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This article, titled "EP18.14: The fetal brain in RASopathies: Noonan genes revisited," explores the neurodevelopmental variability and brain imaging features of patients with RASopathies. The study focuses on describing the fetal brain and associated features of fetuses with confirmed RASopathies. The researchers conducted a retrospective study that included four patients with variants in RIT1, LZTR1, RRAS-2, and PTPN11. The findings highlight the range of features observed in fetal brain imaging and emphasize the importance of prenatal assessment for accurate diagnosis and counseling. [Extracted from the article]

This article, titled "Screening for fetal CNS anomalies: are the actual standards sensitive enough?", discusses the use of ultrasound in detecting central nervous system (CNS) anomalies in fetuses. The study aimed to assess the effectiveness of the current screening criteria and propose potential improvements. Two experts reviewed data from cases of CNS anomalies and found that while the extended axial views increased the detection rate, additional planes were still necessary for a comprehensive assessment and accurate diagnosis. The authors recommend further research into extended views and the addition of supplementary planes for fetal brain imaging. [Extracted from the article]

The collected clinical data included: maternal demographic parameters, spontaneous closure of the pVSD, need for intervention, chromosomal aberrations and postnatal outcome. To evaluate the incidence of chromosomal aberrations and the clinical outcomes following the prenatal diagnosis of isolated perimembranous ventricular septal defect (pVSD). Conclusions Prenatally isolated perimembranous VSD does not appear to be a significant risk factor for chromosomal abnormalities (either macroscopic or microscopic) and has a favourable clinical outcome mainly when classified as small to moderate in size. [Extracted from the article]