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284 results on '"Lei, Chunyan"'

14. Therapeutic effects of tetrahedral framework nucleic acids and tFNAs‐miR22 on retinal ischemia/reperfusion injury.

Author

Xu, Xiaoxiao, Fu, Yanyan, Luo, Delun, Zhang, Lina, Huang, Xi, Chen, Yingying, Lei, Chunyan, Liu, Jinnan, Li, Shiqi, Yu, Zhouyuan, Lin, Yunfeng, and Zhang, Meixia

Subjects
NERVE tissue, VISION disorders, TREATMENT effectiveness, VISION, NUCLEIC acids
Abstract

Retinal ischemia/reperfusion injury (RI/R) is a common pathological process in ophthalmic diseases, which can cause severe visual impairment. The mechanisms underlying RI/R damage and repair are still unclear. Scholars are actively exploring effective intervention strategies to restore impaired visual function. With the development of nucleic acid nanomaterials, tetrahedral framework nucleic acids (tFNAs) have shown promising therapeutic potential in various fields such as stem cells, biosensors, and tumour treatment due to their excellent biological properties. Besides, miRNA‐22‐3p (miR‐22), as an important regulatory factor in neural tissue, has been proven to have positive effects in various neurodegenerative diseases. By stably constructing a complex of tetrahedral framework nucleic acids miR22 (tFNAs‐miR22), we observed that tFNAs‐miR22 had a positive effect on the repair of RI/R injury in retinal neural tissue. Previous studies have shown that tFNAs can effectively deliver miR‐22 into damaged retinal neurons, subsequently exerting neuroprotective effects. Interestingly, we found that there was a certain synergistic effect between tFNAs and miR‐22. tFNAs‐miR22 can selectively activated the ERK1/2 signalling pathway to reduce neuronal apoptosis, accelerate cell proliferation, and restore synaptic functional activity. In this study, we established a simple yet effective small molecule drug for RI/R treatment which may become a promising neuroprotectant for treating this type of vision impairment disease in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Intravitreal Injection of Amyloid β1–42 Activates the Complement System and Induces Retinal Inflammatory Responses and Malfunction in Mouse

Author

Lin, Ru, Fu, Xinyu, Lei, Chunyan, Yang, Mingzhu, Qiu, Yiguo, Lei, Bo, Crusio, Wim E., Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Bowes Rickman, Catherine, editor, Grimm, Christian, editor, Anderson, Robert E., editor, Ash, John D., editor, LaVail, Matthew M., editor, and Hollyfield, Joe G., editor

Published
2019
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23. Stroke in China: advances and challenges in epidemiology, prevention, and management

Author

Wu, Simiao, Wu, Bo, Liu, Ming, Chen, Zhengming, Wang, Wenzhi, Anderson, Craig S, Sandercock, Peter, Wang, Yongjun, Huang, Yining, Cui, Liying, Pu, Chuanqiang, Jia, Jianping, Zhang, Tong, Liu, Xinfeng, Zhang, Suming, Xie, Peng, Fan, Dongsheng, Ji, Xunming, Wong, Ka-Sing Lawrence, Wang, Longde, Wei, Chenchen, Wang, Yanan, Cheng, Yajun, Liu, Yunhai, Li, Xin, Dong, Qiang, Zeng, Jinsheng, Peng, Bin, Xu, Yun, Yang, Yi, Wang, Yilong, Zhao, Gang, Wang, Wei, Xu, Yuming, Yang, Qingwu, He, Zhiyi, Wang, Shaoshi, You, Chao, Gao, Ying, Zhou, Dong, He, Li, Li, Zixiao, Yang, Jie, Lei, Chunyan, Zhao, Yuhua, Liu, Junfeng, Zhang, Shuting, Tao, Wendan, Hao, Zilong, Wang, Deren, and Zhang, Shihong

Published
2019
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34. The Association Between Lipid Profile and Subfoveal Choroidal Thickness in Chinese Patients with Proliferative Diabetic Retinopathy Secondary to Type 2 Diabetes

Author

Lei,Chunyan, Ran,Qibo, Duan,Jianan, Zhang,Meixia, Lei,Chunyan, Ran,Qibo, Duan,Jianan, and Zhang,Meixia

Abstract

Chunyan Lei,1,2,* Qibo Ran,1,2,* Jianan Duan,1,2 Meixia Zhang1,2 1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meixia Zhang, Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Tel +86 18980602236, Email zhangmeixia@scu.edu.cnIntroduction: Extensive studies have studied the factors associated with subfoveal choroidal thickness (SFCT). However, studies of the association between lipid profile and SFCT in patients with proliferative diabetic retinopathy (PDR) in type 2 diabetes remain limited. Thus, we aimed to investigate the relationship between lipid profile and SFCT in patients with PDR.Materials and Methods: This was a retrospective cross-sectional study. The included participants were inpatients who underwent vitrectomy for PDR with type 2 diabetes and contralateral eyes of PDR patients meeting the criteria. Multivariate linear regression analysis was used to determine the independent association between lipid profile and SFCT.Results: A total of 131 participants with PDR were enrolled in the final analysis. The average age of the participants was 55.76 ± 9.88 years, and the average SFCT was 276.10 ± 92.92 μm. Multivariate linear regression model results showed that in the fully adjusted model, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) had a negative association with SFCT (β = − 16.51, 95% CI: − 29.57, − 3.46; P = 0.0148; β = − 42.65, 95% CI: − 82.60, − 2.70; P = 0.0390; β = − 17.89, 95% CI: − 33.24, − 2.54; P = 0.0245, respectively), while triglyceride was not significantly associated wit

Published
2023

37. A Simple Grading Scale for Predicting Symptomatic Intracranial Hemorrhage after Mechanical Thrombectomy.

Author

Lei, Chunyan, Li, Yongyu, Zhou, Xianlian, Lin, Shihan, Zhu, Xiaoyan, Yang, Xinglong, and Chen, Chun

Subjects
*INTRACRANIAL hemorrhage, *STROKE patients, *ISCHEMIC stroke, *RECEIVER operating characteristic curves, *THROMBECTOMY
Abstract

Introduction: Hemorrhagic transformation, especially symptomatic intracranial hemorrhage (sICH), is a common complication after mechanical embolectomy. This study explored a grading scale based on clinical and radiological parameters to predict sICH after mechanical embolectomy. Methods: Demographic and clinical data were retrospectively collected from patients with acute ischemic stroke treated with mechanical embolectomy at West China Hospital. Clinical and radiological factors associated with sICH were identified and used to develop the "STBA" grading scale. This score was then validated using data from an independent sample at the First Affiliated Hospital of Kunming Medical University. Results: We analyzed 268 patients with acute ischemic stroke who were treated with mechanical embolectomy at West China Hospital, of whom 30 (11.2%) had sICH. Patients were rated on an "STBA" score ranging from 0 to 6 based on whether systolic blood pressure was ≥145 mm Hg at admission (yes = 2 points; no = 0 points), time from acute ischemic stroke until groin puncture was ≥300 min (yes = 1; no = 0), blood glucose was ≥8.8 mmol/L (yes = 1; no = 0), and the Alberta Stroke Program Early Computed Tomography score at admission was 0–5 (2 points), 6–7 (1 point), or 8–10 (0 points). The STBA score showed good discrimination in the derivation sample (area under the receiver operating characteristic curve = 0.858) and in the validation sample (area = 0.814). Conclusions: The STBA score may be a reliable clinical scoring system to predict sICH in acute ischemic stroke patients treated with mechanical embolectomy. [ABSTRACT FROM AUTHOR]

Published
2023
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