29 results on '"Legarreta M"'
Search Results
2. Optimal design of a controlled power photovoltaic system with energy storage.
- Author
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Díaz, D., Souto, J. A., Rodríguez, A., Saavedra, S., Casares, J. J., García-Loureiro, A., Varela, R., Rodríguez-Legarreta, M. J., and Rodríguez-Aneiros, J.
- Abstract
The use of renewable energy sources to supply electricity in customer grids is a current practise in developed countries and, particularly, in the case of distributed solar energy generation grids. Even though, the environmental benefits of the practise drive to economic incentives to increase the renewable energies. However, because of the unsteady behaviour of the renewable electric energy sources (Kaldellis et al., 2006), as wind energy and solar photovoltaic production, the increment in the use of these sources produces severe fluctuations in the electric grids. Then, their electric supply to the electric grid is limited and at the same time, an accurate renewable energy production forecast is required. In this work, the feasibility of a new approach to reduce this problem is tested by the application (on a yearly basis) of a simulator of a production-storage controlled system, namely FOTOV, to be applied in the design of a photovoltaic (PV) installation. [ABSTRACT FROM AUTHOR]
- Published
- 2012
3. Effects of crossbreeding on carcass and meat quality of Mexican lambs.
- Author
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Hernández-Cruz, L., Ramírez-Bribiesca, J. E., Guerrero-Legarreta, M. I., Hernández-Mendo, O., Crosby-Galvan, M. M., and Hernández-Calva, L. M.
- Subjects
ANIMAL breeding ,MEAT quality ,CATTLE carcasses ,LAMBS ,SHEEP feeding ,PHENOTYPES - Abstract
The article discusses a study which investigated the effects of crossbreeding on meat quality and carcass of Mexican lambs. It discusses the sensorial and physiochemical characteristics of meat from hair and wool lambs under high grain diet. It explores the body proportions and carcass characteristics of wool and hair lambs. It also describes the effect of phenotype and body part on the chemical composition of lamb meat.
- Published
- 2009
4. Carotenoids digestion in African stargrass (cynodon plectostachyus) determined with in situ techniques in cattle
- Author
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Rosy G. Cruz Monterrosa, Ramírez-Bribiesca, J. E., Guerrero-Legarreta, M. I., and Hernández-Mendo, O.
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animal structures ,disappearance ,cattle ,stargrass ,organic chemicals ,in situ ,food and beverages ,Agrociencias ,macromolecular substances ,digestion ,Carotenoids ,biological factors - Abstract
"Dry matter (DM) and total carotenoids disappearane in the rumen and intestinal passage of African stargrass (AS) were measured in 4 Holstein steers using rumen In situ and a mobile nylon bag technique in duodenum, respectively. A higher proportion of DM and total carotenoids (P
5. Fenología de la frambuesa roja 'Autumn Bliss' en Guerrero, Chihuahua, México
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Parra-Quezada, R. A., Ramírez-Legarreta, M. R., Juan Luis Jacobo-Cuellar, and Arreola-Avila, J. G.
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Rubus idaeus ,calidad de fruto ,floración ,lcsh:SB1-1110 ,Agrociencias ,lcsh:Agriculture (General) ,lcsh:Plant culture ,lcsh:S1-972 ,producción - Abstract
Se estudió la fenología de la frambuesa roja Autumn Bliss en Guerrero, Chihuahua, México. Se establecieron 500 plantas de frambuesa en la primera semana de abril del 2000, a una distancia de 1.5 x 0.5 m, en 10 hileras de 50 plantas cada una. Antes de la plantación se aplicaron 60 t·ha-1 de estiércol de bovino seco. El sistema de riego fue rodado durante los primeros 30 días de establecido el cultivo, posteriormente se estableció una cinta de goteo superficial, con goteros cada metro. La nueva brotación se observó a los 30 días después de la plantación, con emisión de brotes del sistema radical y del tallo. Los nuevos brotes crecieron hasta 180 cm de longitud, los cuales iniciaron la floración en la segunda semana de julio, después de más de 90 días de crecimiento, lo que evadió el problema de heladas tardías. El número de cañas por planta fue de 6.7. El período de flor a cosecha del fruto fue de 33 a 36 días. El inicio de cosecha fue la primera semana de agosto y el final de la misma en la última semana de octubre, una vez que se registraron las primeras heladas. El peso del fruto fluctuó entre 2.6 y 3.6 g. El rendimiento registrado fue de 778 g·planta-1, estimando 10,373 t·ha-1.
6. Diapause quantitative characterization of the codling moth Cydia pomonella L. in Cuauhtémoc, Chihuahua, México,Caracterización cuantitativa de la diapausa de palomilla de la manzana Cydia pomonella L. en Cuauhtémoc, Chihuahua, México
- Author
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Juan Luis Jacobo-Cuellar, Mora-Aguilera, G., Ramírez-Legarreta, M. R., Vera-Graziano, J., Pinto, V. M., López-Collado, J., Ramírez-Guzmán, M. E., and Aceves-Navarro, L. A.
7. Statistics in research vs. research in statistics
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INMACULADA AROSTEGUI, Barrio, I., Legarreta, M. J., and Urkaregi, A.
8. Risk factors for clinical deterioration in patients admitted for COVID-19: A case-control study.
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Uranga A, Villanueva A, Lafuente I, González N, Legarreta MJ, Aguirre U, España PP, Quintana JM, and García-Gutiérrez S
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- Case-Control Studies, Female, Humans, Risk Factors, SARS-CoV-2, COVID-19, Clinical Deterioration
- Abstract
Introduction: There is controversy regarding the best predictors of clinical deterioration in COVID-19., Objective: This work aims to identify predictors of risk factors for deterioration in patients hospitalized due to COVID-19., Methods Design: Nested case-control study within a cohort., Setting: 13 acute care centers of the Osakidetza-Basque Health Service., Participants: patients hospitalized for COVID-19 with clinical deterioration-defined as onset of severe ARDS, ICU admission, or death-were considered cases. Two controls were matched to each case based on age. Sociodemographic data; comorbidities; baseline treatment; symptoms; date of onset; previous consultations; and clinical, analytical, and radiological variables were collected. An explanatory model of clinical deterioration was created by means of conditional logistic regression., Results: A total of 99 cases and 198 controls were included. According to the logistic regression analysis, the independent variables associated with clinical deterioration were: emergency department O
2 saturation ≤90% (OR 16.6; 95%CI 4-68), pathological chest X-ray (OR 5.6; 95%CI 1.7-18.4), CRP > 100 mg/dL (OR 3.62; 95%CI 1.62-8), thrombocytopenia with <150,000 platelets (OR 4; 95%CI 1.84-8.6); and a medical history of acute myocardial infarction (OR 15.7; 95%CI, 3.29-75.09), COPD (OR 3.05; 95%CI 1.43-6.5), or HT (OR 2.21; 95%CI 1.11-4.4). The model's AUC was 0.86. On the univariate analysis, female sex and presence of dry cough and sore throat were associated with better clinical progress, but were not found to be significant on the multivariate analysis., Conclusion: The variables identified could be useful in clinical practice for the detection of patients at high risk of poor outcomes., (Copyright © 2021 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.)- Published
- 2022
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9. Sex differences in suicidal behaviors and aggression in US Veterans.
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McGlade E, Bueler E, DiMuzio J, Sheth C, Legarreta M, and Yurgelun-Todd D
- Subjects
- Adolescent, Adult, Aggression, Female, Hostility, Humans, Male, Middle Aged, Sex Characteristics, Young Adult, Suicidal Ideation, Veterans
- Abstract
Female Veterans are the fastest growing demographic group in the Department of Veterans Affairs. Moreover, suicide rates in female Veterans are increasing, making suicide in female Veterans a topic of vital clinical and research significance. The current study examined the association between suicide, aggression, and mood symptoms by sex. Participants consisted of 264 Veterans (female=54, male=210) ages 18-55. Veterans completed well-validated measures of suicidal behaviors, aggression, anxiety, and depression. Male Veterans reported higher physical aggression, verbal aggression, anger, hostility, and total aggression compared to female Veterans. In male Veterans, lifetime suicidal behavior including ideation and attempts was correlated with total aggression and subscales of physical aggression, verbal aggression, anger, and hostility. However, in female Veterans lifetime suicidal behavior was significantly associated with hostility and anger. There were no between-group differences in measures of suicidal behaviors, anxious or depressive symptoms. These results suggest important differences in the association between aggression and suicidal behavior by sex. These data have significant clinical implications, as males with aggressive traits and females who endorse hostility and anger may be more likely to engage in suicidal behaviors., (Copyright © 2021. Published by Elsevier B.V.)
- Published
- 2021
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10. Cingulate white matter volume and associated cognitive and behavioral impulsivity in Veterans with a history of suicide behavior.
- Author
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Huber RS, McGlade EC, Legarreta M, Subramaniam P, Renshaw PF, and Yurgelun-Todd DA
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- Adolescent, Adult, Aged, Cognition, Humans, Impulsive Behavior, Magnetic Resonance Imaging, Middle Aged, Suicidal Ideation, Young Adult, Veterans, White Matter diagnostic imaging
- Abstract
Background: Suicide is one of the leading causes of death for military personnel and Veterans. Neuroimaging studies have revealed abnormalities in white matter tracts and brain connectivity in suicide behavior (SB); however, reports of alterations in white matter volume and its association with related behaviors are limited. The current study examined the relationship between cingulate white matter volume (WMV), impulsivity, and SB in Veterans., Methods: Fifty-two Veterans, ages 18 to 65, underwent magnetic resonance imaging on a 3T Siemens Verio scanner. Morphometric analysis of brain images was performed to evaluate differences in WMV in cingulate regions of interest. Participants completed the Columbia Suicide Severity Rating Scale to assess lifetime suicide behavior and the Barratt Impulsivity Scale (BIS) and the Continuous Performance Test (CPT) to assess impulsivity., Results: Twenty-nine Veterans had a history of suicidal ideation (SI) and 23 had a history of suicide attempts (SA). Controlling for age, sex, handedness and total white matter volume, reduced WMV was observed in the left rostral anterior cingulate cortex (rACC) in Veterans with SA relative to Veterans with SI, p = .008. Additionally, non-planning on the BIS was negatively correlated with left rACC WMV for Veterans with a history of SA, p = .04. Other subregions of the ACC WMV were negatively correlated with planning and attention impulsivity (BIS) and omission and commission errors (CPT) for attempters., Conclusions: Reduction in rACC WMV in Veterans with SA was negatively correlated with nonplanning measures. These findings are consistent with ACC involvement in inhibitory processes and build on evidence that SB is associated with neurobiological abnormalities and suggest that white matter changes may be related to actual attempts., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2021
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11. Functional connectivity of the anterior cingulate cortex in Veterans with mild traumatic brain injury.
- Author
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Sheth C, Rogowska J, Legarreta M, McGlade E, and Yurgelun-Todd D
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- Adult, Brain Concussion diagnostic imaging, Female, Gyrus Cinguli diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net diagnostic imaging, Young Adult, Attention physiology, Brain Concussion physiopathology, Connectome, Gyrus Cinguli physiopathology, Nerve Net physiopathology, Veterans
- Abstract
Background: Traumatic brain injury (TBI) is one of the most prevalent injuries in the military with mild traumatic brain injury (mTBI) accounting for approximately 70-80 % of all TBI. TBI has been associated with diffuse and focal brain changes to structures and networks underlying cognitive-emotional processing. Although the anterior cingulate cortex (ACC) plays a critical role in emotion regulation and executive function and is susceptible to mTBI, studies focusing on ACC resting state functional connectivity (rs-fc) in Veterans are limited., Methods: Veterans with mTBI (n = 49) and with no history of TBI (n = 25), ages 20-54 completed clinical assessments and an 8-minute resting state functional magnetic resonance imaging (rs-fMRI) on a 3 T Siemens scanner. Imaging results were analyzed with left and right ACC as seed regions using SPM8. Regression analyses were performed with time since injury., Results: Seed-based analysis showed increased connectivity of the left and right ACC with brain regions including middle and posterior cingulate regions, preceneus, and occipital regions in the mTBI compared to the non-TBI group., Conclusions: The rs-fMRI results indicate hyperconnectivity in Veterans with mTBI. These results are consistent with previous studies of recently concussed athletes showing ACC hyperconnectivity. Enhanced top-down control of attention networks necessary to compensate for the microstructural damage following mTBI may explain ACC hyperconnectivity post-mTBI., (Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
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12. Volume and shape analysis of the Hippocampus and amygdala in veterans with traumatic brain injury and posttraumatic stress disorder.
- Author
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Bae S, Sheth C, Legarreta M, McGlade E, Lyoo IK, and Yurgelun-Todd DA
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- Adult, Amygdala diagnostic imaging, Brain Injuries, Traumatic diagnostic imaging, Hippocampus diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Organ Size, Stress Disorders, Post-Traumatic diagnostic imaging, Amygdala pathology, Brain Injuries, Traumatic pathology, Hippocampus pathology, Stress Disorders, Post-Traumatic pathology, Veterans psychology
- Abstract
There is a need to improve the understanding of the neurobiological underpinnings of traumatic brain injury (TBI). Individuals with TBI experience comorbidities such as posttraumatic stress disorder (PTSD) with considerable symptom overlap including depression and hyperarousal, confounding the ability to identify specific TBI-related brain changes. The aims of the current study were to investigate hippocampal and amygdalar volumes in Veterans with TBI with (TBI + PTSD, n = 32) and without (TBI - PTSD, n = 25) PTSD. Shape analysis was employed to reveal any relationship between the hippocampus and depressive symptoms in TBI subgroups. 32 TBI + PTSD, 25 TBI - PTSD, and 25 age-matched healthy male Veterans underwent an MRI scan on a 3 Tesla scanner and a clinical evaluation. The TBI + PTSD and the TBI + hyperarousal (met criteria for the hyperarousal symptom cluster, regardless of PTSD diagnosis) subgroup had trend-level larger left amygdalar volume than the TBI - PTSD subgroup and the TBI - hyperarousal subgroup, respectively. However, there was no significant difference between the TBI group as a whole and healthy controls (HC). There was a significant negative correlation between the Hamilton Rating Scale for Depression score (HAM-D) and left hippocampal volume and a positive correlation between the HAM-D score and left amygdalar volume in the TBI group. Left hippocampal volume was correlated with the HAM-D score only in the TBI + PTSD and not in TBI - PTSD subgroup. Shape analyses revealed a significant correlation between the HAM-D score and the CA1 and subiculum regions of the left hippocampus. Our results suggest that the amygdala may be a neuroanatomical correlate in mediating PTSD-like symptoms in Veterans with TBI. The results of shape analysis suggest that alterations in the CA1 and subiculum subregions of hippocampus may have a role in depression and PTSD.
- Published
- 2020
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13. Neurobiological evidence of sexual dimorphism in limbic circuitry of US Veterans.
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McGlade E, Rogowska J, DiMuzio J, Bueler E, Sheth C, Legarreta M, and Yurgelun-Todd D
- Subjects
- Amygdala, Female, Humans, Magnetic Resonance Imaging, Male, Sex Characteristics, Stress Disorders, Post-Traumatic diagnostic imaging, Veterans
- Abstract
Background: Female Veterans are an increasing patient population in the Department of Veterans Affairs and may have distinct clinical and neurobiological features compared to males., Methods: Nineteen female and 19 male Veterans who met diagnostic criteria for depression/posttraumatic stress disorder (MDD/PTSD) completed diagnostic interviews, symptom measures, and resting-state neuroimaging. Participants completed clinical measures of mood and aggression in addition to magnetic resonance imaging on a 3.0 Tesla Siemens scanner., Results: Females showed increased functional connectivity between the left and right basolateral amygdala (BLA) and the left and right cerebellar and occipital lobes. Sex differences also were evident in the relationship between affective and clinical symptoms with BLA connectivity. Females showed a correlation between revenge planning and decreased connectivity between the left BLA and left occipital lobe and also a correlation between aggression and decreased connectivity between the right BLA and right mid cingulate, right and left medial frontal lobe, and right frontal lobe. Males evidenced a relationship between increased depressive symptoms and increased connectivity between the left BLA and right and left occipital lobe, left calcarine, and other areas associated with visual memory and processing, and interpretation of sensory information. Additionally, males reported higher levels of physical aggression and revenge planning compared to females., Limitations: This study included neuroimaging and self-report clinical measures. Further studies will benefit from multimodal measures, including behavioral measures of aggression., Conclusions: Results suggest that male Veterans report more aggression than females and symptoms of aggression and mood are differentially related to BLA connectivity by sex., Competing Interests: Declaration of Competing Interest The authors declare they have no conflicts of interest., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2020
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14. Increased myoinositol in the anterior cingulate cortex of veterans with a history of traumatic brain injury: a proton magnetic resonance spectroscopy study.
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Sheth C, Prescot AP, Legarreta M, Renshaw PF, McGlade E, and Yurgelun-Todd D
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- Adult, Brain Injuries, Traumatic diagnostic imaging, Female, Gyrus Cinguli diagnostic imaging, Humans, Male, Proton Magnetic Resonance Spectroscopy, Brain Injuries, Traumatic metabolism, Gliosis metabolism, Gyrus Cinguli metabolism, Inositol metabolism, Veterans
- Abstract
Traumatic brain injury (TBI) is one of the most prevalent forms of morbidity in veterans and service members, with mild traumatic brain injury (mTBI) being the most common. The diagnosis of mTBI in veterans is difficult because of mixed etiologies and high comorbidity with other disorders such as posttraumatic stress disorder (PTSD), depression, and substance use. Advanced neuroimaging techniques such as magnetic resonance spectroscopy (MRS) may be useful in identifying neurochemical alterations in TBI, which may aid the development of new targets for therapeutic intervention. Veterans with ( n = 53) and without a history of TBI ( n = 26) underwent single-voxel proton magnetic resonance spectroscopy (
1 H MRS) at 3 Tesla in the anterior cingulate cortex (ACC) using a two-dimensional J -resolved point spectroscopy sequence in addition to completing a clinical battery. TBI diagnosis was made using the research version of the Ohio State University TBI Identification Method. An increased myoinositol (mI)/H2 O ratio was observed in the ACC of the TBI group compared with the non-TBI group during the chronic stage of TBI (average of 139.7 mo after injury), which may be reflective of astrogliosis. Several metabolites in the ACC demonstrated significant associations with TBI variables, including number of TBI with loss of consciousness (LOC) and time since most severe TBI, suggesting that changes in some metabolites may be potential diagnostic and prognostic indicators. NEW & NOTEWORTHY In this study of veterans, we used a state-of-the-art neuroimaging tool to probe the neurometabolic profile of the anterior cingulate cortex in veterans with traumatic brain injury (TBI). We report significantly elevated myoinositol levels in veterans with TBI compared with those without TBI.- Published
- 2020
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15. Reduced gamma-amino butyric acid (GABA) and glutamine in the anterior cingulate cortex (ACC) of veterans exposed to trauma.
- Author
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Sheth C, Prescot AP, Legarreta M, Renshaw PF, McGlade E, and Yurgelun-Todd D
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- Adult, Cross-Sectional Studies, Female, Gyrus Cinguli diagnostic imaging, Gyrus Cinguli metabolism, Humans, Magnetic Resonance Spectroscopy methods, Male, Occupational Diseases diagnostic imaging, Occupational Diseases psychology, Sleep Initiation and Maintenance Disorders psychology, Stress Disorders, Post-Traumatic diagnostic imaging, Stress Disorders, Post-Traumatic psychology, United States, Glutamine metabolism, Occupational Diseases metabolism, Stress Disorders, Post-Traumatic metabolism, Veterans psychology, gamma-Aminobutyric Acid metabolism
- Abstract
Background: Trauma-related diagnoses such as posttraumatic stress disorder (PTSD) are prevalent in veterans. The identification of mechanisms related to stress vulnerability and development of PTSD specifically in a veteran population may aid in the prevention of PTSD and identification of novel treatment targets., Methods: Veterans with PTSD (n = 27), trauma-exposed veterans with no PTSD (TEC, n = 18) and non-trauma-exposed controls (NTEC, n = 28) underwent single-voxel proton (
1 H) magnetic resonance spectroscopy (MRS) at 3 Tesla in the dorsal anterior cingulate cortex (dACC) using a two-dimensional (2D) J-resolved point spectroscopy sequence in addition to completing a clinical battery., Results: The PTSD and TEC groups demonstrated lower gamma-amino butyric acid (GABA)/H2 O (p = 0.02) and glutamine (Gln)/H2 O (p = 0.02) in the dACC as compared to the NTEC group. The PTSD group showed a trend towards higher Glu/GABA (p = 0.053) than the NTEC group. Further, GABA/H2 O in the dACC correlated negatively with sleep symptoms in the PTSD group (p = 0.03) but not in the TEC and NTEC groups., Limitations: Cross-sectional study design, concomitant medications, single voxel measurement as opposed to global changes, absence of measure of childhood or severity of trauma and objective sleep measures, female participants not matched for menstrual cycle phase., Conclusions: Exposure to trauma in veterans may be associated with lower GABA/H2 O and Gln/H2 O in the dACC, suggesting disruption in the GABA-Gln-glutamate cycle. Further, altered Glu/GABA in the dACC in the PTSD group may indicate an excitatory-inhibitory imbalance. Further, lower GABA/H2 O in the ACC was associated with poor sleep in the PTSD group. Treatments that restore GABAergic balance may be particularly effective in reducing sleep symptoms in PTSD., (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2019
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16. Visual-Spatial Memory and Recall Test (V-SMART): validity and reliability.
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Vik P, Legarreta M, and Riffel S
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- Adolescent, Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Male, Middle Aged, Reproducibility of Results, Young Adult, Mental Recall physiology, Neuropsychological Tests standards, Spatial Memory physiology, Spatial Processing physiology
- Abstract
Objective: Nonverbal memory decline is a concern associated with aging. Visuospatial memory tests often do not distinguish between learning, recall, or retrieval, yet such distinctions may help clarify the nature of memory difficulties. Further, many visuospatial tests rely on abilities not directly related to memory (e.g. graphomotor skill). The present study examined the feasibility and initial psychometric evidence of the Visual-Spatial Memory and Recall Test (V-SMART)., Method: Ninety-nine adults (71% women) were recruited from two sources: undergraduate students (n = 37) and healthy older adults (n = 62). Volunteers completed a brief battery of cognitive tests., Results: Internal consistency and interrater reliability were strong. Principal Components Analysis supported the hypothesized learning and recall structure, and correlations with other memory tests supported external validity of the V-SMART as a visuospatial learning measure. Correlations with recall scores were less compelling yet likely reflected the intact recall among this generally healthy sample., Conclusions: These preliminary findings support the V-SMART as a visuospatial memory test. Evidence for validity was acceptable for learning indices; further examination of recall measures is needed.
- Published
- 2018
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17. Alterations in anterior cingulate cortex myoinositol and aggression in veterans with suicidal behavior: A proton magnetic resonance spectroscopy study.
- Author
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Sheth C, Prescot A, Bueler E, DiMuzio J, Legarreta M, Renshaw PF, Yurgelun-Todd D, and McGlade E
- Subjects
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Proton Magnetic Resonance Spectroscopy, Suicidal Ideation, Young Adult, Aggression, Gyrus Cinguli metabolism, Inositol metabolism, Suicide, Attempted statistics & numerical data, Verbal Behavior, Veterans
- Abstract
Studies investigating the neurochemical changes that correspond with suicidal behavior (SB) have not yielded conclusive results. Suicide correlates such as aggression have been used to explore risk factors for SB. Yet the neurobiological basis for the association between aggression and SB is unclear. Aggression and SB are both prevalent in veterans relative to civilian populations. The current study evaluated the relationship between brain chemistry in the anterior (ACC) and the posterior cingulate cortex (POC), as well as the relationship between aggression and SB in a veteran population using proton magnetic resonance spectroscopy (
1 H-MRS). Single-voxel MRS data at 3 Tesla (T) were acquired from the ACC and POC voxels using a 2-dimensional J-resolved point spectroscopy sequence and quantified using the ProFit algorithm. Participants also completed a structured diagnostic interview and a clinical battery. Our results showed that the myoinositol (mI)/H2O ratio in the ACC and POC was significantly higher in veterans who reported SB when compared to veterans who did not. The two groups did not differ significantly with regard to other metabolites. Second, verbal aggression and SB measures positively correlated with mI/H2O in the ACC. Finally, verbal aggression mediated the relationship between mI/H2O in the ACC and SB., (Copyright © 2018 Elsevier B.V. All rights reserved.)- Published
- 2018
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18. Increased efficiency of brain connectivity networks in veterans with suicide attempts.
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Hwang J, Legarreta M, Bueler CE, DiMuzio J, McGlade E, Lyoo IK, and Yurgelun-Todd D
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- Adult, Brain physiology, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Nerve Net physiology, Brain diagnostic imaging, Connectome methods, Nerve Net diagnostic imaging, Suicide, Attempted psychology, Veterans psychology
- Abstract
Background: Suicide is a public health concern for United States veterans and civilians. Prior research has shown neurobiological factors in suicide. However, studies of neuroimaging correlates of suicide risk have been limited. This study applied complex weighted network analyses to characterize the neural connectivity in white matter in veterans with suicide behavior., Methods: Twenty-eight veterans without suicide behavior (NS), 29 with a history of suicidal ideation only (SI), and 23 with prior suicide attempt (SA) completed diffusion tensor brain imaging, the Columbia Suicide Severity Rating Scale and Barratt Impulsiveness Scale (BIS). Structural connectivity networks among 82 parcellated brain regions were produced using whole-brain tractography. Global and nodal metrics of network topology have been calculated., Results: SA had shorter characteristic path length and greater global efficiency and mean weighted degree of global network metrics ( p < 0.024). SA had more hub nodes than NS and SI. The left posterior cingulate cortex (PCC) showed significantly greater weighted degree in SA relative to others ( p < 0.0003). Nonplanning subscale of BIS correlated with the weighted degrees of the left PCC within SA. In rich club connectivity, SA had higher local connections than others ( p = 0.001)., Conclusion: Veterans with prior suicide attempt had altered connectivity networks characteristics in the white matter. These findings may be distinctive neurobiological markers for individuals with suicide attempt. Strong connectivity in the left PCC may be implicated in impulsivity in veterans with suicide attempt.
- Published
- 2018
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19. Suicide Behavior and Chronic Pain: An Exploration of Pain-Related Catastrophic Thinking, Disability, and Descriptions of the Pain Experience.
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Legarreta M, Bueler E, DiMuzio J, McGlade E, and Yurgelun-Todd D
- Subjects
- Adult, Catastrophization epidemiology, Chronic Pain complications, Disabled Persons psychology, Disabled Persons statistics & numerical data, Female, Humans, Interview, Psychological, Male, Middle Aged, Pain Measurement, Psychiatric Status Rating Scales, Risk Factors, Suicide, Attempted statistics & numerical data, United States epidemiology, Veterans psychology, Young Adult, Catastrophization psychology, Chronic Pain psychology, Suicidal Ideation, Suicide, Attempted psychology
- Abstract
This study examined differences in suicidal ideation (SI) and suicide attempts (SAs) among veterans with chronic pain. Pain-specific variables, including catastrophic thinking, disability, and sensory, affective, and evaluative pain descriptors, were a focus. Structured diagnostic and clinical interviews were conducted to examine SI/SA and mental health. Veterans completed the Structured Clinical Interview for DSM-IV and the Columbia-Suicide Severity Rating Scale to assess Axis I symptoms and suicidal behavior(s). Self-report questionnaires were used to evaluate the participants' subjective experience of chronic pain, which included the McGill Pain Questionnaire, Pain Catastrophizing Scale, and Pain Disability Index. The findings add to previous literature by suggesting pain-related catastrophic thinking specifically is related to elevated risk for SA, whereas affective and sensory pain are associated with SI. The study results support the need to assess pain from a multifaceted perspective and to examine the different experiences of pain, such as sensory and affective constructs, when discussing suicide risk in veterans.
- Published
- 2018
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20. Altered Cortical GABA in Female Veterans with Suicidal Behavior: Sex Differences and Clinical Correlates.
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Prescot A, Sheth C, Legarreta M, Renshaw PF, McGlade E, and Yurgelun-Todd D
- Abstract
Background: Suicide is a public health concern in the civilian and veteran populations. Stressful life events are precipitating factors for suicide. The neurochemical underpinnings of the association between stress/trauma and suicide risk are unclear, especially in regards to sex differences. We hypothesized that gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter may be a neurochemical candidate that is critical in the association between stress and suicide risk in veterans., Methods: Proton magnetic resonance spectroscopy (
1 H MRS) at 3.0 Tesla was used to measure in vivo neurochemistry in the anterior cingulate cortex (ACC; predominantly the dorsal ACC) of 81 veterans (16 females), including 57 (11 females) who endorsed past suicidal ideation (SI) and/or suicide attempt (SA) and 24 (5 females) with no history of SI and/or SA. Suicidal behavior (SB) was defined as the presence of SI and/or SA., Results: We observed no significant differences in GABA/ Creatine+phosphocreatine (Cr+PCr) between veterans with SB (SB+) and without SB (SB-). However, the female SB+ group showed significantly reduced GABA/Cr+PCr vs. the female SB- group. We observed a trend-level significant negative correlation between GABA/Cr+PCr and the defensive avoidance (DA) subscale on the Trauma Symptom Inventory (TSI) in the SB+ group. In contrast, the SB- group exhibited a positive relationship between the two variables. Furthermore, we found significant negative correlations between GABA/Cr+PCr and Hamilton Rating Scale for Depression (HAM-D) scores as well as between GABA/Cr+PCr and several subscales of the TSI in female veterans., Conclusions: This study suggests that reduced GABA/Cr+ PCr ratio in the ACC, which may be related to altered inhibitory capacity, may underlie suicide risk in female veterans. Further, the negative association between GABA/Cr+PCr and stress symptomatology and depression scores suggests that MRS studies may shed light on intermediate phenotypes of SB., Competing Interests: Declaration of Conflicting Interests: The authors declare no conflict of interest- Published
- 2018
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21. Orbitofrontal cortical thinning and aggression in mild traumatic brain injury patients.
- Author
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Epstein DJ, Legarreta M, Bueler E, King J, McGlade E, and Yurgelun-Todd D
- Subjects
- Adult, Brain Injuries, Traumatic diagnostic imaging, Case-Control Studies, Humans, Magnetic Resonance Imaging methods, Male, Prefrontal Cortex diagnostic imaging, Aggression physiology, Aggression psychology, Brain Injuries, Traumatic pathology, Brain Injuries, Traumatic psychology, Prefrontal Cortex pathology
- Abstract
Introduction: Although mild traumatic brain injury (mTBI) comprises 80% of all TBI, the morphological examination of the orbitofrontal cortex (OFC) in relation to clinical symptoms such as aggression, anxiety and depression in a strictly mTBI sample has never before been performed., Objectives: The primary objective of the study was to determine if mTBI patients would show morphological differences in the OFC and if the morphology of this region would relate to clinical symptoms., Methods: Using structural images acquired in a 3T MRI machine, the cortical thickness and cortical volume (corrected for total brain volume) of the OFC was collected for healthy control ( N = 27) subjects and chronic mTBI ( N = 55) patients at least one year post injury. Also, during clinical interviews, measures quantifying the severity of clinical symptoms, including aggression, anxiety, and depression, were collected., Results: MTBI subjects displayed increased aggression, anxiety, and depression, and anxiety and depression measures showed a relationship with the number of mTBI in which the subject lost consciousness. The cortical thickness of the right lateral OFC displayed evidence of thinning in the mTBI group; however, after correction for multiple comparisons, this difference was no longer significant. Clinical measures were not significantly related with OFC morphometry., Conclusion: This study found increased aggression, anxiety, and depression, in the mTBI group as well as evidence of cortical thinning in the right lateral OFC. The association between clinical symptoms and the number of mTBI with loss of consciousness suggests the number and severity of mTBI may influence clinical symptoms long after injury. Future studies examining other brain regions involved in the production and regulation of affective processes and inclusion of subjects with well-characterized mood disorders could further elucidate the relationship between mTBI, brain morphology, and clinical symptoms.
- Published
- 2016
- Full Text
- View/download PDF
22. DSM-5 posttraumatic stress disorder symptoms associated with suicide behaviors in veterans.
- Author
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Legarreta M, Graham J, North L, Bueler CE, McGlade E, and Yurgelun-Todd D
- Subjects
- Adult, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Interview, Psychological, Male, Pilot Projects, Psychiatric Status Rating Scales, Suicide, Attempted statistics & numerical data, United States epidemiology, Veterans statistics & numerical data, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic epidemiology, Suicidal Ideation, Suicide, Attempted psychology, Veterans psychology
- Abstract
A connection between suicidality and posttraumatic stress disorder (PTSD) has been consistently demonstrated; however, the underlying relationship between suicidality and PTSD remains unclear. The aim of this study was to examine patterns of DSM-5 PTSD symptom endorsement that differentiated veteran participants with and without a history of suicide behaviors. We enrolled 95 veterans, 32 of whom reported no suicide ideation (SI) or suicide attempts (SA). The 63 remaining participants reported a history of SI, with 28 of the 63 also reporting a historical SA. Participants completed a standardized diagnostic interview (Structured Clinical Interview for DSM-IV-TR; First, Spitzer, Gibbon, & Williams, 2002), structured interview of suicidal behaviors (Columbia-Suicide Severity Rating Scale; Posner et al., 2011), and selected clinical measures. Veterans who reported SI and/or SA were more likely to meet criteria for PTSD on DSM-5 than were veterans who reported neither SI nor SA. Participants who reported SA were more likely to meet criteria for clusters C and D. Finally, at the symptom level, those who reported SI were more likely to report experiencing feelings of alienation. Those who reported a SA were more likely to report avoidance of thoughts and feelings, inability to recall an important aspect of their trauma, persistent negative beliefs, diminished interest, and feelings of alienation. These findings suggest that targeting specific symptoms of PTSD may aid in treatment of suicidal thoughts and behaviors associated with PTSD., ((c) 2015 APA, all rights reserved).)
- Published
- 2015
- Full Text
- View/download PDF
23. [Cardiac prosthesis and pregnancy. Review of 10 cases].
- Author
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Sangínes Martínez A, Escalante Legarreta M, Cervantes Chávez JF, Alcántara Díaz Mirón R, and Ahued Ahued JR
- Subjects
- Abortion, Therapeutic, Adolescent, Adult, Anticoagulants therapeutic use, Female, Heart Failure surgery, Heart Valve Diseases surgery, Humans, Infant, Newborn, Male, Pregnancy Complications, Cardiovascular drug therapy, Pregnancy Complications, Cardiovascular surgery, Rheumatic Heart Disease complications, Risk, Heart Valve Prosthesis, Pregnancy
- Published
- 1981
24. The polycystic ovary. I. Estradiol/testosterone ratio and the use of antiestrogens.
- Author
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Cortés-Gallegos V, Legarreta ME, Aranda IS, and Lopez AC
- Subjects
- Adolescent, Adult, Female, Humans, Ovarian Cysts drug therapy, Ovulation drug effects, Anovulation drug therapy, Clomiphene therapeutic use, Ovarian Cysts blood, Ovary physiopathology, Testosterone blood
- Abstract
Several treatments have been used to induce ovulation in the polycystic ovary. In the following study, estradiol and testosterone plasma concentration were measured and evaluated in 18 women with polycystic ovaries, as one of the factors involved in the antiestrogenic response to Clomiphene Citrate. An estrogen plasma concentration baseline of 50 pg/ml is proposed in order to obtain the antiestrogenic effects. Nevertheless, induction of ovulation was achieved when the estradiol/testosterone ratio was 0.09 or higher (P less than 0.001).
- Published
- 1975
25. The polycystic ovary. II. Progesterone plasma levels after the use of antiestrogens.
- Author
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Cortés-Gallegos V, Legarreta ME, Gómez AG, and Uriarte ME
- Subjects
- Adolescent, Adult, Body Temperature, Female, Humans, Menstruation, Ovarian Cysts drug therapy, Ovarian Cysts pathology, Clomiphene therapeutic use, Ovarian Cysts blood, Progesterone blood
- Abstract
In the present study, the changes observed in the length of the cycle, basal body temperatures, endometrial histology and plasma progesterone in a group of 18 patients with polycystic ovaries, treated with Clomiphene Citrate, is reported. Two distinctive responses were observed depending on the estradiol/testosterone mean concentration found. Regardless of the induction of ovulation, a clear change in the length of the cycle was observed. Progesterone concentration of 2.1-2.9 ng/ml gave a definite rise in BBT, but no endometrial secretory changes were found in parallel with that concentration. Progesterone concentration above 6.1 ng/ml did induce secretory changes in the endometrium.
- Published
- 1975
26. [Jones' metroplasty. Report of 2 cases].
- Author
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Escalante Legarreta M, Ahued Ahued JR, Pineda Guerrero E, and Okhuysen Cerda K
- Subjects
- Adult, Female, Humans, Infant, Newborn, Male, Methods, Pregnancy, Uterus abnormalities, Uterus surgery
- Published
- 1982
27. [Anatomoclinical correlation of 15 cases of metastasic tumors of the ovary].
- Author
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Escalante Legarreta M, Maldonado Mucio P, and Pumaro Esquivel JH
- Subjects
- Adult, Aged, Female, Humans, Middle Aged, Neoplasm Metastasis pathology, Ovarian Neoplasms pathology
- Published
- 1969
28. [Placenta accreta and spontaneous uterine rupture. Report of a clinical case of a primipara with 19 weeks of amenorrhea].
- Author
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Escalante Legarreta M, Eguiarte Pérez J, and Juárez Espinosa A
- Subjects
- Adult, Female, Humans, Hysterectomy, Parity, Placenta Accreta pathology, Placenta Accreta surgery, Pregnancy, Uterine Rupture pathology, Uterine Rupture surgery, Amenorrhea complications, Placenta Accreta complications, Uterine Rupture etiology
- Published
- 1969
29. [Three cases of choriocarcinoma with atypical symptomology confirmed by necropsy].
- Author
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Escalante Legarreta M, Vargas Garcia C, and Ambrosius Diener K
- Subjects
- Adult, Female, Humans, Kidney pathology, Liver pathology, Lung pathology, Pregnancy, Uterus pathology, Choriocarcinoma pathology
- Published
- 1968
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