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8 results on '"Lehman, Terri"'

3. Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs

Author

Ungerleider, Nathan A., primary, Jain, Vaibhav, additional, Wang, Yiping, additional, Maness, Nicholas J., additional, Blair, Robert V., additional, Alvarez, Xavier, additional, Midkiff, Cecily, additional, Kolson, Dennis, additional, Bai, Shanshan, additional, Roberts, Claire, additional, Moss, Walter N., additional, Wang, Xia, additional, Serfecz, Jacqueline, additional, Seddon, Michael, additional, Lehman, Terri, additional, Ma, Tianfang, additional, Dong, Yan, additional, Renne, Rolf, additional, Tibbetts, Scott A., additional, and Flemington, Erik K., additional

Published
2019
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4. The Epstein Barr virus circRNAome

Author

Ungerleider, Nathan, primary, Concha, Monica, additional, Lin, Zhen, additional, Roberts, Claire, additional, Wang, Xia, additional, Cao, Subing, additional, Baddoo, Melody, additional, Moss, Walter N., additional, Yu, Yi, additional, Seddon, Michael, additional, Lehman, Terri, additional, Tibbetts, Scott, additional, Renne, Rolf, additional, Dong, Yan, additional, and Flemington, Erik K., additional

Published
2018
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7. CYP3A43 Pro340Ala Polymorphism and Prostate Cancer Risk in African Americans and Caucasians

Author

Stone, Angie, primary, Ratnasinghe, Luke D., additional, Emerson, Ginny L., additional, Modali, Rama, additional, Lehman, Terri, additional, Runnells, Gail, additional, Carroll, Alindria, additional, Carter, Weleetka, additional, Barnhart, Samuel, additional, Rasheed, Al A., additional, Greene, Graham, additional, Johnson, Don E., additional, Ambrosone, Christine B., additional, Kadlubar, Fred F., additional, and Lang, Nicholas P., additional

Published
2005
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8. The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers.

Author

Foley R, Marignol L, Thomas AZ, Cullen IM, Perry AS, Tewari P, O'Grady A, Kay E, Dunne B, Loftus B, Watson WR, Fitzpatrick JM, Woodson K, Lehman T, Hollywood D, Lynch TH, and Lawler M

Subjects
Adult, Aged, Alleles, Biomarkers metabolism, Case-Control Studies, Cell Line, Tumor, Chi-Square Distribution, Cohort Studies, DNA, Neoplasm analysis, DNA, Neoplasm genetics, Disease Susceptibility, Exons, Gene Frequency, Humans, Immunohistochemistry, Kinetics, Male, Middle Aged, Odds Ratio, Probability, Prostatic Neoplasms pathology, Risk Factors, Hypoxia-Inducible Factor 1, alpha Subunit genetics, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Polymorphism, Genetic, Prostatic Neoplasms genetics, Prostatic Neoplasms metabolism
Abstract

We investigated the role of the C1772T polymorphisms in exon 12 of the Hypoxia-inducible factor-1 alpha (HIF-1alpha) gene C1772T genotype in prostate cancer (PCa) and amplification of the hypoxic response. We identified the heterozygous germline CT genotype as an increased risk factor for clinically localised prostate cancer (Odds ratio = 6.2; p < 0.0001). While immunostaining intensity for HIF-1alpha and VEGF was significantly enhanced in 75% of PCa specimens when compared to matched benign specimens (p < 0.0001), the CT genotype did not modulate the kinetics of HIF-1alpha protein expression in hypoxia in vitro, and was not associated with enhanced expression of hypoxic biomarkers. This study provides the first evidence of an increased risk for clinically localised prostate cancer in men carrying the C1772T HIF-1alpha gene polymorphism. Although our results did not suggest an association between expression of hypoxic biomarkers and genotype status, the correlation may merit further investigation.

Published
2009
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