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3 results on '"Leila Tabrizian"'

1. Crocin mitigated cognitive impairment and brain molecular alterations induced by different intensities of prenatal hypoxia in neonatal rats

Author

Zohreh Ghotbeddin, Mohammad Reza Tabandeh, Mahdi Pourmahdi Borujeni, Fahimeh Fahimi Truski, Mohammad Reza Zalaki Ghorbani Pour, and Leila Tabrizian

Subjects
cognitive behavior, crocin, hypoxia, molecular changes, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Introduction Brain hypoxia has important role to the onset and progression of sporadic form of Alzheimer disease via expression of hypoxia‐inducible factor‐1 (HIF‐1). Crocin by anti‐amyloidogenic property inhibits β‐amyloid formation. However, the molecular mechanism associated with anti‐amyloidogenic activity of crocin is unknown. So, the present study was designed to investigate the effect of crocin on cognitive behavior and expression of HIF‐1α and β‐secretase (BACE1) genes in the brain of neonate rats following different intensities of hypoxia during pregnancy. Material and methods Pregnant female rats were divided into six groups including sham, control crocin treated (CC), hypoxia with three different intensities (H1–H3), and most intense of hypoxic group treated with crocin (H3C) (30 mg/kg; i.p) at P14. Hypoxia induced on the 20th day of pregnancy. Animals in sham and CC were put in hypoxia chamber at the same time of hypoxia group without any hypoxia induction. Morris water maze (MWM) and qRT‐PCR were used to evaluate the cognitive behavior and mRNA levels of BACE1 and HIF‐1α genes in the brain tissues. Results Animal under 7% O2 + 93% N2 condition for 3 hr showed the highest cognitive behavior impairment and upregulated HIF‐1α and BACE1 mRNA in brains of offspring (p

Published
2021
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2. Author response for 'Crocin mitigated cognitive impairment and brain molecular alterations induced by different intensities of prenatal hypoxia in neonatal rats'

Author

Mohammad Reza Zalaki Ghorbani Pour, Zohreh Ghotbeddin, Fahimeh Fahimi Truski, Mohammad Reza Tabandeh, Leila Tabrizian, and Mahdi Pourmahdi Borujeni

Subjects
Crocin, medicine.medical_specialty, chemistry.chemical_compound, Endocrinology, chemistry, business.industry, Internal medicine, medicine, Hypoxia (medical), medicine.symptom, Cognitive impairment, business
Published
2021
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3. Study the effect of crocin in three maternal hypoxia protocols with different oxygen intensities on motor activity and balance in rat offspring

Author

Zohreh Ghotbeddin, Mahdi Pourmahdi Borujeni, Mohammad Reza Tabandeh, Fahimeh Fahimi Truski, and Leila Tabrizian

Subjects
Male, medicine.medical_specialty, Offspring, Saline injection, chemistry.chemical_element, Motor Activity, Oxygen, Crocin, Sham group, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, Animals, 030212 general & internal medicine, Motor activity, Rats, Wistar, Hypoxia, Postural Balance, Movement Disorders, Behavior, Animal, business.industry, General Medicine, Hypoxia (medical), medicine.disease, Crocus, Carotenoids, Rats, Disease Models, Animal, Endocrinology, chemistry, Prenatal Exposure Delayed Effects, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Hypoxia as one of the most common clinical disturbances in pregnancy period can cause destructive changes in motor sensory cortex and can lead to imperfect organization in motor reactions. Crocin, a water-soluble carotenoid, is the most active ingredients of saffron and a lot of studies declare its positive effectiveness on improving motor activity. Since the hypoxia intensity affects its malicious amount on movement, in this paper, we have studied the effect of crocin in three maternal hypoxia protocols with different oxygen intensities on motor activity and balance in rat offspring. In this experiment, female rats (Wistar) were used on the 20th day of pregnancy. The rats were randomly divided into eight experimental groups: sham, crocin, hypoxia with three different intensities: 10% oxygen and 90% nitrogen for 1 h (hypoxia-ɪ), 7% oxygen and 93% nitrogen for 1 h (hypoxia-ɪɪ), 7% oxygen and 93% nitrogen for 3 h (hypoxia-ɪɪɪ) and treated-crocin hypoxia groups. To produce hypoxia, pregnant rats were placed in a hypoxia box. In crocin group, rat offspring received 30 mg/kg crocin via IP injection at P14–28. Control group also received saline injection at the same time. Finally, balance and motor activity in offspring were measured respectively by rotarod and open-field devices. Results showed that motor activity significantly decreased in hypoxia-ɪɪɪ group as compared with sham group (p

Published
2018

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