95 results on '"Lehtimäki, M."'
Search Results
2. Stability of Ruddlesden–Popper-structured oxides in humid conditions
- Author
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Lehtimäki, M., Yamauchi, H., and Karppinen, M.
- Published
- 2013
- Full Text
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3. Isovalent and aliovalent substitution effects on redox chemistry of Sr 2MgMoO 6 − δ SOFC-anode material
- Author
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Vasala, S., Lehtimäki, M., Haw, S.C., Chen, J.M., Liu, R.S., Yamauchi, H., and Karppinen, M.
- Published
- 2010
- Full Text
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4. Uncovering the complex genetic architecture of human lipidome
- Author
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Mishra, B. H. Hamal, primary, Lehtimäki, M., additional, Mishra, P., additional, Val, C.D., additional, Zwir, I., additional, Cloninger, C.R., additional, Kähönen, M., additional, Raitakari, O.T., additional, Hilvo, M., additional, Laaksonen, R., additional, and Lehtimäki, T., additional
- Published
- 2021
- Full Text
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5. HLA B27: A prognostic factor in juvenile chronic arthritis
- Author
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Savolainen, H. A., Lehtimäki, M., Kautiainen, H., Aho, K., and Anttila, P.
- Published
- 1998
- Full Text
- View/download PDF
6. Mortality after surgery in Europe: a 7 day cohort study
- Author
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Pearse, R, Moreno, R, Bauer, P, Pelosi, P, Metnitz, P, Spies, C, Vallet, B, Vincent, J, Hoeft, A, Rhodes, A, Fagnoul, D, van Obbergh, L, Al Subaie, N, Arif, F, Cashman, J, Cecconi, M, Edsell, M, Fossati, N, Hammond, S, Hamilton, M, Lonsdale, D, Moran, C, Siegmueller, C, Velzeboer, F, Wong, P, Awlakpui, E, Scheidemann, M, Wittmann, M, Damster, S, Golder, K, Hewson, R, Januszewska, M, Leva, B, Ramos, V, Hoste, E, Huyghens, L, Jacobs, R, Van Mossevelde, V, Opdenacker, G, Poelaert, J, Spapen, H, Leleu, K, Rijckaert, D, De Decker, K, Foubert, L, De Neve, N, Biston, P, Piagnerelli, M, Collin, V, den Blauwen, N, Clauwaert, C, De Crop, L, Verbeke, A, Derumeaux, P, Gardin, C, Kindt, S, Louage, S, Verhamme, B, Druwé, P, Lahaye, I, Rosseel, F, Rutsaert, R, Vanlinthout, L, De Kock, M, Forget, P, Georges, P, Grosu, I, Kahn, D, Lois, F, Momeni, M, Pospiech, A, Yemnga, B, Jadoul, J, Malbrain, M, Bosinceanu, D, Collard, E, Jorens, P, Reyntiens, D, Smitz, C, Vercauteren, M, Goranović, T, Mazul Sunko, B, Toplice, K, Oremuš, K, Bešlić, G, Duzel, V, Hauptman, A, Peremin, S, Šribar, A, Župčić, M, Brod, S, Mirković, I, Šarić Bauer, Z, Belavić, M, Blažanin, B, Katušin, M, Brozović Krijan, A, Mišković, P, Šimić Korać, N, Topić, J, Žilić, A, Žuni, J, Acan, I, Adanić, M, Ivanov, N, Pavičić Šarić, J, Tomulić, K, Visković, N, Bošnjak, S, Haršanji Drenjančevic, I, Kristek, G, Kvolik, S, Markić, S, Stojanovic Rakipovic, A, Katarina Tot, O, Venzera Azenic, D, Kalagac Fabris, L, Bačak Kocman, I, Balenović, I, Bandić, D, Judith Deutsch, P, Divjak, L, Filipović, I, Gužvinec, Z, Krznarić, Z, Lončarić, Y, Magaš, J, Mitrović, M, Okić, M, Pavlek, M, Ramov, E, Rezek, K, Sekulić, A, Tomasevic, B, Mirić, M, Tomašević, A, Tomić Mahečić, T, Vrbanović, V, Bobinac, M, Božić, A, Debelic, D, Frkovic, V, Batinica, I, Baranović, S, Gavranović, Ž, Kikec, M, Maldini, B, Marić, S, Agnić, I, Delić, N, Dropulić, N, Kljaković Gašpić, T, Ilić, D, Ivančev, B, Karanović, N, Kuščević, D, Marović, Z, Milić, M, Nevešćanin, A, Petković, T, Smoje, M, Brozović, G, Jelisavac, M, Matolić, M, Oberhofer, D, Marija Pavičić, A, Šakić, K, Delija Bozovic, M, Kotorac Krecek, Z, Krobot, R, Andabaka, T, Bratanić, M, Dzepina, O, Kraljev, M, Šeric, J, Šimurina, T, Grujić, R, Nacevski Bulaja, B, Barižon, M, Danira, V, Dražen, B, Dušanka, K, Bašić Halužan, M, Joško, Ž, Katica, R, Labor, M, Grgurević Marinković, T, Mihovilčević, D, Marija, B, Srečko, M, Vranković, S, Kyprianou, T, Neophytou, K, Cerny, V, Cvachovec, K, Belikova, B, Drab, M, Hudacek, K, Krikava, I, Stourac, P, Zadrazilova, K, Bicek, V, Brabcová, M, Klozová, R, Vajter, J, Vymazal, T, Toft, P, Blichfeldt, L, Dilling Hansen, B, Moller, K, Sylvest Nielsen, J, Frederiksen, J, Dohn Andersen, J, Peter Kühne, J, Leivdal, S, Stendell, L, Simonsen, M, Konrad Zoltowski, M, Salman Ali, Z, Freundlich, M, Pilypaite, J, Groes Clausen, N, Thorup, L, Hansen, F, Bestle, M, Steen Hansen, C, Afshari, A, Bastholm Bille, A, Lefort, M, Secher, E, Liboriussen, L, Herodes, V, Härma, E, Marvet, K, Pool, K, Kallas, P, Mägi, T, Sütt, J, Vijar, K, Visk, E, Vinnal, M, Ellermaa, J, Liibusk, L, Tikkerberi, A, Falk, I, Mällo, E, Talving, J, Pettilä, V, Hovilehto, S, Kirsi, A, Mustola, S, Tiainen, P, Toivonen, J, Dabnell, S, Kaminski, T, Sysimetsa, A, Kaukonen, M, Silvasti, P, Vainio, K, Lund, V, Sjövall, S, Saarinen, K, Viitanen, M, Ahonen, T, Alaspää, A, Zittling, R, Saarinen, A, Moisander, A, Wagner, B, Laru Sompa, R, Elomaa, E, Lavonen, L, Nevantaus, J, Geier, K, Kavasmaa, T, Koorits, U, Kubjas, M, Lauritsalo, S, Ottelin, L, Palve, M, Pynnönen, J, Rääbis, I, Saarelainen, M, Heikkilä, T, Kontula, T, Lehtimäki, M, Liimatainen, J, Moilanen Oikarinen, M, Pakarinen, M, Palanne, R, Seppänen, H, Pulkkinen, A, Vääräniemi, H, Koskenkari, J, Sälkiö, S, Vakkala, M, Koskue, T, Loisa, P, Laitio, R, Hautamäki, R, Koivisto, S, Futier, E, Lefrant, J, Leon, A, Bonnet, F, Marret, E, Spielvogel, C, Papageorgiou, C, Szymkiewicz, O, Tounou Akue, F, Aubrun, F, Bonnet, A, Gazon, M, Guiraud, M, Laurent, V, Tachon, G, Demars, N, Dumenil, A, Mercier, F, Landais, A, Mentec, H, Bazin, M, Gonnu, S, Petit, A, Albaladejo, P, Almeras, L, Bataillard, A, Rossi Blancher, M, Yves Lefrant, J, Barthel, F, Hallel, D, Sbai, H, Khalifeh, P, Lidzborski, L, Jully, M, Platon, E, Pottecher, J, Baumgarten, R, Schultz, C, Elmiloudi, F, Lefebvre, J, Waton, K, Sprunck, A, Steib, A, Thibaud, A, Thuet, V, Kieffer, V, Dubois Vallaud, D, Jacob, L, Becanne, X, Cherfaoui, S, Gauzit, R, Godier, A, Lakhdari, M, Samma, C, Bigeon, J, Burtin, P, Halchini, C, Lacroix, M, Pinna, F, Barbes, A, Just, B, Mateu, P, Benayoun, L, Berger, P, Granier, N, Francois Perrigault, P, Libert, N, De Rudnicki, S, Merat, S, Bourdet, B, Ferré, F, Minville, V, Piriou, V, Rague, P, Wallet, F, Lebuffe, G, Desbordes, J, Robin, E, Ichai, C, Orban, J, Marx, G, Sander, M, Gottschalk, A, Piontek, A, Unterberg, M, Hilpert, J, Kees, M, Triltsch, A, Wiegand Löhnert, C, Glöckner, C, Hohn, A, Rose, E, Schröder, S, Wiese, O, Ramminger, A, Dresden, C, de Abreu, M, Heller, A, Marx, C, Neidel, J, Goldmann, A, von Heymann, C, Laetsch, B, Maahs, E, Scholz, L, Frenzel, D, Massarat, K, Lenhart, F, Reichle, F, Rudlof, K, Borchers, F, Buettner, C, Schmutzler, M, Burgard, G, Lucht, A, Wagner, J, Pilge, S, Schneider, G, Untergehrer, G, Bis, B, Krassler, J, Dittmann, J, Haberkorn, J, Eberitsch, J, Eberitsch, K, Nippraschk, T, Wepler, U, Engelen, W, Nau, C, Scholler, A, Schüttler, J, Wintzheimer, S, Bloos, F, Braune, A, Fergen, D, Ludewig, K, Paxian, M, Reinhart, K, Graf, N, Schwarzkopf, K, Berger, K, Habicher, M, Kasperiunaite, R, Savelsberg, S, Krep, H, Reindl, M, Weber, M, Bauer, W, Bingold, F, Christ, S, Friederich, P, Kaviani, R, Auer, P, Bonnländer, G, Drescher, J, Braun, R, Eichenauer, T, Kerner, J, Bierbaum, K, Brünner, H, Grond, S, Perez Platz, U, Andresen, B, Linstedt, U, Stegmann, N, Erkens, U, Kopcke, J, Meyer, A, Brestrich, H, Ernst, S, Merkel, S, Krieger, L, Luers, F, Weyland, A, Noeldge Schomburg, G, Menckie, T, Wasmund, C, Bredtmann, R, Erler, I, Raufhake, C, Haumann, C, Möllemann, A, Oehmichen, U, Sergejewa, O, Lehning, B, Czeslick, E, Geyer, M, Malcharek, M, Sablotzki, A, Stier, M, Feld, F, Rossaint, R, Simon, V, Armaganidis, A, Koulenti, D, Kotanidou, A, Nanas, S, Papastylianou, A, Psevdi, A, Stathopoulos, A, Voulas, A, Kanna, E, Koutsikou, A, Moustaka, A, Chovas, A, Komnos, A, Zafiridis, T, Franses, J, Lavrentieva, A, Koraki, E, Katsenos, C, Flora Kasianidou, M, Nasopoulou, P, Spyropoulou, E, Gousia, C, Katsanoulas, C, Lathyris, D, Kyriazopoulos, G, Sfyras, D, Tsirogianni, A, Kostopanagiotou, G, Lignos, M, Matsota, P, Christopoulos, C, Mouratidou, A, Vrettou, E, Boufidis, S, Moka, E, Arnaoutoglou, E, Koulouras, V, Nakos, G, Papathanakos, G, Anthopoulos, G, Choutas, G, Karapanos, D, Tzani, V, Gkiokas, G, Nastos, K, Nikolakopoulos, F, Dragoumanis, C, Nikitidis, N, Pneumatikos, I, Theodorou, V, Zacharouli, D, Kandi, S, Tasopoulos, K, Arvaniti, K, Matamis, D, Mplougoura, E, Petropoulou, P, Soumpasis, I, Amaniti, E, Giannakou Peftoulidou, M, Gkeka, E, Soultati, I, Kokinou, M, Papatheodorou, L, Stafylaraki, M, Giasnetsova, T, Gritsi Gerogianni, N, Kydona, C, Kiskira, O, Koulentis, I, Apsokardos, A, Dimitropoulos, K, Soldatou, O, Nathanail, C, Papazotos, A, Tsakas, P, Clouva Molyvdas, P, Kolotoura, A, Sartzi, M, Papanikolaou, S, Polakis, P, Karatzas, S, Kyparissi, A, Papavasilopoulou, T, Koukoubani, T, Mastora, E, Spyropoulou Pagdatoglou, K, Nyktari, V, Malliotakis, P, Papaioannou, A, Bekos, V, Maragkou, E, Spring, A, Evagelatos, S, Ioakeimidou, A, Noulas, N, Molnár, Z, Csüllög, E, Elekes, E, Molnár, T, Katona, Z, Kremer, I, Miko, A, Csomos, A, Galambos, Z, Szucs, A, Nyikos, G, Szekeres, G, Szabo, E, Kranitz, K, Simon, M, Szigeti, J, Gaál, E, Havas, A, Ille, A, Bráz, K, Nagy, G, Sigurdsson, G, Sigurbjörnsson, F, Kárason, S, Edda Sigurdardottir, E, Blöndal, Á, Gunnarsson, B, Westbrook, A, Broderick, A, Hafeez, P, Hanumanthaiah, D, Brohan, J, O'Chroinin, D, Bailey, K, Ramamoorthy, K, Doyle, Y, Freir, N, O'Rourke, J, Jonson, P, Saeed, S, Hayes, I, Loughrey, J, Frohlich, S, Mccauley, N, Ryan, D, Fitzpatrick, G, Kevin, L, Thomas, J, Warde, B, Woolhead, A, Duggan, M, Egan, C, Crowley, S, Lebese, S, Bergin, A, Page, R, Collins, D, Mckenny, M, Della Rocca, G, Grasso, S, Bresciani, A, Carmino, L, Ghelfi, S, Lorenzelli, L, Teresa Novelli, M, Pescarmona, C, Roasio, A, Gatta, A, Nastasi, M, Sanseverino, M, Tinti, C, Bianchin, A, Tormena, M, Franco, A, Marini, F, Di Mauro, P, Rapido, F, Tommasino, C, Bellotti, F, Boninsegna, D, Castellani, G, Sances, D, Spano, G, Tredici, S, Vezzoli, D, Fucecchio, I, Bacci, A, Coppini, R, Dell'Unto, S, Mori, E, Rosa Stanzani, M, Tosi, M, Collareta, M, Forfori, F, Franchi, M, Mancino, G, Battistella, M, Baricocchi, E, Bona, F, Debernardi, F, Giacoletto, G, Iacobellis, A, Massucco, P, Moselli, N, Muratore, A, Palomba, G, Sardo, E, De Simone, M, Suita, L, Zocca, E, Bucci, B, Della Corte, F, Piciucco, T, Viarengo, V, Bettelli, G, Cantarini, E, Giampieri, M, Tanfani, A, Recchia, E, Bignami, E, Bruno, G, Costagliola, R, Gandolfi, A, Greco, M, Lembo, R, Monti, G, Nicelli, E, Pasculli, N, Turi, S, Baroselli, A, Brazzoni, M, Buttazzoni, M, Buttera, S, Centonze, C, Serena, G, Spagnesi, L, Toretti, I, Vilardi, A, Zearo, E, Arpino, I, Baraldi, S, Guarnerio, C, Molene, V, Concetta Monea, M, Vaccarisi, E, Vicari, L, Albante, A, Aversano, M, Loiacono, C, Marandola, M, Fusari, M, Petrucci, N, Galla, A, Mascia, A, Primieri, P, Di Noto, A, Gratarola, A, Molin, A, Spagnolo, L, Spena, C, Calligaro, P, Marchiotto, S, Merlini, A, Pedrazzoli, E, Perina, G, Visentin, R, Garbagnati, A, Manetti, B, Snaier, C, Somaini, M, Farnia, A, Nani, R, Pierantonio, N, De Michele, M, Gazzanelli, S, Pugliese, F, Ruberto, F, Bergamini, E, Tassinati, T, Capuzzo, M, Cirillo, V, Tufano, R, Oggioni, R, Parrini, V, Brunori, E, Capone, M, Carbone, L, Corradetti, F, Elisei, D, Fiorentino, S, Francesconi, M, Gattari, D, Gorgoglione, M, Lacobone, E, Minnucci, F, Montironi, C, Riccioni, G, Tappata, G, Zompanti, V, Verdenelli, P, Cerutti, E, Marco Ranieri, V, Golubovska, I, Grigorjevs, S, Rikmane, M, Rozkalne, D, Stepanovs, J, Suba, O, Kazune, S, Miscuk, A, Nemme, J, Oss, P, Sipylaite, J, Macas, A, Ragaisis, V, Kontrimaviciute, E, Tomkute, G, Boerma, C, Fleur Kramer, I, Poeze, M, Maria, J, Pelzer, G, Winsser, L, Nijsten, M, Schoorl, M, Spanjersberg, R, Buhre, W, Dieleman, S, van Klei, W, Bouw, M, Pickkers, P, van der Marieke, A, Schreiner, F, Zandvliet, R, van den Berg, R, De Wit, E, Keijzer, C, Hollmann, M, Preckel, B, van Acker, G, Dennesen, P, Veld, B, Kuijpers Visser, A, Inan, T, Koopman van Gemert, A, Ponssen, H, Brouwer, T, Koopmans, M, van Bommel, J, van Duijn, D, van der Hoven, B, Ormskerk, P, Beck, O, Schiere, S, Reidinga, A, Venema, A, Hoogendoorn, M, Olthof, K, Flaatten, H, Jammer, I, Dokka, V, Arne Monsen, S, Marius Ytrebo, L, Noursadeghi, M, Shahzad, A, Dagfinn Boksasp, O, Roiss, C, Frank Strietzel, H, Gina, A, Berntsen, S, Haugland, H, Ove Vingsnes, S, Axelsson, P, Risom Olsen, T, Katre, S, Aakeroey, K, Mikstacki, A, Tamowicz, B, Boziłow, D, Goch, R, Grabowski, P, Kupisiak, J, Małłek, M, Szyca, R, Kostyrka, W, Choma, R, Jankowski, G, Kościelniak, W, Pietraszek, P, Szarowar, B, Matos, R, França, C, Pais Lacerda, A, Ormonde, L, Rosa, R, Pereira, I, Vitor, P, Completo Bento, H, Raquel Lopes, M, Carvalho, M, Faria, M, Cláudia de Sousa, A, de Freitas, P, Almeida, E, Mealha, R, Vicente, R, Monte, R, Rua, F, Barros, N, Esteves, F, Gouveia Pinheiro, C, Real, V, Miguel Oliveira, V, Fátima Oliveira, M, Martins, I, Pedro Saraiva, J, Pedro Assunção, J, Bártolo, A, Carvalho, A, Correia, C, Martins, S, Milheiro, R, Diaz, A, Imelda Gonçalves, M, Ribeiro, R, Estilita, J, Glória, C, de Almeida, J, Barros, F, Ramos, A, Camara, M, Richard Maul, E, Nobrega, J, Langner, A, Faria Maia, D, Afonso, O, Faria, F, Serra, S, Manuela Botelho, M, Ferreira, P, Mourão, L, Vintém Oliveira, A, Resende, M, Aleman, M, Fonseca, J, Isidoro, M, de Meneses, H, Pêgas, A, Pereira, J, Pereira, L, Ramos, B, Matos, F, Gonçalves Castro, M, Martins, A, Ramos, C, de Sousa, M, Bento, L, Botas, C, Lopes, V, Mendes, R, Grigoras, I, Blaj, M, Damian, M, Lupusoru, A, Ristescu, I, Codreanu, M, Diaconescu, C, Nistor, A, Stanescu Stelian, D, Streanga, L, Berneanu, M, Bordeianu, C, Florenta, C, Iacob, A, Nicoleta Lupu, M, Mocanu, I, Moraru, C, Meran, C, Nicolae, B, Sandu, M, Turcanu, R, Epure, F, Grigore, M, Hotaranu, C, Popescu, N, Baban, O, Baciu, M, Ciobanu, A, Ioan Denciu, C, Gurau, V, Maftei, I, Moldovan, I, Ungureanu, L, Bogdan, P, Corneci, D, Dinu, M, Madalina, D, Rely, M, Silvius, N, Tomescu, D, Gabriela, D, Adrian Dinescu, S, Calin, M, Ionescu, D, Margarit, S, Vasian, H, Albu, C, Balasa, C, Cadrigati, A, Dragulescu, D, Gavra, L, Hentia, C, Macarie, C, Manescu, M, Nediglea, I, Ocica, D, Ovidiu, B, Papurica, M, Plavat, C, Popa, C, Ramneantu, M, Sandesc, D, Sandici, Z, Sarandan, M, Belciu, I, Tincu, E, Ursu, I, Aignatoaie, M, Huzuneanu, M, Cocu, S, Hagau, N, Ciubotaru, R, Copotoiu, S, Copotoiu, R, Ioana, G, Kovacs, J, Leonard, A, Szederjesi, I, Genoveva, V, Mosnegutu, S, Surbatovic, M, Djordjevic, D, Djordjevic, B, Grujic, K, Jovanovic, D, Krstic Lecic, I, Obradovic, J, Zeba, S, Jevdjic, J, Miletic, M, Zunic, F, Bulasevic, A, Brko, R, Gazibegovic, N, Kendrisic, M, Vojinovic, R, Firment, J, Zahorec, R, Capková, J, Grochova, M, Trenkler, S, Griger, M, Bakosova, E, Kvasnica, M, Saniova, B, Sulaj, M, Zacharovska, A, Simkova, A, Číková, A, Gebhardtova, A, Hanuljaková, S, Koutun, J, Martonová, A, Žilinčárová, V, Galkova, K, Krbila, S, Sobona, V, Ocenasova, M, Novak Jankovic, V, Stecher, A, Stivan, F, Grynyuk, A, Damjanovska, M, Kostadinov, I, Knezevic, M, Malivojevic, M, Borovsak, Z, Kamenik, M, Mekiš, D, Osojnik, I, Kosec, L, Ostojič Kapš, S, Aleksic, D, Gerjevič, B, Kalan, K, Ursic, T, Aldecoa, C, Montejo González, J, Artigas, A, Garcia, A, Lisi, A, Perez, I, Perez, G, Poch, N, Vaquer, S, Balciscueta, G, Barrasa, H, Cabanes, S, Maynar, J, Poveda, Y, Quintano Rodero, A, Vallejo, A, Duque, P, Garcia Bunger, B, Adoracion Elvira, M, María Lajara, A, Palencia, M, Ramos, R, Saez Fernandez, A, Tirapu León, J, Iza López, J, Yoldi Murillo, F, Turumbay Ramirez, E, Unzué Rico, P, Patricia, M, Vizcaíno, M, Bernat Álvarez, M, Planas Real, K, Mas Serra, A, Aracil, N, Menendez Bodega, B, Fernández García, R, Álvarez García, M, Gordon, B, Gutiérrez Jodrá, A, De Santos López, A, Llavador Ros, J, Ayala Soto, R, Sepúlveda, I, Pascual Díez, E, Fernández Fernández, L, Soria Gulina, C, Pérez Arviza, L, Fernandez, L, Río Gómez, A, Alonso Martínez, C, Rodríguez Rodríguez, A, Lopez Soto, C, Garcia, C, Lorenzo, M, Pinilla, E, Rico, J, Ruperez, I, Alonso, E, Leira, F, Emilio Maseda, D, Royo, C, Villagran, J, Murillo Candi, G, Eduardo Esteva, G, Mansilla Folgado, R, Joan Fornaguera, N, Calonge Montse, P, Sape Prat, A, Sintes, D, Arteta Arteta, D, García Delgado, H, Fajardo López Cuervo, J, López, M, Ramírez, A, José Saldaña, F, Aliste, P, Hermira Anchuelo, A, García Campos, A, Catalán, M, García Gómez, M, Gonzalez Gonzalaez, O, López López, E, Real Navacerrada, I, de Quevedo, S, Gonzalez Serrano, M, Silvestre, F, Martinez Torrente, F, Arocas, B, Pastor Martinez, E, Soro, M, Maroto, F, Robledo Algarra, R, Silla Aleixandre, I, Argente, G, Lleó, A, Rubio, A, Vicente Sánchez, J, Enríquez Valcárcel, I, Balust, C, Balust, J, Borrat, X, Jose Carretero, M, Gracia, I, Matute, P, Mercadal, J, Pujol, R, Tena, B, Ubre, M, Dorda Albalad, D, Muñoz Alcaide, C, Caballero, J, Camps Cervantes, A, de Nadal Clanchet, M, Montferrer Estruch, N, Ballvé Ferrer, M, Lacasta Fornells, A, Terrer Galera, E, Garcia Martinez, I, Manrique Muñoz, S, Pelavski, A, Tormos Perez, P, Gonzalez Posada, M, de Prat, I, Rello, J, García Serrano, L, Naya Sieiro, J, Silva, L, Colomina Sole, M, Biarnes Suñé, A, Rochera Villach, I, Gómez Herreras, J, Poves, R, Martinez Rafael, B, Martinez Almeida, I, Fernandez Collates, A, Jose Bartolomé, 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N, Wessels, K, Wigmore, T, Meikle, A, Wilson, S, White, S, Bonnett, A, Rushton, A, Williams, C, Zuzan, O, Hall, A, Montgomery, J, Piggot, A, Read, R, Stocker, M, Tamm, T, Agarwal, B, Ward, S, Brown, L, Joy, M, Venkatesh, S, Hughes, T, Zsisku, L, Roy, A, Hooper, V, Mouland, J, Nightingale, J, Rose, S, Chiam, P, Chohan, H, Dickson, C, Gibb, S, Higham, C, Harvey, C, Janarthanan, C, Jones, L, Kapoor, A, Moll, M, Roberts, L, Saunders, D, Arnold, G, Gibbs, C, Jhurgursing, M, Pierro, D, Pritchard, F, Doyle, P, Templeton, M, Wilson, R, Zantua, K, Collyer, T, Featherstone, J, Worton, R, Bruce, J, Mcguigan, K, Price, G, Moreton, S, Pulletz, M, Anderson, H, Baxter, I, Beckingsale, A, Callaghan, M, Datta, A, Gollogly, J, Izod, C, Lobaz, S, Macfie, C, Patel, M, Payne, H, Singh, R, Timms, G, Mcleod, S, O'Brian, P, Horner, E, Joshi, V, Stuart Smith, K, Seale, T, Bolger, C, Collins, H, Ekins, E, Hawkins, L, Jonas, M, Linford, K, Wadams, B, Beach, M, Vizcaychipi, M, Jewsbury, W, Davies, S, Balaji, P, Kangaraj, M, Pissay, N, Smith, N, Gopalakrishnan, S, Mackinnon, J, Strandvik, G, Francis, R, Jennings, A, Keating, M, Kumar, S, Leese, S, Magee, C, Pilsbury, J, Ralph, J, Riddington, D, Sachdeva, R, Snelson, C, Vasanth, S, Wilde, J, Lavender, B, Lyons, R, Watters, M, Adams, T, Dyer, S, Tindall, L, Claxton, A, Netke, M, Akouds, E, Bates, D, Gallagher, H, Hatton, J, Holroyd, W, Mitra, A, Nurse, T, Reed, D, Desikan, S, Barber, R, Childs, S, O'Carroll Kuehn, B, Wyldbore, M, Al Abdaly, A, Amatya, S, Bhaskaran, S, Chandan, G, Chaudhry, S, Chikungwa, M, Earnshaw, G, Grewal, M, Haque, S, Hawkins, J, Javaid, A, Jackson, C, Kamel, M, Marla, R, Mculloch, D, Parker, T, Salib, Y, Saravanmuthu, R, Secker, C, Sockalingam, S, Taylor, A, Austine, P, Kanade, V, Paal, D, Sam Mok, M, Burtenshaw, A, Davis, L, Ellahee, P, Freeman, D, Pierson, R, Wollaston, J, Karmarkar, A, Ball, C, Calton, E, Maxwell, L, Walker, R, Bland, M, Bullock, L, Harrison Briggs, D, Hodge, P, Krige, A, Dempsey, G, Hammell, C, Loveridge, R, Parker, R, Snell, J, Wright, C, Baker, A, Barr, K, Belcher, A, Bonnington, S, Bougeard, A, Fitzgerald, E, Ford, R, Gillard, C, Griffiths, L, Greenberg, L, Huber, J, Mathieu, S, Richardson, N, Tompsett, L, White, N, Patel, S, Corner, V, Thomas, R, Trodd, D, Wilson, J, Copley, E, Flutter, L, Hulme, J, Susarla, J, Thwaites, A, Jayasundera, S, Mcafee, S, Chantler, J, Mckechnie, S, Neely, J, Mouton, R, Scarth, E, Soar, J, Buss, J, Currie, V, Sange, M, Kuttler, A, Power, F, Alexander, D, Dunne, K, Shinner, G, Black, E, Haldane, G, Kerr, J, Saran, T, Ward, G, Jefferies, F, Alexander, P, Royle, A, Nahla, F, Bowles, T, Gregory, M, Ahern, R, Cartlidge, D, Craker, L, Thompson, C, Bidd, H, Giles, J, Manser, A, Parry, G, Chan, P, Das, D, Fahmy, N, Higgins, D, Khader, A, Stone, A, Leonardi, S, Rose, O, Bright, E, Ercole, A, Amir Rafi, M, Ramasamy, R, Sheshgiri, B, Merrill, C, Page, V, Walker, E, Harris, S, Hughes, S, Morrison, A, Razouk, K, Ayman, M, Jakeman, A, Mowatt, C, Paananen, S, Translational Physiology, Other departments, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, Anesthesiology, APH - Amsterdam Public Health, Pearse Rupert, Moreno Rui P., Bauer Peter, Pelosi Paolo, Metnitz Philipp, Spies Claudia, Vallet Benoit, Vincent Jean-Loui, Hoeft Andrea, Rhodes Andrew, Fagnoul David, van Obbergh Luc, Al-Subaie Nawaf, Arif Fuhazia, Cashman Jeremy, Cecconi Maurizio, Edsell Mark, Fossati Nicoletta, Hammond Sarah Jane, Hamilton Mark, Lonsdale Dagan, Moran Carl, Siegmueller Claa, Velzeboer Freya, Wong Patrick, Awlakpui Eli, Scheidemann Mona, Wittmann Maria, Damster Sandrine, Golder Kim, Hewson Russell, Januszewska Marta, Leva Brigitte, Ramos Vasco, Hoste Eric, Huyghens Luc, Jacobs Rita, Van Mossevelde Veerle, Opdenacker Godelieve, Poelaert Jan, Spapen Herbert, Leleu Kri, Rijckaert Dirk, De Decker Koen, Foubert Luc, De Neve Nikolaa, Biston Patrick, Piagnerelli Michael, Collin Vincent, den Blauwen Nadia, Clauwaert Charlotte, De Crop Luc, Verbeke An, Derumeaux Pieter, Gardin Christophe, Kindt Sebastiaan, Louage Sofie, Verhamme Bruno, Druwé Patrick, Lahaye Ingrid, Rosseel Franci, Rutsaert Robert, Vanlinthout Luc, De Kock Marc, Forget Patrice, Georges Pascal, Grosu Irina, Kahn David, Lois Fernande, Momeni Mona, Pospiech Audrey, Yemnga Bernadette, Jadoul Jean-Luc, Malbrain Manu, Bosinceanu Dana, Collard Edith, Jorens Philippe, Reyntiens Dirk, Smitz Carine, Vercauteren Marcel, Goranović Tatjana, Mazul-Sunko Branka, Toplice Krapinske, Oremuš Krešimir, Bešlić Gabrijela, Duzel Viktor, Hauptman Ada, Peremin Sanja, Šribar Andrej, Župčić Miroslav, Brod Slavonski, Mirković Ivan, Šarić Bauer Zlata, Belavić Matija, Blažanin Božidar, Katušin Mirjana Lončarić, Brozović Krijan Antonija, Mišković Petar, Šimić-Korać Nataša, Topić Jasna, Žilić Antonio, Žuni Josip, Acan Ivana, Adanić Mirta, Ivanov Nikola, Pavičić Šarić Jadranka, Tomulić Katarina, Visković Nataša, Bošnjak Silvana, Haršanji Drenjančevic Ivana, Kristek Gordana, Kvolik Slavica, Markić Stela, Stojanovic Rakipovic Andreja, Katarina Tot Ozana, Venzera-Azenic Darija, Kalagac Fabris Lada, Bačak-Kocman Iva, Balenović Igor, Bandić Daniela, Judith Deutsch Patricia Adrianne, Divjak Loredana, Filipović Ina Grčić, Gužvinec Zvonka, Krznarić Zrinka, Lončarić Yvonne, Magaš Jelena Vadlja, Mitrović Marek, Okić Marija, Pavlek Mario, Ramov Elza, Rezek Karolina, Sekulić Ante, Tomasevic Bori, Mirić Mirjana, Tomašević Anita, Tomić Mahečić Tina, Vrbanović Vilena, Bobinac Mirna, Božić Alfred, Debelic Danijela, Frkovic Vedran, Batinica Inga Mladić, Baranović Senka, Gavranović Željka, Kikec Mirna, Maldini Branka, Marić Stela, Agnić Ivan, Delić Nikola, Dropulić Nataša, Kljaković Gašpić Toni, Ilić Darko, Ivančev Božena, Karanović Nenad, Kuščević Dorjan, Marović Zlatko, Milić Matija, Nevešćanin Ana, Petković Tatjana, Smoje Mario, Brozović Gordana, Jelisavac Milana, Matolić Martina, Oberhofer Dagmar, Marija Pavičić Ana, Šakić Kata, Delija Bozovic Margarita, Kotorac Krecek Zvjezdana, Krobot Renata, Andabaka Tatjana, Bratanić Mislav, Dzepina Orjana, Kraljev Martina, Šeric Julija, Šimurina Tatjana, Grujić Rosa, Nacevski-Bulaja Biljana, Barižon Mirna, Danira Vrančić, Dražen Bulaja, Dušanka Kimer, Bašić Halužan Marijana, Joško Žaja, Katica Roca, Labor Magda, Grgurević Marinković Tea, Mihovilčević Danči, Marija Bego, Srečko Marinković, Vranković Srdan, Kyprianou Theodoro, Neophytou Kyriako, Cerny Vladimir, Cvachovec Karel, Belikova Barbora, Drab Michal, Hudacek Kamil, Krikava Ivo, Stourac Petr, Zadrazilova Katarina, Bicek Vladimír, Brabcová Milena, Klozová Radka, Vajter Jaromír, Vymazal Tomáš, Toft Palle, Blichfeldt Louise, Dilling Hansen Bo, Moller Kirsten, Sylvest Nielsen Jeppe, Frederiksen Joachim, Dohn Andersen Johnny, Peter Kühne Jan, Leivdal Siv, Stendell Line, Simonsen Martin, Konrad Zoltowski Marcin, Salman Ali Zahida, Freundlich Morten, Pilypaite Jurgita, Groes Clausen Nicola, Thorup Line, Hansen Frank, Bestle Morten, Steen Hansen Christian, Afshari Arash, Bastholm Bille Ander, Lefort Michele, Secher Erik L., Liboriussen Lisbeth, Herodes Veiko, Härma Eve, Marvet Kadri, Pool Kristiina, Kallas Pille, Mägi Triinu-Kreete, Sütt Jaan, Vijar Kerli, Visk Evelin, Vinnal Mare, Ellermaa Jaanu, Liibusk Liia, Tikkerberi Artur, Falk Ilme, Mällo Esta, Talving Jaak, Pettilä Ville, Hovilehto Seppo, Kirsi Anne, Mustola Seppo, Tiainen Pekka, Toivonen Juhani, Dabnell Sandra, Kaminski Tadeusz, Sysimetsa Anu, Kaukonen Maija, Silvasti Päivi, Vainio Kaisa, Lund Vesa, Sjövall Sari, Saarinen Kari, Viitanen Matti, Ahonen Tommi, Alaspää Ari, Zittling Ritva, Saarinen Aarne, Moisander Annette, Wagner Bodo, Laru-Sompa Raili, Elomaa Esa, Lavonen Leena, Nevantaus Juha, Geier Klau, Kavasmaa Tomi, Koorits Ursula, Kubjas Mare, Lauritsalo Seppo, Ottelin Lauri, Palve Markki, Pynnönen Jari, Rääbis Inga, Saarelainen Minna, Heikkilä Tapani, Kontula Timo, Lehtimäki Markku, Liimatainen Jari, Moilanen-Oikarinen Mari, Pakarinen Marika, Palanne Riku, Seppänen Hanna, Pulkkinen Anni, Vääräniemi Heikki, Koskenkari Juha, Sälkiö Sinikka, Vakkala Merja, Koskue Talvikki, Loisa Pekka, Laitio Ruut, Hautamäki Raku, Koivisto Simo-Pekka, Futier Emmanuel, Lefrant Jean-Yve, Leon Alain, Bonnet Franci, Marret Emmanuel, Spielvogel Catherine, Papageorgiou Chryssa, Szymkiewicz Olga, Tounou-Akue Felix, Aubrun Frederic, Bonnet Aurélie, Gazon Mathieu, Guiraud Michel, Laurent Virginie, Tachon Guillaume, Demars Nadège, Dumenil Anne-Sylvie, Mercier Frederic, Landais Alain, Mentec Herve, Bazin Marie, Gonnu Sophie, Petit Antoine, Albaladejo Pierre, Almeras Luc, Bataillard Amélie, Rossi-Blancher Marine, Yves Lefrant Jean, Barthel Florian, Hallel Dan, Sbai Hicham, Khalifeh Pamela, Lidzborski Lionel, Jully Marion, Platon Ecaterina, Pottecher Julien, Baumgarten Romain, Schultz Christel, Elmiloudi Fayçal, Lefebvre Julie, Waton Karen, Sprunck Adrien, Steib Annick, Thibaud Adrien, Thuet Vincent, Kieffer Vianney, Dubois-Vallaud Delphine, Jacob Laurent, Becanne Xavier, Cherfaoui Salim, Gauzit Remy, Godier Anne, Lakhdari Mourad, Samma Charle, Bigeon Jean-Yve, Burtin Philippe, Halchini Constantin, Lacroix Magali, Pinna Frederic, Barbes Aurélie, Just Bernard, Mateu Philippe, Benayoun Laurent, Berger Philippe, Granier Nathalie, Francois Perrigault Pierre, Libert Nicola, De Rudnicki Stephan, Merat Stéphane, Bourdet Benoit, Ferré Fabrice, Minville Vincent, Piriou Vincent, Rague Philippe, Wallet Florent, Lebuffe Gille, Desbordes Jacque, Robin Emmanuel, Ichai Carole, Orban Jean-Christophe, Marx Gernot, Sander Michael, Gottschalk André, Piontek André, Unterberg Matthia, Hilpert Justu, Kees Martin, Triltsch Andrea, Wiegand-Löhnert Carola, Glöckner Christiane, Hohn Andrea, Rose Elmar, Schröder Stefan, Wiese Oliver, Ramminger Axel, Dresden Caru, de Abreu Marcelo Gama, Heller Axel, Marx Christine, Neidel Julia, Goldmann Anton, von Heymann Christian, Laetsch Beatrix, Maahs Esther, Scholz Lar, Frenzel Dirk, Massarat Kyro, Lenhart Franz-Peter, Reichle Florian, Rudlof Kristina, Borchers Friedrich, Buettner Christoph, Schmutzler Martin, Burgard Gerald, Lucht Alexander, Wagner Jan, Pilge Stefanie, Schneider Gerhard, Untergehrer Gisela, Bis Beata, Krassler Jen, Dittmann Jan, Haberkorn Jörg, Eberitsch Jürgen, Eberitsch Karola, Nippraschk Thoma, Wepler Ulrich, Engelen Wolf-Christian, Nau Carla, Scholler Axel, Schüttler Jürgen, Wintzheimer Simone, Bloos Frank, Braune Anke, Fergen Daniela, Ludewig Katrin, Paxian Marku, Reinhart Konrad, Graf Nikolau, Schwarzkopf Konrad, Berger Katharina, Habicher Marit, Kasperiunaite Ruta, Savelsberg Sabine, Krep Henning, Reindl Michael, Weber Matthia, Bauer Wolfgang, Bingold Florian, Christ Saskia, Friederich Patrick, Kaviani Reza, Auer Patrick, Bonnländer Georg, Drescher Jürgen, Braun Roland, Eichenauer Tim, Kerner John, Bierbaum Kathrin, Brünner Horst, Grond Stefan, Perez-Platz Ursula, Andresen Bent, Linstedt Ulf, Stegmann Nil, Erkens Uwe, Kopcke Jen, Meyer Andrea, Brestrich Hartmut, Ernst Sandra, Merkel Stella, Krieger Lena, Luers Frank, Weyland Andrea, Noeldge-Schomburg Gabriele, Menckie Thoma, Wasmund Christina, Bredtmann Ralph-Dieter, Erler Ine, Raufhake Carsten, Haumann Christine, Möllemann Angela, Oehmichen Uwe, Sergejewa Olga, Lehning Brigitte, Czeslick Elke, Geyer Michaela, Malcharek Michael, Sablotzki Armin, Stier Marina, Feld Florian, Rossaint Rolf, Simon Verena, Armaganidis Apostolo, Koulenti Despoina, Kotanidou Anastasia, Nanas Serafim, Papastylianou Androula, Psevdi Aikaterini, Stathopoulos Anastasio, Voulas Asklepieion, Kanna Efthymia, Koutsikou Anastasia, Moustaka Alexandra, Chovas Achillea, Komnos Apostolo, Zafiridis Tilemacho, Franses Josef, Lavrentieva Athena, Koraki Eleni, Katsenos Chrysostomo, Flora Kasianidou Maria, Nasopoulou Pantelia, Spyropoulou Eleni, Gousia Chrysoula, Katsanoulas Constantine, Lathyris Dimitrio, Kyriazopoulos George, Sfyras Dimitrio, Tsirogianni Athanasia, Kostopanagiotou Georgia, Lignos Mihail, Matsota Paraskevi, Christopoulos Christo, Mouratidou Alexandra, Vrettou Efstratia, Boufidis Spyro, Moka Eleni, Arnaoutoglou Eleni, Koulouras Vasileio, Nakos George, Papathanakos Georgio, Anthopoulos Georgio, Choutas Georgio, Karapanos Dimitrio, Tzani Vaso, Gkiokas Georgio, Nastos Konstantino, Nikolakopoulos Fotio, Dragoumanis Christo, Nikitidis Niko, Pneumatikos Ioanni, Theodorou Vassiliki, Zacharouli Danai, Kandi Stella, Tasopoulos Konstantino, Arvaniti Kostoula, Matamis Dimitrio, Mplougoura Eva, Petropoulou Polixeni, Soumpasis Ioanni, Amaniti Ekaterini, Giannakou-Peftoulidou Maria, Gkeka Eleni, Soultati Ioanna, Kokinou Maria, Papatheodorou Lambrini, Stafylaraki Maria, Giasnetsova Tatiana, Gritsi-Gerogianni Nikoleta, Kydona Christina, Kiskira Olga, Koulentis Ioanni, Apsokardos Alexandro, Dimitropoulos Konstantino, Soldatou Ourania, Nathanail Christodoulo, Papazotos Alexio, Tsakas Pirro, Clouva-Molyvdas Phyllis-Maria, Kolotoura Athina, Sartzi Monika, Papanikolaou Spiro, Polakis Pavlo, Karatzas Styliano, Kyparissi Aikaterini, Papavasilopoulou Theonymfi, Koukoubani Triantafillia, Mastora Evangelia, Spyropoulou-Pagdatoglou Kyriaki, Nyktari Vasileia, Malliotakis Polychroni, Papaioannou Alexandra, Bekos Vasileio, Maragkou Elisavet, Spring Anna, Evagelatos Stavro, Ioakeimidou Aikaterini, Noulas Niko, Molnár Zsolt, Csüllög Emese, Elekes Eniko, Molnár Tamá, Katona Zsuzsana, Kremer Ildiko, Miko Angela, Csomos Ako, Galambos Zsuzsanna, Szucs Ako, Nyikos Gyorgy, Szekeres Gabor, Szabo Ervin, Kranitz Katalin, Simon Melinda, Szigeti Jano, Gaál Emánuel, Havas Attila, Ille Alexandru, Bráz Krisztina, Nagy Geza, Sigurdsson Gisli, Sigurbjörnsson Fridrik T., Sigurdsson Gisli H., Kárason Sigurbergur, Edda Sigurdardottir Elin, Blöndal Ásbjörn, Gunnarsson Björn, Westbrook Andrew, Broderick Alan, Hafeez Parvaiz, Hanumanthaiah Deepak, Brohan Janette, O'Chroinin Donal, Bailey Kevin, Ramamoorthy Karthik, Doyle Yvonne, Freir Noelle, O'Rourke Jame, Jonson Philip, Saeed Sabir, Hayes Ivan, Loughrey John, Frohlich Stephen, Mccauley Nuala, Ryan Donal, Fitzpatrick Gerry, Kevin Leo, Thomas Jubil, Warde Barry, Woolhead Alan, Duggan Michelle, Egan Cara, Crowley Seamu, Lebese Soloman, Bergin Anne, Page Rory, Collins Daniel, Mckenny Michael, Della Rocca Giorgio, Grasso Salvatore, Bresciani Anna, Carmino Livio, Ghelfi Silvia, Lorenzelli Laura, Teresa Novelli Maria, Pescarmona Chiara, Roasio Agostino, Gatta Alessandro, Nastasi Mauro, Sanseverino Manlio, Tinti Carla, Bianchin Andrea, Tormena Maria, Franco Antonio, Marini Federica, Di Mauro Piero, Rapido Francesca, Tommasino Concezione, Bellotti Ferdinando, Boninsegna Daniele, Castellani Gianluca, Sances Daniele, Spano Gianluca, Tredici Stefano, Vezzoli Dario, Fucecchio Igneo, Bacci Alessandro, Coppini Roberta, Dell'Unto Sandro, Mori Emanuele, Rosa Stanzani Maria, Tosi Monica, Collareta Michele, Forfori Francesco, Franchi Matteo, Mancino Giuseppe, Battistella Massimo, Baricocchi Elisa, Bona Francesco, Debernardi Felicino, Giacoletto Gianmarco, Iacobellis Antonio, Massucco Paolo, Moselli Nora, Muratore Andrea, Palomba Graziella, Sardo Elena, De Simone Michele, Suita Luisa, Zocca Edoardo, Bucci Barbara, Della Corte Francesco, Piciucco Tiziana, Viarengo Valeria, Bettelli Gabriella, Cantarini Eugenia, Giampieri Marina, Tanfani Alessandra, Recchia Eugenio, Bignami Elena, Bruno Giovanna, Costagliola Roberto, Gandolfi Azzurra, Greco Massimiliano, Lembo Rosalba, Monti Giacomo, Nicelli Elisa, Pasculli Nicola, Turi Stefano, Baroselli Antonio, Brazzoni Marcella, Buttazzoni Mattia, Buttera Stefania, Centonze Carlo, Serena Giovanni, Spagnesi Lorenzo, Toretti Ilaria, Vilardi Anna, Zearo Ester, Arpino Ine, Baraldi Sara, Guarnerio Chiara, Molene Vincenzo, Concetta Monea Maria, Vaccarisi Enrico, Vicari Luigi, Albante Alida, Aversano Marco, Loiacono Cinzia, Marandola Maurizio, Fusari Maurizio, Petrucci Nicola, Galla Amerigo, Mascia Antonio, Primieri Paolo, Di Noto Anna, Gratarola Angelo, Molin Alessandro, Spagnolo Luigi, Spena Claudio, Calligaro Plinio, Marchiotto Simonetta, Merlini Alberto, Pedrazzoli Eleonora, Perina Giulia, Visentin Renea, Fumagalli Roberto, Garbagnati Andrea, Manetti Bruna, Snaier Chiara, Somaini Marta, Farnia Antonio, Nani Roberto, Pierantonio Novello, De Michele Michele, Gazzanelli Sergio, Pugliese Francesco, Ruberto Franco, Bergamini Elena, Tassinati Tania, Capuzzo Maurizia, Cirillo Vera, Tufano Rosalba, Oggioni Roberto, Parrini Vieri, Brunori Emanuela, Capone Micaela, Carbone Luigi, Corradetti Francesco, Elisei Daniele, Fiorentino Stefano, Francesconi Maurizio, Gattari Diego, Gorgoglione Maria, Lacobone Emanuele, Minnucci Francesco, Montironi Claudio, Riccioni Gianrenato, Tappata Giuseppe, Zompanti Valeria, Verdenelli Paola, Cerutti Elisabetta, Ranieri Vito Marco, Golubovska Iveta, Grigorjevs Sergej, Rikmane Maija, Rozkalne Daina, Stepanovs Jevgenij, Suba Oleg, Kazune Sigita, Miscuk Aleksej, Nemme Jani, Oss Peteri, Sipylaite Jurate, Macas Andriu, Ragaisis Vytauta, Kontrimaviciute Egle, Tomkute Gabija, Boerma Christiaan, Fleur Kramer Irene, Poeze Martijn, Maria John, Pelzer Gerardu, Winsser Lex, Nijsten Maarten, Schoorl Michiel, Spanjersberg Rob, Buhre Wolfgang, Dieleman Stefan, van Klei Wilton, Bouw Martijn, Pickkers Peter, van der Marieke A., Schreiner Frodo, Zandvliet Ria, van den Berg Roy, De Wit Esther, Keijzer Christaan, Hollmann Marku, Preckel Benedikt, van Acker Gij, Dennesen Paul, Veld Ba, Kuijpers-Visser Agne, Inan T., Koopman-van Gemert A., Ponssen Huibert, Brouwer Tammo, Koopmans Matty, van Bommel Jasper, van Duijn Ditty, van der Hoven Ben, Ormskerk Patricia, Beck Oliver, Schiere Sjouke, Reidinga Auke, Venema Allart, Hoogendoorn Marga, Olthof Kee, Flaatten Han, Jammer Ib, Dokka Vegard, Arne Monsen Svein, Marius Ytrebo Lar, Noursadeghi Mostafa, Shahzad Ahmed, Dagfinn Boksasp Ola, Roiss Christoph, Frank Strietzel Han, Gina Anne, Berntsen Schie, Haugland Helge, Ove Vingsnes Svein, Axelsson Patric, Risom Olsen Thoma, Katre Sanjay, Aakeroey Kristin, Mikstacki Adam, Tamowicz Barbara, Boziłow Dominika, Goch Robert, Grabowski Piotr, Kupisiak Jacek, Małłek Małgorzata, Szyca Robert, Kostyrka Włodzimierz, Choma Robert, Jankowski Grzegorz, Kościelniak Władysław, Pietraszek Paweł, Szarowar Bartosz, Matos Ricardo, França Carlo, Pais Lacerda António, Ormonde Lucindo, Rosa Rosário, Pereira Inê, Vitor Paula, Completo Bento Henrique, Raquel Lopes Maria, Carvalho Marque, Faria Manuela, Cláudia de Sousa Ana, de Freitas Pereira, Almeida Eduardo, Mealha Rui, Vicente Rachel, Monte Raquel, Rua Fernando, Barros Nelson, Esteves Francisco, Gouveia Pinheiro Célia Maria, Real Vila, Miguel Oliveira Vítor, Fátima Oliveira Maria, Martins Isabel, Pedro Saraiva José, Pedro Assunção José, Bártolo Anabela, Carvalho Anabela, Correia Carlo, Martins Salomé, Milheiro Ruth, Diaz Alejandro, Imelda Gonçalves Maria, Ribeiro Rosa, Estilita Joana, Glória Carlo, de Almeida José, Barros Filipa, Ramos Armindo, Camara Margarida, Richard Maul Edward, Nobrega Julio, Langner Anuscka, Faria Maia Dionísio, Afonso Ofélia, Faria Filomena, Serra Sofia, Manuela Botelho Maria, Ferreira Pedro, Mourão Luí, Vintém Oliveira Ana, Resende Margarida, Aleman Miguel, Fonseca Jorge, Isidoro Marta, de Meneses Helena, Pêgas António, Pereira José, Pereira Lui, Ramos Bárbara, Matos Francisco, Gonçalves Castro Maria de Lurde, Martins Ana, Ramos Cristina, de Sousa Manuel, Bento Luí, Botas Conceição, Lopes Vitor, Mendes Rosa, Grigoras Ioana, Blaj Mihaela, Damian Mihaela, Lupusoru Andreea, Ristescu Irina, Codreanu Monica, Diaconescu Ciresica, Nistor Alina, Stanescu Stelian Dorin, Streanga Livia, Berneanu Maria, Bordeianu Cristina, Florenta Calarasu, Iacob Alina, Nicoleta Lupu Mary, Mocanu Iulian, Moraru Coca, Meran Carleta, Nicolae Bacalbasa, Sandu Madalina, Turcanu Roxana, Epure Florina, Grigore Monica, Hotaranu Cristina, Popescu Nicoleta, Baban Oleg, Baciu Manuela, Ciobanu Aurica, Ioan Denciu Catalin, Gurau Vitalie, Maftei Ion, Moldovan Ion, Ungureanu Liviu, Bogdan Prodan, Corneci Dan, Dinu Melania, Madalina Dutu, Rely Manolescu, Silvius Negoita, Tomescu Dana, Gabriela Droc, Adrian Dinescu Stelian, Calin Mitre, Ionescu Daniela, Margarit Simona, Vasian Horatiu, Albu Corina, Balasa Carmen, Cadrigati Alina, Dragulescu Dorian, Gavra Loredana, Hentia Ciprian, Macarie Claudiu, Manescu Mihaela, Nediglea Ioan, Ocica Dana, Ovidiu Bedreag, Papurica Mariu, Plavat Cosmin, Popa Claudia, Ramneantu Mihaela, Sandesc Dorel, Sandici Zoran, Sarandan Mihaela, Belciu Ioana, Tincu Eugen, Ursu Irina, Aignatoaie Mariana, Huzuneanu Mariana, Cocu Simona, Hagau Natalia, Ciubotaru Roxana, Copotoiu Sanda-Maria, Copotoiu Ruxandra, Ioana Ghitescu, Kovacs Judit, Leonard Azamfirei, Szederjesi Iano, Genoveva Vanvu, Mosnegutu Simona, Surbatovic Maja, Djordjevic Dragan, Djordjevic Biljana, Grujic Krasimirka, Jovanovic Dusko, Krstic-Lecic Ivana, Obradovic Jovana, Zeba Snjezana, Jevdjic Jasna, Miletic Milo, Zunic Filip, Bulasevic Aleksandra, Brko Radoslava, Gazibegovic Narcisa, Kendrisic Mirjana, Vojinovic Radisa, Firment Jozef, Zahorec Roman, Capková Judita, Grochova Monika, Trenkler Stefan, Griger Martin, Bakosova Erika, Kvasnica Martin, Saniova Beata, Sulaj Miroslav, Zacharovska Andrea, Simkova Alexandra, Číková Andrea, Gebhardtova Andrea, Hanuljaková Slávka, Koutun Juraj, Martonová Andrea, Žilinčárová Veronika, Galkova Katarína, Krbila Stefan, Sobona Viliam, Ocenasova Marieta, Novak-Jankovic Vesna, Stecher Adela, Stivan Feri, Grynyuk Andriy, Damjanovska Marija, Kostadinov Ivan, Knezevic Mile, Malivojevic Marko, Borovsak Zvonko, Kamenik Mirt, Mekiš Dušan, Osojnik Irena, Kosec Lučka, Ostojič Kapš Silva, Aleksic Dragoslav, Gerjevič Božena, Kalan Katja, Ursic Tomaz, Aldecoa Cesar, Montejo González Juan, Artigas Anna, Garcia Andre, Lisi Alberto, Perez Isabel, Perez Gisela, Poch Nuria, Vaquer Sergi, Balciscueta Goiatz, Barrasa Helena, Cabanes Sara, Maynar Javier, Poveda Yolanda, Quintano Rodero Amaia, Vallejo Ana, Duque Patrícia, Garcia-Bunger Beatriz, Adoracion Elvira Maria, María Lajara Ana, Palencia María, Ramos Rafael, Saez Fernandez Ana, Tirapu León Juan, Iza López Jaione, Yoldi Murillo Francisco, Turumbay Ramirez Eva, Unzué Rico Patricia, Patricia Marta, Vizcaíno Martín, Bernat Álvarez Maria José, Planas Real Kenneth, Mas Serra Arantxa, Aracil Norma, Menendez Bodega Begoña, Fernández García Raquel, Álvarez García Marivi, Gordon Borja de la Quintana, Gutiérrez Jodrá Alicia, De Santos López Angela, Llavador Ros Juan José, Ayala Soto Rocío, Sepúlveda Isabel, Pascual Díez Esperanza, Fernández Fernández Luisa, Soria Gulina Carlo, Pérez Arviza Laura, Fernandez Lorena Mouriz, Río Gómez Antía, Alonso Martínez Concepción, Rodríguez Rodríguez Ana Belén, Lopez Soto Carmen, Garcia Clara, Lorenzo Mario, Pinilla Elena, Rico Jesu, Ruperez Irene, Saiz Alonso Eduardo, Leira Fernando, Emilio Maseda David Pestaña, Royo Concepcion, Villagran Jose, Murillo Candi Giralt, Eduardo Esteva Garcia, Mansilla Folgado Raquel, Joan Fornaguera Nadal, Calonge Montse Pijoan, Sape Prat Anna, Sintes Dolore, Arteta Arteta Donaldo, García Delgado Horacio, Fajardo López-Cuervo Juan, López Mikel Celaya, Ramírez Alejandro, José Saldaña Francisco, Aliste Pilar, Hermira Anchuelo Ana, García Campos Ascensión, Catalán Mercede, García Gómez Mónica, Gonzalez Gonzalaez Olga, López López Eloísa, Real Navacerrada Isabel, de Quevedo Sara Arlanzón, Gonzalez Serrano Matilde, Silvestre Francisco Perez-Cerdá, Martinez Torrente Francisco, Arocas Blanca, Pastor Martinez Ernesto, Soro Marina, Maroto Fernando, Robledo Algarra Ruth, Silla Aleixandre Iné, Argente Gemma Rodriguez, Lleó Ana Broseta, Rubio Antonio Vela, Vicente Sánchez José Lui, Enríquez Valcárcel Irene, Balust Clara, Balust Jaume, Borrat Xavier, Jose Carretero Maria, Gracia Isabel, Matute Purificacion, Mercadal Jordi, Pujol Roger, Tena Beatriz, Ubre Marta, Dorda Albalad Dolore, Muñoz Alcaide Concepción, Caballero Jesu, Camps Cervantes Angel, de Nadal Clanchet Miriam, Montferrer Estruch Nuria, Ballvé Ferrer Mercè, Lacasta Fornells Albert, Terrer Galera Eduard, Garcia Martinez Irene, Manrique Muñoz Susana, Pelavski Andre, Tormos Perez Pilar, Gonzalez Posada Miguel Angel, de Prat Ivette Chocron, Rello Jordi, García Serrano Llum, Naya Sieiro José Manuel, Silva Lorena, Colomina Sole Maria Jose, Biarnes Suñé Alfon, Rochera Villach Isabel, Gómez Herreras José Ignacio, Poves Rodrigo, Martinez Rafael Beatriz, Martinez Almeida Icier, Fernandez Collates Angel, Jose Bartolomé Maria, Cimadevilla Bonifacio, González González Antonio Manuel, Rabanal Llevot Jose Manuel, de Terán Mira Juan Carlos Diaz, González Molina Begoña, Pardo Sara, López Sánchez Carlo, Williams Monica, Zaldibar Estibaliz, Muñoz Corsini Lourde, Rodríguez Fraile José Ramón, de la Lastra Maria, Kabiri Sacramento Monir, López Saña Francisco Javier, Trenado Ålvarez Josep, Cantón Bulnes Maria Luisa, Gándara Carrasco Violeta, Crespo Ma del Rocío Míguez, Narváez Cubillos Diana, Laza Laza Enrique, Pérez Ma del Pino Heredia, Arenzana Seisdedos Ángel, Fernández Torres Bartolomé, Santos Ampuero Marian, Chicot Llano Marta, Mata Esperanza, Munoz Manuel, Orts Mar, Planas Antonio, Ramasco Fernando, Roman Carlo, Varela Durán Marina, Fernandez Sabela del Río, Sanduende Otero Yolanda, Lopez Pineiro Susana, Barreiro Pardal Cristina, Fernández Alcantud Jesú, Ayuso Antolinos Mercede, Barrios Francisco, Collantes Casanova Ana, Ruiz Castro Manuel, Infantes Crespo Beatriz, Lancha Felipe Uzuri, Liceras Fuster Marta, Sanz García Máximo, Herrero Garrote Begoña, Moreno Gonzalez Ricardo, Montes Granero Maria José, de la Guía Carlos Lloreda, Chaves López Raquel, de Frutos López Santiago, Marco Martinez Jose Javier, Garcia Mostaza Angel, Jiménez Moreno Antonio, Riquelme Osado Irene, Bardina Pastor Ana, Peña Rosa, Rustarazo Pérez Mónica, Aliaño Piña María, Aranda Romero Carlo, Rodríguez Elena Rodríguez, Pedroviejo Sáez Vicente, Safatle Fernando, Hernández Salvan Javier, Galán Sampedro Mar, de la Torre Patricia Alfaro, Pérez Toro Jonatan, Lasa Unzúe Crsitina, José Vargas Maria, Garcia Bernal David, Echevarria Mercede, Ubeda Iglesias Alejandro, Loza Ana, Rodriguez Morillo Araceli, Diaz Serrano Pedro, Barrientos Sevilla Fernando Caba, Cacho Elena, Calderón Ricardo, Dufur Mercede, Marginet Carolina, Monedero Pablo, José Yepes Maria, Rellán Alvarez Luzdivina, Fernández Carballal Francisca, Pensado Castiñeiras Alberto, Dieguez García Paula, Ramos López Lorena, Rama Maceiras Pablo, Martínez Puente María Socorro, Rey Rilo Maria Teresa, Trujillo Alonso Ana Esther, Rodríguez Fernández Sonia, Omaña García Rafael, Pérez García Aníbal, Bello Puentes Rafael, Nunez Aguado Domingo, Lopez Carballo Carlo, Fernandez Fernandez Ricardo, Toledo Presedo Amadeo, de Rabago Ricardo Bermejo Diaz, Rodriguez Velasco Ana, Jiménez Capel Yolanda, Fernández Cortés Ana, Martínez García Esther, Martinez Gimeno Laura, Klamburg Jordi, Castillo Omedas Rosa, González Núñez Miriam, Llubià Maristany Clara, Moret Ruiz Enrique, Artigas Xavier, Castrillón Sebastian, Espinosa Nieve, Gomez-Caro Ana M., Illa Susana, India Inmaculada, Martín-Huerta Beatriz, Moral Victoria, Moreno Marisa, Iglesias Fernández Cristina, Fernández García Violeta, Picatto Hernández Pedro, Honrubia Checa Angel Alberto, Salvatierra Diaz David, Linero Noguera Manuel, Pujol Varela Ignacio, González Gallego Miguel, Martínez García Oscar, Ariño Irujo José Javier, González Perrino Carlo, Rey Picazo Julio, López Timoneda Francisco, Manzanero Arroyo María, Albalá Blanco Isabel, Martínez Borja Marco, Martín Burcio Sara, Martinez Castro Nilda, Puente Cerdeiriña Aránzazu, de la Torre Concostrina Marta, Viñas Cristina Medrano, Dorado Díaz Trinidad, Avellanosa Esteruelas Juan, Ingelmo Ingelmo Ildefonso, Duran Insuga Paco, Claros Llamas Elisabeth, Martín Lopez Jose Juan, Beltran Martín María, Elías Martín Elena, Ureta Mesa Eva, Loren Monterde Manuela, Alonso Montoiro Paloma, Gonzalez Móstoles Maria Luisa, Velasco Olarte Eva, Martínez Pérez Adolfo, Domínguez Perez Fernando, Serrano Romero Ana, Parise Rous Diego, Mané Ruiz Nuria, Palomo Ruiz Jose Angel, Ruigomez Saiz Alvaro, Terol Alvaro de la Vega, Candela Toha Angel, Alvarez Utrera Fernando, Alberdi Fermín, Elósegui Itxaso, García Javier, Marco Garde Pilar, Itziar Mintegui Escudero, García Sáez Iker, Salas Estibaliz, Zabarte Mercede, Diaz-Boladeras Rosa-Maria, Mora-Guevara Emilio, Ferreras Zamora Julia, Bonet Alfon, Salo Lidia, Salinas Unai, Zaballos Juan, Abella Alvarez Ana, Jimenez Garrido Carlo, Hita Roa Juan Ramón, Gordo Vidal Federico, Garcia-Egea Jorge, Zamora Elson Monica, Seron-Arbeloa Carlo, Mendiola Asensio Miguel Angel, Gastaldo Simeón Rosa, Muñoz Alameda Luis Enrique, Oeding Angulo Guillermo, Aranzubia Monserrat, Juan Arcas Jose, Arevalo Julian, Quesada Belvert Belén, Pérez Calvo César, Cremades Marta, Crespo Pascual, Cuarental Ana, Del Olmo Mercede, Turrión Fernández Pablo, Garcia Vega José Luis Franqueza García Isabel, Herrera Elena, Alcala Llorente Miguel Angel, Martin Rabes Cecilia, de Maeyer Ana Gamo, Pérez Marquez Manuel, López Mendoza Diego, Milicua Muñoz José María, Arias Martínez Natividad, Santos Oviedo Arnoldo, Benavent Garrigues Pau, Alonso Íñigo José, Tormo Ferrandiz Sergi, Sanchez-Morcillo Silvia, Lafuente Sánchez Matilde, Marqués Parra Asunción, Gomar Vidal Sonia, Montoiro Allué Raquel, Zalba Etayo Begoña, Bustamante Rodriguez Raquel, Martin Villen Lui, Molla Jimenez Cristina, de Zayas Ricardo Sala, Dolera Moreno Cristina, SanJose Pacheco Fernando, Anton Pascual Jose Lui, Tejera Gude Fernando, Manteiga Riestra Eva, Cota Delgado Francisco, de la Torre Prados Maria Victoria, Barrios Javier, Cervera-Montes Manuel, García-Sanz Mercede, García Vicente, Sanmiguel Guillermo, López Álvaro Julian, Bornay Barrachima Beatriz, Romero Bermejo Francisco Jose, Martinez Garcia Alberto Garcia Fernandez Pilar, Navarro Ramírez Carolina, Gómez Ramos Jorge, Angel Samaniego Lui, Belenguer-Muncharaz Alberto, Ferrándiz-Selles Amparo, Mateu-Campos Maria-Lidon, Domínguez David, Espinosa Elena, León Teresa, Ojeda Betancor Nazario, Garcia Cortes Javier, Díaz Díaz Juan José, Manzano Canalechevarria Ana, Fores Novales Beatriz, Garcia Peña Jose Manuel, Rodriguez Delgado Toma, Santamaria Roquerio Beatriz, Gomez Sainz Juan Jose, Tebar Soto Teresa, Chew Michelle, Seeman-Lodding Heléne, Dahm Peter, Odenstedt Hergès Helena, Lundborg Christoffer, Söndergaard Sören, Rylander Christian, Sari Ferenc, Oscarsson Tibblin Anna, Adolfsson Anne, Klarin Bengt, Schrey Susann, Merisson Edyta, Rydén Jörgen, Britt Divander Mona, Hedin Annika, Hedlund Daniel, Axelsson Lindkvist Mikael, Jawad Monir, Layous Lona, Wernerman Jan, Björne Håkan, Brattström Olof, Olheden Staffan, Oldner Ander, Sellden Eva, Walder Bernhard, Wickboldt Nadine, Rossi Ariane, Steiner Luziu, Djurdjevic Mirjana, Lussmann Roger, Geisen Martin, Hofer Christoph, Turina Matthia, Grocott Mike, Goldhill David, Everett Lynn, Harris Katy, Wright Maggie, Adams David, Alderson Lorraine, Baker Julie, Christie Iain, Ferguson Colin, Hill Matthew, Holmes Kate, Hutton Andrew, Minto Gary, Moor Paul, Porter Andrew, Struthers Richard, Akotia Niven, Belhaj Alaa, Chang Serene, Collantes Enrique, Eigener Katrin, Husband Michael, Khan Ahsun, Kong Ming-Li, Jane McAlees Eleanor, Macdonald Neil, Niebrzegowska Edyta, Parnell Wendy, Smith Amanda, Chhatwal Ally, Jhingan Smriti, Muswell Richard, Poon Yoyo, Singh Nidhita, Stephens Robert, Vasan Robin, Waife Nicola, Weda Tahmina, Clarke Adrian, Szakmany Tama, Fletcher Simon, Rosbergen Melissa, Blunt Mark, Prince Liz, Wong Kate, Kumar Ram, Stilwell Sarah, Couper Keith, Crooks Neil, Gao-Smith Fang, Melody Teresa, Snaith Catherine, Patel Jaimin, Parekh Dhruv, Yeung Joyce, Loughnan Bernadette, Moosajee Va, Rope Tamsin, Edger Lliam, Dawson Julie, Hadfield Daniel, Hopkins Phil, Mcdonald Lisa, Willars Chri, Campbell Gillian, Craig Jayne, Smith Andrew, Ladipo Karleen, Lockwood Geoff, Moreno Juan, Ballington Ruth, Hamandishe Sibongilele, Rogerson David, Cowman Sarah, Hayden Paul, Pinto Nuno, Sandhar Taj, Arawwawala Dilshan, Brotherston Lauren, Mitchell-Inwang Christine, Walsh Helena, Alagarsamy Famila, Goon Serena, Karcheva Sylvia, Krepska Amy, Mckinney Brian, Patil Vishal, Batchelor Nichola, Day Christopher, Finch Louise, Gibson Charlie, Grayling Matthew, Hubble Sheena, Key William, Knight Thoma, Loosley Alexander, Margetts Paul, Stewart Hannah, Bewley Jeremy, Hurley Katrina, Murphy Ruth, Philpott Catherine, Pollock Kathryn, Sweet Katie, Thomas Matthew, Tucker Katy, Windsor David, Conway Daniel, Gold Steve, Quraishi Tanviha, Cupitt Jason, Baddeley Sally, Brown John David, Foo Irwin, Mantle Damien, Carvalho Peter, Huddart Sam, Kirk-Bayley Justin, Smith Rebecca, Milligan Lisa, Poulose Sonia, Sarkar Som, Nolan Jerry, Pedley Emma, Padkin Andrew, Pesian Siamak, Rajamanickam Satish, Ramkumar Konnur, Thomas Jerry, Crayford Alison, Turner Angu, Bottrill Fiona, Webb Stephen, Jhanji Shaman, Maccallum Niall, Wessels Kate, Wigmore Tim, Meikle Alistair, Wilson Stephen, White Stuart, Bonnett Andrew, Rushton Andrew, Williams Colin, Zuzan Oliver, Hall Andrew, Montgomery Jane, Piggot Ailie, Read Richard, Stocker Mary, Tamm Tiina, Agarwal Banwari, Ward Stephen, Brown Lucy, Joy Manju, Venkatesh Suresh, Hughes Thoma, Zsisku Lajo, Roy Alistair, Hooper Victoria, Mouland Johanna, Nightingale Jeremy, Rose Steve, Chiam Patrick, Chohan Harnita, Dickson Chri, Gibb Sarah, Higham Charley, Harvey Caroline, Janarthanan Chandra, Jones Laura, Kapoor Avinash, Moll Mark, Roberts Louise, Saunders David, Arnold Glenn, Gibbs Claire, Jhurgursing Mhairi, Pierro Dena, Pritchard France, Doyle Patrick, Templeton Maie, Wilson Robert, Zantua Kim, Collyer Thoma, Featherstone Jame, Worton Rachael, Bruce Jean, Mcguigan Kate, Price Grant, Moreton Sarah, Pulletz Mark, Anderson Helen, Baxter Ian, Beckingsale Alex, Callaghan Mark, Datta Ansu, Dawson Jo, Gollogly Jackit, Izod Chri, Lobaz Steve, Macfie Caroline, Patel Manju, Payne Heather, Singh Raj, Timms Gemma, Mcleod Shaun, O'Brian Peter, Horner Elspeth, Joshi Vivekananda, Stuart-Smith Karen, Seale Tania, Bolger Clare, Collins Hannah, Ekins Emma, Hawkins Lesley, Jonas Max, Linford Karen, Wadams Beverley, Beach Madeleine, Vizcaychipi Marcela, Jewsbury William, Davies Simon, Balaji Packianathaswamy, Kangaraj Muthuraj, Pissay Nagesh, Smith Neil, Gopalakrishnan Senthilkumar, Mackinnon John, Strandvik Gustav, Francis Ruth, Jennings Adrian, Keating Matthew, Kumar Sajith, Leese Sarah, Magee Cliona, Pilsbury Jane, Ralph Jame, Riddington David, Sachdeva Rajneesh, Snelson Catherine, Vasanth Suresh, Wilde Judith, Lavender Beth, Lyons Rachel, Watters Malcolm, Adams Tim, Dyer Simon, Tindall Lucy, Claxton Andrew, Netke Meenu, Akouds Esam, Bates Debrah, Gallagher Heather, Hatton Jonathan, Holroyd William, Mitra Atideb, Nurse Trudy, Reed Deborah, Desikan Somi, Barber Russell, Childs Sophie, O'Carroll-Kuehn Britta, Wyldbore Mark, Al-Abdaly Ayad, Amatya Suman, Bhaskaran Sherly, Chandan Garud, Chaudhry Suman, Chikungwa Mose, Earnshaw Greg, Grewal Moni, Haque Shamimul, Hawkins John, Javaid Ahmed, Jackson Clare, Kamel Miriam, Marla Ruchira, Mculloch Dori-Ann, Parker Tom, Salib Yussof, Saravanmuthu Ramesh, Secker Chri, Sockalingam Siva, Taylor Anne, Austine Pauline, Kanade Vrushali, Paal Dora, Sam Mok May Un, Burtenshaw Andrew, Davis Laura, Ellahee Parvez, Freeman David, Pierson Richard, Wollaston Julie, Karmarkar Amara, Ball Clare, Calton Emily, Maxwell Louise, Walker Rachel, Bland Martin, Bullock Lynne, Harrison-Briggs Donna, Hodge Paul, Krige Anton, Dempsey Ged, Hammell Claire, Loveridge Robert, Parker Robert, Snell Jane, Wright Carl, Baker Andy, Barr Katharine, Belcher Alex, Bonnington Sam, Bougeard Anne-Marie, Fitzgerald Emma, Ford Rachael, Gillard Chantal, Griffiths Liz, Greenberg Lizzie, Huber Jonathan, Mathieu Steve, Richardson Neil, Tompsett Laura, White Nigel, Patel Santosh, Corner Victoria, Thomas Richard, Trodd Dawn, Wilson Jennifer, Copley Ed, Flutter Laura, Hulme Jonathan, Susarla Jay, Thwaites Alison, Jayasundera Suraj, Mcafee Sean, Chantler Jonathan, Mckechnie Stuart, Neely Julia, Mouton Ronelle, Scarth Edward, Soar Jasmeet, Buss Joanne, Currie Vicki, Sange Mansoor, Kuttler Anja, Power Fiona, Alexander David, Dunne Kevin, Shinner Guy, Black Euan, Haldane Grant, Kerr Jennie, Saran Taj, Ward Geraldine, Jefferies Fiona, Alexander Peter, Royle Alison, Nahla Farid, Bowles Tim, Gregory Maggie, Ahern Rebecca, Cartlidge David, Craker Lloyd, Thompson Christopher, Bidd Heena, Giles Julian, Manser Amanda, Parry Gareth, Chan Peter, Das Dinesh, Fahmy Nisreen, Higgins David, Khader Ahmed, Stone Alex, Leonardi Silvia, Rose Oliver, Bright Elizabeth, Ercole Ari, Amir Rafi Muhammed, Ramasamy Radhika, Sheshgiri Bengeri, Merrill Colin, Page Valerie, Walker Elaine, Harris Stephen, Hughes Sarah, Morrison Alan, Razouk Khaled, Ayman Mustafa, Jakeman Alicia, Mowatt Chri, Paananen Sami, Supporting clinical sciences, Intensive Care, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, Surgery, and RS: NUTRIM - R2 - Gut-liver homeostasis
- Subjects
Male ,The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients ,Hospital admission, Hospital discharge, Intensive care, Length of stay, Surgical mortality ,Epidemiology ,Iron metabolism Pathogenesis and modulation of inflammation [IGMD 7] ,surgery ,Cohort Studies ,Clinical endpoint ,Medicine ,Hospital Mortality ,Hospital discharge ,education.field_of_study ,Mortality rate ,Medicine (all) ,Confounding ,General Medicine ,Middle Aged ,Surgical mortality ,Operative ,Europe ,Hospitalization ,Treatment Outcome ,Surgical Procedures, Operative ,outcomes, surgery, mortality ,Female ,mortality ,cohort study ,Cohort study ,Human ,Adult ,medicine.medical_specialty ,Critical Care ,Population ,MEDLINE ,Settore MED/41 - ANESTESIOLOGIA ,Humans ,ddc:610 ,Mortality ,education ,surgery, mortality, Europe ,Aged ,Postoperative Care ,Surgical Procedures ,business.industry ,Length of Stay ,Hospital admission ,Surgery ,Clinical outcomes ,Intensive care ,Mann–Whitney U test ,Cohort Studie ,business - Abstract
Item does not contain fulltext BACKGROUND: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe. METHODS: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used chi(2) and Fisher's exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p
- Published
- 2012
7. Effect of air ionization on heart rate and perceived exertion during a bicycle exercise test: A double-blind cross-over study
- Author
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SovijÄrvi, A. R. A., Rosset, S., HyvÄrinen, J., Franssila, A., Graeffe, G., and LehtimÄki, M.
- Published
- 1979
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- View/download PDF
8. How do tourists consume heritage places?
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Ashworth, G.J., Lehtimäki, M., and Faculteit Ruimtelijke Wetenschappen
- Published
- 2008
9. Strategy configuration of a technology center as an innovation system - Historical perspective on the story of Hermia
- Author
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Lehtimäki, M., Teollisuustalous - Teollisuustalous, and Konetekniikan osasto - Department of Mechanical Engineering
- Published
- 2005
10. Particle release of fine filters during different operational conditions of ventilation system
- Author
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Kokotti, H., Halonen, R., Kujanpää, L., Keskikuru, T., Lehtimäki, M., Taipale, Aimo, and Reiman, M.
- Subjects
supply air ,particles ,infiltration ,operation time - Published
- 2002
11. Synthesis of novel Ruddlesden–Popper compounds, (Sr1−xLax)3(Mg1/3+x/2Nb2/3−x/2)2O7 (0.15≤x≤0.33)
- Author
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Lehtimäki, M., primary, Yamauchi, H., additional, and Karppinen, M., additional
- Published
- 2013
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- View/download PDF
12. Isovalent and aliovalent substitution effects on redox chemistry of Sr2MgMoO6−δ SOFC-anode material
- Author
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Vasala, S., primary, Lehtimäki, M., additional, Haw, S.C., additional, Chen, J.M., additional, Liu, R.S., additional, Yamauchi, H., additional, and Karppinen, M., additional
- Published
- 2010
- Full Text
- View/download PDF
13. Degree of order and redox balance in B-site ordered double-perovskite oxides, Sr2MMoO6−δ (M=Mg, Mn, Fe, Co, Ni, Zn)
- Author
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Vasala, S., primary, Lehtimäki, M., additional, Huang, Y.H., additional, Yamauchi, H., additional, Goodenough, J.B., additional, and Karppinen, M., additional
- Published
- 2010
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- View/download PDF
14. Water-containing derivative phases of the Srn+1FenO3n+1 series
- Author
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Lehtimäki, M., primary, Hirasa, A., additional, Matvejeff, M., additional, Yamauchi, H., additional, and Karppinen, M., additional
- Published
- 2007
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15. New Water-Containing Phase Derived from the Sr3Fe2O7-δ Phase of the Ruddlesden−Popper Structure
- Author
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Matvejeff, M., primary, Lehtimäki, M., additional, Hirasa, A., additional, Huang, Y.-H., additional, Yamauchi, H., additional, and Karppinen, M., additional
- Published
- 2005
- Full Text
- View/download PDF
16. Incidence of hip involvement and need for total hip replacement in rheumatoid arthritis. An eight-year follow-up study.
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Lehtimäki, M. Y., Kaarela, K., Hämäläinen, M. M. J., Lehtimäki, M Y, and Hämäläinen, M M
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- 1986
- Full Text
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17. SURVIVORSHIP OF THE CHARNLEY TOTAL HIP ARTHROPLASTY IN JUVENILE CHRONIC ARTHRITIS
- Author
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Lehtimäki, M. Y., primary, Lehto, M. U. K., additional, Kautiainen, H., additional, Savolainen, H. A., additional, and Hämäläinen, M. M. J., additional
- Published
- 1997
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18. Development of test methods for electret filters
- Author
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Lehtimäki, M, primary
- Published
- 1995
- Full Text
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19. Synthesis of novel Ruddlesden–Popper compounds, (Sr1− x La x )3(Mg1/3+ x/2Nb2/3− x/2)2O7 (0.15≤ x ≤0.33).
- Author
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Lehtimäki, M., Yamauchi, H., and Karppinen, M.
- Subjects
- *
MAGNESIUM compound synthesis , *STRONTIUM compounds , *CRYSTAL structure , *LATTICE theory , *SYMMETRY (Physics) , *CATIONS , *CHEMICAL stability - Abstract
Abstract: We have synthesised a new n =2 Ruddlesden–Popper (RP) system, (Sr1− x La x )3(Mg1/3+ x/2Nb2/3− x/2)2O7 (0.15≤ x ≤0.33). Crystal structure investigation of the system revealed orthorhombic lattice symmetry and ordering of the B-site cations, Mg and Nb. The new RP compounds were found to be stable in both highly reducing and oxidising conditions at relatively high temperatures (at least up to 1200°C). [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
20. LOADING AND FILTRATION CHARACTERISTICS OF FILTERING FACEPIECES
- Author
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Chen, C. C., primary, Lehtimäki, M., additional, and Willeke, K., additional
- Published
- 1993
- Full Text
- View/download PDF
21. AEROSOL PENETRATION THROUGH FILTERING FACEPIECES AND RESPIRATOR CARTRIDGES
- Author
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Chen, C.C., primary, Lehtimäki, M., additional, and Willeke, K., additional
- Published
- 1992
- Full Text
- View/download PDF
22. Electrical low pressure impactor
- Author
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Keskinen, J., primary, Pietarinen, K., additional, and Lehtimäki, M., additional
- Published
- 1992
- Full Text
- View/download PDF
23. Isovalent and aliovalent substitution effects on redox chemistry of Sr2MgMoO6− δ SOFC-anode material
- Author
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Vasala, S., Lehtimäki, M., Haw, S.C., Chen, J.M., Liu, R.S., Yamauchi, H., and Karppinen, M.
- Subjects
- *
SUBSTITUTION reactions , *OXIDATION-reduction reaction , *STRONTIUM compounds , *ANODES , *SOLID oxide fuel cells , *CRYSTAL lattices , *ELECTRIC conductivity , *PERFORMANCE evaluation - Abstract
Abstract: An SOFC-anode material, Sr2MgMoO6− δ , is investigated for both isovalent and aliovalent substitution effects at its redox-active cation site. Isovalent WVI-for-MoVI substitution has little effect on crystal and redox chemistry of the phase, whereas aliovalent NbV-for-MoVI substitution lowers the degree of cation order and, rather importantly, creates oxygen vacancies in the lattice. The increased oxygen-vacancy concentration should be a positive factor regarding the SOFC-anode performance, but a disadvantage is that electrical conductivity is slightly depressed in Sr2Mg(Mo,Nb)O6− δ with increasing Nb content. The two systems, Sr2Mg(Mo,W)O6− δ and Sr2Mg(Mo,Nb)O6− δ , are found stable (up to 1000°C or higher) in both reductive (5% H2/Ar) and oxidative (air) atmospheres, the range of oxygen-content variation upon such redox-cycling getting narrower with increasing substitution level. XANES data at the L edges of Mo, W and Nb reveal that in Sr2Mg(Mo,W)O6− δ both Mo and W show variable oxidation states whereas in Sr2Mg(Mo,Nb)O6− δ Nb is more redox-active than Mo. [Copyright &y& Elsevier]
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- 2010
- Full Text
- View/download PDF
24. Degree of order and redox balance in B-site ordered double-perovskite oxides, Sr2 MMoO6− δ (M=Mg, Mn, Fe, Co, Ni, Zn)
- Author
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Vasala, S., Lehtimäki, M., Huang, Y.H., Yamauchi, H., Goodenough, J.B., and Karppinen, M.
- Subjects
- *
PEROVSKITE , *OXIDATION-reduction reaction , *MOLECULAR structure , *ANNEALING of metals , *CHARGE exchange , *STOICHIOMETRY - Abstract
Abstract: We have investigated a series of double-perovskite oxides Sr2 MMoO6− δ (M=Mg, Mn, Fe, Co, Ni, Zn) for redox stability, oxygen content and crystal structure. Phases with M=Co, Ni and Zn were found to be oxygen-stoichiometric and stable under oxidizing conditions, whereas those with M=Mn and Fe were oxygen-deficient and stable under reducing conditions. The M=Mg phase is stable both under reducing and oxidizing conditions, showing variable oxygen contents within 0.00≤δ≤0.04 depending on the annealing conditions. Structural data indicate somewhat depressed values for the degree of M/Mo cation order and also evidence of electron transfer from M II to MoVI for M=Mn, Fe and Co. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
25. Low pressure impactor with electrical concentration detection
- Author
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Keskinen, J., primary, Pietarinen, K., additional, and Lehtimäki, M., additional
- Published
- 1991
- Full Text
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26. Combined electrical and optical detectionin continuous mass monitoring
- Author
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Ukkonen, A., primary, Keskinen, J., additional, and Lehtimäki, M., additional
- Published
- 1991
- Full Text
- View/download PDF
27. Water-containing derivative phases of the Sr n +1Fe n O3 n +1 series
- Author
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Lehtimäki, M., Hirasa, A., Matvejeff, M., Yamauchi, H., and Karppinen, M.
- Subjects
- *
FERRIC oxide , *IRON oxides , *METALLIC oxides , *OXIDE minerals - Abstract
Abstract: The n=1, 2, 3 and ∞ members of the homologous series Sr n +1Fe n O3 n +1 of layered iron oxides are investigated for their tendency to accept additional layers of water in their crystals. The phases possess a Ruddlesden–Popper-type SrO-(SrO-FeO2) n crystal structure, where the n=∞ limit is nothing but the perovskite structure. It is revealed that the n=1, 2 and 3 phases readily accommodate one or two layers of water between adjacent SrO layers, whereas the n=∞ member which lacks the SrO–SrO double-layer unit remains intact in the presence of water. The speed of the water intercalation process is found to decrease with increasing n. Among the layered water derivatives, the n=2 phase with two water molecules per formula unit, i.e. Sr3Fe2O7·2H2O, was found to be most stable. [Copyright &y& Elsevier]
- Published
- 2007
- Full Text
- View/download PDF
28. Hip involvement in seropositive rheumatoid arthritis. Survivorship analysis with a 15-year follow-up.
- Author
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Lehtimäki, M Y, Kautiainen, H, Hämäläinen, M M, Lehto, M U, Ikävalko, M, Repo, A B, Kotaniemi, H A, and Kaarela, K
- Abstract
In a prospective survey of recent arthritis 96 patients had erosive and seropositive rheumatoid arthritis (RA). Severe radiological changes in the hipjoint (Larsen grade 3-5) were observed in 31 (32%) and acetabular protrusion in five (5%) patients 15 years after the onset of arthritis. At the end of follow-up Larsen score 0-100 of peripheral joints (p < 0.015), HAQ (p < 0.001), ESR (p < 0.001), and CRP (p < 0.01) were significantly higher in patients with hip joint destruction than in those without. Secondary amyloidosis was found in eight patients with and in three patients without hip involvement (p = 0.002). In survivorship analysis (the Larsen 0-2 grade hips) an overall predicted rate of survival was 80% after 14 years of rheumatoid arthritis. When analyzed according to HLA-B27 the rate of radiological survival for the patients with a positive test was 62% and 87% for the others (p = 0.02). In conclusion, RA patients with high number of destructive peripheral joints (Larsen score) and high ESR or CRP should be carefully monitored due to the increased risk of hip destruction. [ABSTRACT FROM AUTHOR]
- Published
- 1998
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29. Virtual Impactor as an Accessory to Optical Particle Counters*.
- Author
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Keskinen, J., Janka, K., and Lehtimäki, M.
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- 1987
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30. Method of eliminating the effect of decay products in continuous measurement of 222Rn.
- Author
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Janka, K. and Lehtimäki, M.
- Published
- 1982
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31. On the Behaviour of Radon Daughters in Indoor Air.
- Author
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Lehtimäki, M., Graffe, G., Janka, K., Kulmula, V., and Rajala, M.
- Published
- 1984
32. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes
- Author
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van Zuydam, Natalie R, Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R, Mckeigue, Paul M, Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Robert P, Salem, Rany M, Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M, Jiang, Guozhi, Tam, Claudia H T, Luk, Andrea O Y, Lee, Heung Man, Lim, Cadmon K P, Szeto, Cheuk Chun, Wing Yee, So, Chan, Juliana C N, Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, Mcknight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G, Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Koivula, S, Uggeldahl, T, Forslund, T, Halonen, A, Koistinen, A, Koskiaho, P, Laukkanen, M, Saltevo, J, Tiihonen, M, Forsen, M, Granlund, H, Jonsson, Ac, Nyroos, B, Kinnunen, P, Orvola, A, Salonen, T, Vähänen, A, Paldanius, Kr, Riihelä, M, Ryysy, L, Laukkanen, Kh, Nyländen, P, Sademies, A, Anderson, S, Asplund, B, Byskata, U, Liedes, P, Kuusela, M, Virkkala, T, Nikkola, A, Ritola, E, Niska, Tm, Saarinen, H, Oukko-Ruponen, Se, Virtanen, T, Lyytinen, Va, Kari, Ph, Simonen, T, Kaprio, Sa, Kärkkäinen, J, Rantaeskola, B, Kääriäinen, Tp, Haaga, J, Pietiläinen, Al, Klemetti, S, Nyandoto, T, Rontu, E, Satuli-Autere, S, Toivonen, Kr, Lansimaki, Hv, Ahonen, R, Ivaska-Suomela, M, Jauhiainen, A, Laine, Mm, Pellonpää, T, Puranen, R, Airas, Ma, Laakso, J, Rautavaara, K, Erola, Rm, Jatkola, E, Lönnblad, Tr, Malm, A, Mäkelä, J, Rautamo, E, Hentunen, P, Lagerstam, J, Feodoroff, M, Gordin, D, Heikkilä, O, Hietala, K, Fagerudd, J, Korolainen, M, Kyllönen, L, Kytö, J, Lindh, S, Pettersson-Fernholm, K, Rosengård-Bärlund, M, Sandelin, A, Thorn, L, Tuomikangas, J, Vesisenaho, T, Wadén, J, Sipilä, V, Kalliomäki, Ft, Koskelainen, J, Nikkanen, R, Savolainen, N, Sulonen, H, Valtonen, E, Norvio, L, Hämäläinen, A, Toivanen, E, Parta, Ja, Pirttiniemi, I, Aranko, S, Ervasti, S, Kauppinen-Mäkelin, R, Kuusisto, A, Leppälä, T, Nikkilä, K, Pekkonen, L, Jokelainen, Ks, Kananen, K, Karjalainen, M, Kemppainen, P, Mankinen, Am, Reponen, A, Sankari, M, Suominen, P, Lappalainen, A, Liimatainen, M, Santaholma, J, Aimolahti, A, Huovinen, E, Ilkka, V, Lehtimäki, M, Pälikkö-Kontinen, E, Vanhanen, A, Koskinen, E, Siitonen, T, Huttunen, E, Ikäheimo, R, Karhapää, P, Kekäläinen, P, Laakso, M, Lakka, T, Lampainen, E, Moilanen, L, Tanskanen, S, Niskanen, L, Tuovinen, U, Vauhkonen, I, Voutilainen, E, Rcw, Ma, Chan, Jcn, Huang, Y, Lan, Hy, Lok, S, Tomlinson, B, Tsui, Skw, Yu, W, Yip, Kyl, Chan, Tf, Fan, X, So, Wy, Szeto, Cc, Tang, N, Luk, Ao, Tian, X, Jiang, G, Tam, Cht, Lee, Hm, Lim, Ckp, Chan, Kkh, Xie, F, Acw, Ng, Cheung, Gpy, Yeung, Mw, Mai, S, Zhang, S, Yu, P, Weng, M, Maxwell, Ap, Mcknight, Aj, Savage, Da, Walker, J, Thomas, S, Viberti, Gc, Boulton, Ajm, Marshall, S, Demaine, Ag, Millward, Ba, Bain, Sc, Sandholm, N, Forsblom, C, Harjutsalo, V, Mäkinen, Vp, Ahola, Aj, Dahlström, E, Lehto, M, Lithovius, R, Panduru, Nm, Parkkonen, M, Saraheimo, M, Söderlund, J, Soro-Paavonen, A, Syreeni, A, Thorn, Lm, Tolonen, N, Groop, Ph, Mckay, Gj, Salem, Rm, Isakova, T, Palmer, C, Guiducci, C, Taylor, A, Mirel, Db, Williams, Ww, Hirschhorn, Jn, Florez, Jc, Brennan, Ep, Sadlier, Dm, Martin, F, Godson, C, Mayer, L, Gubitosi-Klug, R, Bourne, P, Schutta, M, Lackaye, Me, Gregory, Ns, Kruger, D, Jones, Jk, Bhan, A, Golden, E, Aiello, L, Larkin, M, Nathan, D, Ziegler, G, Caulder, S, Pittman, C, Luttrell, L, Lopes-Virella, M, Johnson, M, Gunyou, K, Bergenstal, R, Vittetoe, B, Sivitz, W, Flaherty, N, Bantle, J, Hitt, S, Goldstein, D, Hainsworth, D, Cimino, L, Orchard, T, Wigley, C, Dagogo-Jack, S, Strowig, S, Raskin, P, Barnie, A, Zinman, B, Fahlstrom, R, Palmer, J, Harth, J, Driscoll, M, Mcdonald, C, Lipps Hagan, J, May, M, Levandoski, L, White, N, Gatcomb, P, Tamborlane, W, Adelman, D, Colson, S, Molitch, M, Lorenzi, G, Mudaliar, S, Johnsonbaugh, S, Miller, R, Canady, J, Schade, D, Bernal, Ml, Malone, J, Morrison, A, Martin, C, Herman, W, Pop-Busui, R, Cowie, C, Leschek, E, Cleary, P, Lachin, J, Braffett, B, Steffes, M, Arends, V, Blodi, B, Danis, R, Lawrence, D, Wabers, H, Soliman, E, Zhang, Zm, Campbell, C, Hensley, S, Keasler, L, Mark, M, Albertini, M, Boustany, C, Ehlgen, A, Gerl, M, Huber, J, Schölch, C, Zimdahl-Gelling, H, Groop, L, Agardh, E, Ahlqvist, E, Ajanki, T, Al Maghrabi, N, Almgren, P, Apelqvist, J, Bengtsson, E, Berglund, L, Björckbacka, H, Blom-Nilsson, U, Borell, M, Burström, A, Cilio, C, Cinthio, M, Dreja, K, Dunér, P, Engelbertsen, D, Fadista, J, Gomez, M, Goncalves, I, Hedblad, B, Hultgårdh, A, Johansson, Me, Kennbäck, C, Kravic, J, Ladenvall, C, Lernmark, Å, Lindholm, E, Ling, C, Luthman, H, Melander, O, Neptin, M, Nilsson, J, Nilsson, P, Nilsson, T, Nordin, G, Orho-Melander, M, Ottoson-Laakso, E, Persson, A, Persson, M, Persson, Må, Postma, J, Pranter, E, Rattik, S, Sterner, G, Tindberg, L, Wigren, M, Zetterqvist, A, Åkerlund, M, Ostling, G, Kanninen, T, Ahonen-Bishopp, A, Eliasson, A, Herrala, T, Tikka-Kleemola, P, Hamsten, A, Betsholtz, C, Björkholm, A, Foroogh, F, Genové, G, Gertow, K, Gigante, B, He, B, Leander, K, Mcleod, O, Nastase-Mannila, M, Patrakka, J, Silveira, A, Strawbridge, R, Tryggvason, K, Vikström, M, Ohrvik, J, Österholm, Am, Thorand, B, Gieger, C, Grallert, H, Ludwig, T, Nitz, B, Schneider, A, Wang-Sattler, R, Zierer, A, Remuzzi, G, Benigni, A, Donadelli, R, Lesti, Md, Noris, M, Perico, N, Perna, A, Piras, R, Ruggenenti, P, Rurali, E, Dunger, D, Chassin, L, Dalton, N, Deanfield, J, Horsford, J, Rice, C, Rudd, J, Walker, N, Whitehead, K, Wong, M, Colhoun, H, Adams, F, Akbar, T, Belch, J, Deshmukh, H, Dove, F, Ellingford, A, Farran, B, Ferguson, M, Henderson, G, Houston, G, Khan, F, Leese, G, Liu, Y, Livingstone, S, Looker, H, Mccann, M, Mcgurnaghan, S, Morris, A, Newton, D, Pearson, E, Reekie, G, Smith, N, Shore, A, Aizawa, K, Ball, C, Bellenger, N, Casanova, F, Frayling, T, Gates, P, Gooding, K, Hattersley, A, Ling, R, Mawson, D, Shandas, R, Strain, D, Thorn, C, Smith, U, Hammarstedt, A, Häring, H, Pedersen, O, Sesti, G, Fagerholm, E, Toppila, I, Valo, E, Salomaa, V, Havulinna, A, Kristiansson, K, Okamo, P, Peltola, T, Perola, M, Pietilä, A, Ripatti, S, Taimi, M, Ylä-Herttuala, S, Babu, M, Dijkstra, M, Gurzeler, E, Huusko, J, Kholová, I, Merentie, M, Poikolainen, M, Mccarthy, M, Groves, C, Juliusdottir, T, Karpe, F, Lagou, V, Rayner, W, Robertson, N, van Zuydam, N, Cobelli, C, Di Camillo, B, Finotello, F, Sambo, F, Toffolo, G, Trifoglio, E, Bellazzi, R, Barbarini, N, Bucalo, M, Larizza, C, Magni, P, Malovini, A, Marini, S, Mulas, F, Quaglini, S, Sacchi, L, Vitali, F, Ferrannini, E, Boldrini, B, Kozakova, M, Mari, A, Morizzo, C, Mota, L, Natali, A, Palombo, C, Venturi, E, Walker, M, Patrono, C, Pagliaccia, F, Rocca, B, Nuutila, P, Haukkala, J, Knuuti, J, Roivainen, A, Saraste, A, Mckeague, P, Colombo, M, Steckel-Hamann, B, Bokvist, K, Shankar, S, Thomas, M, Gan, Lm, Heinonen, S, Jönsson-Rylander, Ac, Momo, R, Schnecke, V, Unwin, R, Walentinsson, A, Whatling, C, Nogoceke, E, Pacheco, Gd, Formentini, I, Schindler, T, Tortoli, P, Bassi, L, Boni, E, Dallai, A, Guidi, F, Lenge, M, Matera, R, Ramalli, A, Ricci, S, Viti, J, Jablonka, B, Crowther, D, Gassenhuber, J, Hess, S, Hubschle, T, Juretschke, Hp, Rutten, H, Sadowski, T, Wohlfart, P, Brosnan, J, Clerin, V, Fauman, E, Hyde, C, Malarstig, A, Pullen, N, Tilley, M, Tuthill, T, Vangjeli, C, Linda T, Ziemek D., Ahluwalia, Tarunveer S, Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R, Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D, Tregouet, David, Maxwell, Alexander P, Lim, Su Chi, Ronald C W, Ma, Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C, Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N A, Groop, Per-Henrik, Colhoun, Helen M, Groop, Leif C, Mccarthy, Mark, I, Palombo, Carlo, Clinicum, Diabetes and Obesity Research Program, Research Programs Unit, Nefrologian yksikkö, Department of Medicine, Institute for Molecular Medicine Finland, Tiinamaija Tuomi Research Group, Endokrinologian yksikkö, Per Henrik Groop / Principal Investigator, Leif Groop Research Group, HUS Abdominal Center, HUS Internal Medicine and Rehabilitation, and Lee Kong Chian School of Medicine (LKCMedicine)
- Subjects
0301 basic medicine ,Male ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,LOCI ,Genome-wide association study ,Type 2 diabetes ,Bioinformatics ,Kidney Failure ,0302 clinical medicine ,Genome-wide analysis ,80 and over ,Diabetic Nephropathies ,Renal Insufficiency ,Chronic ,Genome-wide analysis, Type 2 Diabetes ,Aged, 80 and over ,RISK ,INSULIN-RESISTANCE ,diabetes ,Diabetes ,STAGE RENAL-DISEASE ,Single Nucleotide ,Middle Aged ,Type 2 Diabetes ,SUSCEPTIBILITY GENES ,Adult ,Aged ,Case-Control Studies ,Diabetes Mellitus, Type 2 ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Kidney Failure, Chronic ,Polymorphism, Single Nucleotide ,Renal Insufficiency, Chronic ,OBESITY ,BIOLOGICAL PATHWAYS ,nephropathy ,Medical genetics ,Type 2 ,kidney ,medicine.medical_specialty ,Diabetic Nephropathies/epidemiology ,Settore BIO/14 - FARMACOLOGIA ,Renal Insufficiency, Chronic/complications ,NEPHROPATHY ,SNP ,030209 endocrinology & metabolism ,Nephropathy ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Diabetes mellitus ,Journal Article ,Diabetes Mellitus ,Internal Medicine ,medicine ,Medicine [Science] ,Polymorphism ,Diabetic Kidney Disease ,METAANALYSIS ,Genetic heterogeneity ,business.industry ,Diabetes Mellitus, Type 2/complications ,association ,Case-control study ,nutritional and metabolic diseases ,Kidney Failure, Chronic/complications ,FAT DISTRIBUTION ,medicine.disease ,030104 developmental biology ,3121 General medicine, internal medicine and other clinical medicine ,Microalbuminuria ,genetic ,business - Abstract
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 × 10-8) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD. ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore)
33. ISAC: A novel air cleaning technique for controlling indoor air quality - Utilization of the induced air flow in the supply air diffuser
- Author
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Taipale, A., Enbom, S., Lehtimäki, M., and Arto Säämänen
- Abstract
This study introduces a new technique for controlling the concentration of indoor air particles. The novel technique is based on the cleaning of the induced air in the supply air diffuser. The idea of the present technique is analogous with the modern room air cooling utilizing active chilled beams. In these devices, the primary supply air flow induces a secondary air flow through a cooling coil. Now, the same idea is utilized for air cleaning purposes, i.e. the induced secondary air is allowed to flow through a special air cleaning device. The performance of the new technique was studied by using a commercially available chilled beam equipped with a unipolar air ionizer for particle charging and an electrostatic collector for particle removal. The results from the laboratory experiments indicate that at least 75 per cent reduction in indoor particle concentration can be achieved with the new technique.
34. Optimization of filtration efficiency and ozone production of the electrostatic precipitator
- Author
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Hautanen, J, primary, Janka, K, additional, Keskinen, J, additional, Lehtimäki, M, additional, and Kivisto, T, additional
- Published
- 1986
- Full Text
- View/download PDF
35. Optical particle counters: Response, resolution and counting efficiency
- Author
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Mäkynen, J., primary, Hakulinen, J., additional, Kivistö, T., additional, and Lehtimäki, M., additional
- Published
- 1982
- Full Text
- View/download PDF
36. Aerosol formation caused by electrostatic precipitator
- Author
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Keskinen, J., primary, Janka, K., additional, Lehtimäki, M., additional, Graeffe, G., additional, and Kulmala, V., additional
- Published
- 1986
- Full Text
- View/download PDF
37. Incidence of Hip Involvement and Need for Total Hip Replacement in Rheumatoid Arthritis:An Eight-year Follow-up Study
- Author
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Lehtimäki, M. Y., primary, Kaarela, K., additional, and Hämäläinen, M. M. J., additional
- Published
- 1986
- Full Text
- View/download PDF
38. The control of radon progeny by air treatment devices
- Author
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Rajala, M., primary, Janka, K., additional, Lehtimäki, M., additional, Kulmala, V., additional, Graeffe, G., additional, and Keskinen, J., additional
- Published
- 1985
- Full Text
- View/download PDF
39. Real time size distribution measurement with electrical low pressure impactor
- Author
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Keskinen, J., Moisio, M., Pietarinen, K., and Lehtimäki, M.
- Published
- 1995
- Full Text
- View/download PDF
40. Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods.
- Author
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Lehtimäki M, Mishra BH, Del-Val C, Lyytikäinen LP, Kähönen M, Cloninger CR, Raitakari OT, Laaksonen R, Zwir I, Lehtimäki T, and Mishra PP
- Subjects
- Humans, Genotype, Phenotype, Unsupervised Machine Learning, Polymorphism, Single Nucleotide, Lipidomics, Machine Learning
- Abstract
Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of plasma lipidome profiled from 1,426 Finnish individuals aged 30-45 years. PGMRA involves biclustering genotype and lipidome data independently followed by their inter-domain integration based on hypergeometric tests of the number of shared individuals. Pathway enrichment analysis was performed on the SNP sets to identify their associated biological processes. We identified 93 statistically significant (hypergeometric p-value < 0.01) lipidome-genotype relations. Genotype biclusters in these 93 relations contained 5977 SNPs across 3164 genes. Twenty nine of the 93 relations contained genotype biclusters with more than 50% unique SNPs and participants, thus representing most distinct subgroups. We identified 30 significantly enriched biological processes among the SNPs involved in 21 of these 29 most distinct genotype-lipidome subgroups through which the identified genetic variants can influence and regulate plasma lipid related metabolism and profiles. This study identified 29 distinct genotype-lipidome subgroups in the studied Finnish population that may have distinct disease trajectories and therefore could be useful in precision medicine research., (© 2023. The Author(s).)
- Published
- 2023
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41. Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice.
- Author
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Ruskamo S, Krokengen OC, Kowal J, Nieminen T, Lehtimäki M, Raasakka A, Dandey VP, Vattulainen I, Stahlberg H, and Kursula P
- Subjects
- Cholesterol metabolism, Cryoelectron Microscopy, Fatty Acids metabolism, Humans, Lipid Bilayers metabolism, Molecular Dynamics Simulation, Myelin P2 Protein genetics, Myelin P2 Protein metabolism, Point Mutation, Protein Binding, Protein Conformation, X-Ray Diffraction, Myelin P2 Protein chemistry, Myelin P2 Protein ultrastructure
- Abstract
Myelin protein P2 is a peripheral membrane protein of the fatty acid-binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human Charcot-Marie-Tooth neuropathy, but the mature myelin sheath assembly mechanism is unclear. Here, cryo-EM of myelin-like proteolipid multilayers revealed an ordered three-dimensional (3D) lattice of P2 molecules between stacked lipid bilayers, visualizing supramolecular assembly at the myelin major dense line. The data disclosed that a single P2 layer is inserted between two bilayers in a tight intermembrane space of ∼3 nm, implying direct interactions between P2 and two membrane surfaces. X-ray diffraction from P2-stacked bicelle multilayers revealed lateral protein organization, and surface mutagenesis of P2 coupled with structure-function experiments revealed a role for both the portal region of P2 and its opposite face in membrane interactions. Atomistic molecular dynamics simulations of P2 on model membrane surfaces suggested that Arg-88 is critical for P2-membrane interactions, in addition to the helical lid domain. Negatively charged lipid headgroups stably anchored P2 on the myelin-like bilayer surface. Membrane binding may be accompanied by opening of the P2 β-barrel structure and ligand exchange with the apposing bilayer. Our results provide an unprecedented view into an ordered, multilayered biomolecular membrane system induced by the presence of a peripheral membrane protein from human myelin. This is an important step toward deciphering the 3D assembly of a mature myelin sheath at the molecular level., (© 2020 Ruskamo et al.)
- Published
- 2020
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42. New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults.
- Author
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Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Hilvo M, Kauhanen D, Juonala M, Viikari J, Kähönen M, Raitakari O, Laaksonen R, and Lehtimäki T
- Subjects
- Apolipoprotein A-I blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Finland, Genotype, Humans, Triglycerides blood, Apolipoproteins E genetics, Ceramides blood, Coronary Artery Disease blood, Coronary Artery Disease genetics, Polymorphism, Genetic genetics
- Abstract
apoE, a key regulator of plasma lipids, mediates altered functionalities in lipoprotein metabolism and thus affects the risk of coronary artery disease (CAD). The significance of different apoE polymorphisms remains unclear; although the ε4 allele is clearly associated with increased cholesterol levels (which inform CAD risk), direct studies about apoE polymorphisms on CAD risk and development have yielded controversial results. Furthermore, certain species of ceramides-complex lipids abundant in plasma LDL-are markers of increased risk of myocardial infarction and cardiovascular death. Using a high-throughput MS approach, we quantified 30 molecular plasma ceramide species from a cohort of 2,160 apoE-genotyped (rs7412, rs429358) young adults enrolled in the population-based Cardiovascular Risk in Young Finns Study. We then searched this lipidome data set to identify new indications of pathways influenced by apoE polymorphisms and possibly related to CAD risk. This approach revealed a previously unreported association between apoE polymorphism and a consistently documented high-risk CAD marker, Cer(d18:1/16:0). Compared with the apoE ε3/3 reference group, plasma levels of apoE ε4 were elevated and those of apoE ε2 were lowered in all subjects without evidence of apoE-by-sex interactions. apoE associated with seven ceramides that are connected to atherogenically potent macrophages and/or lipoprotein particles; these associations could indicate a plausible linkage between apoE polymorphism and ceramide metabolism, leading to adverse plasma LDL metabolism and atherogenesis. In conclusion, new evidence from plasma ceramides links apoE polymorphism with an increased risk of CAD and extends our understanding of the role of apoE in health and disease., (Copyright © 2019 Karjalainen et al.)
- Published
- 2019
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43. The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.
- Author
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Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Juonala M, Ala-Korpela M, Kähönen M, Raitakari O, and Lehtimäki T
- Subjects
- Adult, Alleles, Cross-Sectional Studies, Disease Susceptibility, Female, Gene Frequency, Genotype, Humans, Longitudinal Studies, Male, Young Adult, Apolipoproteins E genetics, Biomarkers blood, Metabolome, Metabolomics methods, Polymorphism, Genetic
- Abstract
Apolipoprotein E (apoE) is the key regulator of plasma lipids, mediating altered functionalities in lipoprotein metabolism - affecting the risk of coronary artery (CAD) and Alzheimer's diseases, as well as longevity. Searching pathways influenced by apoE prior to adverse manifestations, we utilized a metabolome dataset of 228 nuclear-magnetic-resonance-measured serum parameters with a 10-year follow-up from the population-based Young Finns Study cohort of 2,234 apoE-genotyped (rs7412, rs429358) adults, aged 24-39 at baseline. At the end of our follow-up, by limiting FDR-corrected p < 0.05, regression analyses revealed 180/228 apoE-polymorphism-related associations with the studied metabolites, in all subjects - without indications of apoE x sex interactions. Across all measured apoE- and apoB-containing lipoproteins, ε4 allele had consistently atherogenic and ε2 protective effect on particle concentrations of free/esterified cholesterol, triglycerides, phospholipids and total lipids. As novel findings, ε4 associated with glycoprotein acetyls, LDL-diameter and isoleucine - all reported biomarkers of CAD-risk, inflammation, diabetes and total mortality. ApoE-subgroup differences persisted through our 10-year follow-up, although some variation of individual metabolite levels was noticed. In conclusion, apoE polymorphism associate with a complex metabolic change, including aberrations in multiple novel biomarkers related to elevated cardiometabolic and all-cause mortality risk, extending our understanding about the role of apoE in health and disease.
- Published
- 2019
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44. Local structure and composition of PtRh nanoparticles produced through cathodic corrosion.
- Author
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Hersbach TJP, Kortlever R, Lehtimäki M, Krtil P, and Koper MTM
- Abstract
Alloy nanoparticles fulfill an important role in catalysis. As such, producing them in a simple and clean way is much desired. A promising alloy nanoparticle production method is cathodic corrosion, which generates particles by applying an AC voltage to an alloy electrode. However, this harsh AC potential program might affect the final elemental distribution of the nanoparticles. In this work, we address this issue by characterizing the time that is required to create 1 μmol of Rh, Pt
12 Rh88 , Pt55 Rh45 and Pt nanoparticles under various applied potentials. The corrosion time measurements are complemented by structural characterization through transmission electron microscopy, X-ray diffraction and X-ray absorption spectroscopy. The corrosion times indicate that platinum and rhodium corrode at different rates and that the cathodic corrosion rates of the alloys are dominated by platinum. In addition, the structure-sensitive techniques reveal that the elemental distributions of the created alloy nanoparticles indeed exhibit small degrees of elemental segregation. These results indicate that the atomic alloy structure is not always preserved during cathodic corrosion.- Published
- 2017
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45. Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.
- Author
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Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Härtlein M, Moulin M, Kursula I, and Kursula P
- Subjects
- 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase genetics, Animals, Binding Sites genetics, Biocatalysis, Catalytic Domain, Circular Dichroism, Crystallography, X-Ray, Kinetics, Ligands, Mass Spectrometry, Mice, Models, Molecular, Mutation, Protein Binding, Protein Stability, Scattering, Small Angle, Static Electricity, Temperature, X-Ray Diffraction, 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase chemistry, 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase metabolism, Myelin Sheath metabolism, Protein Structure, Tertiary
- Abstract
2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an enzyme highly abundant in the central nervous system myelin of terrestrial vertebrates. The catalytic domain of CNPase belongs to the 2H phosphoesterase superfamily and catalyzes the hydrolysis of nucleoside 2',3'-cyclic monophosphates to nucleoside 2'-monophosphates. The detailed reaction mechanism and the essential catalytic amino acids involved have been described earlier, but the roles of many amino acids in the vicinity of the active site have remained unknown. Here, several CNPase catalytic domain mutants were studied using enzyme kinetics assays, thermal stability experiments, and X-ray crystallography. Additionally, the crystal structure of a perdeuterated CNPase catalytic domain was refined at atomic resolution to obtain a detailed view of the active site and the catalytic mechanism. The results specify determinants of ligand binding and novel essential residues required for CNPase catalysis. For example, the aromatic side chains of Phe235 and Tyr168 are crucial for substrate binding, and Arg307 may affect active site electrostatics and regulate loop dynamics. The β5-α7 loop, unique for CNPase in the 2H phosphoesterase family, appears to have various functions in the CNPase reaction mechanism, from coordinating the nucleophilic water molecule to providing a binding pocket for the product and being involved in product release.
- Published
- 2015
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46. Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant.
- Author
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Laulumaa S, Nieminen T, Lehtimäki M, Aggarwal S, Simons M, Koza MM, Vattulainen I, Kursula P, and Natali F
- Subjects
- Circular Dichroism, Crystallography, X-Ray, Humans, Lipid Bilayers chemistry, Lipid Bilayers metabolism, Molecular Dynamics Simulation, Mutagenesis, Site-Directed, Myelin P2 Protein genetics, Myelin P2 Protein metabolism, Neutron Diffraction, Protein Structure, Secondary, Protein Structure, Tertiary, Recombinant Proteins biosynthesis, Recombinant Proteins chemistry, Recombinant Proteins genetics, Scattering, Radiation, Temperature, Myelin P2 Protein chemistry
- Abstract
Myelin protein P2 is a fatty acid-binding structural component of the myelin sheath in the peripheral nervous system, and its function is related to its membrane binding capacity. Here, the link between P2 protein dynamics and structure and function was studied using elastic incoherent neutron scattering (EINS). The P38G mutation, at the hinge between the β barrel and the α-helical lid, increased the lipid stacking capacity of human P2 in vitro, and the mutated protein was also functional in cultured cells. The P38G mutation did not change the overall structure of the protein. For a deeper insight into P2 structure-function relationships, information on protein dynamics in the 10 ps to 1 ns time scale was obtained using EINS. Values of mean square displacements mainly from protein H atoms were extracted for wild-type P2 and the P38G mutant and compared. Our results show that at physiological temperatures, the P38G mutant is more dynamic than the wild-type P2 protein, especially on a slow 1-ns time scale. Molecular dynamics simulations confirmed the enhanced dynamics of the mutant variant, especially within the portal region in the presence of bound fatty acid. The increased softness of the hinge mutant of human myelin P2 protein is likely related to an enhanced flexibility of the portal region of this fatty acid-binding protein, as well as to its interactions with the lipid bilayer surface requiring conformational adaptations.
- Published
- 2015
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47. Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.
- Author
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Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I, and Kursula P
- Subjects
- Amino Acid Sequence, Cell Line, Cell Membrane metabolism, Humans, Models, Molecular, Molecular Sequence Data, Protein Binding, Protein Conformation, Myelin P2 Protein chemistry, Myelin P2 Protein metabolism
- Abstract
P2 is a fatty acid-binding protein expressed in vertebrate peripheral nerve myelin, where it may function in bilayer stacking and lipid transport. P2 binds to phospholipid membranes through its positively charged surface and a hydrophobic tip, and accommodates fatty acids inside its barrel structure. The structure of human P2 refined at the ultrahigh resolution of 0.93 Å allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network. The orientation of the bound fatty-acid carboxyl group is linked to the protonation states of two coordinating arginine residues. An anion-binding site in the portal region is suggested to be relevant for membrane interactions and conformational changes. When bound to membrane multilayers, P2 has a preferred orientation and is stabilized, and the repeat distance indicates a single layer of P2 between membranes. Simulations show the formation of a double bilayer in the presence of P2, and in cultured cells wild-type P2 induces membrane-domain formation. Here, the most accurate structural and functional view to date on P2, a major component of peripheral nerve myelin, is presented, showing how it can interact with two membranes simultaneously while going through conformational changes at its portal region enabling ligand transfer.
- Published
- 2014
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48. Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family.
- Author
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Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, and Kursula P
- Subjects
- 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase genetics, 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase metabolism, Animals, Binding Sites, Catalysis, Catalytic Domain, Crystallography, X-Ray, Enzyme Activation, Enzyme Stability, Ligands, Mice, Models, Molecular, Mutation, NADP chemistry, NADP metabolism, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Substrate Specificity, Sulfur Compounds chemistry, Temperature, 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase chemistry
- Abstract
2H phosphoesterases catalyze reactions on nucleotide substrates and contain two conserved histidine residues in the active site. Very limited information is currently available on the details of the active site and substrate/product binding during the catalytic cycle of these enzymes. We performed a comprehensive X-ray crystallographic study of mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a membrane-associated enzyme present at high levels in the tetrapod myelin sheath. We determined crystal structures of the CNPase phosphodiesterase domain complexed with substrate, product, and phosphorothioate analogues. The data provide detailed information on the CNPase reaction mechanism, including substrate binding mode and coordination of the nucleophilic water molecule. Linked to the reaction, an open/close motion of the β5-α7 loop is observed. The role of the N terminus of helix α7--unique for CNPase in the 2H family--during the reaction indicates that 2H phosphoesterases differ in their respective reaction mechanisms despite the conserved catalytic residues. Furthermore, based on small-angle X-ray scattering, we present a model for the full-length enzyme, indicating that the two domains of CNPase form an elongated molecule. Finally, based on our structural data and a comprehensive bioinformatics study, we discuss the conservation of CNPase in various organisms., (© 2013.)
- Published
- 2013
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49. Production and crystallization of a panel of structure-based mutants of the human myelin peripheral membrane protein P2.
- Author
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Lehtimäki M, Laulumaa S, Ruskamo S, and Kursula P
- Subjects
- Amino Acid Substitution, Crystallization, Escherichia coli, Humans, Hydrophobic and Hydrophilic Interactions, Models, Molecular, Mutagenesis, Site-Directed, Myelin P2 Protein biosynthesis, Protein Structure, Secondary, Protein Structure, Tertiary, X-Ray Diffraction, Myelin P2 Protein chemistry, Myelin P2 Protein genetics
- Abstract
The myelin sheath is a multilayered membrane that surrounds and insulates axons in the nervous system. One of the proteins specific to the peripheral nerve myelin is P2, a protein that is able to stack lipid bilayers. With the goal of obtaining detailed information on the structure-function relationship of P2, 14 structure-based mutated variants of human P2 were generated and produced. The mutants were designed to potentially affect the binding of lipid bilayers by P2. All mutated variants were also crystallized and preliminary crystallographic data are presented. The structural data from the mutants will be combined with diverse functional assays in order to elucidate the fine details of P2 function at the molecular level.
- Published
- 2012
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50. Wood dust particle and mass concentrations and filtration efficiency in sanding of wood materials.
- Author
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Welling I, Lehtimäki M, Rautio S, Lähde T, Enbom S, Hynynen P, and Hämeri K
- Subjects
- Air Pollutants, Occupational chemistry, Environmental Monitoring instrumentation, Environmental Monitoring methods, Humans, Industry, Particle Size, Ventilation methods, Air Pollutants, Occupational analysis, Dust analysis, Filtration methods, Inhalation Exposure analysis, Occupational Exposure analysis, Wood analysis
- Abstract
The importance of fine particles has become apparent as the knowledge of their effects on health has increased. Fine particle concentrations have been published for outside air, plasma arc cutting, welding, and grinding, but little data exists for the woodworking industry. Sanding was evaluated as the producer of the woodworking industry's finest particles, and was selected as the target study. The number of dust particles in different particle size classes and the mass concentrations were measured in the following environments: workplace air during sanding in plywood production and in the inlet and return air; in the dust emission chamber; and in filter testing. The numbers of fine particles were low, less than 10(4) particles/cm(3) (10(7) particles/L). They were much lower than typical number concentrations near 10(6) particles/cm(3) measured in plasma arc cutting, grinding, and welding. Ultrafine particles in the size class less than 100 nm were found during sanding of MDF (medium density fiberboard) sheets. When the cleaned air is returned to the working areas, the dust content in extraction systems must be monitored continuously. One way to monitor the dust content in the return air is to use an after-filter and measure pressure drop across the filter to indicate leaks in the air-cleaning system. The best after-filtration materials provided a clear increase in pressure drop across the filter in the loading of the filter. The best after-filtration materials proved to be quite effective also for fine particles. The best mass removal efficiencies for fine particles around 0.3 mum were over 80% for some filter materials loaded with sanding wood dust.
- Published
- 2009
- Full Text
- View/download PDF
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