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2. Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author

Brady, Marian C, primary, Ali, Myzoon, additional, VandenBerg, Kathryn, additional, Williams, Linda J, additional, Williams, Louise R, additional, Abo, Masahiro, additional, Becker, Frank, additional, Bowen, Audrey, additional, Brandenburg, Caitlin, additional, Breitenstein, Caterina, additional, Bruehl, Stefanie, additional, Copland, David A, additional, Cranfill, Tamara B, additional, di Pietro-Bachmann, Marie, additional, Enderby, Pamela, additional, Fillingham, Joanne, additional, Galli, Federica Lucia, additional, Gandolfi, Marialuisa, additional, Glize, Bertrand, additional, Godecke, Erin, additional, Hawkins, Neil, additional, Hilari, Katerina, additional, Hinckley, Jacqueline, additional, Horton, Simon, additional, Howard, David, additional, Jaecks, Petra, additional, Jefferies, Elizabeth, additional, Jesus, Luis MT, additional, Kambanaros, Maria, additional, Kang, Eun Kyoung, additional, Khedr, Eman M, additional, Kong, Anthony Pak-Hin, additional, Kukkonen, Tarja, additional, Laganaro, Marina, additional, Lambon Ralph, Matthew A, additional, Laska, Ann Charlotte, additional, Leemann, Béatrice, additional, Leff, Alexander P, additional, Lima, Roxele R, additional, Lorenz, Antje, additional, MacWhinney, Brian, additional, Shisler Marshall, Rebecca, additional, Mattioli, Flavia, additional, Maviş, İlknur, additional, Meinzer, Marcus, additional, Nilipour, Reza, additional, Noé, Enrique, additional, Paik, Nam-Jong, additional, Palmer, Rebecca, additional, Papathanasiou, Ilias, additional, Patrício, Brígida F, additional, Martins, Isabel Pavão, additional, Price, Cathy, additional, Jakovac, Tatjana Prizl, additional, Rochon, Elizabeth, additional, Rose, Miranda L, additional, Rosso, Charlotte, additional, Rubi-Fessen, Ilona, additional, Ruiter, Marina B, additional, Snell, Claerwen, additional, Stahl, Benjamin, additional, Szaflarski, Jerzy P, additional, Thomas, Shirley A, additional, van de Sandt-Koenderman, Mieke, additional, van der Meulen, Ineke, additional, Visch-Brink, Evy, additional, Worrall, Linda, additional, and Wright, Heather Harris, additional

Published
2022
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3. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke

Author

Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, The RELEASE Collaborators, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, and The RELEASE Collaborators

Abstract

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language ( ≥ 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab

Published
2022

4. Complex speech-language therapy interventions for stroke-related aphasia: The RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Harris Wright, Heather, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Harris Wright, Heather

Abstract

Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were used t

Published
2022

5. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses:the RELEASE database of aphasia after stroke

Author

Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Ribeiro Lima, Roxele, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, van de Sandt - Koenderman, WME, Van Der Meulen, Ineke, Visch-Brink, Evy, Wright, Heather Harris, Brady, Marian, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Ribeiro Lima, Roxele, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, van de Sandt - Koenderman, WME, Van Der Meulen, Ineke, Visch-Brink, Evy, Wright, Heather Harris, and Brady, Marian

Abstract

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language (≥10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or a

Published
2022

6. Complex speech-language therapy interventions for stroke-related aphasia:The RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author

Brady, Marian C., Ali, Myzoon, Berg, Kathryn Vanden, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Macwhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavi̧s, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, Berg, Kathryn Vanden, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Macwhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavi̧s, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were use

Published
2022

7. sj-docx-1-wso-10.1177_17474930221097477 – Supplemental material for Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis

Author

Brady, Marian C, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J, Williams, Louise R, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A, Cranfill, Tamara B, Pietro-Bachmann, Marie di, Enderby, Pamela, Fillingham, Joanne, Lucia Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M, Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Charlotte Laska, Ann, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Harris Wright, Heather

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221097477 for Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis by Marian C Brady, Myzoon Ali, Kathryn VandenBerg, Linda J Williams, Louise R Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A Copland, Tamara B Cranfill, Marie di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis MT Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A Lambon Ralph, Ann Charlotte Laska, Béatrice Leemann, Alexander P Leff, Roxele R Lima, Antje Lorenz, Brian MacWhinney, Rebecca Shisler Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P Szaflarski, Shirley A Thomas, Mieke van de Sandt-Koenderman, Ineke van der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright and in International Journal of Stroke

Published
2022
Full Text
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11. Predictors of poststroke aphasia recovery : A systematic review - informed individual participant data meta-analysis

Author

The Rehabilitation and Recovery of People with Aphasia after Stroke (RELEASE) Collaborators, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A.Lambon, Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Whinney, Brian Mac, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Tampere University, Department of Otology and Oral Diseases, and Welfare Sciences

Subjects
515 Psychology, 3112 Neurosciences, behavioral disciplines and activities
Abstract

BACKGROUND AND PURPOSE: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. METHODS: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. RESULTS: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (

Published
2021

13. RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Pavão Martins, Isabel, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Pavão Martins, Isabel, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110

Published
2020

14. Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke

Author

RELEASE Collaboration, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis Mt, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon-Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, RELEASE Collaboration, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis Mt, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon-Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Purpose: Speech and language pathology (SLP) for aphasia is a complex intervention delivered to a heterogeneous population within diverse settings. Simplistic descriptions of participants and interventions in research hinder replication, interpretation of results, guideline and research developments through secondary data analyses. This study aimed to describe the availability of participant and intervention descriptors in existing aphasia research datasets. Method: We systematically identified aphasia research datasets containing ≥10 participants with information on time since stroke and language ability. We extracted participant and SLP intervention descriptions and considered the availability of data compared to historical and current reporting standards. We developed an extension to the Template for Intervention Description and Replication checklist to support meaningful classification and synthesis of the SLP interventions to support secondary data analysis. Result: Of 11, 314 identified records we screened 1131 full texts and received 75 dataset contributions. We extracted data from 99 additional public domain datasets. Participant age (97.1%) and sex (90.8%) were commonly available. Prior stroke (25.8%), living context (12.1%) and socio-economic status (2.3%) were rarely available. Therapy impairment target, frequency and duration were most commonly available but predominately described at group level. Home practice (46.3%) and tailoring (functional relevance 46.3%) were inconsistently available. Conclusion: Gaps in the availability of participant and intervention details were significant, hampering clinical implementation of evidence into practice and development of our field of research. Improvements in the quality and consistency of participant and intervention data reported in aphasia research are required to maximise clinical implementation, replication in research and the generation of insights from secondary data analysis. Systematic review registratio

Published
2020

15. Guillain-Barré syndrome as a complication of SARS-CoV-2 infection

Author

Coen, Matteo, primary, Jeanson, Grégoire, additional, Culebras Almeida, L. Alejandro, additional, Hübers, Annemarie, additional, Stierlin, Florian, additional, Najjar, Iris, additional, Ongaro, Marie, additional, Moulin, Kelly, additional, Makrygianni, Maria, additional, Leemann, Béatrice, additional, Kronig, Ilona, additional, Bertrand, Jérôme, additional, Reny, Jean-Luc, additional, Schibler, Manuel, additional, and Serratrice, Jacques, additional

Published
2020
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18. Conséquences et complications neurologiques de la consommation d'alcool

Author

Sossauer, Laura, Schnider, Armin, and Leemann, Béatrice

Subjects
ddc:616.8
Abstract

In Switzerland, alcohol consumption is often trivialized and widely accepted as normal behavior. However, even in small quantities, repeated alcohol intake can cause injury to both the central nervous system and the peripheral one. Various mechanisms are involved : direct neurotoxicity, metabolic disorders, vitamin deficiencies, systemic injuries (hepatic, cardiovascular, immune), and accidents. This article describes potential neurological complications and their mechanisms, emphasizing the importance of early screenings for abusive consumption.

Published
2018

21. Who participates in aphasia research? An analysis of the REhabilitation and recovery of peopLE with Aphasia after StrokE (RELEASE) data set

Author

Ali, Myzoon, primary, Elders, Andrew, additional, Godwin, Jon, additional, Karachalia Sandri, Anastasia, additional, Williams, Linda J, additional, Williams, Louise R, additional, VandenBerg, Kathryn, additional, Abel, Stefanie, additional, Abo, Masahiro, additional, Becker, Frank, additional, Bowen, Audrey, additional, Brandenburg, Caitlin, additional, Breitenstein, Caterina, additional, Copland, David, additional, Cranfill, Tamara, additional, Di Pietro-Bachmann, Marie, additional, Enderby, Pam, additional, Fillingham, Joanne, additional, Galli, Federica, additional, Gandolfi, Marialuisa, additional, Glize, Bertrand, additional, Godecke, Erin, additional, Hilari, Katerina, additional, Hinckley, Jacqueline, additional, Horton, Simon, additional, Howard, David, additional, Jaecks, Petra, additional, Jefferies, Beth, additional, Jesus, Luis, additional, Kambanaros, Maria, additional, Khedr, Eman, additional, Kong, Anthony PH, additional, Kukkonen, Tarja, additional, Kyoung Kang, Eun, additional, Lambon Ralph, Matthew, additional, Laganaro, Marina, additional, Laska, Ann-Charlotte, additional, Leemann, Béatrice, additional, Leff, Alexander, additional, Lorenz, Antje, additional, MacWhinney, Brian, additional, Mattioli, Flavia, additional, Maviş, İlknur, additional, Meinzer, Marcus, additional, Noé Sebastián, Enrique, additional, Nilipour, Reza, additional, Paik, Nam-Jong, additional, Palmer, Rebecca, additional, Papathanasiou, Ilias, additional, Patricio, Brigida, additional, Pavão Martins, Isabel, additional, Price, Cathy, additional, Prizl Jakovac, Tatjana, additional, Rochon, Elizabeth, additional, Rose, Miranda L, additional, Rosso, Charlotte, additional, Ribeiro Lima, Roxele, additional, Rubi-Fessen, Ilona, additional, Ruiter, Marina, additional, Shisler Marshall, Rebecca, additional, Small, Steve, additional, Snell, Claerwen, additional, Stahl, Benjamin, additional, Szaflarski, Jerzy P, additional, Thomas, Shirley, additional, Van Der Meulen, Ineke, additional, Van De Sandt-Koenderman, Mieke, additional, Visch-Brink, Evy, additional, Worrall, Linda, additional, Wright, Heather Harris, additional, and Brady, Marian C, additional

Published
2018
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22. Changes in oro-facial function and hand-grip strength during a two year observation period after stroke

Author

Schimmel Martin Leemann Béatrice Schnider Armin Herrmann FR Kiliaridis S Müller Frauke

Subjects
stomatognathic diseases
Abstract

Objectives Recovery from stroke related oro facial impairment has rarely been investigated. In this longitudinal study chewing efficiency maximum lip and bite force as well as masseter muscle thickness were evaluated and compared with hand grip force. Materials and Methods Thirty one (31) hospitalized stroke patients and 24 controls were recruited for this prospective case control study with two year follow up. Chewing efficiency was evaluated with a color mixing ability test lip forces with a traction dynamometer bite force with a digital gauge masseter muscle thickness using ultrasound measurements and grip strength with a hand dynamometer. Results During the 2 year observation period patients were evaluated 4 times. Twenty one (21) patients dropped out of the study. Stroke patients showed significantly impaired chewing efficiency and lower lip forces than controls with no significant improvement over time. Bite forces were not different between ipsi and contralesional sides in contrast to contralesional hand grip strength which was significantly impaired and did not improve during the observation period. On the first examination with a median of 40 days after stroke masseter thickness was reduced contra lesional but did not continue to show significant side differences during follow up. Conclusions and Clinical Relevance Impaired chewing efficiency and reduced lip force are quantifiable symptoms which seem not to improve in the absence of oro facial rehabilitation procedures. Further research is needed to evaluate the predictive value of oro facial parameters on functional outcome after stroke.

Published
2013
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23. Behaviorally spontaneous confabulation in limbic encephalitis: The roles of reality filtering and strategic monitoring

Author

NAHUM, LOUIS, PTAK, RADEK, LEEMANN, BÉATRICE, LALIVE, PATRICE, SCHNIDER, ARMIN, NAHUM, LOUIS, PTAK, RADEK, LEEMANN, BÉATRICE, LALIVE, PATRICE, and SCHNIDER, ARMIN

Abstract

Behaviorally spontaneous confabulation is characterized by a confusion of reality evident in currently inappropriate acts that patients justify with confabulations and in disorientation. Here, we describe a 38-year-old woman lawyer hospitalized because of non-herpetic, presumably autoimmune, limbic encephalitis. For months, she considered herself at work and desperately tried to respect her falsely believed professional obligations. In contrast to a completely erroneous concept of reality, she did not confabulate about her remote personal past. In tasks proposed to test strategic retrieval monitoring, she produced no confabulations. As expected, she failed in tasks of reality filtering, previously shown to have high sensitivity and specificity for behaviorally spontaneous confabulation and disorientation: she failed to suppress the interference of currently irrelevant memories and she had deficient extinction capacity. The observation underscores the special status of behaviorally spontaneous confabulation among confabulatory phenomena and of reality filtering as a thought control mechanism. We suggest that different processes may underlie the generation of false memories and their verbal expression. We also emphasize the need to present theories of confabulation together with experimental tasks that allow one to empirically verify the theories and to explore underlying physiological mechanisms. (JINS, 2010, 16, 995-1005.)

Published
2017

24. Récupération après une lésion cérébrale : facteurs décisifs en rééducation

Author

Leemann, Béatrice

Subjects
Plasticité cérébrale, Rééducation neurologique, Accident vasculaire cérébral, Traumatisme cranio-cérébral
Abstract

En se basant sur une revue de la littérature et sur l'expérience personnelle ce travail décrit les principaux facteurs modifiables dont il faut tenir compte pour soutenir la récupération après une lésion cérébrale vasculaire ou traumatique. Il comprend 2 chapitres principaux: 1) comment éviter, reconnaître et traiter les complications supplémentaires. 2) comment diminuer le déficit se basant sur ce que l'on sait de la plasticité cérébrale.

Published
2016
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25. Détection et prise en charge d'un trouble de déglutition neurologique

Author

Leemann, Béatrice, Sergi, Sabrina, Sahinpasic, Leila, and Schnider, Armin

Subjects
Deglutition Disorders/diagnosis/physiopathology/rehabilitation, Nutrition Assessment, Treatment Outcome, Patient Education as Topic, Risk Factors, fungi, food and beverages, Bronchopneumonia/prevention & control, Humans, Enteral Nutrition/methods, Malnutrition/prevention & control, ddc:616.8, Esophagoscopy/methods
Abstract

Neurologic dysphagia is frequent and has consequences which can be severe, such as, denutrition andpneumonia. In most cases, it can be detected with a clinical exam. The management includes some general measures, an adaptation of textures, specific rehabilitation, and nutritional assessment to judge whether complementary enteral nutrition is needed.

Published
2016

26. Anaplastic Medullary Ependymoma Presenting as Subarachnoid Hemorrhage

Author

Nicastro, Nicolas, Schnider, Armin, and Leemann, Béatrice

Subjects
Article Subject, cardiovascular diseases
Abstract

A-41-year old man presented with violent thunderclap headache and a bilateral proprioceptive sensibility deficit of the upper limbs. Cerebral CT scan and MRI were negative. Lumbar puncture confirmed subarachnoid hemorrhage (SAH), but cerebral angiography was negative. Three months later, the patient presented with paraparesis, and a thorough work-up revealed a diffuse, anaplastic extramedullary C7-D10 ependymoma with meningeal carcinomatosis considered the source of hemorrhage. The patient went through a D5-D8 laminectomy, temozolomide chemotherapy, and radiotherapy. The situation remained stable for a few months. In this paper, we would like to emphasize that spinal masses should be considered in cases of SAH with negative diagnostic findings for aneurysms or arteriovenous malformation.

Published
2013
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27. Iron-Deficiency Anemia as a Rare Cause of Cerebral Venous Thrombosis and Pulmonary Embolism

Author

Nicastro, Nicolas, Schnider, Armin, and Leemann, Béatrice

Subjects
Article Subject, hemic and lymphatic diseases
Abstract

Cerebral venous thrombosis (CVT) is a relatively rare cause of stroke and has a wide spectrum of unspecific symptoms, which may delay diagnosis. There are many etiologies, including hematological disorders, trauma, infection, and dehydration. Iron-deficiency anemia (IDA) has been reported as an extremely rare cause of CVT, especially in adults.

Published
2012
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28. Facial blindsight

Author

Solcà, Marco, primary, Guggisberg, Adrian G., additional, Schnider, Armin, additional, and Leemann, Béatrice, additional

Published
2015
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29. Oral health-related quality of life in hospitalised stroke patients

Author

Schimmel, Martin, Leemann, Béatrice, Christou, Panayiotis, Kiliaridis, Stavros, Schnider, Armin, Herrmann, François, and Muller, Frauke

Subjects
Male, Facial Paralysis, Anxiety/psychology, Pain, Paralysis/physiopathology/psychology, Oral Health, Anxiety, Facial Paralysis/physiopathology/psychology, Cerebral Hemorrhage/physiopathology/psychology, Brain Ischemia, Eating, Humans, Paralysis, Disabled Persons, Interpersonal Relations, Brain Ischemia/physiopathology/psychology, Lip/physiopathology, Aged, Cerebral Hemorrhage, Eating/physiology, Jaw, Edentulous, Partially, Disabled Persons/psychology, Denture Retention, ddc:617.6, Pain/psychology, humanities, Lip, ddc:616.8, Hospitalization, Stroke, stomatognathic diseases, Jaw, Edentulous, Partially/classification, ddc:618.97, Quality of Life, Denture, Partial, Removable, Mastication, Female, Stress, Mechanical, Mastication/physiology, Stroke/physiopathology/psychology
Abstract

OBJECTIVE The aim of this study was to test the hypothesis that impairment of orofacial function following stroke affects the patients' oral health related quality of life (OHRQoL). MATERIAL AND METHODS From the University Hospitals of Geneva 31 stroke patients (18 men 13 women mean age 69.0 ± 12.7 years) with unilateral facial and limb palsy were recruited (patient group PG). In the study the Oral Health Impact Profile (OHIP) EDENT was utilised to assess OHRQoL. Further examinations comprised a test of masticatory efficiency and lip force stroke severity National Institute of Health Stroke Scale and dental state. The control group (CG) consisted of 24 subjects with similar age gender and dental state. RESULTS The PG mean OHIP EDENT sum score was 18.8 ± 15.5 and proved higher than one of the CG indicating a lower OHRQoL in the PG (p < 0.01). The score of the sub domains 'functional limitation' and 'physical pain' were significantly higher in PG (p < 0.03 and p < 0.02 respectively). The masticatory efficiency was significantly lower in the PG (p < 0.0001) and was associated with the OHIP EDENT sum score and its sub domains except for 'physical disability'. This effect was not present in the CG. CONCLUSION The OHRQoL is significantly reduced in hospitalised stroke patients whereby functional impairment seems predominant when compared with psychological and psycho social aspects.

Published
2010

30. Evolution inhabituellement favorable d'un Locked-in syndrome secondaire à une thrombose basilaire

Author

Leemann, Béatrice and Schnider, Armin

Subjects
Arterial Occlusive Diseases/rehabilitation/*surgery, Male, Quadriplegia/*etiology/*rehabilitation, Basilar Artery/*surgery, Activities of Daily Living, Humans, Walking, Prognosis, ddc:616.8, Aged
Abstract

Locked-in syndrome (LIS) after basilar artery occlusion is associated with poor prognosis. For a patient with LIS, rehabilitation aims to restore communication, avoid complications, and ensure a certain comfort. We describe a case with remarkable recovery. After 2 years the patient was independent for daily living activities, walks independently and has comprehensible speech.

Published
2010

31. Masseter muscle thickness in hospitalised stroke patients

Author

Schimmel, Martin, Leemann, Béatrice, Christou, Panayiotis, Schnider, Armin, Muller, Frauke, and Kiliaridis, Stavros

Subjects
Male, Facial Paralysis/etiology, Cephalometry, Transducers, Masseter Muscle/*pathology/ultrasonography, Hospitalization, ddc:617.6, ddc:616.8, Intracranial Hemorrhages/complications, Brain Ischemia/complications, ddc:618.97, Humans, Female, ddc:610, Paresis/etiology, Stroke/etiology/*pathology, Aged, Muscle Contraction/physiology
Abstract

The aim of the study was to investigate the thickness of the masseter muscles in stroke patients when compared to a control group (CG). Hospitalised stroke patients (18 men, 13 women; age 69.0 +/- 12.7 years) were compared to a CG (13 men, 11 women; age 68.8 +/- 10.8 years) composed to correspond to in age, gender and dental state. The thickness of the masseter muscle was recorded by means of a real-time ultrasound scanner on both sides, twice under contraction and twice in relaxed condition. In the stroke patients, the thickness of the masseter muscle of the affected side (aff) was smaller than the one of the non-affected side (non-aff) both, under contraction (aff 13.1 +/- 2.4 mm; non-aff 13.8 +/- 2.3 mm, P

Published
2010

32. Impossibilité à la fermeture volontaire des paupières : une apraxie ?

Author

Leemann, Béatrice and Schnider, Armin

Subjects
Apraxie, Paupières, ddc:616.8
Abstract

L'impossibilité de fermer volontairement les yeux, alors que l'activité réflexe, automatique et syncinétique des paupières est conservée, est un phénomène rare. A partir de l'observation d'une patiente et de la revue des cas dans la littérature, est décrit le mécanisme et les syndromes possibles à la base de ce fait: syndrome pseudobulbaire, obligation à garder les yeux ouverts, impersistance et apraxie. Le lien entre apraxie palpébrale et les autres troubles praxiques est recherché mais l'apraxie palpébrale se révèle être une entité clinique autonome.

Published
2004

41. Impairment of semantic memory after basal forebrain and fornix lesion.

Author

Solcà, Marco, Di Pietro, Marie, Schnider, Armin, and Leemann, Béatrice

Subjects
SEMANTIC memory, PROSENCEPHALON, POSITRON emission tomography, ORGAN rupture, TEMPORAL lobe, BRAIN physiology
Abstract

Semantic memory impairment is classically associated with lesion of the anterior temporal lobe. We report the case of a patient with severe semantic knowledge impairment and anterograde amnesia after bilateral ischemic lesion of the fornix and of the basal forebrain following surgical clipping of an aneurysm of the anterior communicating artery. Fluorodeoxyglucose positron emission tomography (FDG-PET) showed a temporal hypometabolism. Severe semantic impairment is a rare complication after rupture of an anterior communicating artery aneurysm and may result from disconnection of the temporal lobe. [ABSTRACT FROM AUTHOR]

Published
2015
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45. Crossover Trial of Subacute Computerized Aphasia Therapy for Anomia With the Addition of Either Levodopa or Placebo.

Author

Leemann, Béatrice, Laganaro, Marina, Chetelat-Mabillard, Daphné, and Schnider, Armin

Abstract

Background. The effect of levodopa on recovery from aphasia is controversial. Objective. To determine whether levodopa enhances the effect of intensive computer-assisted therapy (CAT) of anomia in the postacute stage of aphasia. Methods. Double-blind multiple case study with intrasubject crossover design comparing the effect of levodopa (100 mg) versus placebo, each given for 2 weeks. Subjects. Twelve patients with onset of aphasia from 2 to 9 weeks after stroke or traumatic brain injury were compared on naming performance on items trained and not trained with CAT. Subjects were randomized to either levodopa or placebo first, separated by a 1-week washout, and then switched to the other drug intervention for the second 2-week CAT intervention. The subjects also received routine aphasia therapies during these periods. Results. All patients improved their naming performance for items trained by CAT in both periods (P = .001). No significant difference was found between the placebo and levodopa phases. Conclusion. Administration of levodopa for 2 weeks during the postacute stage of aphasia did not augment the positive effects of subacute intensive language treatment with CAT for a spoken naming task. [ABSTRACT FROM PUBLISHER]

Published
2011
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46. ▪ Le Wolf motor function test

Author

Bürge, Elisabeth, Kupper, Danièle, and Leemann, Béatrice

Abstract

L’utilisation d’outils d’évaluation validés est indispensable pour documenter l’évolution du membre supérieur parétique suite à un accident vasculaire cérébral. Or, peu de tests à disposition sont validés en français. Parmi les tests existants, le choix s’est porté sur le Wolf motor function test(WFMT) parce qu’il évalue le domaine des activités et permet de coter la qualité gestuelle et le temps d’exécution.

Published
2010
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47. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke

Author

<p>National Institute for Health Research (NIHR) Health Services and Delivery Research Tavistock Trust for Aphasia Chief Scientist Office Scottish Government Health and Social Care Directorates</p>, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, The RELEASE Collaborators, <p>National Institute for Health Research (NIHR) Health Services and Delivery Research Tavistock Trust for Aphasia Chief Scientist Office Scottish Government Health and Social Care Directorates</p>, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, and The RELEASE Collaborators

Abstract

Williams, L. R., Ali, M., VandenBerg, K., Williams, L. J., Abo, M., Becker, F., . . . Brady, M. C. (2021). Utilising a systematic review-based approach to create a database of individual participant data for meta-and network meta-analyses: The RELEASE database of aphasia after stroke. Aphasiology. Advance online publication. https://doi.org/10.1080/02687038.2021.1897081

48. RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Pavão Martins, Isabel, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Pavão Martins, Isabel, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Brady, M. C., Ali, M., VandenBerg, K., Williams, L. J., Williams, L. R., Abo, M., ... & Bruehl, S. (2020). RELEASE: a protocol for a systematic review based, individual participant data, meta-and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. Aphasiology, 34(2), 137-157. https://www.tandfonline.com/doi/full/10.1080/02687038.2019.1643003

49. Impossibilité à la fermeture volontaire des paupières: une apraxie ?

Author

Leemann, Béatrice and Leemann, Béatrice

Abstract

L'impossibilité de fermer volontairement les yeux, alors que l'activité réflexe, automatique et syncinétique des paupières est conservée, est un phénomène rare. A partir de l'observation d'une patiente et de la revue des cas dans la littérature, est décrit le mécanisme et les syndromes possibles à la base de ce fait: syndrome pseudobulbaire, obligation à garder les yeux ouverts, impersistance et apraxie. Le lien entre apraxie palpébrale et les autres troubles praxiques est recherché mais l'apraxie palpébrale se révèle être une entité clinique autonome.

50. Behaviorally spontaneous confabulation in limbic encephalitis: The roles of reality filtering and strategic monitoring

Author

NAHUM, LOUIS, PTAK, RADEK, LEEMANN, BÉATRICE, LALIVE, PATRICE, SCHNIDER, ARMIN, NAHUM, LOUIS, PTAK, RADEK, LEEMANN, BÉATRICE, LALIVE, PATRICE, and SCHNIDER, ARMIN

Abstract

Behaviorally spontaneous confabulation is characterized by a confusion of reality evident in currently inappropriate acts that patients justify with confabulations and in disorientation. Here, we describe a 38-year-old woman lawyer hospitalized because of non-herpetic, presumably autoimmune, limbic encephalitis. For months, she considered herself at work and desperately tried to respect her falsely believed professional obligations. In contrast to a completely erroneous concept of reality, she did not confabulate about her remote personal past. In tasks proposed to test strategic retrieval monitoring, she produced no confabulations. As expected, she failed in tasks of reality filtering, previously shown to have high sensitivity and specificity for behaviorally spontaneous confabulation and disorientation: she failed to suppress the interference of currently irrelevant memories and she had deficient extinction capacity. The observation underscores the special status of behaviorally spontaneous confabulation among confabulatory phenomena and of reality filtering as a thought control mechanism. We suggest that different processes may underlie the generation of false memories and their verbal expression. We also emphasize the need to present theories of confabulation together with experimental tasks that allow one to empirically verify the theories and to explore underlying physiological mechanisms. (JINS, 2010, 16, 995-1005.)

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