121 results on '"Lehmann, Jonas"'
Search Results
2. Comparison of the neurotoxic potency of different ultrafine particle fractions from diesel engine exhaust following direct and simulated inhalation exposure
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Gerber, Lora-Sophie, de Leijer, Dirk C.A., Rujas Arranz, Andrea, Lehmann, Jonas M.M.L., Verheul, Meike E., Cassee, Flemming R., and Westerink, Remco H.S.
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- 2024
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3. Technology and energy choices for fleet asset decarbonization under cost uncertainty
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Lehmann, Jonas and Winkenbach, Matthias
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- 2025
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4. Generic Models for Group Actions
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Duman, Julien, Hartmann, Dominik, Kiltz, Eike, Kunzweiler, Sabrina, Lehmann, Jonas, Riepel, Doreen, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Boldyreva, Alexandra, editor, and Kolesnikov, Vladimir, editor
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- 2023
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5. A matheuristic for the Two-Echelon Multi-Trip Vehicle Routing Problem with mixed pickup and delivery demand and time windows
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Lehmann, Jonas and Winkenbach, Matthias
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- 2024
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6. In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure
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Gerber, Lora-Sophie, de Leijer, Dirk C.A., Rujas Arranz, Andrea, Lehmann, Jonas M.M.L., Verheul, Meike E., Cassee, Flemming R., and Westerink, Remco H.S.
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- 2024
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7. TIGIT+ NK cells in combination with specific gut microbiota features predict response to checkpoint inhibitor therapy in melanoma patients
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Tsakmaklis, Anastasia, Farowski, Fedja, Zenner, Rafael, Lesker, Till Robin, Strowig, Till, Schlößer, Hans, Lehmann, Jonas, von Bergwelt-Baildon, Michael, Mauch, Cornelia, Schlaak, Max, Knuever, Jana, Schweinsberg, Viola, Heinzerling, Lucie M., and Vehreschild, Maria J. G. T.
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- 2023
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8. Group Action Key Encapsulation and Non-Interactive Key Exchange in the QROM
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Duman, Julien, Hartmann, Dominik, Kiltz, Eike, Kunzweiler, Sabrina, Lehmann, Jonas, Riepel, Doreen, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Agrawal, Shweta, editor, and Lin, Dongdai, editor
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- 2022
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9. T-cells of invasive candidiasis patients show patterns of T-cell-exhaustion suggesting checkpoint blockade as treatment option
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Mellinghoff, Sibylle C., Thelen, Martin, Bruns, Christiane, Garcia-Marquez, Maria, Hartmann, Pia, Lammertz, Tatjana, Lehmann, Jonas, Nowag, Angela, Stemler, Jannik, Wennhold, Kerstin, Cornely, Oliver A., von Bergwelt-Baildon, Michael S., and Schlößer, Hans A.
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- 2022
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10. Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma
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Garcia-Marquez, Maria A., Thelen, Martin, Reinke, Sarah, Keller, Diandra, Wennhold, Kerstin, Lehmann, Jonas, Veldman, Johanna, Borchmann, Sven, Rosenwald, Andreas, Sasse, Stephanie, Diepstra, Arjan, Borchmann, Peter, Engert, Andreas, Klapper, Wolfram, von Bergwelt-Baildon, Michael, Bröckelmann, Paul J., and Schlößer, Hans A.
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- 2022
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11. Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides
- Author
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Garcia-Marquez, Maria Alejandra, primary, Thelen, Martin, additional, Bauer, Eugen, additional, Maas, Lukas, additional, Wennhold, Kerstin, additional, Lehmann, Jonas, additional, Keller, Diandra, additional, Nikolić, Miloš, additional, George, Julie, additional, Zander, Thomas, additional, Schröder, Wolfgang, additional, Müller, Philipp, additional, Yazbeck, Ali M, additional, Bruns, Christiane, additional, Thomas, Roman, additional, Gathof, Birgit, additional, Quaas, Alexander, additional, Peifer, Martin, additional, Hillmer, Axel M, additional, von Bergwelt-Baildon, Michael, additional, and Schlößer, Hans Anton, additional
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- 2024
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12. Group Action Key Encapsulation and Non-Interactive Key Exchange in the QROM
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Duman, Julien, primary, Hartmann, Dominik, additional, Kiltz, Eike, additional, Kunzweiler, Sabrina, additional, Lehmann, Jonas, additional, and Riepel, Doreen, additional
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- 2022
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13. In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure
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Gerber, Lora Sophie, de Leijer, Dirk C.A., Rujas Arranz, Andrea, Lehmann, Jonas M.M.L., Verheul, Meike E., Cassee, Flemming R., Westerink, Remco H.S., Gerber, Lora Sophie, de Leijer, Dirk C.A., Rujas Arranz, Andrea, Lehmann, Jonas M.M.L., Verheul, Meike E., Cassee, Flemming R., and Westerink, Remco H.S.
- Abstract
Combustion-derived particulate matter (PM) is a major source of air pollution. Efforts to reduce diesel engine emission include the application of biodiesel. However, while urban PM exposure has been linked to adverse brain effects, little is known about the direct effects of PM from regular fossil diesel (PMDEP) and biodiesel (PMBIO) on neuronal function. Furthermore, it is unknown to what extent the PM-induced effects in the lung (e.g., inflammation) affect the brain. This in vitro study investigates direct and indirect toxicity of PMDEP and PMBIO on the lung and brain and compared it with effects of clean carbon particles (CP). PM were generated using a common rail diesel engine. CP was sampled from a spark generator. First, effects of 48 h exposure to PM and CP (1.2–3.9 µg/cm2) were assessed in an in vitro lung model (air–liquid interface co-culture of Calu-3 and THP1 cells) by measuring cell viability, cytotoxicity, barrier function, inflammation, and oxidative and cell stress. None of the exposures caused clear adverse effects and only minor changes in gene expression were observed. Next, the basal medium was collected for subsequent simulated inhalation exposure of rat primary cortical cells. Neuronal activity, recorded using microelectrode arrays (MEA), was increased after acute (0.5 h) simulated inhalation exposure. In contrast, direct exposure to PMDEP and PMBIO (1–100 µg/mL; 1.2–119 µg/cm2) reduced neuronal activity after 24 h with lowest observed effect levels of respectively 10 µg/mL and 30 µg/mL, indicating higher neurotoxic potency of PMDEP, whereas neuronal activity remained unaffected following CP exposure. These findings indicate that combustion-derived PM potently inhibit neuronal function following direct exposure, while the lung serves as a protective barrier. Furthermore, PMDEP exhibit a higher direct neurotoxic potency than PMBIO, and the data suggest that the neurotoxic effects is caused by adsorbed chemicals rather t
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- 2024
14. In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure
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IRAS OH Toxicology, IRAS – One Health Toxicology, Gerber, Lora Sophie, de Leijer, Dirk C.A., Rujas Arranz, Andrea, Lehmann, Jonas M.M.L., Verheul, Meike E., Cassee, Flemming R., Westerink, Remco H.S., IRAS OH Toxicology, IRAS – One Health Toxicology, Gerber, Lora Sophie, de Leijer, Dirk C.A., Rujas Arranz, Andrea, Lehmann, Jonas M.M.L., Verheul, Meike E., Cassee, Flemming R., and Westerink, Remco H.S.
- Published
- 2024
15. The Service Network Fleet Transition Problem
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Lehmann, Jonas, primary, Gvozdjak, Anne, additional, and Winkenbach, Matthias, additional
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- 2024
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16. Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy
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Thelen, Martin, Wennhold, Kerstin, Lehmann, Jonas, Garcia-Marquez, Maria, Klein, Sebastian, Kochen, Elena, Lohneis, Philipp, Lechner, Axel, Wagener-Ryczek, Svenja, Plum, Patrick Sven, Velazquez Camacho, Oscar, Pfister, David, Dörr, Fabian, Heldwein, Matthias, Hekmat, Khosro, Beutner, Dirk, Klussmann, Jens Peter, Thangarajah, Fabinshy, Ratiu, Dominik, Malter, Wolfram, Merkelbach-Bruse, Sabine, Bruns, Christiane Josephine, Quaas, Alexander, von Bergwelt-Baildon, Michael, and Schlößer, Hans A.
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- 2021
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17. Alcohol dehydrogenase on inorganic powders: Zeta potential and particle agglomeration as main factors determining activity during immobilization
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Sigurdardóttir, Sigyn Björk, Lehmann, Jonas, Grivel, Jean‐Claude, Zhang, Wenjing, Kaiser, Andreas, and Pinelo, Manuel
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- 2019
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18. Influence of carbon nanoparticle modification on the mechanical and electrical properties of epoxy in small volumes
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Leopold, Christian, Augustin, Till, Schwebler, Thomas, Lehmann, Jonas, Liebig, Wilfried V., and Fiedler, Bodo
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- 2017
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19. Figure S2 from CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
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Wennhold, Kerstin, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Schran, Simon, primary, Preugszat, Ella, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Shimabukuro-Vornhagen, Alexander, primary, Ercanoglu, Meryem S., primary, Klein, Florian, primary, Thangarajah, Fabinshy, primary, Eidt, Sebastian, primary, Löser, Heike, primary, Bruns, Christiane, primary, Quaas, Alexander, primary, von Bergwelt-Baildon, Michael, primary, and Schlößer, Hans A., primary
- Published
- 2023
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20. Table S1 from CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
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Wennhold, Kerstin, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Schran, Simon, primary, Preugszat, Ella, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Shimabukuro-Vornhagen, Alexander, primary, Ercanoglu, Meryem S., primary, Klein, Florian, primary, Thangarajah, Fabinshy, primary, Eidt, Sebastian, primary, Löser, Heike, primary, Bruns, Christiane, primary, Quaas, Alexander, primary, von Bergwelt-Baildon, Michael, primary, and Schlößer, Hans A., primary
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- 2023
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21. Data from CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
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Wennhold, Kerstin, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Schran, Simon, primary, Preugszat, Ella, primary, Garcia-Marquez, Maria, primary, Lechner, Axel, primary, Shimabukuro-Vornhagen, Alexander, primary, Ercanoglu, Meryem S., primary, Klein, Florian, primary, Thangarajah, Fabinshy, primary, Eidt, Sebastian, primary, Löser, Heike, primary, Bruns, Christiane, primary, Quaas, Alexander, primary, von Bergwelt-Baildon, Michael, primary, and Schlößer, Hans A., primary
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- 2023
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22. TIGIT+ NK cells in combination with specific gut microbiota features predict response to checkpoint inhibitor therapy in melanoma patients.
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Tsakmaklis, Anastasia, Farowski, Fedja, Zenner, Rafael, Lesker, Till Robin, Strowig, Till, Schlößer, Hans, Lehmann, Jonas, von Bergwelt-Baildon, Michael, Mauch, Cornelia, Schlaak, Max, Knuever, Jana, Schweinsberg, Viola, Heinzerling, Lucie M., and Vehreschild, Maria J. G. T.
- Subjects
KILLER cells ,GUT microbiome ,IMMUNE checkpoint inhibitors ,IPILIMUMAB ,RANDOM forest algorithms ,MELANOMA - Abstract
Background: Composition of the intestinal microbiota has been correlated to therapeutic efficacy of immune checkpoint inhibitors (ICI) in various cancer entities including melanoma. Prediction of the outcome of such therapy, however, is still unavailable. This prospective, non-interventional study was conducted in order to achieve an integrated assessment of the connection between a specific intestinal microbiota profile and antitumor immune response to immune checkpoint inhibitor therapy (anti-PD-1 and/or anti-CTLA-4) in melanoma patients. Methods: We assessed blood and stool samples of 29 cutaneous melanoma patients who received immune checkpoint inhibitor therapy. For functional and phenotypical immune analysis, 12-color flow cytometry and FluoroSpot assays were conducted. Gut microbiome was analyzed with shotgun metagenomics sequencing. To combine clinical, microbiome and immune variables, we applied the Random Forest algorithm. Results: A total of 29 patients was analyzed in this study, among whom 51.7% (n = 15) reached a durable clinical benefit. The Immune receptor TIGIT is significantly upregulated in T cells (p = 0.0139) and CD56
high NK cells (p = 0.0037) of responders. Several bacterial taxa were associated with response (e.g. Ruminococcus torques) or failure (e.g. Barnesiella intestinihominis) to immune therapy. A combination of two microbiome features (Barnesiella intestinihominis and the Enterobacteriaceae family) and one immune feature (TIGIT+ CD56high NK cells) was able to predict response to ICI already at baseline (AUC = 0.85; 95% CI: 0.841–0.853). Conclusions: Our results reconfirm a link between intestinal microbiota and response to ICI therapy in melanoma patients and furthermore point to TIGIT as a promising target for future immunotherapies. [ABSTRACT FROM AUTHOR]- Published
- 2023
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23. Supplementary Table from Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance
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Datta, Rabi R., primary, Schran, Simon, primary, Persa, Oana-Diana, primary, Aguilar, Claire, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Garcia-Marquez, Maria A., primary, Wennhold, Kerstin, primary, Preugszat, Ella, primary, Zentis, Peter, primary, von Bergwelt-Baildon, Michael S., primary, Quaas, Alexander, primary, Bruns, Christiane J., primary, Kurschat, Christine, primary, Mauch, Cornelia, primary, Löser, Heike, primary, Stippel, Dirk L., primary, and Schlößer, Hans A., primary
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- 2023
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24. Data from Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance
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Datta, Rabi R., primary, Schran, Simon, primary, Persa, Oana-Diana, primary, Aguilar, Claire, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Garcia-Marquez, Maria A., primary, Wennhold, Kerstin, primary, Preugszat, Ella, primary, Zentis, Peter, primary, von Bergwelt-Baildon, Michael S., primary, Quaas, Alexander, primary, Bruns, Christiane J., primary, Kurschat, Christine, primary, Mauch, Cornelia, primary, Löser, Heike, primary, Stippel, Dirk L., primary, and Schlößer, Hans A., primary
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- 2023
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25. Supplementary Figure from Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance
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Datta, Rabi R., primary, Schran, Simon, primary, Persa, Oana-Diana, primary, Aguilar, Claire, primary, Thelen, Martin, primary, Lehmann, Jonas, primary, Garcia-Marquez, Maria A., primary, Wennhold, Kerstin, primary, Preugszat, Ella, primary, Zentis, Peter, primary, von Bergwelt-Baildon, Michael S., primary, Quaas, Alexander, primary, Bruns, Christiane J., primary, Kurschat, Christine, primary, Mauch, Cornelia, primary, Löser, Heike, primary, Stippel, Dirk L., primary, and Schlößer, Hans A., primary
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- 2023
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26. Parameter Investigation for the In-Situ Hybridization Process by Deep Drawing of Dry Fiber-Metal-Laminates
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Kruse, Moritz, Lehmann, Jonas, Ben Khalifa, Noomane, Liewald, Mathias, Verl, Alexander, Bauernhansl, Thomas, and Möhring, Hans-Christian
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Deep drawing ,Engineering ,Fiber-metal-laminates ,Formability - Abstract
A newly developed in-situ-hybridization single-step process for the manufacturing of formed fiber-metal-laminates (FML) was introduced in previous works. During the deep drawing process, the fabric layer is infiltrated with a low-viscous thermoplastic matrix in a resin transfer molding process. The matrix polymerizes after the forming is completed. First parts could be manufactured successfully, but the influence of many process parameters continues to be unknown. The interaction of fiber and metal layer (DC04) on the formability of the FML is experimentally investigated by the deep drawing of FML parts without matrix injection. Parameters tested were the blank holding force, tool lubrication as well as different surface treatments of the metal sheet. Fiber breakage was observed after deep drawing of the dry FML. The deep drawn metal sheets were analyzed by surface strain measurements. The formability was then assessed by comparing the measured surface strains to a forming limit curve obtained by Nakajima-tests of the metal-fiber-metal stack. The results of the parameter investigation during dry deep drawing are analyzed to understand the influence of the process parameters on the in-situ hybridization process containing matrix injection.
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- 2023
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27. Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells
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Thelen, Martin, primary, Keller, Diandra, additional, Lehmann, Jonas, additional, Wennhold, Kerstin, additional, Weitz, Hendrik, additional, Bauer, Eugen, additional, Gathof, Birgit, additional, Brüggemann, Monika, additional, Kotrova, Michaela, additional, Quaas, Alexander, additional, Mallmann, Christoph, additional, Chon, Seung-Hun, additional, Hillmer, Axel M, additional, Bruns, Christiane, additional, von Bergwelt-Baildon, Michael, additional, Garcia-Marquez, Maria Alejandra, additional, and Schlößer, Hans Anton, additional
- Published
- 2022
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28. TissueGrinder, a novel technology for rapid generation of patient-derived single cell suspensions from solid tumors by mechanical tissue dissociation
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Scheuermann, Stefan, primary, Lehmann, Jonas M., additional, Ramani Mohan, Ramkumar, additional, Reißfelder, Christoph, additional, Rückert, Felix, additional, Langejürgen, Jens, additional, and Pallavi, Prama, additional
- Published
- 2022
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29. Electrospun aluminum silicate nanofibers as novel support material for immobilization of alcohol dehydrogenase
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Aziz, Iram, primary, Sigurdardóttir, Sigyn Björk, additional, Lehmann, Jonas, additional, Nambi, Ashwin, additional, Zhang, Wenjing, additional, Pinelo, Manuel, additional, and Kaiser, Andreas, additional
- Published
- 2022
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30. Electrospun aluminum silicate nanofibers as novel support material for immobilization of alcohol dehydrogenase
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Aziz, Iram, Sigurdardóttir, Sigyn Björk, Lehmann, Jonas, Nambi, Ashwin, Zhang, Wenjing, Pinelo, Manuel, Kaiser, Andreas, Aziz, Iram, Sigurdardóttir, Sigyn Björk, Lehmann, Jonas, Nambi, Ashwin, Zhang, Wenjing, Pinelo, Manuel, and Kaiser, Andreas
- Abstract
Ceramic materials with high surface area, large and open porosity are considered excellent supports for enzyme immobilization owing to their stability and reusability. The present study reports the electrospinning of aluminum silicate nanofiber supports from sol-gel precursors, the impact of different fabrication parameters on the microstructure of the nanofibers and their performance in enzyme immobilization. A change in nanofiber diameter and pore size of the alumina silicate nanofibers was observed upon varying specific processing parameters, such as the sol- composition (precursor and polymer concentration), the electrospinning parameters and the subsequent heat treatment (calcination temperature). The enzyme, alcohol dehydrogenase, was immobilized on the aluminum silicate nanofibers by physical adsorption and covalent bonding. Activity retention of 17 and 42 % was obtained after 12 days of storage and repeated reaction cycles for physically adsorbed and covalently bonded ADH, respectively. The immobilization of alcohol dehydrogenase on aluminum silicate nanofibers resulted in high enzyme loading and activity retention. However, a marked decrease in the enzyme activity during storage for physically adsorbed enzymes was observed, which was ascribed to leakage of the enzymes from the nanofibers. Such fibers are also able to improve enzyme stability and promote a higher residual activity of the immobilized enzyme as compared to the free enzyme. The results shown in this study thus suggest that aluminum silicate nanofibers, with their high surface area, are promising support materials for the immobilization of enzymes.
- Published
- 2022
31. Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance
- Author
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Datta, Rabi R., Schran, Simon, Persa, Oana-Diana, Aguilar, Claire, Thelen, Martin, Lehmann, Jonas, Garcia-Marquez, Maria A., Wennhold, Kerstin, Preugszat, Ella, Zentis, Peter, Von Bergwelt-Baildon, Michael S., Quaas, Alexander, Bruns, Christiane J., Kurschat, Christine, Mauch, Cornelia, Loeser, Heike, Stippel, Dirk L., Schloesser, Hans A., Datta, Rabi R., Schran, Simon, Persa, Oana-Diana, Aguilar, Claire, Thelen, Martin, Lehmann, Jonas, Garcia-Marquez, Maria A., Wennhold, Kerstin, Preugszat, Ella, Zentis, Peter, Von Bergwelt-Baildon, Michael S., Quaas, Alexander, Bruns, Christiane J., Kurschat, Christine, Mauch, Cornelia, Loeser, Heike, Stippel, Dirk L., and Schloesser, Hans A.
- Abstract
Purpose: An increased risk to develop cancer is one of the most challenging negative side effects of long-term immunosuppression in organ transplant recipients and impaired cancer immunosur-veillance is assumed as underlying mechanism. This study aims to elucidate transplant-related changes in the tumor immune micro-environment (TME) of cancer. Experimental Design: Data from 123 organ transplant recipients (kidney, heart, lung, and liver) were compared with historic data from non-immunosuppressed patients. Digital image analysis of whole-section slides was used to assess abundance and spatial distribution of T cells and tertiary lymphoid structures (TLS) in the TME of 117 tumor samples. Expression of programmed cell death 1 ligand 1 (PD-L1) and human-leucocyte-antigen class I (HLA-I) was assessed on tissue microarrays. Results: We found a remarkably reduced immune infiltrate in the center tumor (CT) regions as well as the invasive margins (IM) of post-transplant cancers. These differences were more pronounced in the IM than in the CT and larger for CD8 thorn T cells than for CD3 thorn T cells. The Immune-score integrating results from CT and IM was also lower in transplant recipients. Density of TLS was lower in cancer samples of transplant recipients. The fraction of samples with PD-L1 expression was higher in controls whereas decreased expression of HLA-I was more common in transplant recipients. Conclusions: Our study demonstrates the impact of immunosup-pression on the TME and supports impaired cancer immunosurveil-lance as important cause of post-transplant cancer. Modern immu-nosuppressive protocols and cancer therapies should consider the distinct immune microenvironment of post-transplant malignancies.
- Published
- 2022
32. Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells
- Author
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Thelen, Martin, Keller, Diandra, Lehmann, Jonas, Wennhold, Kerstin, Weitz, Hendrik, Bauer, Eugen, Gathof, Birgit, Brueggemann, Monika, Kotrova, Michaela, Quaas, Alexander, Mallmann, Christoph, Chon, Seung-Hun, Hillmer, Axel M., Bruns, Christiane, von Bergwelt-Baildon, Michael, Garcia-Marquez, Maria Alejandra, Schloesser, Hans Anton, Thelen, Martin, Keller, Diandra, Lehmann, Jonas, Wennhold, Kerstin, Weitz, Hendrik, Bauer, Eugen, Gathof, Birgit, Brueggemann, Monika, Kotrova, Michaela, Quaas, Alexander, Mallmann, Christoph, Chon, Seung-Hun, Hillmer, Axel M., Bruns, Christiane, von Bergwelt-Baildon, Michael, Garcia-Marquez, Maria Alejandra, and Schloesser, Hans Anton
- Abstract
BackgroundSpecific immune response is a hallmark of cancer immunotherapy and shared tumor-associated antigens (TAAs) are important targets. Recent advances using combined cellular therapy against multiple TAAs renewed the interest in this class of antigens. Our study aims to determine the role of TAAs in esophago-gastric adenocarcinoma (EGA).MethodsRNA expression was assessed by NanoString in tumor samples of 41 treatment-nai''ve EGA patients. Endogenous T cell and antibody responses against the 10 most relevant TAAs were determined by FluoroSpot and protein-bound bead assays. Digital image analysis was used to evaluate the correlation of TAAs and T-cell abundance. T-cell receptor sequencing, in vitro expansion with autologous CD40-activated B cells (CD40Bs) and in vitro cytotoxicity assays were applied to determine specific expansion, clonality and cytotoxic activity of expanded T cells.Results68.3% of patients expressed >= 5 TAAs simultaneously with coregulated clusters, which were similar to data from The Cancer Genome Atlas (n=505). Endogenous cellular or humoral responses against >= 1 TAA were detectable in 75.0% and 53.7% of patients, respectively. We found a correlation of T-cell abundance and the expression of TAAs and genes related to antigen presentation. TAA-specific T-cell responses were polyclonal, could be induced or enhanced using autologous CD40Bs and were cytotoxic in vitro. Despite the frequent expression of TAAs co-occurrence with immune responses was rare.ConclusionsWe identified the most relevant TAAs in EGA for monitoring of clinical trials and as therapeutic targets. Antigen-escape rather than missing immune response should be considered as mechanism underlying immunotherapy resistance of EGA.
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- 2022
33. Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance
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Datta, Rabi R., primary, Schran, Simon, additional, Persa, Oana-Diana, additional, Aguilar, Claire, additional, Thelen, Martin, additional, Lehmann, Jonas, additional, Garcia-Marquez, Maria A., additional, Wennhold, Kerstin, additional, Preugszat, Ella, additional, Zentis, Peter, additional, von Bergwelt-Baildon, Michael S., additional, Quaas, Alexander, additional, Bruns, Christiane J., additional, Kurschat, Christine, additional, Mauch, Cornelia, additional, Löser, Heike, additional, Stippel, Dirk L., additional, and Schlößer, Hans A., additional
- Published
- 2022
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34. Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma
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Garcia-Marquez, Maria A., primary, Thelen, Martin, additional, Reinke, Sarah, additional, Keller, Diandra, additional, Wennhold, Kerstin, additional, Lehmann, Jonas, additional, Veldman, Johanna, additional, Borchmann, Sven, additional, Rosenwald, Andreas, additional, Sasse, Stephanie, additional, Diepstra, Arjan, additional, Borchmann, Peter, additional, Engert, Andreas, additional, Klapper, Wolfram, additional, von Bergwelt-Baildon, Michael, additional, Bröckelmann, Paul J., additional, and Schlößer, Hans A., additional
- Published
- 2021
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35. CD86(+) Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
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Wennhold, Kerstin, Thelen, Martin, Lehmann, Jonas, Schran, Simon, Preugszat, Ella, Garcia-Marquez, Maria, Lechner, Axel, Shimabukuro-Vornhagen, Alexander, Ercanoglu, Meryem S., Klein, Florian, Thangarajah, Fabinshy, Eidt, Sebastian, Loeser, Heike, Bruns, Christiane, Quaas, Alexander, von Bergwelt-Baildon, Michael, Schloesser, Hans A., Wennhold, Kerstin, Thelen, Martin, Lehmann, Jonas, Schran, Simon, Preugszat, Ella, Garcia-Marquez, Maria, Lechner, Axel, Shimabukuro-Vornhagen, Alexander, Ercanoglu, Meryem S., Klein, Florian, Thangarajah, Fabinshy, Eidt, Sebastian, Loeser, Heike, Bruns, Christiane, Quaas, Alexander, von Bergwelt-Baildon, Michael, and Schloesser, Hans A.
- Abstract
The role of B cells in antitumor immunity and their impact on emerging immunotherapies is increasingly gaining attention. B-cell effector functions include not only secretion of antibodies, but also presentation of antigens to T cells. A physiologic B-cell subset with immunostimulatory properties was described in humans, defined by a high expression of CD86 and down regulation of CD21. We used multicolor flow cytometry and IHC to elucidate abundance and spatial distribution of these antigen-presenting B cells (BAPC) in blood (peripheral blood mononuclear cells, PBMC) and tumor samples of 237 patients with cancer. Antigen-specific T-cell responses to cancer testis antigens were determined using tetramer staining and sorted BAPCs in FluoroSpot assays for selected patients. We found that BAPCs were increased in the tumor microenvironment of 9 of 10 analyzed cancer types with site-specific variation. BAPCs were not increased in renal cell carcinoma, whereas we found a systemic increase with elevated fractions in tumor-infiltrating lymphocytes (TIL) and PBMCs of patients with colorectal cancer and gastroesophageal adenocarcinoma. BA PCs were localized in lymphoid follicles of tertiary lymphoid structures (TLS) and were enriched in tumors with increased numbers of TLSs. BAPCs isolated from tumor-draining lymph nodes of patients with cancer showed increased percentages of tumor antigen-specific B cells and induced responses of autologous T cells in vitro. Our results highlight the relevance of BAPCs as professional antigen-presenting cells in tumor immunity and provide a mechanistic rationale for the observed correlation of B-cell abundance and response to immune checkpoint inhibition.
- Published
- 2021
36. CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses
- Author
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Wennhold, Kerstin, primary, Thelen, Martin, additional, Lehmann, Jonas, additional, Schran, Simon, additional, Preugszat, Ella, additional, Garcia-Marquez, Maria, additional, Lechner, Axel, additional, Shimabukuro-Vornhagen, Alexander, additional, Ercanoglu, Meryem S., additional, Klein, Florian, additional, Thangarajah, Fabinshy, additional, Eidt, Sebastian, additional, Löser, Heike, additional, Bruns, Christiane, additional, Quaas, Alexander, additional, von Bergwelt-Baildon, Michael, additional, and Schlößer, Hans A., additional
- Published
- 2021
- Full Text
- View/download PDF
37. TissueGrinder, a novel technology for rapid generation of patient-derived single cell suspensions from solid tumors by mechanical tissue dissociation
- Author
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Scheuermann, Stefan, primary, Lehmann, Jonas M., additional, Mohan, Ramkumar Ramani, additional, Reißfelder, Christoph, additional, Rückert, Felix, additional, Langejürgen, Jens, additional, and Pallavi, Prama, additional
- Published
- 2021
- Full Text
- View/download PDF
38. Introducing Residual Stresses on Sheet Metals by Slide Hardening under Stress Superposition
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Lehmann, Jonas, primary, Chen, Hui, additional, Kruse, Moritz, additional, and Ben Khalifa, Noomane, additional
- Published
- 2021
- Full Text
- View/download PDF
39. Towards additive manufacturing of dielectric accelerating structures
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Kellermeier, Max, primary, Zinsli, Simon, additional, Dorda, Ulrich, additional, Ischebeck, Rasmus, additional, Lehmann, Jonas, additional, Hermann, Benedikt, additional, Flöttmann, Klaus, additional, Lemery, François, additional, Dinter, Hannes, additional, Lombosi, Csaba, additional, Magjar, Marijo, additional, Stingelin, Lukas, additional, Hillert, Wolfgang, additional, and Aßmann, Ralph, additional
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- 2020
- Full Text
- View/download PDF
40. Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction
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Lehmann, Michael H., Lehmann, Jonas M., and Erfle, Volker
- Subjects
autophagy ,viruses ,Mini Review ,Immunology ,Simian Acquired Immunodeficiency Syndrome ,HIV Infections ,virus ,astrocyte ,Animals ,Humans ,nef Gene Products, Human Immunodeficiency Virus ,Chemokine CCL2 ,Neurons ,chemokine ,virus diseases ,neuron ,AIDS ,Gene Expression Regulation ,inflammation ,Blood-Brain Barrier ,Astrocytes ,Host-Pathogen Interactions ,Disease Progression ,HIV-1 ,Simian Immunodeficiency Virus ,dementia - Abstract
C-C motif chemokine ligand 2 (CCL2) is a chemoattractant for leukocytes including monocytes, T cells, and natural killer cells and it plays an important role in maintaining the integrity and function of the brain. However, there is accumulating evidence that many neurological diseases are attributable to a dysregulation of CCL2 expression. Acquired immune deficiency syndrome (AIDS) encephalopathy is a severe and frequent complication in individuals infected with the human immunodeficiency virus (HIV) or the simian immunodeficiency virus (SIV). The HIV and SIV Nef protein, a progression factor in AIDS pathology, can be transferred by microvesicles including exosomes and tunneling nanotubes (TNT) within the host even to uninfected cells, and Nef can induce CCL2 expression. This review focuses on findings which collectively add new insights on how Nef-induced CCL2 expression contributes to neurotropism and neurovirulence of HIV and SIV and elucidates why adjuvant targeting of CCL2 could be a therapeutic option for HIV-infected persons.
- Published
- 2019
41. Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction
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Lehmann, Michael H., Lehmann, Jonas M., and Erfle, Volker
- Subjects
ddc - Published
- 2018
42. Influence of carbon nanoparticle modification on the mechanical and electrical properties of epoxy in small volumes
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Leopold, Christian, Augustin, Till, Schwebler, Thomas, Lehmann, Jonas, Liebig, Wilfried V., Fiedler, Bodo, Leopold, Christian, Augustin, Till, Schwebler, Thomas, Lehmann, Jonas, Liebig, Wilfried V., and Fiedler, Bodo
- Abstract
The influence of nanoparticle morphology and filler content on the mechanical and electrical properties of carbon nanoparticle modified epoxy is investigated regarding small volumes. Three types of particles, representing spherical, tubular and layered morphologies are used. A clear size effect of increasing true failure strength with decreasing volume is found for neat and carbon black modified epoxy. Carbon nanotube (CNT) modified epoxy exhibits high potential for strength increase, but dispersion and purity are critical. In few layer graphene modified epoxy, particles are larger than statistically distributed defects and initiate cracks, counteracting any size effect. Different toughness increasing mechanisms on the nano- and micro-scale depending on particle morphology are discussed based on scanning electron microscopy images. Electrical percolation thresholds in the small volume fibres are significantly higher compared to bulk volume, with CNT being found to be the most suitable morphology to form electrical conductive paths. Good correlation between electrical resistance change and stress strain behaviour under tensile loads is observed. The results show the possibility to detect internal damage in small volumes by measuring electrical resistance and therefore indicate to the high potential for using CNT modified polymers in fibre reinforced plastics as a multifunctional, self-monitoring material with improved mechanical properties.
- Published
- 2018
43. Enzyme Immobilization on Inorganic Surfaces for Membrane Reactor Applications: Mass Transfer Challenges, Enzyme Leakage and Reuse of Materials
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Sigurdardóttir, Sigyn Björk, primary, Lehmann, Jonas, additional, Ovtar, Simona, additional, Grivel, Jean‐Claude, additional, Negra, Michela Della, additional, Kaiser, Andreas, additional, and Pinelo, Manuel, additional
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- 2018
- Full Text
- View/download PDF
44. Serotonin Shapes the Migratory Potential of NK Cells - An in vitro Approach
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Zimmer, Philipp, Bloch, Wilhelm, Kieven, Markus, Loevenich, Lukas, Lehmann, Jonas, Holthaus, Michelle, Theurich, Sebastian, Schenk, Alexander, Zimmer, Philipp, Bloch, Wilhelm, Kieven, Markus, Loevenich, Lukas, Lehmann, Jonas, Holthaus, Michelle, Theurich, Sebastian, and Schenk, Alexander
- Abstract
Increased serotonin (5-HT) levels have been shown to influence natural killer cell (NK cell) function. Acute exercise mobilizes and activates NK cells and further increases serum 5-HT concentrations in a dose-dependent manner. The aim of this study was to investigate the impact of different serum 5-HT concentrations on NK cell migratory potential and cytotoxicity. The human NK cell line KHYG-1 was assigned to 4 conditions, including 3 physiological concentrations of 5-HT (100, 130 or 170 mu g/l 5-HT) and one control condition. NK cells were analyzed regarding cytotoxicity, migratory potential and expression of adhesion molecules. No treatment effect on NK cell cytotoxicity and expression of integrin subunits was detected. Migratory potential was increased in a dose dependent manner, indicating the highest protease activity in cells that were incubated with 170 mu g/l 5-HT (170 mu g/l vs. control, p < 0.001, 170 mu g/l vs. 100 mu g/l, p < 0.001; 170 mu g/l vs. 130 mu g/l, p = 0.003; 130 mu g/l vs. control, p < 0.001, 130 mu g/l vs. 100 mu g/l, p < 0.001). These results suggest that elevated 5-HT serum levels play a mediating role in NK cell function. As exercise has been shown to be involved in NK cell mobilization and redistribution, the influence of 5-HT should be investigated in ex vivo and in vivo experiments.
- Published
- 2017
45. Lehmann, Jonas
- Author
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Lehmann, Jonas and Lehmann, Jonas
- Published
- 2017
46. Multi-messenger Observations of a Binary Neutron Star Merger
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Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Afrough, M., Agarwal, B., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Allen, B., Allen, G., Allocca, A., Altin, P. A., Amato, A., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arnaud, N., Arun, K. G., Ascenzi, S., Ashton, G., Ast, M., Aston, S. M., Astone, P., Atallah, D. V., Aufmuth, P., Aulbert, C., AultONeal, K., Austin, C., Avila-Alvarez, A., Babak, S., Bacon, P., Bader, M. K. M., Bae, S., Baker, P. T., Baldaccini, F., Ballardin, G., Ballmer, S. W., Banagiri, S., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barkett, K., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Barthelmy, S. D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Beer, C., Bejger, M., Belahcene, I., Bell, A. S., Berger, B. K., Bergmann, G., Bero, J. J., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. A., Billingsley, G., Billman, C. R., Birch, Johnny, Birney, Ross, Birnholtz, O., Biscans, S., Biscoveanu, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bock, O., Bode, N., Boer, M., Bogaert, G., Bohe, A., Bondu, F., Bonilla, E., Bonnand, R., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossie, K., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Branchesi, M., Brau, J. E., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J. E., Brooks, A. F., Brown, D. A., Brown, D. D., Brunett, S., Buchanan, C. C., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Canizares, P., Cannon, K. C., Cao, H., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Carney, M. F., Diaz, J. Casanueva, Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., Cerdá-Durán, P., Cerretani, G., Cesarini, E., Chamberlin, S. J., Chan, Marina, Chao, S., Charlton, P., Chase, E., Chassande-Mottin, E., Chatterjee, D., Chatziioannou, K., Cheeseboro, B. D., Chen, H. Y., Chen, X., Chen, Y. B., Cheng, Haynes Pak Hay, Chia, H., Chincarini, A., Chiummo, A., Chmiel, T., Cho, H. S., Cho, M., Chow, J. H., Christensen, N., Chu, Q., Chua, A. J. K., Chua, S., Chung, A. K. W., Chung, S., Ciani, G., Ciolfi, R., Cirelli, C. E., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Cleva, F., Cocchieri, C., Coccia, E., Cohadon, P.-F., Cohen, D., Colla, A., Collette, C. G., Cominsky, L. R., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corley, K. R., Cornish, N., Corsi, A., Cortese, S., Costa, C. A., Coughlin, M. W., Coughlin, S. B., Coulon, J.-P., Countryman, S. T., Couvares, P., Covas, P. B., Cowan, E. E., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Crowder, S. G., Cullen, T. J., Cumming, A., Cunningham, L., Cuoco, E., Dal Canton, T., Dálya, G., Danilishin, S. L., D’Antonio, S., Danzmann, K., Dasgupta, A., Da Silva Costa, C. F., Dattilo, V., Dave, I., Davier, M., Davis, D., Daw, E. J., Day, B., De, S., DeBra, D., Degallaix, J., Laurentis, M. De, Deléglise, S., Pozzo, W. Del, Demos, N., Denker, T., Dent, T., Pietri, R. De, Dergachev, V., Rosa, R. De, DeRosa, R. T., Rossi, C. De, DeSalvo, R., Varona, O. de, Devenson, J., Dhurandhar, S., Díaz, M. C., Fiore, L. Di, Giovanni, M. Di, Girolamo, T. Di, Lieto, A. Di, Pace, S. Di, Palma, I. Di, Renzo, F. Di, Doctor, Z., Dolique, V., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Douglas, R., Álvarez, M. Dovale, Downes, T. P., Drago, M., Dreissigacker, C., Driggers, J. C., Du, Z., Ducrot, M., Dupej, P., Dwyer, S. E., Edo, T. B., Edwards, M. C., Effler, A., Eggenstein, H.-B., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenstein, R. A., Essick, R. C., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fee, C., Fehrmann, H., Feicht, J., Fejer, M. M., Fernandez-Galiana, A., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Finstad, D., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fitz-Axen, M., Flaminio, R., Fletcher, M., Fong, H., Font, J. A., Forsyth, P. W. F., Forsyth, S. S., Fournier, J.-D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fries, E. M., Fritschel, P., Frolov, V. V., Fulda, P., Fyffe, M., Gabbard, H., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gammaitoni, L., Ganija, M. R., Gaonkar, S. G., Garcia-Quiros, C., Garufi, F., Gateley, B., Gaudio, S., Gaur, G., Gayathri, V., Gehrels, N., Gemme, G., Genin, E., Gennai, A., George, D., George, J., Gergely, L., Germain, V., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gill, K., Glover, L., Goetz, E., Goetz, R., Gomes, Sean, Goncharov, B., González, G., Castro, J. M. Gonzalez, Gopakumar, A., Gorodetsky, M. L., Gossan, S. E., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Granata, M., Grant, A., Gras, S., Gray, C., Greco, G., Green, A. C., Gretarsson, E. M., Griswold, B., Groot, P., Grote, H., Grunewald, S., Gruning, P., Guidi, G. M., Guo, Xueshi, Gupta, A., Gupta, M. K., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Halim, O., Hall, B. R., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hanson, J., Hardwick, T., Harms, J., Harry, G. M., Harry, I. W., Hart, M. J., Haster, C.-J., Haughian, K., Healy, J., Heidmann, A., Heintze, M. C., Heitmann, H., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennig, J., Heptonstall, A. W., Heurs, M., Hild, S., Hinderer, T., Hoak, D., Hofman, D., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Houston, E. A., Howell, E. J., Hreibi, A., Hu, Y. M., Huerta, E. A., Huet, D., Hughey, B., Husa, S., Huttner, S. H., Huynh-Dinh, T., Indik, N., Inta, R., Intini, G., Isa, H. N., Isac, J.-M., Isi, M., Iyer, B. R., Izumi, K., Jacqmin, T., Jani, K., Jaranowski, P., Jawahar, S., Jiménez-Forteza, F., Johnson, W. W., Jones, D. I., Jones, Rasmus Thomas, Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karki, S., Karvinen, K. S., Kasprzack, M., Katolik, M., Katsavounidis, E., Katzman, W., Kaufer, S., Kawabe, K., Kéfélian, F., Keitel, D., Kemball, A. J., Kennedy, R., Kent, C., Key, J. S., Khalili, F. Y., Khan, I., Khan, S., Khan, Zarghuna, Khazanov, E. A., Kijbunchoo, N., Kim, Chunglee, Kim, J. C., Kim, K., Kim, W., Kim, W. S., Kim, Y.-M., Kimbrell, S. J., King, E. J., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klimenko, S., Knowles, T. D., Koch, P., Koehlenbeck, S. M., Koley, S., Kondrashov, V., Kontos, A., Korobko, M., Korth, W. Z., Kowalska, I., Kozak, D. B., Krämer, C., Kringel, V., Krishnan, B., Królak, A., Kuehn, G., Kumar, P., Kumar, R., Kumar, Shailesh, Kuo, L., Kutynia, A., Kwang, S., Lackey, B. D., Lai, K. H., Landry, Mark, Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., Larson, S. L., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lee, C. H., Lee, H. K., Lee, H. M., Lee, H. W., Lee, Kelvin, Lehmann, Jonas, Lenon, A., Leonardi, M., Leroy, N., Letendre, N., Levin, Y., Li, T. G. F., Linker, S. D., Littenberg, T. B., Liu, J., Lo, R. K. L., Lockerbie, N. A., London, L. T., Lord, J. E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Lynch, R., Ma, Y., Macas, R., Macfoy, S., Machenschalk, B., MacInnis, M., Macleod, D. M., Hernandez, I. Magaña, Magaña-Sandoval, F., Zertuche, L. Magaña, Magee, R. M., Majorana, E., Maksimovic, I., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsh, P., Martelli, F., Martellini, L., Martin, I. W., Martin, R. M., Martynov, D. V., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Matichard, F., Matone, L., Mavalvala, N., Mazumder, N., McCarthy, R., McClelland, D. E., McCormick, S., McCuller, L., McGuire, S. C., McIntyre, G., McIver, J., McManus, D. J., McNeill, L., McRae, T., McWilliams, S. T., Meacher, D., Meadors, G. D., Mehmet, M., Meidam, J., Mejuto-Villa, E., Melatos, A., Mendell, G., Mercer, R. A., Merilh, E. L., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Miao, H., Michel, C., Middleton, H., Mikhailov, E. E., Milano, L., Miller, A. L., Miller, B. B., Miller, J., Millhouse, M., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Ming, J., Mishra, C., Mitra, Susanta, Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Moffa, D., Moggi, A., Mogushi, K., Mohan, M., Mohapatra, S. R. P., Montani, M., Moore, C. J., Moraru, D., Moreno, G., Morriss, S. R., Mours, B., Mow-Lowry, C. M., Mueller, G., Muir, A. W., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Muratore, M., Murray, P. G., Napier, K., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Nevin, L., Newport, J. M., Newton, G., Ng, K. K. Y., Nguyen, P., Nguyen, T. T., Nichols, D., Nielsen, A. B., Nissanke, S., Nitz, A., Noack, A., Nocera, F., Nolting, D., North, C., Nuttall, L. K., Oberling, J., O’Dea, G. D., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Okada, M. A., Oliver, M., Oppermann, P., Oram, Richard J., O’Reilly, B., Ormiston, R., Ortega, L. F., O’Shaughnessy, R., Ossokine, S., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Page, J., Page, M. A., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pal-Singh, A., Pan, Howard, Pan, Huang-Wei, Pang, B., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Papa, M. A., Parida, A., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patil, M., Patricelli, B., Pearlstone, B. L., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Penn, S., Perez, C. J., Perreca, A., Perri, L. M., Pfeiffer, H. P., Phelps, M., Piccinni, O. J., Pichot, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Pirello, M., Pitkin, M., Poe, M., Poggiani, R., Popolizio, P., Porter, E. K., Post, A., Powell, J., Prasad, J., Pratt, J. W. W., Pratten, G., Predoi, V., Prestegard, T., Price, L. R., Prijatelj, M., Principe, M., Privitera, S., Prodi, G. A., Prokhorov, L. G., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qi, Hanhong, Quetschke, V., Quintero, E. A., Quitzow-James, R., Raab, F. J., Rabeling, D. S., Radkins, H., Raffai, P., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramos-Buades, A., Rapagnani, P., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Ren, W., Reyes, S. 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- Abstract
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 . An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ∼10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position and days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta.
- Published
- 2017
47. Serotonin Shapes the Migratory Potential of NK Cells – An in vitro Approach
- Author
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Zimmer, Philipp, additional, Bloch, Wilhelm, additional, Kieven, Markus, additional, Lövenich, Lukas, additional, Lehmann, Jonas, additional, Holthaus, Michelle, additional, Theurich, Sebastian, additional, and Schenk, Alexander, additional
- Published
- 2017
- Full Text
- View/download PDF
48. Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives.
- Author
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Zimmer, Philipp, Schenk, Alexander, Kieven, Markus, Holthaus, Michelle, Lehmann, Jonas, Lövenich, Lukas, and Bloch, Wilhelm
- Subjects
CYTOTOXIC T cells ,PHYSICAL activity ,CYTOKINES ,CD antigens ,AEROBIC exercises - Abstract
With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field. [ABSTRACT FROM AUTHOR]
- Published
- 2017
49. An overview of the WPI benchmark suite
- Author
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Finkel, David, primary, Kinicki, Robert E., additional, and Lehmann, Jonas A., additional
- Published
- 1991
- Full Text
- View/download PDF
50. Tertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation.
- Author
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Lehmann J, Thelen M, Kreer C, Schran S, García-Marquez MA, Cisic I, Siepmann K, Hagen EM, Eckel HNC, Lohneis P, Kruger S, Boeck S, Ormanns S, Rudelius M, Werner J, Popp F, Klein F, von Bergwelt-Baildon MS, Bruns CJ, Quaas A, Wennhold K, and Schlößer HA
- Abstract
Tertiary lymphoid structures (TLS) in cancer are considered ectopic hotspots for immune activation that are similar to lymphoid follicles in secondary lymphoid organs (SLO). This study elucidates shared and TLS/SLO-specific features in pancreatic ductal adenocarcinoma (PDAC). TLS abundance was related to superior survival and T-cell abundance in 110 treatment-naïve PDAC samples, underlining their clinical relevance. Immunofluorescence microscopy identified structural homologies between TLS and SLO. In RNA-expression analyses of laser-microdissected TLS and paired SLOs, we observed largely overlapping expression patterns of immune-related gene clusters, but distinct expression patterns of T-cell and complement-associated genes. Immune cells in TLS expressed essential markers of germinal center formation. Increased activation of tumor-draining lymph nodes in patients with high numbers of TLS highlights the relevance of these tumor-related structures to systemic immune response. In line with this, we identified an overlap of expanded B-cell receptor clonotypes in TLS and SLO, which suggests a vivid cross-talk between the two compartments. . We conclude that combined therapeutic approaches exploiting TLS-mediated antitumor immune responses may improve susceptibility of PDAC to immunotherapy.
- Published
- 2024
- Full Text
- View/download PDF
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