased in groups B and C, whereas the necrotic core portion decreased in only group B (all p
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- 2021
38. Novel 4DCT Method to Measure Regional Left Ventricular Endocardial Shortening Before and After Transcatheter Mitral Valve Implantation
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Colvert, Gabrielle M, Manohar, Ashish, Contijoch, Francisco J, Yang, James, Glynn, Jeremy, Blanke, Philipp, Leipsic, Jonathon A, and McVeigh, Elliot R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Bioengineering ,Cardiovascular ,Biomedical Imaging ,Heart Disease ,Mitral regurgitation ,myocardial strain ,LV function ,TMVI ,4DCT ,LV remodeling ,LV Remodeling ,Mitral Regurgitation ,Myocardial Strain - Abstract
BackgroundRegional left ventricular (LV) mechanics in mitral regurgitation (MR) patients, and local changes in function after transcatheter mitral valve implantation (TMVI) have yet to be evaluated. Herein, we introduce a method for creating high resolution maps of endocardial function from 4DCT images, leading to detailed characterization of changes in local LV function. These changes are particularly interesting when evaluating the effect of the Tendyne™ TMVI device in the region of the epicardial pad.MethodsRegional endocardial shortening from CT (RSCT) was evaluated in Tendyne (Abbott Medical) TMVI patients with 4DCT exams pre- and post-implantation. Regional function was evaluated in 90 LV segments (5 longitudinal × 18 circumferential). LV volumes and ejection fraction (EF) were also computed. A reproducibility study was performed in a subset of patients to determine the precision of RSCT measurements in this population.ResultsBaseline and local changes in RSCT post TMVI were highly variable and extremely spatially heterogeneous. Both inter- and intra-observer variability were low and demonstrated the high precision of RSCT for evaluating regional LV function.ConclusionRSCT is a reproducible metric which can be evaluated in patients with highly abnormal regional LV function and geometry. After TMVI, significant spatially heterogeneous changes in RSCT were observed in all subjects; therefore, it is unlikely that the functional state of TMVI patients can be fully described by changes in LV volume or EF. Measurement of RSCT provides precise characterization of the spatially heterogeneous effects of MR and TMVI on LV function and remodeling.
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- 2021
39. Valve-in-Valve Transcatheter Mitral Valve Replacement: A Large First-in-Human 13-Year Experience
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Akodad, Mariama, Trpkov, Cvet, Cheung, Anson, Ye, Jian, Chatfield, Andrew G., Alosail, Abdulmajeed, Besola, Laura, Yu, Maggie, Leipsic, Jonathon A., Lounes, Youcef, Meier, David, Yang, Cathevine, Nestelberger, Thomas, Tzimas, Georgios, Sathananthan, Janarthanan, Wood, David A., Moss, Rob R., Blanke, Philipp, Sathananthan, Gnalini, and Webb, John G.
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- 2023
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40. Integration and Application of Radiologic Patterns From Clinical Practice Guidelines on Idiopathic Pulmonary Fibrosis and Fibrotic Hypersensitivity Pneumonitis
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Marinescu, Daniel-Costin, Hague, Cameron J., Muller, Nestor L., Murphy, Darra, Churg, Andrew, Wright, Joanne L., Al-Arnawoot, Amna, Bilawich, Ana-Maria, Bourgouin, Patrick, Cox, Gerard, Durand, Celine, Elliot, Tracy, Ellis, Jennifer, Fisher, Jolene H., Fladeland, Derek, Grant-Orser, Amanda, Goobie, Gillian C., Guenther, Zachary, Haider, Ehsan, Hambly, Nathan, Huynh, James, Johannson, Kerri A., Karjala, Geoffrey, Khalil, Nasreen, Kolb, Martin, Leipsic, Jonathon, Lok, Stacey, MacIsaac, Sarah, McInnis, Micheal, Manganas, Helene, Marcoux, Veronica, Mayo, John, Morisset, Julie, Scallan, Ciaran, Sedlic, Tony, Shapera, Shane, Sun, Kelly, Tan, Victoria, Wong, Alyson W., Zheng, Boyang, and Ryerson, Christopher J.
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- 2023
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41. Predictors of Cerebral Embolic Debris During Transcatheter Aortic Valve Replacement: The SafePass 2 First-in-Human Study
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Grubman, Daniel, Ahmad, Yousif, Leipsic, Jonathon A., Blanke, Philipp, Pasupati, Sanjeevan, Webster, Mark, Nazif, Tamin M., Parise, Helen, and Lansky, Alexandra J.
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- 2023
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42. Coronary Atherosclerosis Phenotypes in Focal and Diffuse Disease
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Sakai, Koshiro, Mizukami, Takuya, Leipsic, Jonathon, Belmonte, Marta, Sonck, Jeroen, Nørgaard, Bjarne L., Otake, Hiromasa, Ko, Brian, Koo, Bon-kwon, Maeng, Michael, Jensen, Jesper Møller, Buytaert, Dimitri, Munhoz, Daniel, Andreini, Daniele, Ohashi, Hirofumi, Shinke, Toshiro, Taylor, Charles A., Barbato, Emanuele, Johnson, Nils P., De Bruyne, Bernard, and Collet, Carlos
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- 2023
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43. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints
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Arnold, Suzanne, Bapat, Vinayak, Berry, Natalia, Blanke, Philipp, Burkhoff, Daniel, Coylewright, Megan, Duggal, Neal, Galper, Benjamin, George, Isaac, Guerrero, Mayra, Hamid, Nadira, Jagadeesan, Vikrant, Kodali, Susheel, Krucoff, Mitch, Lang, Roberto, Madhavan, Mahesh, McLaughin, Vallerie, Mehran, Roxana, Philippon, Francois, Sethi, Sanjum S., Simonato, Matheus, Smith, Robert, Sodhi, Nishtha, Spertus, John, Stocker, Thomas J., Stone, Gregg, Hahn, Rebecca T., Lawlor, Matthew K., Davidson, Charles J., Badhwar, Vinay, Sannino, Anna, Spitzer, Ernest, Lurz, Philipp, Lindman, Brian R., Topilsky, Yan, Baron, Suzanne J., Chadderdon, Scott, Khalique, Omar K., Tang, Gilbert H.L., Taramasso, Maurizio, Grayburn, Paul A., Badano, Luigi, Leipsic, Jonathon, Lindenfeld, JoAnn, Windecker, Stephan, Vemulapalli, Sreekanth, Redfors, Bjorn, Alu, Maria C., Cohen, David J., Rodés-Cabau, Josep, Ailawadi, Gorav, Mack, Michael, Ben-Yehuda, Ori, Leon, Martin B., and Hausleiter, Jörg
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- 2023
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44. Relevance of Motion Artifacts in Planning Computed Tomography on Outcomes After Transcatheter Aortic Valve Implantation
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Toggweiler, Stefan, Loretz, Lucca, Wolfrum, Mathias, Buhmann, Ralf, Fornaro, Jürgen, Bossard, Matthias, Attinger-Toller, Adrian, Cuculi, Florim, Roos, Justus, Leipsic, Jonathon A., and Moccetti, Federico
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- 2023
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45. Multimodality assessment of high- vs. low-gradient aortic stenosis using echocardiography and cardiac CT
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Zeb, Irfan, Uqaily, Raafay, Gonuguntla, Karthik, Ludhwani, Dipesh, Abdelhaleem, Ahmed, Leipsic, Jonathon, Hahn, Rebecca T., Pibarot, Philippe, Sankaramangalam, Kesavan, Kuzhandai, Dhivya, Sattar, Yasar, Raina, Sameer, Sudarshan, Balla, Kawsara, Mohammad, Hamirani, Yasmin, and Daggubati, Ramesh
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- 2023
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46. Impact of Post-PCI FFR Stratified by Coronary Artery
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Collet, Carlos, Johnson, Nils P., Mizukami, Takuya, Fearon, William F., Berry, Colin, Sonck, Jeroen, Collison, Damien, Koo, Bon-Kwon, Meneveau, Nicolas, Agarwal, Shiv Kumar, Uretsky, Barry, Hakeem, Abdul, Doh, Joon-Hyung, Da Costa, Bruno R., Oldroyd, Keith G., Leipsic, Jonathon A., Morbiducci, Umberto, Taylor, Charles, Ko, Brian, Tonino, Pim A.L., Perera, Divaka, Shinke, Toshiro, Chiastra, Claudio, Sposito, Andrei C., Leone, Antonio Maria, Muller, Olivier, Fournier, Stephane, Matsuo, Hitoshi, Adjedj, Julien, Amabile, Nicolas, Piróth, Zsolt, Alfonso, Fernando, Rivero, Fernando, Ahn, Jung-Min, Toth, Gabor G., Ihdayhid, Abdul, West, Nick E.J., Amano, Tetsuya, Wyffels, Eric, Munhoz, Daniel, Belmonte, Marta, Ohashi, Hirofumi, Sakai, Koshiro, Gallinoro, Emanuele, Barbato, Emanuele, Engstrøm, Thomas, Escaned, Javier, Ali, Ziad A., Kern, Morton J., Pijls, Nico H.J., Jüni, Peter, and De Bruyne, Bernard
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- 2023
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47. Effects of renin-angiotensin-aldosterone-system inhibitors on coronary atherosclerotic plaques: The PARADIGM registry
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Williams, Curtis, Han, Donghee, Takagi, Hidenobu, Fordyce, Christopher B., Sellers, Stephanie, Blanke, Philipp, Lin, Fay Y., Shaw, Leslee J., Lee, Sang-Eun, Andreini, Daniele, Al-Mallah, Mouaz H., Budoff, Matthew J., Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Conte, Edoardo, Marques, Hugo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Hadamitzky, Martin, Maffei, Erica, Pontone, Gianluca, Shin, Sanghoon, Kim, Yong-Jin, Lee, Byoung Kwon, Chun, Eun Ju, Sung, Ji Min, Virmani, Renu, Samady, Habib, Stone, Peter H., Berman, Daniel S., Narula, Jagat, Bax, Jeroen J., Leipsic, Jonathon A., and Chang, Hyuk-Jae
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- 2023
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48. The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis
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Ngan David A, Wilcox Pearce G, Aldaabil May, Li Yuexin, Leipsic Jonathon A, Sin Don D, and Man SF
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background In cystic fibrosis (CF) patients, it has been suggested that systemic inflammation may be an important risk factor for poor health outcomes. The relationship of plasma inflammatory biomarkers to lung function and hospitalization history remains largely unexplored. Methods This cross-sectional study included 58 consecutive, clinically stable adults from the CF Clinic at St. Paul's Hospital (Vancouver, Canada). Blood levels of interleukin (IL)-6, IL-1β, C-reactive protein (CRP), interleukin (IL)-6, IL-1β, granzyme B (GzmB), chemokine C-C motif ligand 18 (CCL18/PARC), surfactant protein D (SP-D), lipopolysaccharide (LPS)-binding protein, and soluble cluster of differentiation 14 (sCD14) were measured using enzyme-linked immunosorbent assays, and LPS levels were measured using a Limulus amebocyte lysate assay. Spirometry was also performed. Multivariable linear regression analysis was used to assess relationships of the blood biomarkers to lung function. Results Lung function impairment was independently associated with elevated plasma levels of CRP (P < 0.01), IL-6 (P = 0.04), IL-1β (P < 0.01), and LBP (P < 0.01). Increasing age (P < 0.01), reduced body mass index (P = 0.02), prior hospitalizations (P = 0.03), and presence of Pseudomonas aeruginosa in sputum cultures (P < 0.01) were also associated with reduced lung function. Elevated concentrations of LPS in plasma were associated with a previous history of hospitalization (P < 0.05). There was a trend towards an increase in plasma IL-6 (P = 0.07) and IL-1β (P = 0.06) levels in patients who were previously hospitalized. Conclusions IL-6 and IL-1β are promising systemic biomarkers for lung function impairment and history of hospitalization in adult patients with CF.
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- 2012
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49. The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease
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Jin, Han-Young, Weir-McCall, Jonathan R, Leipsic, Jonathon A, Son, Jang-Won, Sellers, Stephanie L, Shao, Michael, Blanke, Philipp, Ahmadi, Amir, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, de Araujo Goncalves, Pedio, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Chinnaiyan, Kavitha, Raff, Gilbert, Al-Mallah, Mouaz H, Lin, Fay Y, Min, James K, Sung, Ji Min, Lee, Sang-Eun, and Chang, Hyuk-Jae
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Biomedical Imaging ,Heart Disease ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Artery Disease ,Coronary Vessels ,Disease Progression ,Humans ,Plaque ,Atherosclerotic ,Predictive Value of Tests ,Risk Factors ,Vascular Calcification ,atherosclerosis ,coronary artery calcium ,coronary artery disease ,coronary computed tomography angiography ,statins ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
ObjectivesThe aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease.BackgroundCoronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in response to medical therapy.MethodsThis analysis included 925 patients with 2,568 lesions from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry, in which patients underwent clinically indicated serial coronary computed tomography angiography. Plaque calcification was examined by using CPV and percent CPV (PCPV), calculated as (CPV/plaque volume) × 100 at a per-plaque and per-patient level (summation of all individual plaques).ResultsCPV was strongly correlated with plaque volume (r = 0.780; p
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- 2021
50. Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study
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Conte, Edoardo, Dwivedi, Aeshita, Mushtaq, Saima, Pontone, Gianluca, Lin, Fay Y, Hollenberg, Emma J, Lee, Sang-Eun, Bax, Jeroen, Cademartiri, Filippo, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, Feuchtner, Gudrun, Hadamitzky, Martin, Kim, Yong-Jin, Baggiano, Andrea, Leipsic, Jonathon, Maffei, Erica, Marques, Hugo, Plank, Fabian, Raff, Gilbert L, van Rosendael, Alexander R, Villines, Todd C, Weirich, Harald G, Al’Aref, Subhi J, Baskaran, Lohendran, Cho, Iksung, Danad, Ibrahim, Han, Donghee, Heo, Ran, Lee, Ji Hyun, Stuijfzand, Wijnand J, Gransar, Heidi, Lu, Yao, Sung, Ji Min, Park, Hyung-Bok, Al-Mallah, Mouaz H, de Araújo Gonçalves, Pedro, Berman, Daniel S, Budoff, Matthew J, Samady, Habib, Shaw, Leslee J, Stone, Peter H, Virmani, Renu, Narula, Jagat, Min, James K, Chang, Hyuk-Jae, and Andreini, Daniele
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Atherosclerosis ,Biomedical Imaging ,Aging ,Clinical Research ,Heart Disease - Coronary Heart Disease ,Cardiovascular ,Acute Coronary Syndrome ,Aged ,Computed Tomography Angiography ,Coronary Angiography ,Coronary Artery Disease ,Female ,Humans ,Male ,Plaque ,Atherosclerotic ,atherosclerosis ,gender medicine ,cardiac CT ,high-risk plaque features ,CCTA ,Cardiovascular medicine and haematology - Abstract
AimsAlthough there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).Methods and resultsWithin the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (
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- 2021
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