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45 results on '"Lee, Z. Y."'

1. A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE)

Author

Davies, T. W., Kelly, E., van Gassel, R. J. J., van de Poll, M. C. G., Gunst, J., Casaer, M. P., Christopher, K. B., Preiser, J. C., Hill, A., Gundogan, K., Reintam-Blaser, A., Rousseau, A.-F., Hodgson, C., Needham, D. M., Schaller, S. J., McClelland, T., Pilkington, J. J., Sevin, C. M., Wischmeyer, P. E., Lee, Z. Y., Govil, D., Chapple, L., Denehy, L., Montejo-González, J. C., Taylor, B., Bear, D. E., Pearse, R. M., McNelly, A., Prowle, J., and Puthucheary, Z. A.

Published
2023
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2. Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)

Author

Davies, T. W., van Gassel, R. J. J., van de Poll, M., Gunst, J., Casaer, M. P., Christopher, K. B., Preiser, J. C., Hill, A., Gundogan, K., Reintam-Blaser, A., Rousseau, A. F., Hodgson, C., Needham, D. M., Castro, M., Schaller, S., McClelland, T., Pilkington, J. J., Sevin, C. M., Wischmeyer, P. E., Lee, Z. Y., Govil, D., Li, A., Chapple, L., Denehy, L., Montejo-González, J. C., Taylor, B., Bear, D. E., Pearse, R., McNelly, A., Prowle, J., and Puthucheary, Z. A.

Published
2022
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6. Additional file 1 of Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)

Author

Davies, T. W., van Gassel, R. J. J., van de Poll, M., Gunst, J., Casaer, M. P., Christopher, K. B., Preiser, J. C., Hill, A., Gundogan, K., Reintam-Blaser, A., Rousseau, A. F., Hodgson, C., Needham, D. M., Castro, M., Schaller, S., McClelland, T., Pilkington, J. J., Sevin, C. M., Wischmeyer, P. E., Lee, Z. Y., Govil, D., Li, A., Chapple, L., Denehy, L., Montejo-González, J. C., Taylor, B., Bear, D. E., Pearse, R., McNelly, A., Prowle, J., and Puthucheary, Z. A.

Abstract

Additional file 1. Supplementary methods, results, figures and tables.

Published
2022
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12. P13 Safety and efficacy of sacubitril-valsartan initiation during and after acute decompensated heart failure with reduced ejection fraction

Author

Tan, C T, primary, Koh, K T, additional, Onn, Y Y, additional, Ho, K H, additional, Said, A, additional, Mohd Amin, N H, additional, Shu, F E P, additional, Khiew, N Z, additional, Cham, Y L, additional, Fong, A Y Y, additional, Ong, T K, additional, Eng, S Y, additional, Lee, Z Y, additional, and Madzlan, N, additional

Published
2020
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37. THERMOELASTICITY OF MULTILAYERED CYLINDERS.

Author

Jane, K. C. and Lee, Z. Y.

Subjects
*THERMOELASTICITY, *ENGINE cylinders, *LAPLACE transformation
Abstract

Thermoelasticity of multilayered cylinders subjected to known temperatures at traction free boundaries are considered. Laplace transform and finite difference methods are used to analyze problems. Using the Laplace transform with respect to time, the general solutions of the governing equations are obtained in transform domain. The solution is obtained using the matrix similarity transformation and inverse Laplace transform. We obtained solutions for the temperature and thermal stress distributions in a transient state. Moreover, the computational procedures established in this article can solve the generalized thermoelasticity problem for a multilayered composite cylinder with nonhomogeneous materials. [ABSTRACT FROM AUTHOR]

Published
1999
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44. CXCR4 expression is associated with pelvic lymph node metastasis in cervical adenocarcinoma.

Author

Yang YC, Lee ZY, Wu CC, Chen TC, Chang CL, and Chen CP

Subjects
Adenocarcinoma metabolism, Adult, Cell Line, Tumor, Cell Movement drug effects, Cell Proliferation drug effects, Cell Survival drug effects, Chemokine CXCL12, Chemokines, CXC metabolism, Chemokines, CXC pharmacology, Female, HeLa Cells, Humans, Lymph Nodes metabolism, Middle Aged, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3 metabolism, Oncogene Protein v-akt metabolism, Pelvis, U937 Cells, Uterine Cervical Neoplasms metabolism, Adenocarcinoma pathology, Lymphatic Metastasis, Receptors, CXCR4 metabolism, Uterine Cervical Neoplasms pathology
Abstract

The aim of this study is to investigate the expression of CXCR4 receptor in cervical adenocarcinoma and related mechanisms involved in pelvic lymph node metastasis. Immunohistochemistry was used to evaluate the expression of CXCR4 and the association of pelvic lymph node metastasis in archived tissue from clinical stage IB cervical adenocarcinomas (n = 37) and from benign specimens obtained at hysterectomy for other causes (n = 48). The HeLa cell (cervical adenocarcinoma-derived cell) line that expresses CXCR4 was used to study the interaction between the CXCR4 receptor and stromal cell-derived factor 1alpha (SDF-1alpha). Cell migration assays, cell numbers, flow cytometry, cell proliferation assay, and western blot were used to study the function of CXCR4 and its downstream signal transduction. The positive cases were semiquantitatively divided into three score classes according to their staining. Tumors with strong CXCR4 stainings were more likely to have pelvic lymph node metastasis than those with weak or negative stainings (87.5% vs 34.5%; P = 0.014). Only 25% of the benign specimens had weak or negative staining for CXCR4. Functioning CXCR4 receptor was expressed on HeLa cells. SDF-1alpha provoked significant signal transduction events, including chemotaxis and rescue from apoptosis. These actions were apparently mediated by the activation and phosphorylation of the extracellular signal-regulated kinase 1/2 and AKT pathways. We conclude CXCR4 expression is associated with cervical adenocarcinoma cell migration and proliferation, and primary cervical adenocarcinoma cells expressing CXCR4 are significantly more likely to metastasize to pelvic lymph nodes.

Published
2007
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