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3. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P., additional, Li, Fan, additional, Spatz, Erica S., additional, Caraballo, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C., additional, Lu, Yuan, additional, Krumholz, Harlan M., additional, Spertus, John A., additional, D’Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H., additional

Published
2024
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7. Impact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P., additional, Li, Fan, additional, Spatz, Erica S., additional, Caraballo‐Cordovez, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C., additional, Lu, Yuan, additional, Krumholz, Harlan M., additional, Spertus, John A., additional, D'Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H., additional

Published
2023
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9. Association of Marital/Partner Status with Hospital Readmission Among Young Adults With Acute Myocardial Infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P, additional, Li, Fan, additional, Spatz, Erica S, additional, Caraballo, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C, additional, Lu, Yuan, additional, Krumholz, Harlan M, additional, Spertus, John A, additional, D’Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H, additional

Published
2023
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11. Abstract P405: Low Social Support Mediates the Effect of Marital Stress on 12-month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P, additional, Li, Fan, additional, Spatz, Erica S, additional, Caraballo, Cesar, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C, additional, Lu, Yuan, additional, Krumholz, Harlan M, additional, Spertus, John, additional, DONOFRIO, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H, additional

Published
2023
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35. Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells

Author

Leifheit Erica C, Meyer-Siegler Katherine L, and Vera Pedro L

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The importance of various inflammatory cytokines in maintaining tumor cell growth and viability is well established. Increased expression of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) has previously been associated with various types of adenocarcinoma. Methods MIF IHC was used to localize MIF in human bladder tissue. ELISA and Western blot analysis determined the synthesis and secretion of MIF by human bladder transitional cell carcinoma cells. The effects of MIF inhibitors (high molecular weight hyaluronate (HA), anti-MIF antibody or MIF anti-sense) on cell growth and cytokine expression were analyzed. Results Human bladder cancer cells (HT-1376) secrete detectable amounts of MIF protein. Treatment with HA, anti-MIF antibody and MIF anti-sense reduced HT-1376 cell proliferation, MIF protein secretion, MIF gene expression and secreted inflammatory cytokines. Our evidence suggests MIF interacts with the invariant chain, CD74 and the major cell surface receptor for HA, CD44. Conclusions This study is the first to report MIF expression in the human bladder and these findings support a role for MIF in tumor cell proliferation. Since MIF participates in the inflammatory response and bladder cancer is associated with chronic inflammatory conditions, these new findings suggest that neutralizing bladder tumor MIF may serve as a novel therapeutic treatment for bladder carcinoma.

Published
2004
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37. Abstract WMP98: Associations Between Long-term Co, No2, O3, Pm2.5, And So2Exposure And 30-day All-cause Hospital Readmission Among Stroke Patients In The Us: 2014-2015

Author

Tran, Phoebe, Leifheit, Erica C, Warren, Joshua, Goldstein, Larry B, and Lichtman, Judith H

Abstract

Objective:There are known associations between long-term air pollution exposure and greater stroke incidence, morbidity, and mortality; however, there is little research on the association of pollutant exposure with poststroke hospital readmission.Methods:We assessed associations of average annual CO, NO2, O3, PM2.5, and SO2exposure with 30-day all-cause hospital readmission in US fee-for-service Medicare beneficiaries age ≥65 years hospitalized for ischemic stroke in 2014-2015. We fit Cox models to assess 30-day readmission as a function of these pollutants, adjusted for patient and hospital factors and temperature. We repeated the models stratified by performance of the treating hospital on the Centers for Medicare & Medicaid Services (CMS) risk-standardized 30-day all-cause readmission for stroke measure to determine if the results were independent of performance: Low (CMS rate for hospital <25th percentile of national rate), High (>75thpercentile), and Middle (all others).Results:There were 448148 patients discharged with stroke in 2014-2015 of whom 12.5% were readmitted. Average 2-year CO, O3, PM2.5, and SO2values during the study were below national standards. In adjusted analyses, each 1 standard deviation increase in average annual NO2and SO2exposure was associated with a 3.6% (95% CI 2.9%-4.4%) and a 2.0% (95% CI 1.1%-3.0%) increased readmission risk within 30-days, respectively (Table). Associations between long-term air pollution exposure and increased readmissions persisted across performance categories.Conclusion:Long-term air pollution exposure was associated with increased 30-day readmissions after stroke at pollutant levels below national standards across hospital performance categories. Additional research is needed to determine whether improvements in air quality lead to reductions in poststroke hospital readmissions.

Published
2023
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39. Association of Marital/Partner Status with Hospital Readmission Among Young Adults With Acute Myocardial Infarction.

Author

Zhu C, Dreyer RP, Li F, Spatz ES, Caraballo C, Mahajan S, Raparelli V, Leifheit EC, Lu Y, Krumholz HM, Spertus JA, D'Onofrio G, Pilote L, and Lichtman JH

Abstract

Introduction: Despite evidence supporting the benefits of marriage on cardiovascular health, the impact of marital/partner status on the long-term readmission of young acute myocardial infarction (AMI) survivors is less clear. We aimed to examine the association between marital/partner status and 1-year all-cause readmission, and explore sex differences, among young AMI survivors., Methods: Data were from the VIRGO study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients), which enrolled young adults aged 18-55 years with AMI (2008-2012). The primary end point was all-cause readmission within 1 year of hospital discharge, obtained from medical record, patient interviews, and adjudicated by a physician panel. We performed Cox proportional hazards models with sequential adjustment for demographic, socioeconomic, clinical and psychosocial factors. Sex-marital/partner status interaction was also tested., Results: Of the 2,979 adults with AMI (2002 women [67.2%]; mean age 48 [interquartile range, 44-52] years), unpartnered individuals were more likely to experience all-cause readmissions compared with married/partnered individuals within the first year after hospital discharge (34.6% versus 27.2%, hazard ratio [HR]=1.31; 95% confidence interval [CI], 1.15-1.49). The association attenuated but remained significant after adjustment for demographic and socioeconomic factors (adjusted HR, 1.16; 95%CI, 1.01-1.34), and was not significant after further adjusting for clinical factors and psychosocial factors (adjusted HR, 1.10; 95%CI, 0.94-1.28). Sex-marital/partner status interaction was not significant (p=0.69). Sensitivity analysis using data with multiple imputation, and restricting outcomes to cardiac readmission yielded comparable results., Conclusions: In a cohort of young adults aged 18-55 years, unpartnered status was associated with 1.3-fold increased risk of all-cause readmission within 1 year of AMI discharge. Further adjustment for demographic, socioeconomic, clinical and psychosocial factors attenuated the association, suggesting that these factors may explain disparities in readmission between married/partnered versus unpartnered young adults. Whereas young women experienced more readmission compared to similar-aged men, the association between marital/partner status and 1-year readmission did not vary by sex.

Published
2023
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