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9 results on '"Lei, Shiying"'

3. Diverse functions of Tribbles homolog 3 in cancers and its potential as a therapeutic target.

Author

Lei, Shiying, Sun, Jiajun, Xie, Yifang, Xiao, Xiaojuan, He, Xiaofeng, Lin, Sheng, Zhang, Huifang, Huang, Zineng, Wang, Haiqin, Wu, Xusheng, Peng, Hongling, and Liu, Jing

Subjects
*DRUG resistance, *PEPTIDE drugs, *CARCINOGENESIS, *CAUSES of death, *CANCER invasiveness
Abstract

Currently, cancer is the second leading cause of death worldwide, and potential targeted drugs and molecular pathways for cancer development and progression have been a hot research topic worldwide. In recent years, the importance of the kinase superfamily in diseases has been well demonstrated by studies on various molecular mechanisms of kinases and the successful application of their inhibitors in diseases. Pseudokinases are members of the kinase superfamily, which have been increasingly documented to play a crucial role in cancers year after year. As a member of pseudokinases, tribbles homolog 3 (TRIB3) also exerts diverse functions in different cancers through different interacting proteins and molecular pathways, especially in tumor immunity, stemness, drug resistance, metabolism, and autophagy. In addition, peptide drugs targeting TRIB3 have high specificity in preclinical studies, which shows great promise for TRIB3 application in diseases including cancers. In this review, we dissect diverse functions played by TRIB3 in different cancers, describing the underlying mechanisms in detail. Notably, inhibitors and agonists currently available for TRIB3 are discussed, indicating the potential for TRIB3 as a therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Continuous emulsification for LRZ emulsion explosives production.

Author

Zhang Dengtai, Lei Shiying, Li Mingrieng, Zhang Dengtai, Lei Shiying, and Li Mingrieng

Abstract

The selection of an appropriate continuous emulsifying method is discussed, and the formulation, ingredients and performances of LRZ emulsion explosives produced by the use of such a technology presented. A comprehensive evaluation and some suggestions for improvement are presented., The selection of an appropriate continuous emulsifying method is discussed, and the formulation, ingredients and performances of LRZ emulsion explosives produced by the use of such a technology presented. A comprehensive evaluation and some suggestions for improvement are presented.

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