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To perform a systematic review and meta-analysis of severe adverse events (SAE) reported in early trials combining molecularly targeted therapies (MTT) with radiotherapy (RT), and to compare them to standard therapy. A summary data meta-analysis was performed and compared to the historical standard. Inclusion criteria were phase I and/or II trials published between 2000 and 2011, with glioblastoma multiforme patients treated with RT and MTT. Pooled incidence rates (IR) of SAE were estimated as well as the pooled median progression-free survival (PFS) and overall survival (OS). Nineteen prospective trials (9 phase I, 1 phase I/II and 9 phase II) out of 29 initially selected were included (n = 755 patients). The exact number of patients who had experienced SAE was mentioned in 37 % of the trials, concerning only 17 % of the patients. Information such as the period during which adverse events were monitored, the planned treatment duration, and late toxicity were not reported in the trials. The pooled IR of overall SAE was 131.2 (95 % CI 88.8-193.7) per 1000 person-months compared to 74.7 (63.6-87.8) for standard therapy (p < 0.01). Significant differences were observed for gastrointestinal events (p = 0.05) and treatment-related deaths (p = 0.02), in favour of standard therapy. No significant difference was observed in PFS and OS. Reporting a summary of toxicity data in early clinical trials should be stringently standardized. The use of MTT with RT compared to standard therapy increased SAE while yielded comparable survival in glioblastoma multiforme patients. [ABSTRACT FROM AUTHOR]

Introduction: Faced with the lack of human resources manage people living with HIV/AIDS (PLWHA) in developing countries, community health workers (CHWs) provide support to health professionals. The objective of this study was to describe the characteristics of CHWs and study the impact of their intervention on HIV care. A literature search was performed on Pubmed and the websites of international organizations., Methods: A literature review was conducted, including studies describing the impact of the CHWs' intervention on the care of PLWHA., Results: Thirteen articles were selected concerning twelve studies. The names and functions of CHWs are multiple; training and remuneration are very heterogeneous. Nevertheless, the impact of their intervention appears to be positive. Trials comparing community-based care versus hospital care show no difference between the two in terms of survival, retention, viral load or CD4 counts. The support provided by CHWs improves quality of life, compliance and self-confidence and decreases stigma (qualitative studies). It also allows coverage of previously remote areas., Conclusion: CHWs have various names, functions, formations and salaries. Their actions appear to have a positive impact both on the therapeutic management of PLHIV and on strengthening health systems. Recognition of CHWs by health systems remains marginal and remains a public health priority.