Search

Your search keyword '"Lee, Yeon Kyung"' showing total 433 results
Start Over Author "Lee, Yeon Kyung"
433 results on '"Lee, Yeon Kyung"'

4. Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblasts Derived from Umbilical Cord Mesenchymal Stem Cells for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial.

Author

Baek, Seung-Hoon, Shim, Bum-Jin, Won, Heejae, Lee, Sunray, Lee, Yeon Kyung, Park, Hyun Sook, and Kim, Shin-Yoon

Subjects
MESENCHYMAL stem cells, LABORATORY test panels, FEMUR head, VISUAL analog scale, ANTIBODY titer
Abstract

Although mesenchymal stem cells (MSCs) insertion has gained recent attention as a joint-preserving procedure, no study has conducted direct intralesional implantation of human umbilical cord-derived MSCs (hUCMSCs) in patients with ONFH. This is a protocol for a phase 1 clinical trial designed to assess the safety and exploratory efficacy of human umbilical cord-derived osteoblasts (hUC-Os), osteogenic differentiation-induced cells from hUCMSCs, in patients with early-stage ONFH. Nine patients with Association Research Circulation Osseous (ARCO) stage 1 or 2 will be assigned to a low-dose (1 × 107 hUC-O cells, n = 3), medium-dose (2 × 107 cells, n = 3), and high-dose group (4 × 107 cells, n = 3) in the order of their arrival at the facility, and, depending on the occurrence of dose-limiting toxicity, up to 18 patients can be enrolled by applying the 3 + 3 escalation method. We will perform hUC-O (CF-M801) transplantation combined with core decompression and follow-up for 12 weeks according to the study protocol. Safety will be determined through adverse event assessment, laboratory tests including a panel reactive antibody test, vital sign assessment, physical examination, and electrocardiogram. Efficacy will be explored through the change in pain visual analog scale, Harris hip score, Western Ontario and McMaster Universities Osteoarthritis Index, ARCO stage, and also size and location of necrotic lesion according to Japanese Investigation Committee classification before and after the procedure. Joint preservation is important, particularly in younger, active patients with ONFH. Confirmation of the safety and efficacy of hUC-Os will lead to a further strategy to preserve joints for those suffering from ONFH and improve our current knowledge of cell therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. N‐Heterocyclic Carbene–Graphene Nanotransistor Based on Covalent Bond for Ultrastable Biosensors

Author

Kim, Kyung Ho, primary, Seo, Sung Eun, additional, Park, Seon Joo, additional, Kim, Jinyeong, additional, Park, Chul Soon, additional, Le, Thanh‐Hai, additional, Lee, Chang‐Seop, additional, Kim, Yu Kyung, additional, Kim, Hye‐Yeon, additional, Jun, Sangmi, additional, Kwak, Jisung, additional, Lee, Yeon Kyung, additional, Yoon, Hyeonseok, additional, Song, Hyun Seok, additional, and Kwon, Oh Seok, additional

Published
2024
Full Text
View/download PDF

22. Data from Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

Author

Kang, Sang Soo, primary, Han, Kyung-Seok, primary, Ku, Bo Mi, primary, Lee, Yeon Kyung, primary, Hong, Jinpyo, primary, Shin, Hye Young, primary, Almonte, Antoine G., primary, Woo, Dong Ho, primary, Brat, Daniel J., primary, Hwang, Eun Mi, primary, Yoo, Seung Hyun, primary, Chung, Chun Kee, primary, Park, Sung-Hye, primary, Paek, Sun Ha, primary, Roh, Eun Joo, primary, Lee, Sung joong, primary, Park, Jae-Yong, primary, Traynelis, Stephen F., primary, and Lee, C. Justin, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 4 from Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

Author

Kang, Sang Soo, primary, Han, Kyung-Seok, primary, Ku, Bo Mi, primary, Lee, Yeon Kyung, primary, Hong, Jinpyo, primary, Shin, Hye Young, primary, Almonte, Antoine G., primary, Woo, Dong Ho, primary, Brat, Daniel J., primary, Hwang, Eun Mi, primary, Yoo, Seung Hyun, primary, Chung, Chun Kee, primary, Park, Sung-Hye, primary, Paek, Sun Ha, primary, Roh, Eun Joo, primary, Lee, Sung joong, primary, Park, Jae-Yong, primary, Traynelis, Stephen F., primary, and Lee, C. Justin, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figure 1 from Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

Author

Kang, Sang Soo, primary, Han, Kyung-Seok, primary, Ku, Bo Mi, primary, Lee, Yeon Kyung, primary, Hong, Jinpyo, primary, Shin, Hye Young, primary, Almonte, Antoine G., primary, Woo, Dong Ho, primary, Brat, Daniel J., primary, Hwang, Eun Mi, primary, Yoo, Seung Hyun, primary, Chung, Chun Kee, primary, Park, Sung-Hye, primary, Paek, Sun Ha, primary, Roh, Eun Joo, primary, Lee, Sung joong, primary, Park, Jae-Yong, primary, Traynelis, Stephen F., primary, and Lee, C. Justin, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Methods from Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

Author

Kang, Sang Soo, primary, Han, Kyung-Seok, primary, Ku, Bo Mi, primary, Lee, Yeon Kyung, primary, Hong, Jinpyo, primary, Shin, Hye Young, primary, Almonte, Antoine G., primary, Woo, Dong Ho, primary, Brat, Daniel J., primary, Hwang, Eun Mi, primary, Yoo, Seung Hyun, primary, Chung, Chun Kee, primary, Park, Sung-Hye, primary, Paek, Sun Ha, primary, Roh, Eun Joo, primary, Lee, Sung joong, primary, Park, Jae-Yong, primary, Traynelis, Stephen F., primary, and Lee, C. Justin, primary

Published
2023
Full Text
View/download PDF

26. In Vitro Tracking of Human Umbilical Vein Endothelial Cells Using Ultra-Sensitive Quantum Dot-Embedded Silica Nanoparticles

Author

Kim, Jaehi, primary, Lee, Sunray, additional, Lee, Yeon Kyung, additional, Seong, Bomi, additional, Kim, Hyung-Mo, additional, Kyeong, San, additional, Kim, Wooyeon, additional, Ham, Kyeongmin, additional, Pham, Xuan-Hung, additional, Hahm, Eunil, additional, Mun, Ji Yeon, additional, Safaa, Mukhtar Anthony, additional, Lee, Yoon-Sik, additional, Jun, Bong-Hyun, additional, and Park, Hyun-Sook, additional

Published
2023
Full Text
View/download PDF

36. EGF Receptor-Targeting Cancer Therapy Using CD47-Engineered Cell-Derived Nanoplatforms

Author

Choi,Moon Jung, Choi,Kang Chan, Lee,Do Hyun, Jeong,Hwa Yeon, Kang,Seong Jae, Kim,Min Woo, Jeong,In Ho, You,Young Myoung, Lee,Jin Suk, Lee,Yeon Kyung, Im,Chan Su, Park,Yong Serk, Choi,Moon Jung, Choi,Kang Chan, Lee,Do Hyun, Jeong,Hwa Yeon, Kang,Seong Jae, Kim,Min Woo, Jeong,In Ho, You,Young Myoung, Lee,Jin Suk, Lee,Yeon Kyung, Im,Chan Su, and Park,Yong Serk

Abstract

Moon Jung Choi,1 Kang Chan Choi,1 Do Hyun Lee,1 Hwa Yeon Jeong,1 Seong Jae Kang,1 Min Woo Kim,1 In Ho Jeong,1 Young Myoung You,1 Jin Suk Lee,2 Yeon Kyung Lee,1 Chan Su Im,1 Yong Serk Park1 1Department of Biomedical Laboratory Science, Yonsei University, Wonju, Republic of Korea; 2Department of Anatomy, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaCorrespondence: Chan Su Im; Yong Serk Park, Department of Biomedical Laboratory Science, Yonsei University, Wonju, Gangwon, 220-710, Republic of Korea, Email chanzzhu@nate.com; parkys@yonsei.ac.krIntroduction: Avoiding phagocytic cells and reducing off-target toxicity are the primary hurdles in the clinical application of nanoparticles containing therapeutics. For overcoming these errors, in this study, nanoparticles expressing CD47 proteins inhibiting the phagocytic attack of immune cells were prepared and then evaluated as an anti-cancer drug delivery vehicle.Methods: The CD47+ cell-derived nanoparticles (CDNs) were prepared from the plasma membranes of human embryonic kidney cells transfected with a plasmid encoding CD47. And the doxorubicin (DOX) was loaded into the CDNs, and anti-EGF receptor (EGFR) antibodies were conjugated to the surface of the CDNs to target tumors overexpressing EGFR.Results: The CD47+iCDNs-DOX was successfully synthesized having a stable structure. The CD47+CDNs were taken up less by RAW264.7 macrophages compared to control CDNs. Anti-EGFR CD47+CDNs (iCDNs) selectively recognized EGFR-positive MDA-MB-231 cells in vitro and accumulated more effectively in the target tumor xenografts in mice. Moreover, iCDNs encapsulating doxorubicin (iCDNs-DOX) exhibited the highest suppression of tumor growth in mice, presumably due to the enhanced DOX delivery to tumor tissues, compared to non-targeting CDNs or CD47- iCDNs.Discussion: These results suggest that the clinical application of biocompatible cell membrane-derived nanocarriers could be facilitated by functionalization with macro

Published
2022

37. Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study

Author

Yin, Xianyong, Kim, Kwangwoo, Suetsugu, Hiroyuki, Bang, So-Young, Wen, Leilei, Koido, Masaru, Ha, Eunji, Liu, Lu, Sakamoto, Yuma, Jo, Sungsin, Leng, Rui-Xue, Otomo, Nao, Kwon, Young-Chang, Sheng, Yujun, Sugano, Nobuhiko, Hwang, Mi Yeong, Li, Weiran, Mukai, Masaya, Yoon, Kyungheon, Cai, Minglong, Ishigaki, Kazuyoshi, Chung, Won Tae, Huang, He, Takahashi, Daisuke, Lee, Shin-Seok, Wang, Mengwei, Karino, Kohei, Shim, Seung-Cheol, Zheng, Xiaodong, Miyamura, Tomoya, Kang, Young Mo, Ye, Dongqing, Nakamura, Junichi, Suh, Chang-Hee, Tang, Yuanjia, Motomura, Goro, Park, Yong-Beom, Ding, Huihua, Kuroda, Takeshi, Choe, Jung-Yoon, Li, Chengxu, Niiro, Hiroaki, Park, Youngho, Shen, Changbing, Miyamoto, Takeshi, Ahn, Ga-Young, Fei, Wenmin, Takeuchi, Tsutomu, Shin, Jung-Min, Li, Keke, Kawaguchi, Yasushi, Lee, Yeon-Kyung, Wang, Yong-Fei, Amano, Koichi, Park, Dae Jin, Yang, Wanling, Tada, Yoshifumi, Lau, Yu Lung, Yamaji, Ken, Zhu, Zhengwei, Shimizu, Masato, Atsumi, Takashi, Suzuki, Akari, Sumida, Takayuki, Okada, Yukinori, Matsuda, Koichi, Matsuo, Keitaro, Kochi, Yuta, Yamamoto, Kazuhiko, Ohmura, Koichiro, Kim, Tae-Hwan, Yang, Sen, Yamamoto, Takuaki, Kim, Bong-Jo, Shen, Nan, Ikegawa, Shiro, Lee, Hye-Soon, Zhang, Xuejun, Terao, Chikashi, Cui, Yong, Bae, Sang-Cheol, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Yin, Xianyong, Kim, Kwangwoo, Suetsugu, Hiroyuki, Bang, So-Young, Wen, Leilei, Koido, Masaru, Ha, Eunji, Liu, Lu, Sakamoto, Yuma, Jo, Sungsin, Leng, Rui-Xue, Otomo, Nao, Kwon, Young-Chang, Sheng, Yujun, Sugano, Nobuhiko, Hwang, Mi Yeong, Li, Weiran, Mukai, Masaya, Yoon, Kyungheon, Cai, Minglong, Ishigaki, Kazuyoshi, Chung, Won Tae, Huang, He, Takahashi, Daisuke, Lee, Shin-Seok, Wang, Mengwei, Karino, Kohei, Shim, Seung-Cheol, Zheng, Xiaodong, Miyamura, Tomoya, Kang, Young Mo, Ye, Dongqing, Nakamura, Junichi, Suh, Chang-Hee, Tang, Yuanjia, Motomura, Goro, Park, Yong-Beom, Ding, Huihua, Kuroda, Takeshi, Choe, Jung-Yoon, Li, Chengxu, Niiro, Hiroaki, Park, Youngho, Shen, Changbing, Miyamoto, Takeshi, Ahn, Ga-Young, Fei, Wenmin, Takeuchi, Tsutomu, Shin, Jung-Min, Li, Keke, Kawaguchi, Yasushi, Lee, Yeon-Kyung, Wang, Yong-Fei, Amano, Koichi, Park, Dae Jin, Yang, Wanling, Tada, Yoshifumi, Lau, Yu Lung, Yamaji, Ken, Zhu, Zhengwei, Shimizu, Masato, Atsumi, Takashi, Suzuki, Akari, Sumida, Takayuki, Okada, Yukinori, Matsuda, Koichi, Matsuo, Keitaro, Kochi, Yuta, Yamamoto, Kazuhiko, Ohmura, Koichiro, Kim, Tae-Hwan, Yang, Sen, Yamamoto, Takuaki, Kim, Bong-Jo, Shen, Nan, Ikegawa, Shiro, Lee, Hye-Soon, Zhang, Xuejun, Terao, Chikashi, Cui, Yong, Bae, Sang-Cheol, and Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head

Abstract

Objective Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes underlying the 110 SLE loci that were identified in the latest East Asian GWAS meta-analysis. Methods We built gene expression predictive models in blood B cells, CD4(+) and CD8(+) T cells, monocytes, natural killer cells and peripheral blood cells of 105 Japanese individuals. We performed a transcriptome-wide association study (TWAS) using data from the latest genome-wide association meta-analysis of 208 370 East Asians and searched for candidate genes using TWAS and three data-driven computational approaches. Results TWAS identified 171 genes for SLE (p<1.0x10(-5)); 114 (66.7%) showed significance only in a single cell type; 127 (74.3%) were in SLE GWAS loci. TWAS identified a strong association between CD83 and SLE (p<7.7x10(-8)). Meta-analysis of genetic associations in the existing 208 370 East Asian and additional 1498 cases and 3330 controls found a novel single-variant association at rs72836542 (OR=1.11, p=4.5x10(-9)) around CD83. For the 110 SLE loci, we identified 276 gene candidates, including 104 genes at recently-identified SLE novel loci. We demonstrated in vitro that putative causal variant rs61759532 exhibited an allele-specific regulatory effect on ACAP1, and that presence of the SLE risk allele decreased ACAP1 expression. Conclusions Cell-level TWAS in six types of immune cells complemented SLE gene discovery and guided the identification of novel genetic associations. The gene findings shed biological insights into SLE genetic associations.

Published
2022

47. Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus

Author

Suetsugu, Hiroyuki, primary, Kim, Kwangwoo, additional, Yamamoto, Takuaki, additional, Bang, So-Young, additional, Sakamoto, Yuma, additional, Shin, Jung-Min, additional, Sugano, Nobuhiko, additional, Kim, Ji Soong, additional, Mukai, Masaya, additional, Lee, Yeon-Kyung, additional, Ohmura, Koichiro, additional, Park, Dae Jin, additional, Takahashi, Daisuke, additional, Ahn, Ga-Young, additional, Karino, Kohei, additional, Kwon, Young-Chang, additional, Miyamura, Tomoya, additional, Kim, Jihye, additional, Nakamura, Junichi, additional, Motomura, Goro, additional, Kuroda, Takeshi, additional, Niiro, Hiroaki, additional, Miyamoto, Takeshi, additional, Takeuchi, Tsutomu, additional, Ikari, Katsunori, additional, Amano, Koichi, additional, Tada, Yoshifumi, additional, Yamaji, Ken, additional, Shimizu, Masato, additional, Atsumi, Takashi, additional, Seki, Taisuke, additional, Tanaka, Yoshiya, additional, Kubo, Toshikazu, additional, Hisada, Ryo, additional, Yoshioka, Tomokazu, additional, Yamazaki, Mihoko, additional, Kabata, Tamon, additional, Kajino, Tomomichi, additional, Ohta, Yoichi, additional, Okawa, Takahiro, additional, Naito, Yohei, additional, Kaneuji, Ayumi, additional, Yasunaga, Yuji, additional, Ohzono, Kenji, additional, Tomizuka, Kohei, additional, Koido, Masaru, additional, Matsuda, Koichi, additional, Okada, Yukinori, additional, Suzuki, Akari, additional, Kim, Bong-Jo, additional, Kochi, Yuta, additional, Lee, Hye-Soon, additional, Ikegawa, Shiro, additional, Bae, Sang-Cheol, additional, and Terao, Chikashi, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results