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2 results on '"Leeuwen, AV"'

1. Bivalent Vaccine Effectiveness Against Type-Specific HPV Positivity: Evidence for Cross-Protection Against Oncogenic Types among Dutch STI Clinic Visitors

Author

Woestenberg, PJ, King, AJ, van Benthem, BH, Donken, R, Leussink, S, van der Klis, FRM, de Melker, HE, van der Sande, M A J, Hoebe, CJ, Bogaards, JA, Adema, D, Buist-Arkema, R, Beerens, A, Luijt, D, Meijer, S, Schirm, J, Peeters, M, Rossen, JWA (John), Verbakel, H, Esch, PV, Verweij, J, Baltissen - van der Eijk, Annemiek, Huisman, RC, Kerkhof, C, Korff, MH, Schutten, M (Martin), Velzing, J, Verduyn-Lunel, F, Lakbiach, S, Rosmalen, PV, Schuurman, R (Rob), Abma, D, Adams, K, Bruisten, S, Linde, I, Oostvogel, P, Touwen, C, Vermeulen, W, Brink, A, Nelissen, J, Wolffs, P, Duijvendijk, N, Schneeberger, P, Poppel, MDV, Melchers, W, Poort, Y, Hooghiemstra, M, Huisman, H, Weel, J, Bosma, F, Geeraedts, F, Polman, I, Van Goor, P, Wolfhagen, M, De Mooij, C, Koolwijk, EV, Peters, M, Swanink, C, Tiemessen, R, Zwet, TV, Janssen, J, Pelsers, M, Waal, W, Aalfs, G, Kiewiet, J, Sanders, P, Buel-Bruins, HV, Bokhoven-Rombouts, CV, Cornelissen, P, Kersten, M, Ruitenbeek, CV, Molenaar, I, van Doorn, E, Masthoff, L, Pannekoek, E, Sigurdsson, V, Bugter, M, Götz, H, Linden, M, Mattijssen, M, Stam, J, Swaders, E, Groot, FD, Postma, F, Brouwers, E, Niekamp, A, Smit, M, Botraby, A, Bukasa, D, Haan, CD, Vliet, P, Taconis, T, Graas, MD, Hondelink, I, Kampman, C, Gelissen-Hansen, A, Koning, ID, Kruchten, HV, Pas, MVD, Fennema, H, Heijman, T, Hogewoning, A, Leeuwen, AV, Rooijen, MV, Neienhuijsen, F, Pelgrim, M, Woestenberg, PJ, King, AJ, van Benthem, BH, Donken, R, Leussink, S, van der Klis, FRM, de Melker, HE, van der Sande, M A J, Hoebe, CJ, Bogaards, JA, Adema, D, Buist-Arkema, R, Beerens, A, Luijt, D, Meijer, S, Schirm, J, Peeters, M, Rossen, JWA (John), Verbakel, H, Esch, PV, Verweij, J, Baltissen - van der Eijk, Annemiek, Huisman, RC, Kerkhof, C, Korff, MH, Schutten, M (Martin), Velzing, J, Verduyn-Lunel, F, Lakbiach, S, Rosmalen, PV, Schuurman, R (Rob), Abma, D, Adams, K, Bruisten, S, Linde, I, Oostvogel, P, Touwen, C, Vermeulen, W, Brink, A, Nelissen, J, Wolffs, P, Duijvendijk, N, Schneeberger, P, Poppel, MDV, Melchers, W, Poort, Y, Hooghiemstra, M, Huisman, H, Weel, J, Bosma, F, Geeraedts, F, Polman, I, Van Goor, P, Wolfhagen, M, De Mooij, C, Koolwijk, EV, Peters, M, Swanink, C, Tiemessen, R, Zwet, TV, Janssen, J, Pelsers, M, Waal, W, Aalfs, G, Kiewiet, J, Sanders, P, Buel-Bruins, HV, Bokhoven-Rombouts, CV, Cornelissen, P, Kersten, M, Ruitenbeek, CV, Molenaar, I, van Doorn, E, Masthoff, L, Pannekoek, E, Sigurdsson, V, Bugter, M, Götz, H, Linden, M, Mattijssen, M, Stam, J, Swaders, E, Groot, FD, Postma, F, Brouwers, E, Niekamp, A, Smit, M, Botraby, A, Bukasa, D, Haan, CD, Vliet, P, Taconis, T, Graas, MD, Hondelink, I, Kampman, C, Gelissen-Hansen, A, Koning, ID, Kruchten, HV, Pas, MVD, Fennema, H, Heijman, T, Hogewoning, A, Leeuwen, AV, Rooijen, MV, Neienhuijsen, F, and Pelgrim, M

Published
2018

2. Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody.

Author

Rispens T, Leeuwen Av, Vennegoor A, Killestein J, Aalberse RC, Wolbink GJ, and Aarden LA

Subjects
Animals, Antibodies, Monoclonal chemistry, Antibodies, Monoclonal, Humanized, Humans, Immunoglobulin Fc Fragments chemistry, Immunoglobulin G blood, Immunoglobulin G chemistry, Multiple Sclerosis drug therapy, Natalizumab, Protein Binding, Rabbits, Antibodies, Monoclonal blood, Enzyme-Linked Immunosorbent Assay methods
Abstract

Human immunoglobulin G4 (IgG4) is a poor trigger of effector functions and, therefore, is the preferred subclass for therapeutic monoclonal antibodies that merely aim to block their in vivo targets. An example is natalizumab, a recombinant IgG4 antibody directed against α4-integrin and used for treatment of multiple sclerosis. Efficient treatment requires that the pharmacokinetics of therapeutic monoclonal antibodies can be accurately monitored. For natalizumab, this requires special precautions due to recently reported structural peculiarities of human IgG4. Here we describe the development of an assay to determine serum levels of natalizumab. Compared with other IgG subclasses, human IgG4 possesses unique structural properties that influence its interactions in both in vivo and in vitro settings. Thus, IgG4 undergoes Fab arm exchange in vivo, resulting in effectively monovalent antibodies. Furthermore, IgG4 is able to bind to other human and nonhuman IgG via Fc interactions. We demonstrate how these features can interfere with measurement of specific IgG4 and describe how we addressed these issues, resulting in an assay that is not sensitive to Fab arm exchange by natalizumab or to IgG4 Fc interactions., (Copyright © 2011 Elsevier Inc. All rights reserved.)

Published
2011
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