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1. Embryonic, placental and foetal growth and development

Author

Ganzevoort, Wessel, Painter, Rebecca C., Leemhuis, Aleid G., de Bakker, Bernadette S., Steegers-Theunissen, Régine P. M., Faas, Marijke M., Steegers, Eric A.P., editor, de Groot, Christianne J.M., editor, Hilders, Carina G.J.M., editor, Hoek, Annemieke, editor, Jaddoe, Vincent W.V., editor, Schoenmakers, Sam, editor, and Zweemer, Ronald P., editor

Published
2024
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3. Structured Multidisciplinary Follow-Up After Pediatric Intensive Care: A Model for Continuous Data-Driven Health Care Innovation

Author

de Sonnaville, Eleonore S. V., van Woensel, Job B. M., van Goudoever, Johannes B., Otten, Marieke H., Teela, Lorynn, Aarnoudse-Moens, Cornelieke S. H., Terheggen-Lagro, Suzanne W. J., van der Hulst, Annelies E., Engelen, Marc, Königs, Marsh, Oosterlaan, Jaap, Knoester, Hennie, Rotteveel, Joost, Haarman, Eric G., Oostrom, Kim J., van Zelm - van Eldik, Margreet J., Ernest van Heurn, L.W., Gorter, Ramon R., Derikx, Joep P.M., van Kaam, Anton H., Leemhuis, Aleid G., Blom, Nico A., and Kuipers, Irene M.

Published
2023
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7. Neurodevelopmental outcome at 5.5 years in Dutch preterm infants born at 24-26 weeks' gestational age: the EPI-DAF study

Author

van Beek, Pauline E., Rijken, Monique, Broeders, Lisa, ter Horst, Hendrik J., Koopman-Esseboom, Corine, de Kort, Ellen, Laarman, A.R.C., Mulder-de Tollenaer, S.M., Steiner, Katerina, Swarte, Renate M.C., van Westering-Kroon, Elke, Oei, Guid, Leemhuis, Aleid G., Andriessen, Peter, van Beek, Pauline E., Rijken, Monique, Broeders, Lisa, ter Horst, Hendrik J., Koopman-Esseboom, Corine, de Kort, Ellen, Laarman, A.R.C., Mulder-de Tollenaer, S.M., Steiner, Katerina, Swarte, Renate M.C., van Westering-Kroon, Elke, Oei, Guid, Leemhuis, Aleid G., and Andriessen, Peter

Abstract

OBJECTIVE: After lowering the Dutch threshold for active treatment from 25 to 24 completed weeks' gestation, survival to discharge increased by 10% in extremely preterm live born infants. Now that this guideline has been implemented, an accurate description of neurodevelopmental outcome at school age is needed.DESIGN: Population-based cohort study.SETTING: All neonatal intensive care units in the Netherlands.PATIENTS: All infants born between 240/7 and 266/7 weeks' gestation who were 5.5 years' corrected age (CA) in 2018-2020 were included.MAIN OUTCOME MEASURES: Main outcome measure was neurodevelopmental outcome at 5.5 years. Neurodevelopmental outcome was a composite outcome defined as none, mild or moderate-to-severe impairment (further defined as neurodevelopmental impairment (NDI)), using corrected cognitive score (Wechsler Preschool and Primary Scale of Intelligence Scale-III-NL), neurological examination and neurosensory function. Additionally, motor score (Movement Assessment Battery for Children-2-NL) was assessed. All assessments were done as part of the nationwide, standardised follow-up programme.RESULTS: In the 3-year period, a total of 632 infants survived to 5.5 years' CA. Data were available for 484 infants (77%). At 5.5 years' CA, most cognitive and motor (sub)scales were significantly lower compared with the normative mean. Overall, 46% had no impairment, 36% had mild impairment and 18% had NDI. NDI-free survival was 30%, 49% and 67% in live born children at 24, 25 and 26 weeks' gestation, respectively (p<0.001).CONCLUSIONS: After lowering the threshold for supporting active treatment from 25 to 24 completed weeks' gestation, a considerable proportion of the surviving extremely preterm children did not have any impairment at 5.5 years' CA.

Published
2024

8. Doppler ultrasound of umbilical and middle cerebral artery in third trimester small‐for‐gestational age fetuses to decide on timing of delivery for suspected fetal growth restriction: A cohort with nested RCT (DRIGITAT).

Author

Marijnen, Mauritia C., Kamphof, Hester D., Damhuis, Stefanie E., Smies, Maddy, Leemhuis, Aleid G., Wolf, Hans, Gordijn, Sanne J., Ganzevoort, Wessel, Schaaf, J. M., de Boer, M. A., Zwart, J. J., Huisjes, A. J. M., Veerbeek, J. H. W., van Laar, J. O. E. H., Al‐Nasiry, S., Bremer, H. A., Hermsen, B. B. J., van de Nieuwenhof, H. P., Sueters, M., and van der Ham, D. P.

Subjects
FETAL growth retardation, DOPPLER ultrasonography, CEREBRAL arteries, SMALL for gestational age, FETUS
Abstract

Objective: To assess the association of the umbilicocerebral ratio (UCR) with adverse perinatal outcome in late preterm small‐for‐gestational age (SGA) fetuses and to investigate the effect on perinatal outcomes of immediate delivery. Design: Multicentre cohort study with nested randomised controlled trial (RCT). Setting: Nineteen secondary and tertiary care centres. Population: Singleton SGA pregnancies (estimated fetal weight [EFW] or fetal abdominal circumference [FAC] <10th centile) from 32 to 36+6 weeks. Methods: Women were classified: (1) RCT‐eligible: abnormal UCR twice consecutive and EFW below the 3rd centile at/or below 35 weeks or below the 10th centile at 36 weeks; (2) abnormal UCR once or intermittent; (3) never abnormal UCR. Consenting RCT‐eligible patients were randomised for immediate delivery from 34 weeks or expectant management until 37 weeks. Main outcome measures: A composite adverse perinatal outcome (CAPO), defined as perinatal death, birth asphyxia or major neonatal morbidity. Results: The cohort consisted of 690 women. The study was halted prematurely for low RCT‐inclusion rates (n = 40). In the RCT‐eligible group, gestational age at delivery, birthweight and birthweight multiple of the median (MoM) (0.66, 95% confidence interval [CI] 0.59–0.72) were significantly lower and the CAPO (n = 50, 44%, p < 0.05) was more frequent. Among patients randomised for immediate delivery there was a near‐significant lower birthweight (p = 0.05) and higher CAPO (p = 0.07). EFW MoM, pre‐eclampsia, gestational hypertension and Doppler classification were independently associated with the CAPO (area under the curve 0.71, 95% CI 0.67–0.76). Conclusions: Perinatal risk was effectively identified by low EFW MoM and UCR. Early delivery of SGA fetuses with an abnormal UCR at 34–36 weeks should only be performed in the context of clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Embryonic, placental and foetal growth and development

Author

Ganzevoort, Wessel, Painter, Rebecca C., van Wassenaer-Leemhuis, Aleid G., de Bakker, Bernadette S., Steegers-Theunissen, Régine P. M., Faas, Marijke M., Steegers, Eric A.P., editor, Fauser, Bart C.J.M., editor, Hilders, Carina G.J.M., editor, Jaddoe, Vincent W.V., editor, Massuger, Leon F.A.G., editor, van der Post, Joris A.M., editor, and Schoenmakers, Sam, editor

Published
2019
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11. Neurodevelopmental outcome at 5.5 years in Dutch preterm infants born at 24–26 weeks’ gestational age: the EPI-DAF study

Author

van Beek, Pauline E, primary, Rijken, Monique, additional, Broeders, Lisa, additional, ter Horst, Hendrik J, additional, Koopman-Esseboom, Corine, additional, de Kort, Ellen, additional, Laarman, A R C, additional, Mulder - de Tollenaer, S M, additional, Steiner, Katerina, additional, Swarte, Renate M C, additional, van Westering-Kroon, Elke, additional, Oei, Guid, additional, Leemhuis, Aleid G, additional, and Andriessen, Peter, additional

Published
2023
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14. Identifying effect modifiers of systemic hydrocortisone treatment initiated 7–14 days after birth in ventilated very preterm infants on long-term outcome: secondary analysis of a randomised controlled trial.

Author

Halbmeijer, Nienke Marjolein, Sonnaert, Michel, Swarte, Renate M., Koopman-Esseboom, Corine, van Stuijvenberg, Margriet, Tollenaer, Susanne Mulder-de, Tan, Ratna N. G. B., Mohns, Thilo, Bruneel, Els, Steiner, Katerina, Kramer, Boris W., Debeer, Anne, van Weissenbruch, Mirjam M., Marechal, Yoann, Blom, Henry, Plaskie, Katleen, Offringa, Martin, Merkus, Maruschka P., Onland, Wes, and Leemhuis, Aleid G.

Published
2024
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15. Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia

Author

Katz, Trixie A., primary, van Kaam, Anton H., additional, Mugie, Suzanne M., additional, Aarnoudse-Moens, Cornelieke S.H., additional, de Groof, Femke, additional, van Kempen, Anne A.M.W., additional, van den Heuvel, Maria E. N, additional, Vogelzang, Judith, additional, Rijpert, Maarten, additional, Schiering, Irene A., additional, Koomen-Botman, Irene, additional, Visser, Fenna, additional, Leemhuis, Aleid G., additional, and Onland, Wes, additional

Published
2023
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16. Identifying effect modifiers of systemic hydrocortisone treatment initiated 7–14 days after birth in ventilated very preterm infants on long-term outcome: secondary analysis of a randomised controlled trial

Author

Halbmeijer, Nienke Marjolein, primary, Sonnaert, Michel, additional, Swarte, Renate M, additional, Koopman-Esseboom, Corine, additional, van Stuijvenberg, Margriet, additional, Mulder-de Tollenaer, Susanne, additional, Tan, Ratna N G B, additional, Mohns, Thilo, additional, Bruneel, Els, additional, Steiner, Katerina, additional, Kramer, Boris W, additional, Debeer, Anne, additional, van Weissenbruch, Mirjam M, additional, Marechal, Yoann, additional, Blom, Henry, additional, Plaskie, Katleen, additional, Offringa, Martin, additional, Merkus, Maruschka P, additional, Onland, Wes, additional, Leemhuis, Aleid G, additional, and van Kaam, Anton H, additional

Published
2023
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18. Gestational age and socio‐demographic factors associated with school performance at the age of 12 years, a population‐based study

Author

Burger, Renée J., primary, Roseboom, Tessa J., additional, Ganzevoort, Wessel, additional, Gordijn, Sanne J., additional, Pajkrt, Eva, additional, Abu‐Hanna, Ameen, additional, Eskes, Martine, additional, Leemhuis, Aleid G., additional, Mol, Ben W., additional, de Groot, Christianne J. M., additional, and Ravelli, Anita C. J., additional

Published
2023
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19. Duration of Neonatal Antibiotic Exposure in Preterm Infants in Association with Health and Developmental Outcomes in Early Childhood

Author

Deianova, Nancy, primary, de Boer, Nanne K., additional, Aoulad Ahajan, Hafsa, additional, Verbeek, Cilla, additional, Aarnoudse-Moens, Cornelieke S. H., additional, Leemhuis, Aleid G., additional, van Weissenbruch, Mirjam M., additional, van Kaam, Anton H., additional, Vijbrief, Daniel C., additional, Hulzebos, Chris V., additional, Giezen, Astrid, additional, Cossey, Veerle, additional, de Boode, Willem P., additional, de Jonge, Wouter J., additional, Benninga, Marc A., additional, Niemarkt, Hendrik J., additional, and de Meij, Tim G. J., additional

Published
2023
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21. Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia.

Author

Katz, Trixie A., van Kaam, Anton H., Mugie, Suzanne M., Aarnoudse-Moens, Cornelieke S.H., de Groof, Femke, van Kempen, Anne A.M.W., van den Heuvel, Maria E. N, Vogelzang, Judith, Rijpert, Maarten, Schiering, Irene A., Koomen-Botman, Irene, Visser, Fenna, Leemhuis, Aleid G., and Onland, Wes

Subjects
PREMATURE infants, BRONCHOPULMONARY dysplasia, NEURAL development, LOGISTIC regression analysis, GESTATIONAL age
Abstract

Introduction: The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). Methods: This single-center retrospective cohort study included infants born between 2009 and 2016 at a gestational age (GA) <30 weeks with moderate or severe BPD at 36 weeks' postmenstrual age. Perinatal characteristics, (social) demographics, and comorbidities were collected from the electronic patient records. Odds ratios for NDI were calculated with univariate and multivariate logistic regression analyses adjusting for potential confounders. Results: Of the 602 eligible infants, 123 infants were diagnosed with BPD. NDI was present in 30.3% and 56.1% at 2- and 5-years CA, respectively. The only independent risk factors associated with NDI in the multivariate analyses were birthweight (adjusted odds ratio [aOR] 0.74, 95% CI 0.57–0.95; aOR 0.70, 95% CI 0.54–0.91, respectively), small for GA (SGA) (aOR 3.25, 95% CI 1.09–9.61; aOR 5.44, 95% CI 1.62–18.2, respectively) at both time points, and male gender at 5-years CA (OR 2.49, 95% CI 1.11–5.57). Conclusion: Birthweight and SGA are independent risk factors for NDI at 2- and 5-years CA and male gender at 5-years CA in preterm infants with BPD. In contrast, well-known other risk factors for NDI in the general population of preterm infants, such as GA, maternal education, and neonatal comorbidities were not independently associated with NDI. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years' corrected age

Author

SToP-BPD Study Group, Halbmeijer, Nienke Marjolein, Onland, Wes, Cools, Filip, Swarte, Renate M, van der Heide-Jalving, Marja, Dijk, Peter, Mulder-de Tollenaer, Susanne, Tan, Ratna N G B, Mohns, Thilo, Bruneel, Els, van Heijst, Arno F J, Kramer, Boris, Debeer, Anne, van Weissenbruch, Mirjam M, Marechal, Yoann, Blom, Henry, Plaskie, Katleen, Offringa, Martin, van Wassenaer-Leemhuis, Aleid G, van Kaam, Anton H, Aarnoudse-Moens, Cornelieke S H, Neonatology, Brussels Heritage Lab, UZB Other, Clinical sciences, Growth and Development, STOP-BPD Study Group, RS: MHeNs - R3 - Neuroscience, RS: GROW - R4 - Reproductive and Perinatal Medicine, and MUMC+: MA Medische Staf Kindergeneeskunde (9)

Subjects
BIRTH, MORTALITY, SCHOOL-AGE, MULTICENTER, Obstetrics and Gynecology, General Medicine, BRONCHOPULMONARY DYSPLASIA, THERAPY, neonatology, DEXAMETHASONE, Pediatrics, Perinatology and Child Health, SURVIVAL, Human medicine, Pediatrics, Perinatology, and Child Health, CHILDREN BORN, Child development, INITIATED 7
Abstract

ObjectiveTo report the parent-reported behavioural outcomes of infants included in the Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants study at 2 years’ corrected age (CA).DesignRandomised placebo-controlled trial.SettingDutch and Belgian neonatal intensive care units.PatientsInfants born InterventionInfants were randomly assigned to a 22-day course of systemic hydrocortisone (cumulative dose 72.5 mg/kg; n=182) or placebo (n=190).Main outcome measuresParent-reported behavioural outcomes at 2 years’ CA assessed with the Child Behavior Checklist (CBCL 1½−5).ResultsParents completed the CBCL of 183 (70% (183/262)) infants (hydrocortisone group, n=96; placebo group, n=87). Multiple imputation was used to account for missing data. Infants with critically elevated T-scores (>55) were found in 22.9%, 19.1% and 29.4% of infants for total, internalising and externalising problems, respectively; these scores were not significantly different between groups (mean difference −1.52 (95% CI −4.00 to 0.96), −2.40 (95% CI −4.99 to 0.20) and −0.81 (95% CI −3.40 to 1.77), respectively). In the subscales, we found a significantly lower T-score for anxiety problems in the hydrocortisone group (mean difference −1.26, 95% CI −2.41 to –0.12).ConclusionThis study found high rates of behaviour problems at 2 years’ CA following very preterm birth, but these problems were not associated with hydrocortisone treatment initiated between 7 and 14 days after birth in ventilated preterm infants.Trial registration numberNTR2768; EudraCT 2010-023777-19.

Published
2023

24. Comparison of new bronchopulmonary dysplasia definitions on long-term outcomes in preterm infants

Author

Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Katz, Trixie A, van Kaam, Anton H, Schuit, Ewoud, Mugie, Suzanne M, Aarnoudse-Moens, Cornelieke S H, Weber, Elske H, de Groof, Femke, van Laerhoven, Henriette, Counsilman, Clare E, van der Schoor, Sophie R D, Rijpert, Maarten, Schiering, Irene A, Wilms, Janneke, Leemhuis, Aleid G, Onland, Wes, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Katz, Trixie A, van Kaam, Anton H, Schuit, Ewoud, Mugie, Suzanne M, Aarnoudse-Moens, Cornelieke S H, Weber, Elske H, de Groof, Femke, van Laerhoven, Henriette, Counsilman, Clare E, van der Schoor, Sophie R D, Rijpert, Maarten, Schiering, Irene A, Wilms, Janneke, Leemhuis, Aleid G, and Onland, Wes

Published
2023

27. Neurodevelopmental outcome at 5.5 years in Dutch preterm infants born at 24–26 weeks’ gestational age: the EPI-DAF study

Author

van Beek, Pauline E, Rijken, Monique, Broeders, Lisa, ter Horst, Hendrik J, Koopman-Esseboom, Corine, de Kort, Ellen, Laarman, A R C, Mulder - de Tollenaer, S M, Steiner, Katerina, Swarte, Renate M C, van Westering-Kroon, Elke, Oei, Guid, Leemhuis, Aleid G, and Andriessen, Peter

Abstract

ObjectiveAfter lowering the Dutch threshold for active treatment from 25 to 24 completed weeks’ gestation, survival to discharge increased by 10% in extremely preterm live born infants. Now that this guideline has been implemented, an accurate description of neurodevelopmental outcome at school age is needed.DesignPopulation-based cohort study.SettingAll neonatal intensive care units in the Netherlands.PatientsAll infants born between 240/7and 266/7weeks’ gestation who were 5.5 years’ corrected age (CA) in 2018–2020 were included.Main outcome measuresMain outcome measure was neurodevelopmental outcome at 5.5 years. Neurodevelopmental outcome was a composite outcome defined as none, mild or moderate-to-severe impairment (further defined as neurodevelopmental impairment (NDI)), using corrected cognitive score (Wechsler Preschool and Primary Scale of Intelligence Scale-III-NL), neurological examination and neurosensory function. Additionally, motor score (Movement Assessment Battery for Children-2-NL) was assessed. All assessments were done as part of the nationwide, standardised follow-up programme.ResultsIn the 3-year period, a total of 632 infants survived to 5.5 years’ CA. Data were available for 484 infants (77%). At 5.5 years’ CA, most cognitive and motor (sub)scales were significantly lower compared with the normative mean. Overall, 46% had no impairment, 36% had mild impairment and 18% had NDI. NDI-free survival was 30%, 49% and 67% in live born children at 24, 25 and 26 weeks’ gestation, respectively (p<0.001).ConclusionsAfter lowering the threshold for supporting active treatment from 25 to 24 completed weeks’ gestation, a considerable proportion of the surviving extremely preterm children did not have any impairment at 5.5 years’ CA.

Published
2024
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28. Amnioinfusion Compared With No Intervention in Women With Second-Trimester Rupture of Membranes: A Randomized Controlled Trial

Author

van Kempen, Liselotte E. M., van Teeffelen, Augustinus S., de Ruigh, Annemijn A., Oepkes, Dick, Haak, Monique C., van Leeuwen, Elisabeth, Woiski, Mallory, Porath, Martina M., Bax, Caroline J., van Wassenaer-Leemhuis, Aleid G., Mulder, Antonius L., van der Ham, David P., Willekes, Christine, Franssen, Maureen T., Derks, Jan B., Schuit, Ewoud, Mol, Ben W., and Pajkrt, Eva

Published
2019
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30. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years’ corrected age: follow-up of a randomised clinical trial

Author

Halbmeijer, Nienke Marjolein, primary, Onland, Wes, additional, Cools, Filip, additional, Swarte, Renate M, additional, van der Heide-Jalving, Marja, additional, Dijk, Peter, additional, Mulder-de Tollenaer, Susanne, additional, Tan, Ratna N G B, additional, Mohns, Thilo, additional, Bruneel, Els, additional, van Heijst, Arno F J, additional, Kramer, Boris, additional, Debeer, Anne, additional, van Weissenbruch, Mirjam M, additional, Marechal, Yoann, additional, Blom, Henry, additional, Plaskie, Katleen, additional, Offringa, Martin, additional, van Wassenaer-Leemhuis, Aleid G, additional, van Kaam, Anton H, additional, and Aarnoudse-Moens, Cornelieke S H, additional

Published
2023
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31. Childhood outcomes after induction of labour or expectant management for PPROM: PPROMEXIL 10 year follow-up

Author

Simons, Noor E., primary, de Ruigh, Annemijn, additional, Hooft, Janneke van't, additional, Aarnoudse-Moens, Cornelieke, additional, van Wely, Madelon, additional, van der ham, david, additional, van Teeffelen, Stijn, additional, Roseboom, Tessa J., additional, Mol, Ben W., additional, Leemhuis, Aleid G., additional, and Pajkrt, Eva, additional

Published
2023
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32. Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams

Author

Schmidt, Barbara, D'Ilario, Judy, Cairnie, Janice, Dix, Joanne, Anne Adams, Beth, Warriner, Erin, Kim, Mee-Hai Marie, Anderson, Peter, Davis, Peter, Doyle, Lex, Argus, Brenda, Callanan, Catherine, Davis, Noni, Duff, Julianne, McDonald, Marion, Asztalos, Elizabeth, Hohn, Denise, Lacy, Maralyn, Haslam, Ross, Barnett, Christopher, Goodchild, Louise, Lontis, Rosslyn Marie, Fraser, Simon, Keng, Julie, Saunders, Kerryn, Opie, Gillian, Kelly, Elaine, Woods, Heather, Marchant, Emma, Turner, Anne-Marie, Magrath, Emma, Williamson, Amanda, Bairam, Aida, Bélanger, Sylvie, Fraser, Annie, Blayney, Marc, Lemyre, Brigitte, Frank, Jane, Solimano, Alfonso, Synnes, Anne, Grunau, Ruth E., Hubber-Richard, Philippa, Rogers, Marilyn, Mackay, Margot, Petrie-Thomas, Julianne, Butt, Arsalan, van Wassenaer, Aleid, Nuytemans, Debbie, Houtzager, Bregje, van Sonderen, Loekie, Regev, Rivka, Itzchack, Netter, Arnon, Shmuel, Chalaf, Adiba, Ohlsson, Arne, O'Brien, Karel, Hamilton, Anne-Marie, Chan, May Lee, Sankaran, Koravangattu, Proctor, Pat, Golan, Agneta, Goldsch-Lerman, Esther, Reynolds, Graham, Dromgool, Barbara, Meskell, Sandra, Parr, Vanessa, Maher, Catherine, Broom, Margaret, Kecskes, Zsuzsoka, Ringland, Cathy, McMillan, Douglas, Spellen, Elizabeth, Sauve, Reginald S., Christianson, Heather, Anseeuw-Deeks, Deborah, Creighton, Dianne, Heath, Jennifer, Alvaro, Ruben, Chiu, Aaron, Porter, Ceceile, Turner, Gloria, Moddemann, Diane, Granke, Naomi, Penner, Karen, Bow, Jane, Mulder, Antonius, Wassenberg, Renske, van der Hoeven, Markus, Clarke, Maxine, Parfitt, Judy, Parker, Kevin, Nwaesei, Chukwuma, Ryan, Heather, Saunders, Cory, Schulze, Andreas, Wermuth, Inga, Hilgendorff, Anne, Flemmer, Andreas W., Herlenius, Eric, Legnevall, Lena, Lagercrantz, Hugo, Matthew, Derek, Amos, Wendy, Tulsiani, Suresh, Tan-Dy, Cherrie, Turner, Marilyn, Phelan, Constance, Shinwell, Eric S., Levine, Michael, Juster-Reicher, Ada, Khairy, May, Grier, Patricia, Vachon, Julie, Perepolkin, Larissa, Barrington, Keith J., Sinha, Sunil Kumar, Tin, Win, Fritz, Susan, Walti, Herve, Royer, Diane, Halliday, Henry, Millar, David, Mayes, Clifford, McCusker, Christopher, McLaughlin, Olivia, Fahnenstich, Hubert, Tillmann, Bettina, Weber, Peter, Wariyar, Unni, Embleton, Nicholas, Swamy, Ravi, Bucher, Hans U., Fauchere, Jean-Claude., Dietz, Vera, Harikumar, Chidambara, Anderson, Peter J., Asztalos, Elizabeth V., Davis, Peter G., Dewey, Deborah, Doyle, Lex W., Roberts, Robin S., Gent, Michael, Fraser, William, Hey, Edmund, Perlman, Max, Thorpe, Kevin, Gray, Shari, Chambers, Carole, Costantini, Lorrie, Yacura, Wendy, McGean, Erin, Scapinello, Lori, Manley, Brett J., Böhm, Birgitta, and van Wassenaer-Leemhuis, Aleid G.

Published
2015
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34. Pessary or progesterone to prevent preterm birth in women with short cervical length:protocol of the 4-6 year follow-up of a randomised controlled trial (Quadruple-P)

Author

van Limburg Stirum, Emilie V J, van der Windt, Larissa I, van Dijk, Charlotte E, van Baar, Anneloes L, Leemhuis, Aleid G, van Wely, Madelon, de Boer, Marjon A, van 't Hooft, Janneke, Oudijk, Martijn A, Pajkrt, Eva, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Leerstoel Bogt, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Leerstoel Bogt, Graduate School, Obstetrics and Gynaecology, APH - Personalized Medicine, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), Neonatology, Other Research, Center for Reproductive Medicine, APH - Methodology, and Obstetrics and gynaecology

Subjects
Medicine(all), Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Developmental neurology & neurodisability, Infant, Newborn, General Medicine, Fetal medicine, Cervix Uteri, Pessaries, Maternal medicine, Cervical Length Measurement, Pregnancy, Humans, Multicenter Studies as Topic, Premature Birth, Female, Child, Progesterone, Follow-Up Studies, Randomized Controlled Trials as Topic
Abstract

IntroductionVaginal progesterone and a cervical pessary are both interventions that are investigated for the prevention of preterm birth (PTB). Thus far, beneficial or harmful effects of these interventions on long-term child health and development are described, but evidence is not robust enough to draw firm conclusions. With this follow-up study, we intent to investigate if progesterone or a pessary is superior for the prevention of PTB considering the child’s health at 4–6 years of corrected age.Methods and analysisThis study is a follow-up study of the Quadruple-P trial; a multicentre, randomised clinical trial (NL42926.018.13, Eudractnumber 2013-002884-24) which randomises women with an asymptomatic midtrimester short cervix to daily progesterone or a pessary for the prevention of PTB. All children born to mothers who participated in the Quadruple-P study (n=628 singletons and n=332 multiples) will be eligible for follow-up at 4–6 years of corrected age. Children will be assessed using parental questionnaires. Main outcomes are child (neuro)development and behaviour. Other outcomes include child mortality, growth and general health. A composite of adverse child outcomes will be compared between the progesterone and pessary groups reporting OR and the corresponding 95% CI. Analyses will be performed separately for singletons and multiples and using the intention-to-treat approach.Ethics and disseminationThe Medical Research Ethics Committee from Amsterdam UMC confirmed that de Medical Research Involving Human Subjects Act (WMO) did not apply to our study (W20_481 #20.531). Results will be published in a peer-reviewed journal and shared with stakeholders and participants. This protocol is published before analysis of the results.Trial registration numberDutch Trial Register (NL9646).

Published
2022

35. Long-term outcomes following antenatal exposure to low-dose aspirin: study protocol for the 4-year follow-up of the APRIL randomised controlled trial

Author

Landman, Anadeijda J E M C, Van limburg stirum, Emilie V J, Van 't hooft, Janneke, Leemhuis, Aleid G, Finken, Martijn J J, Van baar, Anneloes L, Roseboom, Tessa J, Ravelli, Anita C J, Van wely, Madelon, Oosterlaan, Jaap, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, De boer, Marjon A, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Graduate School, Obstetrics and Gynaecology, Neonatology, Other Research, Epidemiology and Data Science, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, Amsterdam Reproduction & Development (AR&D), Medical Informatics, APH - Methodology, Center for Reproductive Medicine, APH - Personalized Medicine, General Paediatrics, APH - Quality of Care, Paediatrics, Obstetrics and gynaecology, Pediatrics, Amsterdam Gastroenterology Endocrinology Metabolism, Leerstoel Baar, and Development and Treatment of Psychosocial Problems

Subjects
Medicine(all), Aspirin, Tumor Necrosis Factor Ligand Superfamily Member 13, Infant, Newborn, PAEDIATRICS, General Medicine, Fetal medicine, Maternal medicine, PERINATOLOGY, Pregnancy, Child, Preschool, Humans, Premature Birth, EPIDEMIOLOGY, Female, Child, Follow-Up Studies, Randomized Controlled Trials as Topic
Abstract

IntroductionThe use of low-dose aspirin by pregnant women to prevent preterm pre-eclampsia is gradually increasing. The administration of aspirin during pregnancy improves perinatal outcome, which could translate into improved child outcome in the long term. However, antenatal exposure to aspirin could have adverse effects on child development that may manifest later in life. The aim of this follow-up study is to assess the long-term effects of antenatal exposure to low-dose aspirin compared with placebo on survival, (neuro)development, behaviour and general health at 4 years corrected age.Methods and analysisThis is a follow-up study of the Dutch double-blind randomised controlled APRIL trial which assessed the effectiveness of treatment with aspirin (80 mg daily) compared with placebo for the prevention of preterm birth in women with a previous spontaneous preterm birth. Treatment was initiated before 16 weeks of gestation and continued until 36 weeks or birth. We aim to follow-up all 379 children born to women who participated in the APRIL trial and survived the neonatal period, at the corrected age of 4 years. The main outcomes are (neuro)development as assessed by the Ages and Stages Questionnaire, and behaviour as assessed by the Strength and Difficulties Questionnaire. Additional outcomes include mortality, growth and general health from birth up to 4 years, and a composite outcome including mortality, abnormal (neuro)development and problem behaviour. Analyses will be performed by intention-to-treat using a superiority design.Ethics and disseminationInstitutional Review Board approval was obtained from the Medical Research Ethics Committee from Amsterdam Medical Center (no. W20 289#20.325). The results will be published in a peer-reviewed journal and presented at conferences.Trial registration numberThe APRIL trial (NTR5675, NL5553; EudraCT number 2015-003220-31) and the APRIL follow-up study (NL8950) are registered in the Dutch trial register. The study is funded by the Amsterdam Reproduction & Development research institute.

Published
2022

36. Comparison of new bronchopulmonary dysplasia definitions on long-term outcomes in preterm infants

Author

Katz, Trixie A., primary, van Kaam, Anton H., additional, Schuit, Ewoud, additional, Mugie, Suzanne M., additional, Aarnoudse-Moens, Cornelieke S.H., additional, Weber, Elske H., additional, de Groof, Femke, additional, van Laerhoven, Henriette, additional, Counsilman, Clare E., additional, van der Schoor, Sophie R.D., additional, Rijpert, Maarten, additional, Schiering, Irene A., additional, Wilms, Janneke, additional, Leemhuis, Aleid G., additional, and Onland, Wes, additional

Published
2022
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37. Pessary or progesterone to prevent preterm birth in women with short cervical length: protocol of the 4–6 year follow-up of a randomised controlled trial (Quadruple-P)

Author

van Limburg Stirum, Emilie V J, primary, van der Windt, Larissa I, additional, van Dijk, Charlotte E, additional, van Baar, Anneloes L, additional, Leemhuis, Aleid G, additional, van Wely, Madelon, additional, de Boer, Marjon A, additional, van 't Hooft, Janneke, additional, Oudijk, Martijn A, additional, and Pajkrt, Eva, additional

Published
2022
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41. Long-term outcomes following antenatal exposure to low-dose aspirin: study protocol for the 4-year follow-up of the APRIL randomised controlled trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Landman, Anadeijda J E M C, Van limburg stirum, Emilie V J, Van 't hooft, Janneke, Leemhuis, Aleid G, Finken, Martijn J J, Van baar, Anneloes L, Roseboom, Tessa J, Ravelli, Anita C J, Van wely, Madelon, Oosterlaan, Jaap, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, De boer, Marjon A, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Landman, Anadeijda J E M C, Van limburg stirum, Emilie V J, Van 't hooft, Janneke, Leemhuis, Aleid G, Finken, Martijn J J, Van baar, Anneloes L, Roseboom, Tessa J, Ravelli, Anita C J, Van wely, Madelon, Oosterlaan, Jaap, Painter, Rebecca C, Pajkrt, Eva, Oudijk, Martijn A, and De boer, Marjon A

Published
2022

42. Pessary or progesterone to prevent preterm birth in women with short cervical length.: Protocol of the 4–6 year follow-up of a randomised controlled trial (Quadruple-P)

Author

Development and Treatment of Psychosocial Problems, Leerstoel Baar, Leerstoel Bogt, van Limburg Stirum, Emilie V J, van der Windt, Larissa I, van Dijk, Charlotte E, van Baar, Anneloes L, Leemhuis, Aleid G, van Wely, Madelon, de Boer, Marjon A, van 't Hooft, Janneke, Oudijk, Martijn A, Pajkrt, Eva, Development and Treatment of Psychosocial Problems, Leerstoel Baar, Leerstoel Bogt, van Limburg Stirum, Emilie V J, van der Windt, Larissa I, van Dijk, Charlotte E, van Baar, Anneloes L, Leemhuis, Aleid G, van Wely, Madelon, de Boer, Marjon A, van 't Hooft, Janneke, Oudijk, Martijn A, and Pajkrt, Eva

Published
2022

43. Machine Learning Prediction Models for Neurodevelopmental Outcome After Preterm Birth: A Scoping Review and New Machine Learning Evaluation Framework

Author

van Boven, Menne R., Henke, Celina E., Leemhuis, Aleid G., Hoogendoorn, Mark, van Kaam, Anton H., Königs, Marsh, Oosterlaan, Jaap, van Boven, Menne R., Henke, Celina E., Leemhuis, Aleid G., Hoogendoorn, Mark, van Kaam, Anton H., Königs, Marsh, and Oosterlaan, Jaap

Abstract

BACKGROUND AND OBJECTIVES: Outcome prediction of preterm birth is important for neonatal care, yet prediction performance using conventional statistical models remains insufficient. Machine learning has a high potential for complex outcome prediction. In this scoping review, we provide an overview of the current applications of machine learning models in the prediction of neurodevelopmental outcomes in preterm infants, assess the quality of the developed models, and provide guidance for future application of machine learning models to predict neurodevelopmental outcomes of preterm infants. METHODS: A systematic search was performed using PubMed. Studies were included if they reported on neurodevelopmental outcome prediction in preterm infants using predictors from the neonatal period and applying machine learning techniques. Data extraction and quality assessment were independently performed by 2 reviewers. RESULTS: Fourteen studies were included, focusing mainly on very or extreme preterm infants, predicting neurodevelopmental outcome before age 3 years, and mostly assessing outcomes using the Bayley Scales of Infant Development. Predictors were most often based on MRI. The most prevalent machine learning techniques included linear regression and neural networks. None of the studies met all newly developed quality assessment criteria. Studies least prone to inflated performance showed promising results, with areas under the curve up to 0.86 for classification and R2 values up to 91% in continuous prediction. A limitation was that only 1 data source was used for the literature search. CONCLUSIONS: Studies least prone to inflated prediction results are the most promising. The provided evaluation framework may contribute to improved quality of future machine learning models.

Published
2022
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44. Two-year neurodevelopmental outcome in children born extremely preterm:The EPI-DAF study

Author

Van Beek, Pauline E., Rijken, Monique, Broeders, Lisa, Ter Horst, Hendrik J., Koopman-Esseboom, Corine, De Kort, Ellen, Laarman, Céleste, Mulder-De Tollenaer, Susanne M., Steiner, Katerina, Swarte, Renate M.C., Van Westering-Kroon, Elke, Oei, S. Guid, Leemhuis, Aleid G., Andriessen, Peter, Van Beek, Pauline E., Rijken, Monique, Broeders, Lisa, Ter Horst, Hendrik J., Koopman-Esseboom, Corine, De Kort, Ellen, Laarman, Céleste, Mulder-De Tollenaer, Susanne M., Steiner, Katerina, Swarte, Renate M.C., Van Westering-Kroon, Elke, Oei, S. Guid, Leemhuis, Aleid G., and Andriessen, Peter

Abstract

Objective In 2010, the Dutch practice regarding initiation of active treatment in extremely preterm infants was lowered from 25 completed weeks' to 24 completed weeks' gestation. The nationwide Extremely Preterm Infants - Dutch Analysis on Follow-up Study was set up to provide up-to-date data on neurodevelopmental outcome at 2 years' corrected age (CA) after this guideline change. Design: National cohort study. Patients All live born infants between 240/7 weeks' and 266/7 weeks' gestational age who were 2 years' CA in 2018-2020. Main outcome measure Impairment at 2 years' CA, based on cognitive score (Bayley-III-NL), neurological examination and neurosensory function. Results 651 of 991 live born infants (66%) survived to 2 years' CA, with data available for 554 (85%). Overall, 62% had no impairment, 29% mild impairment and 9% moderate-to-severe impairment (further defined as neurodevelopmental impairment, NDI). The percentage of survivors with NDI was comparable for infants born at 24 weeks', 25 weeks' and 26 weeks' gestation. After multivariable analysis, severe brain injury and low maternal education were associated with higher odds on NDI. NDI-free survival was 48%, 67% and 75% in neonatal intensive care unit (NICU)-admitted infants at 24, 25 and 26 weeks' gestation, respectively. Conclusions Lowering the threshold has not been accompanied by a large increase in moderate-to-severely impaired infants. Among live-born and NICU-admitted infants, an increase in NDI-free survival was observed from 24 weeks' to 26 weeks' gestation. This description of a national cohort with high follow-up rates gives an accurate description of the range of outcomes that may occur after extremely preterm birth.

Published
2022

45. Severity of Bronchopulmonary Dysplasia and Neurodevelopmental Outcome at 2 and 5 Years Corrected Age

Author

Katz, Trixie A., primary, Vliegenthart, Roseanne J.S., additional, Aarnoudse-Moens, Cornelieke S.H., additional, Leemhuis, Aleid G., additional, Beuger, Sabine, additional, Blok, Geert Jan, additional, van Brakel, Monique J.M., additional, van den Heuvel, Maria E.N., additional, van Kempen, Anne A.M.W., additional, Lutterman, Claire, additional, Rijpert, Maarten, additional, Schiering, Irene A., additional, Ran, Nicolien C., additional, Visser, Fenna, additional, Wilms, Janneke, additional, van Kaam, Anton H., additional, and Onland, Wes, additional

Published
2022
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46. Two-year neurodevelopmental outcome in children born extremely preterm: the EPI-DAF study

Author

van Beek, Pauline E, primary, Rijken, Monique, additional, Broeders, Lisa, additional, ter Horst, Hendrik J, additional, Koopman-Esseboom, Corine, additional, de Kort, Ellen, additional, Laarman, Céleste, additional, Mulder-de Tollenaer, Susanne M, additional, Steiner, Katerina, additional, Swarte, Renate MC, additional, van Westering-Kroon, Elke, additional, Oei, S Guid, additional, Leemhuis, Aleid G, additional, and Andriessen, Peter, additional

Published
2022
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47. Ontwikkelingsproblemen bij vroeggeborenen

Author

de Grauw, Anne M., van Beek, Pauline E., Leemhuis, Aleid G., Neonatology, Other Research, and Amsterdam Reproduction & Development (AR&D)

Abstract

The French EPIPAGE-2 study evaluated a large group of premature born children (24-34 weeks' gestational age (GA))) at age 5.5 years. Outcome information of the whole cohort was presented after careful imputation including/using the variable socio-economic-status (SES), because participation rate improved with increasing SES. Survival improved with increasing GA. Survival without moderate or severe impairment was 20% in children born at 24-26 weeks' GA, but among the survivors 75% had no or mild impairment. Mild cognitive impairment rates were comparable and common among all GA groups (25-28%) and thus frequent in prematures. School problems were also common. In addition to prematurity, SES is an important risk factor for developmental impairment. Follow-up programs for premature infants beyond 30 weeks' GA are less common and may need extra attention in low SES families. Future studies should focus on both prevention of prematurity and programs to improve outcome.

Published
2021

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