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1. Efficacy of 1060 nm Diode Laser for Non-Invasive Subcutaneous Fat Reduction in Mini-Pigs

Author

Lee YJ, Hong N, Choi ES, Choi SH, Kim EY, Park HJ, and Ahn JC

Subjects
diode laser, fat, abdominal, non-invasive, preclinical, Dermatology, RL1-803
Abstract

Yea-Jin Lee,1,2 Namgue Hong,2 Eun Seo Choi,3 Sun-Hyang Choi,2 Eun Young Kim,2 Hyeong Ju Park,4 Jin-Chul Ahn1,2 1Department of Medicine, Dankook University, Cheonan-si, 31116, Republic of Korea; 2Medical Laser Research Center, Graduate School of Medicine, Dankook University, Cheonan-si, 31116, Republic of Korea; 3Department of Physics, Chosun University, Gwangju, 61452, Republic of Korea; 4Bio&Health Photonics Research Center, Korea Photonics Technology Institute, Gwangju, 61007, Republic of KoreaCorrespondence: Hyeong Ju Park; Jin-Chul Ahn, Email phj020603@kopti.re.kr; jcahn@dankook.ac.krPurpose: To evaluate the efficacy and safety of abdominal fat reduction in mini-pigs, utilizing at 1060 nm diode laser with a wavelength of 1060 nm.Patients and Methods: The laser system non-invasively disrupts adipose tissue; its effectiveness and safety were evaluated by ultrasound imaging and histological analysis. Laser irradiation was performed with various powers, and the cooling function was activated to prevent skin surface damage.Results: The dermal tissue temperature increased to at least 43°C during laser exposure, leading to a decrease in abdominal fat thickness after 30 days. Blood tests revealed no significant changes in kidney and liver function but showed increased blood levels of nonessential free acids (NEFAs), likely due to the release of fatty tissue-derived free fatty acids. Histological evaluation demonstrated rapid transformation of adipose tissue into collagen, muscle fibers, and intracellular fibrous tissue.Conclusion: The 1060 nm laser showed promise as a non-invasive and safe tool for reducing abdominal fat.Keywords: diode laser, fat, abdominal, non-invasive, preclinical

Published
2024

2. Development and Psychometric Properties of the Health Belief Model Scale for Premature Birth Prevention (HBM-PBP) for Women of Childbearing Age

Author

Kim SH, Jung SY, Kim Y, and Lee YJ

Subjects
health belief model, premature birth, reproducibility of results, surveys and questionnaires, women, Gynecology and obstetrics, RG1-991
Abstract

Sun-Hee Kim,1 Sun Young Jung,1 Yoonjung Kim,2 Yu-Jin Lee1 1College of Nursing, Research Institute of Nursing Science, Daegu Catholic University, Daegu, Republic of Korea; 2College of Nursing, Konyang University, Daejeon, Republic of KoreaCorrespondence: Yoonjung Kim, #209 College of Nursing, Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon, 35365, Republic of Korea, Tel +82 42 600 8583, Fax +82 42 600 3277 2850, Email ykim@konyang.ac.krPurpose: This study aimed to develop the Health Belief Model scale for premature birth prevention (HBM-PBP) and evaluated its psychometric properties in women of childbearing age.Methods: This study employed a cross-sectional design and included 724 women of childbearing age with intentions of future childbirth or in their first trimester of pregnancy. An item pool was formulated from the literature and in-depth interviews based on the health belief model. Content validation was conducted by experts and through cognitive interviews with women of childbearing age. Construct and concurrent validity and reliability were evaluated using factor analysis, Pearson’s correlation analysis, and Cronbach’s alpha.Results: The HBM-PBP consisted of 96 items, including perceived susceptibility (21 items, 5 subscales), severity (26 items, 5 subscales), benefits (27 items, 5 subscales), and barriers (22 items, 5 subscales). Convergent and discriminant validity were supported. The Cronbach’s alpha coefficient of the domains ranged from 0.87 to 0.94.Conclusion: The HBM-PBP is a valid and reliable measurement scale with good psychometric properties. It can be used to measure health beliefs in women, either as a whole or in individual domains. Health professionals can leverage the HBM-PBP to discern women’s health beliefs on premature birth, facilitating tailored interventions and educational efforts.Keywords: health belief model, premature birth, reproducibility of results, surveys and questionnaires, women

Published
2024

3. Effects of Parallel Contact Cooling on Pulsed-Type, Bipolar Radiofrequency-Induced Tissue Reactions in an in vivo Porcine Model

Author

Cho SB, Lee YJ, Kang SY, Choi M, Kim B, and Ahn JC

Subjects
radiofrequency, parallel contact cooling, thermoelectric cooling, bipolar, alternating current, gated pulse, tissue reaction, porcine model, Dermatology, RL1-803
Abstract

Sung Bin Cho,1,* Yea-Jin Lee,2,* Sun Young Kang,3 Min Choi,3 Bora Kim,3 Jin-Chul Ahn2 1Yonsei Seran Dermatology and Laser Clinic, Seoul, Korea; 2Medical Laser Research Center, College of Medicine, Dankook University, Cheonan, Korea; 3R&D Center, Shenb Co., Ltd, Seoul, Korea*These authors contributed equally to this workCorrespondence: Jin-Chul Ahn, Medical Laser Research Center, College of Medicine, Dankook University, Cheonan, 31116, Korea, Tel +82.41-550-1811, Fax +82.41-550-7706, Email jcahn@dankook.ac.krBackground: Skin cooling during laser or radiofrequency (RF) treatments is a method to minimize thermal damage to the epidermis, reduce pain, and decrease post-treatment downtime. We evaluated the effect of parallel contact cooling (PCC) on RF-induced thermal reactions in minipig skin in vivo after bipolar microneedling RF treatment.Methods: RF treatments were administered at frequencies of 0.5, 1, and 2 MHz with single (500 ms), six (1000 ms), and ten (5000 ms) sub-pulse packs to minipig skin with or without PCC. Subsequently, thermometric imaging and histology were used to analyze skin reactions to RF.Results: Thermometric images showed that PCC promptly lowered skin temperature in the RF-treated area, with this effect persisting for over 60s. Regardless of the PCC, RF treatments lasting for 500 ms with a single pulse pack resulted in peri-electrode coagulative necrosis (PECN) zones and inter-electrode non-necrotic thermal reaction (IENT) zones in the dermis. In contrast, treatment lasting 5000 ms with 10 sub-pulse packs produced distinct IENT without notable PECN over a wide dermal area. Skin specimens obtained at 1 h and 3, 7, and 14 days after PCC-assisted RF treatments showed a higher degree of thermal tissue reactions in the deeper dermal regions compared to those after RF treatments without PCC.Conclusion: PCC-assisted RF treatment, utilizing an invasive bipolar microneedling device, enhanced RF-induced skin reactions in the mid to deep dermis while preserving the epidermis and upper papillary dermis from excessive thermal tissue injury.Keywords: radiofrequency, parallel contact cooling, thermoelectric cooling, bipolar, alternating current, gated pulse, tissue reaction, porcine model

Published
2024

4. Pretreatment Circulating Albumin, Platelet, and RDW-SD Associated with Worse Disease-Free Survival in Patients with Breast Cancer

Author

Chen CC, Tang WH, Wu CC, Lee TL, Tsai IT, Hsuan CF, Wang CP, Chung FM, Lee YJ, Yu TH, and Wei CT

Subjects
breast cancer, albumin, platelet, rdw-sd, disease-free survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Chia‐Chi Chen,1– 4 Wei-Hua Tang,5,6 Cheng-Ching Wu,2,7,8 Thung-Lip Lee,7,9 I-Ting Tsai,2,10 Chin-Feng Hsuan,2,7,11 Chao-Ping Wang,7,9 Fu-Mei Chung,7 Yau-Jiunn Lee,12 Teng-Hung Yu,2,7,* Ching-Ting Wei4,13,* 1Department of Pathology, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan; 2School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan; 3Department of Physical Therapy, I-Shou University, Kaohsiung, 82445, Taiwan; 4The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan; 5Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Yuli Branch, Hualien, 98142, Taiwan; 6Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan; 7Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan; 8Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, I-Shou, University, Kaohsiung, 82445, Taiwan; 9School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan; 10Department of Emergency, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan; 11Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, I-Shou University, Kaohsiung, Taiwan; 12Lee’s Endocrinologic Clinic, Pingtung, 90000, Taiwan; 13Division of General Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan*These authors contributed equally to this workCorrespondence: Teng-Hung Yu; Ching-Ting Wei, E-Da Hospital, I-Shou University, No. 1, Yi-Da Road, Jiau-Shu Village, Yan-Chao District, Kaohsiung, 82445, Taiwan, Tel +886-7-615-1100 ext. 5914 or 5018, Email tenghungy@gmail.com; triplet0826@gmail.comObjective: Breast cancer is the second most common malignancy globally and a leading cause of cancer death in women. Analysis of factors related to disease-free survival (DFS) has improved understanding of the disease and characteristics related to recurrence. The aim of this study was to investigate the predictors of DFS in patients with breast cancer to enable the identification of patients at high risk who may benefit from prevention interventions.Methods: We retrospectively analyzed 559 women with breast cancer who underwent treatment between 2004 and 2022. The study endpoint was DFS. Recurrence was defined as local recurrence, regional recurrence, distant metastases, contralateral breast cancer, other second primary cancer, and death. Baseline tumor-related characteristics, treatment-related characteristics, sociodemographic and biochemical data were analyzed using Cox proportional hazards analysis.Results: The median DFS was 45 months (range, 2 to 225 months). Breast cancer recurred in 86 patients (15.4%), of whom 10 had local recurrence, 10 had regional recurrence, 17 had contralateral breast cancer, 29 had distant metastases, 10 had second primary cancer, and 10 patients died. Multivariate forward stepwise Cox regression analysis showed that AJCC stage III, Ki67 ≥ 14%, albumin, platelet, and red cell distribution width-standard deviation (RDW-SD) were predictors of worse DFS. In addition, the effects of albumin, platelet, and RDW-SD on disease recurrence were confirmed by structural equation model (SEM) analysis.Conclusion: In addition to the traditional predictors of worse DFS such as AJCC stage III and Ki67 ≥ 14%, lower pretreatment circulating albumin, higher pretreatment circulating platelet count and RDW-SD could significantly predict worse DFS in this study, and SEM delineated possible causal pathways and inter-relationships of albumin, platelet, and RDW-SD contributing to the disease recurrence among Chinese women with breast cancer.Keywords: breast cancer, albumin, platelet, RDW-SD, disease-free survival

Published
2024

5. A Pilot Study for Effectiveness of Non-Pharmacological versus Pharmacological Treatment Strategies for Lumbar Disc Herniation: A Pragmatic Randomized Controlled Trial

Author

Kim D, Kim ES, Lee YJ, Lee JY, Park KS, Jung SY, Yang C, Han CH, and Ha IH

Subjects
conservative treatment, intervertebral disc displacement, low back pain, sciatica, Medicine (General), R5-920
Abstract

Doori Kim,1 Eun-San Kim,1 Yoon Jae Lee,1 Jee Young Lee,2 Kyong Sun Park,3 So Young Jung,4 Changsop Yang,5 Chang-Hyun Han,6,7 In-Hyuk Ha1 1Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, 06110, Republic of Korea; 2Department of Korean Internal Medicine, Integrative Cancer Center, Cha Ilsan Medical Center, Goyang-si, Gyeonggi-do, Republic of Korea; 3Jaseng Hospital of Korean Medicine, Seoul, 06110, Republic of Korea; 4Clinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea; 5Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 6Korean Convergence Medical Science, University of Science & Technology (UST), School of Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea; 7KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of KoreaCorrespondence: In-Hyuk Ha, Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 540 Gangnam-daero, Gangnam-gu, Seoul, 06110, Republic of Korea, Tel +82-2-2222-2740, Fax +82-2-2222-2737, Email hanihata@gmail.com Chang-Hyun Han, KM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea, Tel +82-(0)42-868-9498, Fax +82-(0)42-869-2775, Email chhan@kiom.re.krPurpose: We aimed to compare the efficacy, safety, and cost-effectiveness of non-pharmacological- and pharmacological treatment strategies for Lumbar disc herniation (LDH) in pragmatic clinical settings.Patients and Methods: This study was a pilot, two-armed, parallel pragmatic randomized controlled trial. Thirty patients aged 19– 70 years with a numeric rating scale (NRS) score ≥ 5 for sciatica and confirmed LDH on magnetic resonance imaging (MRI) were included. Participants were assigned in a 1:1 ratio to non-pharmacological (non-Phm) or pharmacological (Phm) treatment group. They were treated for 8 weeks and a total follow-up period was 26 weeks after randomization. Non-Phm treatment included acupuncture, spinal manual therapy, etc., Phm included medication, injection, nerve block, etc., The primary outcome was a numeric rating scale (NRS) of radiating leg pain. NRS for low back pain, Oswestry disability index, visual analog scale, Fear-Avoidance Beliefs Questionnaire, patient global impression of change, Short Form-12 Health Survey, version 2, 5-level European Quality of Life-5 dimensions (EQ-5D) were also measured. Linear mixed model was used to evaluated the difference in change of outcomes from baseline between two groups. An economic evaluation was conducted using incremental cost-effectiveness ratios.Results: There was no significant difference between the two groups in the intervention period, but non-Phm group showed significantly greater degree of improvement in follow-up of Week 14. Difference in the NRS for sciatica and ODI were 1.65 (95% CI 0.59 to 2.71, p=0.003) and 8.67 (95% CI 1.37 to 15.98, p=0.21), respectively in Week 14. The quality-adjusted life year (QALY) value calculated by EQ-5D and Short Form-6 Dimension were 0.006 (95% CI − 0.012 to 0.024, p=0.472) and 0.015 (95% CI − 0.008 to 0.038, p=0.195) higher in non-Phm group than in Phm group. The cost was lower in non-Phm group than in Phm group (Difference: − 682, 95% CI − 3349 to 1699, p=0.563).Conclusion: We confirmed that the non-Phm treatment could be more cost-effective treatments than Phm treatments and feasibility of a large-scale of main study in future.Keywords: conservative treatment, intervertebral disc displacement, low back pain, sciatica

Published
2023

6. A Pragmatic Randomized Controlled Trial on the Effectiveness and Safety of Pharmacopuncture for Chronic Lower Back Pain

Author

Park KS, Kim C, Kim JW, Kim S, Lee JY, Lee YJ, Lee J, Kim MJ, Choi YE, Yang C, Han CH, and Ha IH

Subjects
low back pain, pharmacopuncture, physiotherapy, oswestry disability index, roland–morris disability questionnaire, pragmatic randomized controlled trial, randomized controlled trial, Medicine (General), R5-920
Abstract

Kyoung Sun Park,1 Changnyun Kim,2 Joo Won Kim,3 Sang‐Don Kim,4 Jee Young Lee,5 Yoon Jae Lee,5 Jinho Lee,1 Min Ji Kim,6 Young Eun Choi,6 Changsop Yang,7 Chang-Hyun Han,7,8,&ast; In-Hyuk Ha5,&ast; 1Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; 2Daejeon Jaseng Hospital of Korean Medicine, Daejeon, Republic of Korea; 3Bucheon Jaseng Hospital of Korean Medicine, Bucheon, Republic of Korea; 4Haeundae Jaseng Hospital of Korean Medicine, Busan, Republic of Korea; 5Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea; 6Clinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 7Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 8Korean Convergence Medical Science, Korea Institute of Oriental Medicine School, University of Science & Technology, Daejeon, Republic of Korea&ast;These authors contributed equally to this workCorrespondence: Chang-Hyun Han, Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea, Tel +82 42 868 9498, Email chhan@kiom.re.kr In-Hyuk Ha, Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea, Tel +82 2 2222 2740, Email hanihata@gmail.comPurpose: Chronic lower back pain (LBP) is a major global health concern. Pharmacopuncture has been widely used to treat LBP in Korea; however, randomized clinical trials (RCT) or active control have not been conducted to evaluate its effectiveness. Therefore, this RCT aimed to compare the effectiveness of pharmacopuncture and physical therapy (PT) for the treatment of chronic LBP.Patients and Methods: A two-arm, parallel, and multicenter RCT was conducted at four hospitals of Korean medicine. Participants with chronic LBP were randomly assigned at a 1:1 ratio using block randomization to undergo 10 sessions of pharmacopuncture or PT over 5 weeks and followed up for 25 weeks. The numerical rating scale (NRS) and visual analog scale scores of LBP and radiating leg pain and the Oswestry disability index (ODI), 5-level EuroQol-5 dimension (EQ-5D-5L), and the patient global impression of change were recorded at baseline and at 6, 13, and 25 weeks. An intention-to-treat analysis was conducted as the primary analysis using a linear mixed model.Results: One-hundred patients (mean age, 49.27 years; 58 women) were recruited. At 6 weeks after randomization, pharmacopuncture showed statistically superior results compared with PT in LBP (difference in NRS, 1.54; 95% CI, 0.94– 2.13), function (difference in ODI, 4.52%; 95% CI, 0.93– 8.11%), and quality of life (difference in EQ-5D-5L) scores (− 0.05; 95% CI, − 0.08 to − 0.01). This effect persisted for 25 weeks. In the survival analysis for participants with at least a 50% reduction in the NRS scores of LBP during the 182-day follow-up, the pharmacopuncture group showed significantly faster recovery than the PT group (P< 0.001, Log rank test).Conclusion: Pharmacopuncture significantly reduced pain and improved functional outcomes and quality of life in patients with low back pain compared with physical therapy. Based on the findings of this study, pharmacopuncture could be recommended as a treatment for patients with chronic low back pain.Keywords: low back pain, pharmacopuncture, physiotherapy, Oswestry disability index, Roland–Morris disability questionnaire, pragmatic randomized controlled trial

Published
2023

7. Efficacy and Safety of SIKD1977 in Combination with Standard Treatment for Postherpetic Neuralgia: Study Protocol for a Double Blind, Placebo-Controlled, Randomized, Multicenter, Phase 2 Clinical Trial

Author

Jo HR, Kim YG, Sung WS, Park KS, Lee YJ, Cho SY, Seo BK, Kwon YE, and Kim EJ

Subjects
postherpetic neuralgia, herbal medicine, sikd1977, sogeonjungtang, randomized controlled trial, protocol, Medicine (General), R5-920
Abstract

Hyo-Rim Jo,1 Yong-Gyun Kim,2 Won-Suk Sung,1 Kyoung Sun Park,3 Yoon Jae Lee,4 Sun Young Cho,5 Byung-Kwan Seo,6 Young-Ee Kwon,2 Eun-Jung Kim1 1Department of Acupuncture & Moxibustion, Dongguk University Bundang Oriental Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; 2Central Research Institute, Samik Pharmaceutical Company LTD., Incheon, Republic of Korea; 3Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; 4Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Korea; 5IntegroMedLab Company Ltd., Seoul, Republic of Korea; 6Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, Seoul, Republic of KoreaCorrespondence: Eun-Jung Kim, Department of Acupuncture & Moxibustion, Dongguk University Bundang Oriental Hospital, 268, Buljeong-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea, Tel +82-31-710-3719, Fax +82-31-710-3780, Email hanijjung@naver.comPurpose: Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster, associated with poor quality of life and increased patient and healthcare resource expenditure. This randomized controlled trial aims to evaluate the efficacy and safety of SIKD1977 (Sogeonjungtang) in combination with standard treatment and estimate an effective dose for treating PHN.Patients and Methods: This is a protocol for a randomized, placebo-controlled, double-blind, multicenter trial. A total of 90 eligible participants with PHN will be recruited from three hospitals and randomly allocated to high-dose group, low-dose group, or placebo group in a 1:1:1 ratio. The trial will involve a 6-week oral administration of SIKD1977/placebo, and a 1-week follow-up period. The primary outcome will be the weekly average change in average daily pain score (ADPS) from baseline to the end of treatment. The secondary outcomes will include the weekly average changes in ADPS from baseline to week 2, 4, and 7, differences in Short-Form McGill Pain Questionnaire, Visual analogue scale, 5-level EuroQol-5 dimensions, Patient Global Impression of Change, and consumption of rescue drugs. All adverse events will be assessed during the trial.Conclusion: This study will provide evidence for the efficacy and safety of SIKD1977, and an effective dose for PHN.Trial Registration: This protocol has been registered in the Clinical Research Information Service with the identification code KCT0007939.Keywords: postherpetic neuralgia, herbal medicine, SIKD1977, Sogeonjungtang, randomized controlled trial, protocol

Published
2023

8. Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study

Author

Yang SH, Yoon J, Lee YJ, Park B, and Jung DH

Subjects
lipid accumulation product index, prospective cohort study, incident type 2 diabetes, koreans, Specialties of internal medicine, RC581-951
Abstract

Seung Ho Yang, Jihyun Yoon, Yong-Jae Lee, Byoungjin Park, Dong-Hyuk Jung Department of Family Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaCorrespondence: Dong-Hyuk Jung; Byoungjin Park, Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 363 Dongbaekjukjeondae-ro, Giheung-gu, Yongin-si, Gyeonggi-do, 16995, Republic of Korea, Tel +82-31-5189-8762 ; +82 31 5189 8763, Fax +82-31-5189-8567, Email balsan2@yuhs.ac; bjpark96@yuhs.acPurpose: The lipid accumulation product (LAP) has been a potential indicator of central lipid accumulation status. This study aimed to assess the longitudinal association between LAP index and incident type 2 diabetes among non-obese Korean adults using a large, community-based Korean cohort observed over 12 years.Patients and Methods: This study included 4281 non-diabetic adults without generalized obesity and abdominal obesity and aged 40– 69 years from the Korean Genome and Epidemiology Study. The participants were divided into four groups according to LAP index quartiles, calculated as (waist circumference [cm] - 65) x (triglycerides [mmol/L]) in men and (waist circumference [cm] - 58) x (triglycerides [mmol/L]) in women. We prospectively assessed hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes using multivariate Cox proportional hazard regression models.Results: Overall, 608 (14.2%) participants developed type 2 diabetes during the follow-up period. HRs for incident type 2 diabetes in the second, third, and fourth LAP quartile were 1.32 (95% CI: 0.97– 1.79), 1.51 (95% CI: 1.11– 2.06), and 2.14 (95% CI: 1.56– 2.94), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and impaired glucose tolerance.Conclusion: A high LAP index can be an additional indicator for new-onset T2DM among middle-aged and elderly non-obese Koreans.Keywords: lipid accumulation product index, prospective cohort study, incident type 2 diabetes, Koreans

Published
2022

9. The Effectiveness of Pharmacopuncture in Patients with Lumbar Spinal Stenosis: A Protocol for a Multi-Centered, Pragmatic, Randomized, Controlled, Parallel Group Study

Author

Lee JY, Park KS, Kim S, Seo JY, Cho HW, Nam D, Park Y, Kim EJ, Lee YJ, and Ha IH

Subjects
lss, constriction, non-surgical intervention, acupuncture, pragmatic clinical trial, protocol, Medicine (General), R5-920
Abstract

Jee Young Lee,1 Kyoung Sun Park,2 Suna Kim,3 Ji Yeon Seo,4 Hyun-Woo Cho,5 Dongwoo Nam,6 Yeoncheol Park,6 Eun-Jung Kim,7 Yoon Jae Lee,1 In-Hyuk Ha1 1Jaseng Spine & Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea; 2Jaseng Clinical Research Center, Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; 3Jaseng Clinical Research Center, Daejeon Jaseng Hospital of Korean Medicine, Daejeon, Republic of Korea; 4Jaseng Clinical Research Center, Bucheon Jaseng Hospital of Korean Medicine, Bucheon, Republic of Korea; 5Jaseng Clinical Research Center, Haeundae Jaseng Hospital of Korean Medicine, Busan, Republic of Korea; 6Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea; 7Department of Acupuncture & Moxibustion, College of Korean Medicine, Dongguk University Bundang Oriental Hospital, Seongnam, Republic of KoreaCorrespondence: In-Hyuk Ha, Jaseng Spine & Joint Research Institute, Jaseng Medical Foundation, 540, Gangnamdae-ro, Gangnam-gu, Seoul, 06110, Republic of Korea, Tel +82-2-2222-2740, Email hanihata@gmail.comPurpose: Lumbar spinal stenosis (LSS) is a chronic degenerative disease. Non-surgical intervention is recommended, considering the risks and benefits for the affected age group, as well as the characteristics of the disease. However, to date, no studies have compared various non-surgical interventions to ascertain the appropriate first-line non-surgical treatment for LSS. Therefore, the objective of this study will be to assess the efficacy of pharmacopuncture as a non-surgical, conservative treatment for LSS.Patients and Methods: A multi-centered, pragmatic, parallel-group study will be conducted. In total, 98 patients will be recruited at seven institutes; recruitment began in May 2022. After two treatment sessions per week over a period of 12 weeks, follow-up assessments will be held at weeks 13, 25, and 53.Results: The efficacy of pharmacopuncture and conservative care will be pragmatically compared in patients radiologically diagnosed with LSS. Pain severity will be measured using the numeric rating scale and visual analog scale. Walking distance will also be evaluated. Patient-centered evaluations will include the Zurich Claudication Questionnaire, Short-Form 12 for Health-Related Quality of Life, EuroQoL 5 Dimension 5 Levels, and Patient Global Impression of Change.Conclusion: The results of this study will confirm the efficacy of pharmacopuncture in comparison to conventional non-surgical treatment and will thus facilitate the prioritization of patient-centered interventions for LSS.Trial registration: This study was registered at Clinicaltrials.gov (registration identifier: NCT05242497) and CRiS (registration identifier: KCT0007145).Keywords: LSS, constriction, non-surgical intervention, acupuncture, pragmatic clinical trial, protocol

Published
2022

10. Effectiveness and Safety of Pharmacopuncture Therapy for Chronic Low Back Pain: A Protocol for a Pragmatic Randomized Controlled Trial

Author

Park KS, Kim S, Seo JY, Cho H, Lee JY, Lee YJ, Lee J, Kim MJ, Choi YE, Yang CS, Han CH, and Ha IH

Subjects
low back pain, pharmacopuncture, physical therapy, pragmatic randomized controlled trial, protocol, musculoskeletal disorder, korean medicine, Medicine (General), R5-920
Abstract

Kyoung Sun Park,1 Suna Kim,2 Ji Yeon Seo,3 HyunWoo Cho,4 Jee Young Lee,5 Yoon Jae Lee,5 Jinho Lee,1 Min Ji Kim,6 Young Eun Choi,6 Chang Sop Yang,7 Chang-Hyun Han,7,8,&ast; In-Hyuk Ha5,&ast; 1Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; 2Daejeon Jaseng Hospital of Korean Medicine, Daejeon, Republic of Korea; 3Bucheon Jaseng Hospital of Korean Medicine, Bucheon, Republic of Korea; 4Haeundae Jaseng Hospital of Korean Medicine, Busan, Republic of Korea; 5Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea; 6Clinical Research Coordinating Team, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 7KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 8 Korean Convergence Medicine, University of Science & Technology (UST), Campus of Korea Institute of Oriental Medicine, Daejeon, Republic of Korea&ast;These authors contributed equally to this workCorrespondence: In-Hyuk Ha, Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 2F Vision Tower, 540 Gangnam-daero, Gangnam-gu, Seoul, 06110, Republic of Korea, Tel +82 2 2222 2740, Email hanihata@gmail.comPurpose: Chronic low back pain (LBP) is a common musculoskeletal disorder that affects everyday life; moreover, it occasionally causes disability and increases medical expenditure. This pragmatic randomized clinical trial aims to investigate the effects of pharmacopuncture on chronic LBP by comparing the effectiveness of pharmacopuncture and physiotherapy strategies.Patients and Methods: In this two-armed, parallel, multi-center randomized controlled study, the participants will randomly undergo 10 sessions of pharmacopuncture therapy or physiotherapy over five weeks based on the randomization outcomes. The primary outcome will be the numeric rating scale (NRS) score of LBP. The secondary outcomes will include the NRS score of radiating leg pain, visual analog scale (VAS) score of LBP and radiating leg pain, Oswestry disability index, the Korean version of the Roland–Morris disability questionnaire, patient global impression of change (PGIC), short Form-12 health survey version 2, and 5-level EuroQol-5 dimension (EQ-5D-5L).Conclusion: This protocol aims to examine the comparative effectiveness of pharmacopuncture, which is a widely used therapy in Korean medicine, with respect to the standard therapy through a pragmatic randomized controlled trial to present useful data to facilitate clinical or policy decision making.Trial Registration: Clinicaltrials.gov (NCT04833309); Clinical Research Information Service (KCT0006088).Keywords: low back pain, pharmacopuncture, physical therapy, pragmatic randomized controlled trial, protocol, musculoskeletal disorder, Korean medicine

Published
2022

11. Cognitive Appraisal of Sleep and Brain Activation in Response to Sleep-Related Sounds in Healthy Adults

Author

Hwang Y, Lee KH, Kim N, Lee J, Lee HY, Jeon JE, Lee YJ, and Kim SJ

Subjects
anterior cingulate cortex, appraisal, functional magnetic resonance imaging, sleep-related sounds, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Yunjee Hwang,1 Kyung Hwa Lee,2,3 Nambeom Kim,4 Jooyoung Lee,5 Ha Young Lee,2 Jeong Eun Jeon,2 Yu Jin Lee,2 Seog Ju Kim5 1Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea; 2Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University, College of Medicine and Hospital, Seoul, Republic of Korea; 3Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea; 4Department of Biomedical Engineering Research Center, Gachon University, Incheon, Republic of Korea; 5Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of KoreaCorrespondence: Yu Jin Lee, Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University, College of Medicine and Hospital, Seoul, Republic of Korea, Email ewpsyche@snu.ac.kr Seog Ju Kim, Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea, Email ksj7126@skku.eduPurpose: Sounds play important roles in promoting and disrupting sleep. How our brain processes sleep-related sounds and individual differences in processing sleep-related sounds must be determined to understand the role of sound in sleep. We investigated neural responses to sleep-related sounds and their associations with cognitive appraisals of sleep.Participants and Methods: Forty-four healthy adults heard sleep-related and neutral sounds during functional magnetic resonance imaging using a 3T scanner. They also completed the Dysfunctional Beliefs and Attitudes about Sleep (DBAS) questionnaire, which was used to assess cognitive appraisals of sleep. We conducted a voxel-wise whole-brain analysis to compare brain activation in response to sleep-related and neutral sounds. We also examined the association between the DBAS score and brain activity in response to sleep-related sounds (vs neutral sounds) using region of interest (ROI) and whole-brain correlation analyses. The ROIs included the anterior cingulate cortex (ACC), anterior insula (AI), and amygdala.Results: The whole-brain analysis revealed increased activation in the temporal regions and decreased activation in the ACC in response to sleep-related sounds compared to neutral sounds. The ROI and whole-brain correlation analyses showed that higher DBAS scores, indicating a negative appraisal of sleep, were significantly correlated with increased activation of the ACC, right medial prefrontal cortex, and brainstem in response to sleep-related sounds.Conclusion: These results indicate that the temporal cortex and ACC, which are implicated in affective sound processing, may play important roles in the processing of sleep-related sounds. The positive association between the neural responses to sleep-related sounds and DBAS scores suggest that negative and dysfunctional appraisals of sleep may be an important factor in individual differences in the processing of sleep-related sounds.Keywords: anterior cingulate cortex, appraisal, functional magnetic resonance imaging, sleep-related sounds

Published
2022

12. Evidence of White Matter Integrity Changes in the Anterior Cingulum Among Shift Workers: A Cross-Sectional Study

Author

Lee J, Kim M, Kim N, Hwang Y, Lee KH, Lee YJ, and Kim SJ

Subjects
shift work, dti, cingulum, sleep, activity, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Jiye Lee,1,&ast; Minjeong Kim,1,&ast; Nambeom Kim,2 Yunjee Hwang,1 Kyung Hwa Lee,3,4 Jooyoung Lee,1 Yu Jin Lee,3 Seog Ju Kim1 1Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea; 2Department of Biomedical Engineering Research Center, Gachon University, Incheon, Republic of Korea; 3Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University, College of Medicine and Hospital, Seoul, Republic of Korea; 4Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea&ast;These authors contributed equally to this workCorrespondence: Yu Jin Lee, Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University, College of Medicine and Hospital, Seoul, Republic of Korea, Email ewpsyche@snu.ac.kr Seog Ju Kim, Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea, Email ksj7126@skku.eduIntroduction: We investigated the white matter integrity in shift and non-shift workers and its associations with sleep and activity.Methods: Diffusion tensor imaging (DTI) was performed on 61 shift workers and 31 non-shift workers. Their sleep and activity profiles were assessed using the Pittsburgh Sleep Quality Index (PSQI), sleep diaries, and actigraphy. Fractional anisotropy (FA) (a measure of white matter integrity) was calculated using DTI tractography.Results: Shift workers exhibited higher FA values in the bilateral anterior cingulum than did non-shift workers. An increased FA in the right anterior cingulum was correlated with poor sleep quality (ie, a high PSQI score) in shift workers. An increased FA in the right anterior cingulum was also correlated with higher actigraphic activity indices (the mesor and M10 indices) in shift workers.Discussion: The white matter integrity of the anterior cingulum was altered in shift workers, perhaps in association with sleep and activity disturbances.Keywords: shift work, DTI, cingulum, sleep, activity

Published
2022

13. Perceptions on Data Quality, Use, and Management Following the Adoption of Tablet-Based Electronic Health Records: Results from a Pre–Post Survey with District Health Officers in Ghana

Author

Lee S, Lee YJ, Kim S, Choi W, Jeong Y, Rhim NJ, Seo I, and Kim SY

Subjects
mhealth, maternal and child health, sub-saharan africa, lmic, Medicine (General), R5-920
Abstract

Seohyun Lee,1 Young-Ji Lee,2 SeYeon Kim,2 Wonil Choi,2 Yoojin Jeong,2 Nina Jinjoo Rhim,3 Ilwon Seo,4 Sun-Young Kim2,5 1Department of Global Public Administration, Yonsei University Mirae Campus, Wonju, Republic of Korea; 2Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea; 3Good Neighbors International, Seoul, Republic of Korea; 4Good Neighbors Ghana, Accra, Ghana; 5Institute of Health and Environment, Seoul National University, Seoul, Republic of KoreaCorrespondence: Sun-Young Kim, Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea, Tel +82-2-880-2768, Fax +82-2-762-2888, Email sykim22@snu.ac.krPurpose: An electronic health record (EHR) system known as the e-Tracker was introduced in community health facilities in Ghana and numerous advantages were expected for clinical staff, as evidenced by previous literature. However, little is known about public health officials’ views, specifically in low-resource settings. This study aimed to investigate the perceptions of district health officers on data quality, use, and management following the adoption of tablet-based electronic health records in Ghana.Methods: A pre- and post-survey was conducted in two regions of Ghana that adopted the e-Tracker for the entire districts during the early stages of the national rollout. Sociodemographic information, internet connection environment, and perceptions on data quality, use, and management were measured. McNemar’s test and Wilcoxon Signed-Rank test were performed to identify changes in perceptions. Chi-square test and Mann–Whitney U-test were used to find any statistical differences in demographic characteristics between the two regions.Results: Twenty-four out of 25 districts in Volta and 24 out of 26 districts in Eastern regions participated in both pre- and post-surveys, with a total of 73 participants. In terms of efficiency in data management, the district health officers reported reduced time commitment in data validation and aggregation. Within less than a year, however, no statistically significant improvement was found in data quality and the use of electronic data for relevant tasks.Conclusion: A new EHR system in low-resource settings can rapidly improve efficiency in data management from the public health officials’ perspectives. Further impact evaluation is warranted to assess the long-term effect of the EHR system.Keywords: mHealth, maternal and child health, Sub-Saharan Africa, LMIC

Published
2022

14. Association Between C-Reactive Protein and Relative Handgrip Strength in Postmenopausal Korean Women Aged 45–80 Years: A Cross-Sectional Study

Author

Son DH, Song SA, and Lee YJ

Subjects
c-reactive protein, hand strength, menopause, inflammation, sarcopenia, Geriatrics, RC952-954.6
Abstract

Da-Hye Son,1,2,&ast; Seung-Ah Song,1,&ast; Yong-Jae Lee1 1Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea; 2Department of Integrative Medicine, Yonsei University Graduate School, Seoul, Korea&ast;These authors contributed equally to this workCorrespondence: Yong-Jae Lee, Department of Family Medicine, Yonsei University College of Medicine Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Korea, Tel +82 2 2019 2630; +82 10 7292 9169, Fax +82 3462 8209, Email ukyjhome@yuhs.acBackground: Chronic inflammation plays a key role in the pathophysiology of frailty and loss of physical performance, which are closely associated with sarcopenia. In women, the decline in muscle mass and strength is accelerated after menopause. Thus, we examined the association between high sensitivity C-reactive protein (hs-CRP) and relative handgrip strength (HGS) in postmenopausal women.Methods: This cross-sectional study included 2171 postmenopausal women aged ≥ 45 years who participated in the Korean National Health and Nutrition Survey (KNHNES) between 2015 and 2018. Relative HGS was categorized into quartiles as follows: Q1, < 0.810 (kg/BMI); Q2, 0.810– 0.968 (kg/BMI); Q3, 0.969– 1.119 (kg/BMI); Q4, > 1.119 (kg/BMI). The odds ratios (ORs) and 95% confidence intervals (95% CIs) for high hs-CRP (> 1.0 mg/L, 75 percentile of the current samples) were calculated across relative HGS quartiles using multiple logistic regression analysis.Results: The prevalence of high hs-CRP decreased with relative HGS quartiles. Compared to the highest quartile, the OR (95% CI) of the lowest relative HGS quartile for high hs-CRP was 3.266 (2.227– 4.789) after adjusting for age, hypertension, diabetes mellitus, dyslipidemia, education, household income, physical activity, strength exercise, smoking, and alcohol ingestion.Conclusion: Serum hs-CRP level was inversely and independently associated with relative HGS. Our findings indicate that low-grade inflammation is inversely associated with muscle strength in postmenopausal women.Keywords: C-reactive protein, hand strength, menopause, inflammation, sarcopenia

Published
2022

15. Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study

Author

Kouli, O, Murray, V, Bhatia, S, Cambridge, WA, Kawka, M, Shafi, S, Knight, SR, Kamarajah, SK, McLean, KA, Glasbey, JC, Khaw, RA, Ahmed, W, Akhbari, M, Baker, D, Borakati, A, Mills, E, Thavayogan, R, Yasin, I, Raubenheimer, K, Ridley, W, Sarrami, M, Zhang, G, Egoroff, N, Pockney, P, Richards, T, Bhangu, A, Creagh-Brown, B, Edwards, M, Harrison, EM, Lee, M, Nepogodiev, D, Pinkney, T, Pearse, R, Smart, N, Vohra, R, Sohrabi, C, Jamieson, A, Nguyen, M, Rahman, A, English, C, Tincknell, L, Kakodkar, P, Kwek, I, Punjabi, N, Burns, J, Varghese, S, Erotocritou, M, McGuckin, S, Vayalapra, S, Dominguez, E, Moneim, J, Salehi, M, Tan, HL, Yoong, A, Zhu, L, Seale, B, Nowinka, Z, Patel, N, Chrisp, B, Harris, J, Maleyko, I, Muneeb, F, Gough, M, James, CE, Skan, O, Chowdhury, A, Rebuffa, N, Khan, H, Down, B, Fatimah Hussain, Q, Adams, M, Bailey, A, Cullen, G, Fu, YXJ, McClement, B, Taylor, A, Aitken, S, Bachelet, B, Brousse de Gersigny, J, Chang, C, Khehra, B, Lahoud, N, Lee Solano, M, Louca, M, Rozenbroek, P, Rozitis, E, Agbinya, N, Anderson, E, Arwi, G, Barry, I, Batchelor, C, Chong, T, Choo, LY, Clark, L, Daniels, M, Goh, J, Handa, A, Hanna, J, Huynh, L, Jeon, A, Kanbour, A, Lee, A, Lee, J, Lee, T, Leigh, J, Ly, D, McGregor, F, Moss, J, Nejatian, M, O'Loughlin, E, Ramos, I, Sanchez, B, Shrivathsa, A, Sincari, A, Sobhi, S, Swart, R, Trimboli, J, Wignall, P, Bourke, E, Chong, A, Clayton, S, Dawson, A, Hardy, E, Iqbal, R, Le, L, Mao, S, Marinelli, I, Metcalfe, H, Panicker, D, R, HH, Ridgway, S, Tan, HH, Thong, S, Van, M, Woon, S, Woon-Shoo-Tong, XS, Yu, S, Ali, K, Chee, J, Chiu, C, Chow, YW, Duller, A, Nagappan, P, Ng, S, Selvanathan, M, Sheridan, C, Temple, M, Do, JE, Dudi-Venkata, NN, Humphries, E, Li, L, Mansour, LT, Massy-Westropp, C, Fang, B, Farbood, K, Hong, H, Huang, Y, Joan, M, Koh, C, Liu, YHA, Mahajan, T, Muller, E, Park, R, Tanudisastro, M, Wu, JJG, Chopra, P, Giang, S, Radcliffe, S, Thach, P, Wallace, D, Wilkes, A, Chinta, SH, Li, J, Phan, J, Rahman, F, Segaran, A, Shannon, J, Zhang, M, Adams, N, Bonte, A, Choudhry, A, Colterjohn, N, Croyle, JA, Donohue, J, Feighery, A, Keane, A, McNamara, D, Munir, K, Roche, D, Sabnani, R, Seligman, D, Sharma, S, Stickney, Z, Suchy, H, Tan, R, Yordi, S, Ahmed, I, Aranha, M, El Sabawy, D, Garwood, P, Harnett, M, Holohan, R, Howard, R, Kayyal, Y, Krakoski, N, Lupo, M, McGilberry, W, Nepon, H, Scoleri, Y, Urbina, C, Ahmad Fuad, MF, Ahmed, O, Jaswantlal, D, Kelly, E, Khan, MHT, Naidu, D, Neo, WX, O'Neill, R, Sugrue, M, Abbas, JD, Abdul-Fattah, S, Azlan, A, Barry, K, Idris, NS, Kaka, N, Mc Dermott, D, Mohammad Nasir, MN, Mozo, M, Rehal, A, Shaikh Yousef, M, Wong, RH, Curran, E, Gardner, M, Hogan, A, Julka, R, Lasser, G, Ní Chorráin, N, Ting, J, Browne, R, George, S, Janjua, Z, Leung Shing, V, Megally, M, Murphy, S, Ravenscroft, L, Vedadi, A, Vyas, V, Bryan, A, Sheikh, A, Ubhi, J, Vannelli, K, Vawda, A, Adeusi, L, Doherty, C, Fitzgerald, C, Gallagher, H, Gill, P, Hamza, H, Hogan, M, Kelly, S, Larry, J, Lynch, P, Mazeni, NA, O'Connell, R, O'Loghlin, R, Singh, K, Abbas Syed, R, Ali, A, Alkandari, B, Arnold, A, Arora, E, Azam, R, Breathnach, C, Cheema, J, Compton, M, Curran, S, Elliott, JA, Jayasamraj, O, Mohammed, N, Noone, A, Pal, A, Pandey, S, Quinn, P, Sheridan, R, Siew, L, Tan, EP, Tio, SW, Toh, VTR, Walsh, M, Yap, C, Yassa, J, Young, T, Agarwal, N, Almoosawy, SA, Bowen, K, Bruce, D, Connachan, R, Cook, A, Daniell, A, Elliott, M, Fung, HKF, Irving, A, Laurie, S, Lee, YJ, Lim, ZX, Maddineni, S, McClenaghan, RE, Muthuganesan, V, Ravichandran, P, Roberts, N, Shaji, S, Solt, S, Toshney, E, Arnold, C, Baker, O, Belais, F, Bojanic, C, Byrne, M, Chau, CYC, De Soysa, S, Eldridge, M, Fairey, M, Fearnhead, N, Guéroult, A, Ho, JSY, Joshi, K, Kadiyala, N, Khalid, S, Khan, F, Kumar, K, Lewis, E, Magee, J, Manetta-Jones, D, Mann, S, McKeown, L, Mitrofan, C, Mohamed, T, Monnickendam, A, Ng, AYKC, Ortu, A, Patel, M, Pope, T, Pressling, S, Purohit, K, Saji, S, Shah Foridi, J, Shah, R, Siddiqui, SS, Surman, K, Utukuri, M, Varghese, A, Williams, CYK, Yang, JJ, Billson, E, Cheah, E, Holmes, P, Hussain, S, Murdock, D, Nicholls, A, Patel, P, Ramana, G, Saleki, M, Spence, H, Thomas, D, Yu, C, Abousamra, M, Brown, C, Conti, I, Donnelly, A, Durand, M, French, N, Goan, R, O'Kane, E, Rubinchik, P, Gardiner, H, Kempf, B, Lai, YL, Matthews, H, Minford, E, Rafferty, C, Reid, C, Sheridan, N, Al Bahri, T, Bhoombla, N, Rao, BM, Titu, L, Chatha, S, Field, C, Gandhi, T, Gulati, R, Jha, R, Jones Sam, MT, Karim, S, Patel, R, Saunders, M, Sharma, K, Abid, S, Heath, E, Kurup, D, Patel, A, Ali, M, Cresswell, B, Felstead, D, Jennings, K, Kaluarachchi, T, Lazzereschi, L, Mayson, H, Miah, JE, Reinders, B, Rosser, A, Thomas, C, Williams, H, Al-Hamid, Z, Alsadoun, L, Chlubek, M, Fernando, P, Gaunt, E, Gercek, Y, Maniar, R, Ma, R, Matson, M, Moore, S, Morris, A, Nagappan, PG, Ratnayake, M, Rockall, L, Shallcross, O, Sinha, A, Tan, KE, Virdee, S, Wenlock, R, Donnelly, HA, Ghazal, R, Hughes, I, Liu, X, McFadden, M, Misbert, E, Mogey, P, O'Hara, A, Peace, C, Rainey, C, Raja, P, Salem, M, Salmon, J, Tan, CH, Alves, D, Bahl, S, Baker, C, Coulthurst, J, Koysombat, K, Linn, T, Rai, P, Sharma, A, Shergill, A, Ahmed, M, Ahmed, S, Belk, LH, Choudhry, H, Cummings, D, Dixon, Y, Dobinson, C, Edwards, J, Flint, J, Franco Da Silva, C, Gallie, R, Gardener, M, Glover, T, Greasley, M, Hatab, A, Howells, R, Hussey, T, Khan, A, Mann, A, Morrison, H, Ng, A, Osmond, R, Padmakumar, N, Pervaiz, F, Prince, R, Qureshi, A, Sawhney, R, Sigurdson, B, Stephenson, L, Vora, K, Zacken, A, Cope, P, Di Traglia, R, Ferarrio, I, Hackett, N, Healicon, R, Horseman, L, Lam, LI, Meerdink, M, Menham, D, Murphy, R, Nimmo, I, Ramaesh, A, Rees, J, Soame, R, Dilaver, N, Adebambo, D, Brown, E, Burt, J, Foster, K, Kaliyappan, L, Knight, P, Politis, A, Richardson, E, Townsend, J, Abdi, M, Ball, M, Easby, S, Gill, N, Ho, E, Iqbal, H, Matthews, M, Nubi, S, Nwokocha, JO, Okafor, I, Perry, G, Sinartio, B, Vanukuru, N, Walkley, D, Welch, T, Yates, J, Yeshitila, N, Bryans, K, Campbell, B, Gray, C, Keys, R, Macartney, M, Chamberlain, G, Khatri, A, Kucheria, A, Lee, STP, Reese, G, Roy choudhury, J, Tan, WYR, Teh, JJ, Ting, A, Kazi, S, Kontovounisios, C, Vutipongsatorn, K, Amarnath, T, Balasubramanian, N, Bassett, E, Gurung, P, Lim, J, Panjikkaran, A, Sanalla, A, Alkoot, M, Bacigalupo, V, Eardley, N, Horton, M, Hurry, A, Isti, C, Maskell, P, Nursiah, K, Punn, G, Salih, H, Epanomeritakis, E, Foulkes, A, Henderson, R, Johnston, E, McCullough, H, McLarnon, M, Morrison, E, Cheung, A, Cho, SH, Eriksson, F, Hedges, J, Low, Z, May, C, Musto, L, Nagi, S, Nur, S, Salau, E, Shabbir, S, Thomas, MC, Uthayanan, L, Vig, S, Zaheer, M, Zeng, G, Ashcroft-Quinn, S, Brown, R, Hayes, J, McConville, R, French, R, Gilliam, A, Sheetal, S, Shehzad, MU, Bani, W, Christie, I, Franklyn, J, Khan, M, Russell, J, Smolarek, S, Varadarassou, R, Ahmed, SK, Narayanaswamy, S, Sealy, J, Shah, M, Dodhia, V, Manukyan, A, O'Hare, R, Orbell, J, Chung, I, Forenc, K, Gupta, A, Agarwal, A, Al Dabbagh, A, Bennewith, R, Bottomley, J, Chu, TSM, Chu, YYA, Doherty, W, Evans, B, Hainsworth, P, Hosfield, T, Li, CH, McCullagh, I, Mehta, A, Thaker, A, Thompson, B, Virdi, A, Walker, H, Wilkins, E, Dixon, C, Hassan, MR, Lotca, N, Tong, KS, Batchelor-Parry, H, Chaudhari, S, Harris, T, Hooper, J, Johnson, C, Mulvihill, C, Nayler, J, Olutobi, O, Piramanayagam, B, Stones, K, Sussman, M, Weaver, C, Alam, F, Al Rawi, M, Andrew, F, Arrayeh, A, Azizan, N, Hassan, A, Iqbal, Z, John, I, Jones, M, Kalake, O, Keast, M, Nicholas, J, Patil, A, Powell, K, Roberts, P, Sabri, A, Segue, AK, Shah, A, Shaik Mohamed, SA, Shehadeh, A, Shenoy, S, Tong, A, Upcott, M, Vijayasingam, D, Anarfi, S, Dauncey, J, Devindaran, A, Havalda, P, Komninos, G, Mwendwa, E, Norman, C, Richards, J, Urquhart, A, Allan, J, Cahya, E, Hunt, H, McWhirter, C, Norton, R, Roxburgh, C, Tan, JY, Ali Butt, S, Hansdot, S, Haq, I, Mootien, A, Sanchez, I, Vainas, T, Deliyannis, E, Tan, M, Vipond, M, Chittoor Satish, NN, Dattani, A, De Carvalho, L, Gaston-Grubb, M, Karunanithy, L, Lowe, B, Pace, C, Raju, K, Roope, J, Taylor, C, Youssef, H, Munro, T, Thorn, C, Wong, KHF, Yunus, A, Chawla, S, Datta, A, Dinesh, AA, Field, D, Georgi, T, Gwozdz, A, Hamstead, E, Howard, N, Isleyen, N, Jackson, N, Kingdon, J, Sagoo, KS, Schizas, A, Yin, L, Aung, E, Aung, YY, Franklin, S, Han, SM, Kim, WC, Martin Segura, A, Rossi, M, Ross, T, Tirimanna, R, Wang, B, Zakieh, O, Ben-Arzi, H, Flach, A, Jackson, E, Magers, S, Olu abara, C, Rogers, E, Sugden, K, Tan, H, Veliah, S, Walton, U, Asif, A, Bharwada, Y, Bowley, D, Broekhuizen, A, Cooper, L, Evans, N, Girdlestone, H, Ling, C, Mann, H, Mehmood, N, Mulvenna, CL, Rainer, N, Trout, I, Gujjuri, R, Jeyaraman, D, Leong, E, Singh, D, Smith, E, Anderton, J, Barabas, M, Goyal, S, Howard, D, Joshi, A, Mitchell, D, Weatherby, T, Badminton, R, Bird, R, Burtle, D, Choi, NY, Devalia, K, Farr, E, Fischer, F, Fish, J, Gunn, F, Jacobs, D, Johnston, P, Kalakoutas, A, Lau, E, Loo, YNAF, Louden, H, Makariou, N, Mohammadi, K, Nayab, Y, Ruhomaun, S, Ryliskyte, R, Saeed, M, Shinde, P, Sudul, M, Theodoropoulou, K, Valadao-Spoorenberg, J, Vlachou, F, Arshad, SR, Janmohamed, AM, Noor, M, Oyerinde, O, Saha, A, Syed, Y, Watkinson, W, Ahmadi, H, Akintunde, A, Alsaady, A, Bradley, J, Brothwood, D, Burton, M, Higgs, M, Hoyle, C, Katsura, C, Lathan, R, Louani, A, Mandalia, R, Prihartadi, AS, Qaddoura, B, Sandland-Taylor, L, Thadani, S, Thompson, A, Walshaw, J, Teo, S, Ali, S, Bawa, JH, Fox, S, Gargan, K, Haider, SA, Hanna, N, Hatoum, A, Khan, Z, Krzak, AM, Li, T, Pitt, J, Tan, GJS, Ullah, Z, Wilson, E, Cleaver, J, Colman, J, Copeland, L, Coulson, A, Davis, P, Faisal, H, Hassan, F, Hughes, JT, Jabr, Y, Mahmoud Ali, F, Nahaboo Solim, ZN, Sangheli, A, Shaya, S, Thompson, R, Cornwall, H, De Andres Crespo, M, Fay, E, Findlay, J, Groves, E, Jones, O, Killen, A, Millo, J, Thomas, S, Ward, J, Wilkins, M, Zaki, F, Zilber, E, Bhavra, K, Bilolikar, A, Charalambous, M, Elawad, A, Eleni, A, Fawdon, R, Gibbins, A, Livingstone, D, Mala, D, Oke, SE, Padmakumar, D, Patsalides, MA, Payne, D, Ralphs, C, Roney, A, Sardar, N, Stefanova, K, Surti, F, Timms, R, Tosney, G, Bannister, J, Clement, NS, Cullimore, V, Kamal, F, Lendor, J, McKay, J, Mcswiggan, J, Minhas, N, Seneviratne, K, Simeen, S, Valverde, J, Watson, N, Bloom, I, Dinh, TH, Hirniak, J, Joseph, R, Kansagra, M, Lai, CKN, Melamed, N, Patel, J, Randev, J, Sedighi, T, Shurovi, B, Sodhi, J, Vadgama, N, Abdulla, S, Adabavazeh, B, Champion, A, Chennupati, R, Chu, K, Devi, S, Haji, A, Schulz, J, Testa, F, Davies, P, Gurung, B, Howell, S, Modi, P, Pervaiz, A, Zahid, M, Abdolrazaghi, S, Abi Aoun, R, Anjum, Z, Bawa, G, Bhardwaj, R, Brown, S, Enver, M, Gill, D, Gopikrishna, D, Gurung, D, Kanwal, A, Kaushal, P, Khanna, A, Lovell, E, McEvoy, C, Mirza, M, Nabeel, S, Naseem, S, Pandya, K, Perkins, R, Pulakal, R, Ray, M, Reay, C, Reilly, S, Round, A, Seehra, J, Shakeel, NM, Singh, B, Vijay Sukhnani, M, Brown, L, Desai, B, Elzanati, H, Godhaniya, J, Kavanagh, E, Kent, J, Kishor, A, Liu, A, Norwood, M, Shaari, N, Wood, C, Wood, M, Brown, A, Chellapuri, A, Ferriman, A, Ghosh, I, Kulkarni, N, Noton, T, Pinto, A, Rajesh, S, Varghese, B, Wenban, C, Aly, R, Barciela, C, Brookes, T, Corrin, E, Goldsworthy, M, Mohamed Azhar, MS, Moore, J, Nakhuda, S, Ng, D, Pillay, S, Port, S, Abdullah, M, Akinyemi, J, Islam, S, Kale, A, Lewis, A, Manjunath, T, McCabe, H, Misra, S, Stubley, T, Tam, JP, Waraich, N, Chaora, T, Ford, C, Osinkolu, I, Pong, G, Rai, J, Risquet, R, Ainsworth, J, Ayandokun, P, Barham, E, Barrett, G, Barry, J, Bisson, E, Bridges, I, Burke, D, Cann, J, Cloney, M, Coates, S, Cripps, P, Davies, C, Francis, N, Green, S, Handley, G, Hathaway, D, Hurt, L, Jenkins, S, Johnston, C, Khadka, A, McGee, U, Morris, D, Murray, R, Norbury, C, Pierrepont, Z, Richards, C, Ross, O, Ruddy, A, Salmon, C, Shield, M, Soanes, K, Spencer, N, Taverner, S, Williams, C, Wills-Wood, W, Woodward, S, Chow, J, Fan, J, Guest, O, Hunter, I, Moon, 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2022
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16. Long-Term Follow-Up of Patients with Neck Pain Associated with Ossification of the Posterior Longitudinal Ligament Treated with Integrative Complementary and Alternative Medicine: A Retrospective Analysis and Questionnaire Survey

Author

Namgoong J, Lee YH, Ju AR, Chai J, Choi D, Choi HJ, Seo JY, Park KS, Lee YJ, Lee J, and Ha IH

Subjects
integrative medicine, korean medicine, opll, neck pain, Medicine (General), R5-920
Abstract

Jin Namgoong,1 Yun-Ha Lee,1 Ah Ra Ju,1 Jiwon Chai,1 DongJoo Choi,1 Hyo Jung Choi,1 Ji-Yeon Seo,1 Kyoung Sun Park,2 Yoon Jae Lee,1,3 Jinho Lee,2 In-Hyuk Ha1,3 1Bucheon Jaseng Hospital of Korean Medicine, 414 KR in Sangdong, Bucheon-si, Gyeonggi-do, Republic of Korea; 2Jaseng Hospital of Korean Medicine, Seoul, Republic of Korea; 3Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of KoreaCorrespondence: In-Hyuk Ha, Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 3F JS Tower, 538 Gangnam-daero, Gangnam-gu, Seoul, 06110, Republic of Korea, Tel +82 2 2222 2740, Fax +82 2 3218 2244, Email hanihata@gmail.comPurpose: Integrative Korean medicine treatment (KMT) is a conservative treatment approach for the ossification of the posterior longitudinal ligament (OPLL) in Korea; nonetheless, relevant studies focusing on KMT for OPLL are lacking. A multicenter retrospective analysis of patient medical records and a questionnaire survey were conducted to investigate the effectiveness of integrative KMT in patients with OPLL treated for neck pain.Patients and Methods: A total of 78 inpatients radiologically diagnosed with OPLL and treated for neck pain at four Korean medicine hospitals from April 1, 2016, to December 31, 2019, were enrolled. The primary index was an improvement in the numeric rating scale (NRS) score for neck pain, whereas the secondary outcome indices were improvements in the NRS score for arm pain, neck disability index (NDI) score, and EuroQol 5-dimension 5-level (EQ-5D-5L) score.Results: At discharge, the NRS score for neck pain, NRS score for arm pain, and NDI score decreased by 2.47 (95% confidence interval [CI], − 2.81 to − 2.14), 1.32 (95% CI, − 1.73 to − 0.91), and 16.02 (95% CI, − 18.89 to − 13.15), respectively, as compared with the scores at admission (p < 0.001). The EQ-5D-5L score increased by 0.12 (95% CI, 0.09 to 0.16) as compared with the score at admission (p < 0.001). This trend was also evident during follow-up. With respect to Patient Global Impression of Change evaluation, 33 (61.1%) patients claimed to have very much improved, whereas 17 (31.5%) patients reported to have much improved.Conclusion: Inpatients with OPLL who received integrative KMT showed improvements in neck pain, arm pain, the NDI, and quality of life, which were retained throughout the follow-up period.Keywords: integrative medicine, Korean medicine, OPLL, neck pain

Published
2022

17. Folic Acid and Chitosan-Functionalized Gold Nanorods and Triangular Silver Nanoplates for the Delivery of Anticancer Agents

Author

Lee YJ, Kim YJ, and Park Y

Subjects
folic acid, chitosan, triangular silver nanoplates, gold nanorods, anticancer activity, photothermal therapy, hela cells, Medicine (General), R5-920
Abstract

You Jeong Lee, Yeon-Jeong Kim, Youmie Park College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae, Gyeongnam, 50834, Republic of KoreaCorrespondence: Youmie Park, Tel +82-55-320-3884, Fax +82-55-320-3940, Email youmiep@inje.ac.krBackground: Advances in the field of nanotechnology have shed light on the applications of nanoparticles for cancer treatment.Methods: Folic acid and chitosan-functionalized gold nanorods (FACS-R) and triangular silver nanoplates (FACS-T) were synthesized and their properties were elucidated by UV-visible spectrophotometry, Fourier-transform infrared spectroscopy, field emission transmission electron microscopy and high-resolution X-ray diffraction.Results: The average size of the FACS-R was determined to be a transverse length of 13.1 ± 1.8 nm and a longitudinal length of 47.2 ± 8.9 nm with an aspect ratio of 3.6. The average size of FACS-T was measured to be 31.8 ± 7.7 nm. Colloidal solutions of FACS-R and FACS-T were stable on the shelf at ambient temperature for 14 days in the dark. Anticancer agents were encapsulated in FACS-R and FACS-T. FACS-T showed a higher encapsulation efficiency with docetaxel, paclitaxel and diallyl disulfide than FACS-R. The cell viability on human gastric adenocarcinoma cells (AGS), human epithelial cervix adenocarcinoma cells (HeLa) and human colorectal adenocarcinoma cells (HT-29) after treatment with anticancer agent-encapsulated FACS-R and FACS-T was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Interestingly, paclitaxel-encapsulated FACS-R and FACS-T showed the highest percentages of early and late apoptosis on HeLa cells. A cell cycle analysis demonstrated increased G2/M arrest on HeLa cells with docetaxel and paclitaxel-encapsulated FACS-R and FACS-T. The FACS-T induced more G2/M arrest on HeLa cells than the FACS-R. To assess applications in near-infrared photothermal therapy (PTT), the cell viability on HeLa cells with the anticancer agent-encapsulated FACS-R and FACS-T was assessed in the presence or absence of 808 nm laser irradiation. The results showed that 808 nm laser irradiation significantly decreased cell viability.Conclusion: Collectively, the triangular silver nanoplates were more effective than the gold nanorods for PTT. We believe that as-prepared nanoparticles have remarkable features and will become promising future nanomedicine.Keywords: folic acid, chitosan, triangular silver nanoplates, gold nanorods, anticancer activity, photothermal therapy, HeLa cells

Published
2022

18. Long-Term Follow-Up of Inpatients with Cervical Myelopathy Who Received Integrative Korean Medicine Treatment: A Retrospective Analysis and Questionnaire Survey Study

Author

Cho HW, Park JH, Yoo DH, Hwang DW, Kim SD, Kim ES, Park KS, Lee YJ, Lee J, Yang CS, Han CH, and Ha IH

Subjects
cervical myelopathy, korean medicine, acupuncture, musculoskeletal manipulations, pharmacopuncture, shinbaro, Medicine (General), R5-920
Abstract

Hyun Woo Cho,1 Ju Hun Park,1 Dong Hwi Yoo,1 Dong Wook Hwang,1 Sang Don Kim,1 Eun-San Kim,2 Kyoung Sun Park,3 Yoon Jae Lee,2 Jinho Lee,3 Changsop Yang,4 Chang Hyun Han,4,5 In-Hyuk Ha2 1Haeundae Jaseng Hospital of Korean Medicine, Busan, 48102, Republic of Korea; 2Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, 06110, Republic of Korea; 3Jaseng Hospital of Korean Medicine, Seoul, 06110, Republic of Korea; 4KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea; 5Korean Convergence Medical Science, Korea Institute of Oriental Medicine School, University of Science & Technology, Daejeon, 34054, Republic of KoreaCorrespondence: Chang Hyun Han, Clinical Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea, Tel +82 42-868-9498, Email chhan@kiom.re.kr In-Hyuk Ha, Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 3F 538 Gangnam-daero, Gangnam-gu, Seoul, 06110, Republic of Korea, Tel +82 2-2222-2740, Email hanihata@gmail.comPurpose: Cervical myelopathy (CM) is generally considered an indication for surgery in Western medicine. Case reports have indicated that Korean medicine (KM) treatments are effective in improving CM-associated symptoms. We investigated the effectiveness of non-surgical KM treatment of CM patients through a retrospective chart review and follow-up survey.Patients and Methods: We retrospectively analyzed the medical records and surveyed follow-up data of CM patients with neurological symptoms admitted to KM hospitals between January 2011 and January 2018. The admission and discharge assessments included the numeric rating scale (NRS) for neck and arm pain, neck disability index (NDI), and 5-level EuroQol 5-dimension (EQ-5D-5L). A follow-up survey was conducted about whether surgery was subsequently performed or recommended, symptom recurrence, discomfort in daily living, current treatment, as well as NRS, NDI, EQ-5D-5L, and patient global impression of change (PGIC) scores.Results: The NRS for neck pain decreased from 4.88 ± 2.03 (95% CI: 4.23‒5.52) at admission to 3.23 ± 1.64 (95% CI: 2.70‒3.75) at discharge and 2.24 ± 1.84 (95% CI: 1.43‒3.05) at follow-up. The NRS for radiating arm pain decreased from 5.42 ± 1.55 (95% CI: 4.93‒5.92) to 3.77 ± 1.54 (95% CI: 3.28‒4.27) at discharge and 2.43 ± 1.60 (95% CI: 1.72‒3.13) at follow-up. The NDI decreased significantly from 36.24 ± 18.79 (95% CI: 30.24‒42.24) at admission to 30.89 ± 15.54 (95% CI: 25.93‒35.86) at discharge and 13.35 ± 11.95 (95% CI: 8.08‒18.63) at follow-up. The EQ-5D score improved significantly from 0.70 ± 0.21 (95% CI: 0.63‒0.77) to 0.78 ± 0.17 (95% CI: 0.73‒0.84) at discharge and 0.84 ± 0.08 (95% CI: 0.80‒0.88) at follow-up. At the follow-up, four patients experienced persistent pain and were undergoing treatment (19.1%), while 20 patients (95.8%) reported symptom improvement.Conclusion: From a long-term perspective, integrative KM treatment may help to reduce pain and improve function, and improve quality of life of CM patients.Keywords: cervical myelopathy, Korean medicine, acupuncture, musculoskeletal manipulations, pharmacopuncture, Shinbaro

Published
2022

19. Relationship of the Triglyceride-Glucose Index with Subclinical White Matter Hypersensitivities of Presumed Vascular Origin Among Community-Dwelling Koreans

Author

Jung DH, Park B, and Lee YJ

Subjects
triglyceride-glucose index, white matter hypersensitivities, endothelial dysfunction, insulin resistance, cerebral small vessel disease, Medicine (General), R5-920
Abstract

Dong-Hyuk Jung, Byoungjin Park, Yong-Jae Lee Department of Family Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of KoreaCorrespondence: Yong-Jae LeeDepartment of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea, Tel +82-2-2019-2630, Fax +82-2-3463-3882, Email ukyjhome@yuhs.acDong-Hyuk JungDepartment of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, 363 Dongbaekjukjeondae-ro, Giheung-gu, Yongin-si, Gyeonggi-do, 16995, Republic of Korea, Tel +82-31-5189-8762, Fax +82-31-5189-8809, Email balsan2@yuhs.acPurpose: The triglyceride-glucose (TyG) index, a widely accessible measure, has been a surrogate indicator of peripheral insulin resistance, and its clinical importance continues to grow in East Asia. We hypothesized that the TyG index is relevant to subclinical white matter hypersensitivities (WMHs) of presumed vascular origin among community-dwelling Koreans.Methods: We investigated the relationship between the TyG index and WMHs on brain magnetic resonance imaging scans in 2417 Koreans over 45 years of age without a history of cancer, stroke, or ischemic heart disease. The study population was divided into four groups according to the TyG index quartiles. Using multiple logistic regression analysis, we assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for WMHs across the TyG index quartiles.Results: The prevalence of WMHs was significantly higher in the fourth TyG index quartile, with an overall rate of 9.3%. After adjusting for potential confounding variables, the ORs of WMHs for the TyG index quartiles were 1.00, 1.47 (95% CI, 0.91– 2.40), 1.76 (95% CI, 1.05– 2.97), and 6.79 (95% CI, 3.85– 1.54), respectively.Conclusion: We found that higher TyG index values were associated with the brain’s WMHs of presumed vascular origin. Our findings suggest that the serum TyG index could be an additional valuable biomarker for assessing the risk of cerebral small vessel disease in the preclinical stage.Keywords: triglyceride-glucose index, white matter hypersensitivities, endothelial dysfunction, insulin resistance, cerebral small vessel disease

Published
2022

20. Extraction of heavy-flavor transport coefficients in QCD matter

Author

Rapp, R, Gossiaux, PB, Andronic, A, Averbeck, R, Masciocchi, S, Beraudo, A, Bratkovskaya, E, Braun-Munzinger, P, Cao, S, Dainese, A, Das, SK, Djordjevic, M, Greco, V, He, M, van Hees, H, Inghirami, G, Kaczmarek, O, Lee, YJ, Liao, J, Liu, SYF, Moore, G, Nahrgang, M, Pawlowski, J, Petreczky, P, Plumari, S, Prino, F, Shi, S, Song, T, Stachel, J, Vitev, I, and Wang, XN

Subjects
nucl-th, hep-ph, nucl-ex, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract

We report on broadly based systematic investigations of the modeling components for open heavy-flavor diffusion and energy loss in strongly interacting matter in their application to heavy-flavor observables in high-energy heavy–ion collisions, conducted within an EMMI Rapid Reaction Task Force framework. Initial spectra including cold-nuclear-matter effects, a wide variety of space-time evolution models, heavy-flavor transport coefficients, and hadronization mechanisms are scrutinized in an effort to quantify pertinent uncertainties in the calculations of nuclear modification factors and elliptic flow of open heavy-flavor particles in nuclear collisions. We develop procedures for error assessments and criteria for common model components to improve quantitative estimates for the (low-momentum) heavy-flavor diffusion coefficient as a long-wavelength characteristic of QCD matter as a function of temperature, and for energy loss coefficients of high-momentum heavy-flavor particles.

Published
2018

21. Polysomnographic Sleep and Attentional Deficits in Traumatized North Korean Refugees

Author

Lee J, Jeon S, Kim S, Seo Y, Park J, Lee YJ, and Kim SJ

Subjects
attention, sleep, trauma, north korean refugees, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Jooyoung Lee,1 Sehyun Jeon,2 Somin Kim,1 Yumin Seo,1 Jinme Park,3 Yu Jin Lee,4 Seog Ju Kim1 1Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea; 2Department of Psychiatry, Korea University Anam Hospital, Seoul, Republic of Korea; 3Department of Psychology, University of Konstanz, Konstanz, Germany; 4Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University, College of Medicine and Hospital, Seoul, Republic of KoreaCorrespondence: Seog Ju KimDepartment of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, 81 Ilwon-ro, Kangnam-gu, #06351, Seoul, 135-710, KoreaTel +82-2-3410-3583Fax +82-2-3410-0050Email ksj7126@skku.eduIntroduction: Attentional deficits and sleep problems are common in refugees who have experienced trauma. In the present study, we used polysomnography (PSG) to investigate the relationship between attentional deficits and objective measures of sleep structure in traumatized North Korean refugees.Methods: We recruited 32 North Korean refugees (mean age = 33.78 ± 14.33 years) and 39 South Korean participants (mean age = 35.03 ± 11.08 years). Sustained attention and divided attention were assessed using the Computerized Attention Test. We conducted an overnight PSG to objectively assess sleep structure. The participants also completed the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Impact of Event Scale-Revised (IES-R), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and Insomnia Severity Index (ISI).Results: The North Korean refugees showed more commission errors (CEs, p < 0.05) and a larger standard deviation (SD) of the reaction time (RT) (p < 0.05) in the sustained attention task compared to the South Korean participants. Furthermore, the North Korean refugees showed a shorter period of wake after sleep onset (WASO, p < 0.01), less time spent in N1 (p < 0.05), and more time spent in N2 (p < 0.05). The larger SD of RT in the sustained attention task in the North Korean refugees was positively correlated with WASO (r = 0.62, p < 0.01) and N1 stage (r = 0.47, p < 0.05) after controlling for age, sex, BDI, BAI, and IES-R.Conclusion: The North Korean refugees showed poorer performance on the sustained attention task. Nocturnal PSG revealed shorter WASO and time spent in N1 in this population, which are independently associated with the preservation of attentional capacity. These data suggest that traumatized refugees may compensate for attentional deficits induced by their traumatic experiences via increased sleep continuity.Keywords: attention, sleep, trauma, North Korean refugees

Published
2021

22. Bowling: Occupational Hazards of the Wrist and Hand in Elite Tenpin Bowlers

Author

Lee YJ, Harmony TCY, Jamal-Azmi IS, Gunasagaran J, and Ahmad TS

Subjects
sports injuries, athletes, tendinopathies, dequervain’s tenosynovitis, kinematics, Orthopedic surgery, RD701-811
Abstract

INTRODUCTION: Bowling is an immensely popular, but scarcely researched sport associated with overuse injuries in its participants. The purpose of this study was to investigate and report on the incidence of common upper extremity complaints in elite bowling athletes. MATERIALS AND METHODS: All Malaysian national level bowlers (n=39) were evaluated via questionnaire on their upper limb symptoms. A focused, relevant clinical examination was performed on each subject to exclude de Quervain’s tenosynovitis, tennis and golfer's elbow, carpal tunnel syndrome and trigger finger. The athletes were then allowed to resume bowling for two hours before completing another symptom-related questionnaire. RESULTS: Pain was the predominantly observed symptom, with a predilection for the wrist, ring and middle fingers, and thumb. De Quervain’s tenosynovitis was found in 53.8% (n=21) of the subjects, with 52.4% and 42.9% of them experiencing pain during and after training, respectively. Other repetitive injury-related disorders were also considerably more common than in their non-playing limb and the general population. CONCLUSION: The incidence of de Quervain’s tenosynovitis was exceptionally high in this population. Further studies on sports kinematics are needed to prevent long term morbidities in these athletes.

Published
2021
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23. Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans

Author

Jung DH, Lee YJ, and Park B

Subjects
hepatic steatosis, alanine aminotransferase, prospective cohort study, ischemic heart disease, extrahepatic complication, Geriatrics, RC952-954.6
Abstract

Dong-Hyuk Jung,1,2 Yong Jae Lee,3,4 Byoungjin Park1 1Department of Family Medicine, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 2Department of Health Promotion Centre, Yongin Severance Hospital, Yongin-si, Gyeonggi-do, 16995, Republic of Korea; 3Department of Family Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; 4Department of Family Medicine, Gangnam Severance Hospital, Seoul, 06273, Republic of KoreaCorrespondence: Byoungjin ParkDepartment of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, 363 Dongbaekjukjeondae-Ro, Giheung-Gu, Yongin-si, Gyeonggi-do, 16995, Republic of KoreaTel + 82 31 5189 8763Email bjpark96@yuhs.acPurpose: Hepatic steatosis has been associated with some cardiovascular risks. Increased alanine aminotransferase (ALT) was suggested to be linked to endothelial dysfunction. We prospectively investigated the joint effect of hepatic steatosis and elevated ALT within the normal range on incident ischemic heart disease (IHD) risk as an extrahepatic complication.Patients and Methods: We assessed 16,541 participants without diabetes using data from a health risk assessment study (HERAS) and Korean Health Insurance Review and Assessment (HIRA) data. We defined elevated ALT within the normal range as 30– 40 IU/L in men and 23– 40 IU/L in women, according to previous Korean epidemiological data. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazards regression models over a 50-month period after the baseline survey.Results: During the follow-up period, 368 (2.2%) participants developed IHD. Compared to the group with no hepatic steatosis and controlled ALT, the HRs for IHD were 1.68 (95% CI, 1.16– 2.42) in the group with hepatic steatosis and elevated ALT after adjusting for confounding variables.Conclusion: Hepatic steatosis and elevated ALT levels within the normal range may jointly affect the development of IHD among nondiabetic adults. This indicates that lifestyle advice and vascular health management should be recommended among individuals with hepatic steatosis and elevated ALT, even if it falls within the normal range.Keywords: hepatic steatosis, alanine aminotransferase, prospective cohort study, ischemic heart disease, extrahepatic complication

Published
2021

24. Ultrasound-Guided Thoracic Paravertebral Block as a Sympathetic Blockade for Upper Extremity Neuropathic Pain: A Prospective Pilot Study

Author

Kim J, Lee HJ, Lee YJ, Lee CS, Yoo Y, and Moon JY

Subjects
neuropathic pain, upper extremity, paravertebral block, sympathetic block, ultrasound, Medicine (General), R5-920
Abstract

Jeongsoo Kim,1 Ho-Jin Lee,1,2 Young-Ju Lee,3 Chang-Soon Lee,1,2,4 Yongjae Yoo,1,2,4 Jee Youn Moon1,2,4 1Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; 3Department of Anesthesiology and Pain Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea; 4Integrated Cancer Management Center, Seoul National University Cancer Hospital, Seoul, Republic of KoreaCorrespondence: Jee Youn MoonDepartment of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of KoreaTel +82-2-2072-2462Fax +82-2-763-9390Email jymoon0901@gmail.comPurpose: Ultrasound-guided thoracic paravertebral block (US-TPVB) is considered a treatment option for the management of acute pain in various pain-related conditions. We conducted a prospective pilot study to evaluate the possibility of US-TPVB as a sympathetic blockade in patients with neuropathic pain disorders in the upper extremities.Patients and Methods: A total of 12 patients underwent US-TPVB between the T2 and T3 paravertebral space with 10 mL of 1% mepivacaine. The temperature change (°C) before and after the procedure was compared between the ipsilateral and contralateral hands. We counted the proportion of patients showing a temperature increase ≥ 1.5°C and compared a change in the pain intensity before and after the procedure.Results: The median increase in the temperature change between the ipsilateral and contralateral hands was 1.54°C (interquartile range, 1.28– 2.20). There were seven patients (58.3%) who showed a temperature difference ≥ 1.5°C between both hands after the US-TPVB. Eleven patients (91.7%) reported a reduction in pain according to the score on the 11-point numerical rating scale. No serious complications relevant to the procedure were reported.Conclusion: US-TPVB could be a useful technique for sympathetic blockade in patients with upper extremity pain.Keywords: neuropathic pain, upper extremity, paravertebral block, sympathetic block, ultrasound

Published
2020

25. Associations of 25-Hydroxyvitamin D Levels and Arthritis with Sleep Duration: The Korean National Health and Nutrition Examination Survey 2008–2014

Author

Kim SY, Lee MH, Lim WJ, Kim SI, and Lee YJ

Subjects
vitamin d, arthritis, sleep duration, korean national health and nutrition examination survey (knhanes), Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Sun-Young Kim,1 Mi Hyun Lee,2 Weon-Jeong Lim,1 Soo In Kim,3 Yu Jin Lee2 1Department of Psychiatry, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; 2Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University Hospital, Seoul University College of Medicine, Seoul, Republic of Korea; 3Department of Psychiatry, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of KoreaCorrespondence: Yu Jin LeeDepartment of Psychiatry and Center for Sleep and Chronobiology, Seoul National University Hospital, Seoul National University College of Medicine, 103 Daehak-Ro, Jongno-Gu, Seoul 03080, Republic of KoreaTel +82-2-2072-2456Fax +82-2-744-7241Email ewpsyche@snu.ac.krPurpose: The mean sleep duration of Koreans is 7 hours 49 minutes, which is the lowest among Organization for Economic Cooperation and Development countries. Although vitamin D deficiency and arthritis are considered modifiable factors influencing restorative sleep, mean vitamin D levels are low (17.33 ng/mL) and arthritis is prevalent among Koreans. This study investigated whether vitamin D deficiency and arthritis increase the risk of short sleep duration.Patients and Methods: The current study used data from the Korean National Health and Nutrition Examination Survey (KNHANES) for 46,405 Korean adults. Vitamin D levels were measured using a radioimmunoassay kit. Sleep duration and arthritis history were assessed using a self-reported questionnaire. Sleep duration was categorized as optimal (7 to < 9 hours/day), short (< 7 hours/day), and long (≥ 9 hours/day). Vitamin D levels were grouped as vitamin D sufficiency (≥ 20 ng/mL), insufficiency (10– 19.99 ng/mL), and deficiency (< 10 ng/mL). Multiple imputation was used to compensate for missing data. Multinomial logistic regression was used to examine the associations of vitamin D and arthritis status with sleep duration. The regressions were adjusted for covariates, and each model was adjusted for vitamin D and arthritis.Results: Among these participants, 23,078 (49.73%) and 3518 (7.58%) had short and long sleep duration, respectively; 26,724 (57.59%) and 4349 (9.37%) exhibited vitamin D insufficiency and deficiency, respectively; and 4709 (10.15%) were arthritis patients. Compared with vitamin D sufficiency, vitamin D insufficiency and deficiency were associated with short sleep duration (vitamin D insufficiency group: OR = 1.07, 95% CI = 1.01– 1.13; vitamin D deficiency group: OR = 1.13, 95% CI = 1.03– 1.24). The presence of arthritis was associated with short sleep duration (OR = 1.14, 95% CI = 1.06– 1.22) compared with its absence. The interaction between vitamin D deficiency and the presence of arthritis was significantly associated with short sleep duration. However, long sleep duration was not significantly associated with vitamin D levels or arthritis status.Conclusion: Low vitamin D levels and the presence of arthritis were associated with an increased risk of short sleep duration. Additionally, there was a positive interaction effect between vitamin D deficiency and arthritis on short sleep duration.Keywords: vitamin D, arthritis, sleep duration, Korean National Health and Nutrition Examination Survey, KNHANES

Published
2020

26. A Genome-Wide Association Study in Early COPD: Identification of One Major Susceptibility Loci

Author

Lee YJ, Choi SH, Kwon SY, Lee Y, Lee JK, Heo EY, Chung HS, and Kim DK

Subjects
early chronic obstructive pulmonary disease, genome-wide association study, single nucleotide polymorphism (snp), hla-dq gene, Diseases of the respiratory system, RC705-779
Abstract

Ye-Jin Lee,1 SeungHo Choi,2 Sung-Youn Kwon,2 Yunhwan Lee,2 Jung Kyu Lee,3 Eun Young Heo,3 Hee Soon Chung,3,4 Deog Kyeom Kim3,4 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea; 2Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 135-984 Korea; 3Division of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea; 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaCorrespondence: Deog Kyeom KimDivision of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Boramae-Gil 41, Dongjak-gu, Seoul 156-707, Republic of KoreaTel +82-2-870-3207Fax +82-2-831-0714Email kimdkmd@gmail.comBackground: Identifying the genetic basis of airflow limitation is one of the most interesting issues for understanding chronic obstructive pulmonary disease (COPD) pathophysiology. Several studies have shown that some genetic variants associated with COPD have been identified in genome-wide association study (GWAS), especially in patients with moderate to severe COPD; genetic susceptibility for airflow limitation in the early COPD phase has not been widely studied.Objective: We investigated the genetic variants in early COPD.Methods: The present study analyzed Gene-environment interaction and phenotype (GENIE) cohort that included participants who received health screening examination. The association between single nucleotide polymorphism (SNP) and susceptibility to early COPD (FEV1 predicted ≥ 50% and FEV1/FVC < 0.7) was tested.Results: A total of 130 patients with early COPD and 3478 controls (1700 ever smokers and 1778 never smokers) were recruited. When compared with the total controls, certain SNPs (rs2818103, rs875033, rs9354627, rs34552148) on chromosome 6 were included at the top of our list (p= 5.6 × 10– 7 ∼ 9.6 × 10– 6) although they did not reach genome-wide significance. When compared with the never smoker controls, two SNPs (rs2857210, rs2621419) of the HLA-DQB2 gene class were persistently associated with susceptibility to early COPD.Conclusion: Certain SNPs located on chromosome 6 or the HLA-DQB2 gene were the top-scoring SNPs for the association with susceptibility to early COPD in the Korean GENIE cohort.Keywords: early chronic obstructive pulmonary disease, genome-wide association study, single nucleotide polymorphism, SNP, HLA-DQ gene

Published
2020

27. Common and Unique Factors and the Bidirectional Relationship Between Chronic Kidney Disease and Nonalcoholic Fatty Liver in Type 2 Diabetes Patients

Author

Lee YJ, Wang CP, Hung WC, Tang WH, Chang YH, Hu DW, Lu YC, Yu TH, Wu CC, Chung FM, and Hsu CC

Subjects
bidirectional relationship, chronic kidney disease, non-alcoholic fatty liver disease, risk factor, structural equation modeling, type 2 diabetes mellitus, Specialties of internal medicine, RC581-951
Abstract

Yau-Jiunn Lee,1 Chao-Ping Wang,2,3 Wei-Chin Hung,2,4 Wei-Hua Tang,1 Yu-Hung Chang,1 Der-Wei Hu,1 Yung-Chuan Lu,3,5 Teng-Hung Yu,2,4 Cheng-Ching Wu,2,4,6 Fu-Mei Chung,2 Chia-Chang Hsu4,7,8 1Lee’s Endocrinology Clinic, Pingtung 90000, Taiwan; 2Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan; 3School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan; 4The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan; 5Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan; 6Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445, Taiwan; 7Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan; 8Health Examination Center, E-Da Dachang Hospital, Kaohsiung 80794, TaiwanCorrespondence: Chia-Chang HsuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, TaiwanTel +886-7-615-1100 ext. 5914 or 5018Email aladarhsu1107@gmail.comPurpose: This study aimed to investigate the common and unique risk factors and bidirectional relationship between chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).Patients and Methods: This was a cross-sectional study of patients with T2DM enrolled in a disease management program at two specialized diabetes outpatient clinics. Common and unique risk factors for CKD and NAFLD were examined using structural equation models (SEMs). SEMs were also used to examine direct and indirect effects of NAFLD on CKD and those of CKD on NAFLD.Results: A total of 1992 subjects with T2DM were enrolled in this study. In multivariate analysis, NAFLD was independently associated with the odds of CKD (adjusted odds ratio=1.59, 95% confidence interval=1.12– 2.25, P=0.009). SEMs showed that age, triglyceride, uric acid (UA), albumin, and HbA1c levels had statistically significant direct effects on CKD, and the final model could explain 22% of the variability in CKD. Age, triglycerides, body mass index (BMI), UA, white blood cell (WBC) count, serum glutamic pyruvic transaminase (SGPT) level, and smoking status had statistically significant direct effects on NAFLD, and the final model could explain 43% of the variability in NAFLD. The common risk factors contributing to both CKD and NAFLD were age, triglycerides, and UA. The unique risk factors were albumin and HbA1c for CKD, and BMI, WBC, SGPT, and smoking for NAFLD. In addition, SEM analysis also confirmed the bidirectional causal relationship between NAFLD and CKD.Conclusion: Common and unique risk factors and a bidirectional relationship existed between CKD and NAFLD in our patients with T2DM.Keywords: bidirectional relationship, chronic kidney disease, nonalcoholic fatty liver disease, risk factor, structural equation modeling, type 2 diabetes mellitus

Published
2020

28. Fracture toughness of silicate glasses: Insights from molecular dynamics simulations

Author

Yu, Y, Wang, B, Lee, YJ, and Bauchy, M

Subjects
cond-mat.mtrl-sci, cond-mat.dis-nn
Abstract

Understanding, predicting and eventually improving the resistance to fracture of silicate materials is of primary importance to design new glasses that would be tougher, while retaining their transparency. However, the atomic mechanism of the fracture in amorphous silicate materials is still a topic of debate. In particular, there is some controversy about the existence of ductility at the nano-scale during the crack propagation. Here, we present simulations of the fracture of three archetypical silicate glasses using molecular dynamics. We show that the methodology that is used provide realistic values of fracture energy and toughness. In addition, the simulations clearly suggest that silicate glasses can show different degrees of ductility, depending on their composition.

Published
2015

29. Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial

Author

Cerana, S, Dictar, MO, Bonvehi, P, Tregnaghi, JP, Fein, L, Ashley, D, Singh, M, Hayes, T, Playford, G, Morrissey, O, Thaler, J, Kuehr, T, Greil, R, Pecherstorfer, M, Duck, L, Van Eygen, K, Aoun, M, De Prijck, B, Franke, FA, Barrios, CHE, Mendes, AVA, Serrano, SV, Garcia, RF, Moore, F, Camargo, JFC, Pires, LA, Alves, RS, Radinov, A, Oreshkov, K, Minchev, V, Hubenova, AI, Koynova, T, Ivanov, I, Rabotilova, B, Petrov, PA, Chilingirov, P, Karanikolov, S, Raynov, J, Grimard, D, McNeil, S, Kumar, D, Larratt, LM, Weiss, K, Delage, R, Diaz-Mitoma, FJ, Cano, PO, Couture, F, Carvajal, P, Yepes, A, Torres Ulloa, R, Fardella, P, Caglevic, C, Rojas, C, Orellana, E, Gonzalez, P, Acevedo, A, Galvez, KM, Gonzalez, ME, Franco, S, Restrepo, JG, Rojas, CA, Bonilla, C, Florez, LE, Ospina, AV, Manneh, R, Zorica, R, Vrdoljak, DV, Samarzija, M, Petruzelka, L, Vydra, J, Mayer, J, Cibula, D, Prausova, J, Paulson, G, Ontaneda, M, Palk, K, Vahlberg, A, Rooneem, R, Galtier, F, Postil, D, Lucht, F, Laine, F, Launay, O, Laurichesse, H, Duval, X, Cornely, OA, Camerer, B, Panse, J, Zaiss, M, Derigs, H-G, Menzel, H, Verbeek, M, Georgoulias, V, Mavroudis, D, Anagnostopoulos, A, Terpos, E, Cortes, D, Umanzor, J, Bejarano, S, Galeano, RW, Wong, RSM, Hui, P, Pedrazzoli, P, Ruggeri, L, Aversa, F, Bosi, A, Gentile, G, Rambaldi, A, Contu, A, Marei, L, Abbadi, A, Hayajneh, W, Kattan, J, Farhat, F, Chahine, G, Rutkauskiene, J, Marfil Rivera, LJ, Lopez Chuken, YA, Franco Villarreal, H, Lopez Hernandez, J, Blacklock, H, Lopez, RI, Alvarez, R, Gomez, AM, Quintana, TS, Moreno Larrea, MDC, Zorrilla, SJ, Alarcon, E, Samanez, FCA, Caguioa, PB, Tiangco, BJ, Mora, EM, Betancourt-Garcia, RD, Hallman-Navarro, D, Feliciano-Lopez, LJ, Velez-Cortes, HA, Cabanillas, F, Ganea, DE, Ciuleanu, TE, Ghizdavescu, DG, Miron, L, Cebotaru, CL, Cainap, CI, Anghel, R, Dvorkin, MV, Gladkov, OA, Fadeeva, NV, Kuzmin, AA, Lipatov, ON, Zbarskaya, II, Akhmetzyanov, FS, Litvinov, IV, Afanasyev, BV, Cherenkova, M, Lioznov, D, Lisukov, IA, Smirnova, YA, Kolomietz, S, Halawani, H, Goh, YT, Drgona, L, Chudej, J, Matejkova, M, Reckova, M, Rapoport, BL, Szpak, WM, Malan, DR, Jonas, N, Jung, CW, Lee, DG, Yoon, SS, Lopez Jimenez, J, Duran Martinez, I, Rodriguez Moreno, JF, Solano Vercet, C, de la Camara, R, Batlle Massana, M, Yeh, S-P, Chen, C-Y, Chou, H-H, Tsai, C-M, Chiu, C-H, Siritanaratkul, N, Norasetthada, L, Sriuranpong, V, Seetalarom, K, Akan, H, Dane, F, Ozcan, MA, Ozsan, GH, Kalayoglu Besisik, SF, Cagatay, A, Yalcin, S, Peniket, A, Mullan, SR, Dakhil, KM, Sivarajan, K, Suh, JJ-G, Sehgal, A, Marquez, F, Gomez, EG, Mullane, MR, Skinner, WL, Behrens, RJ, Trevarthe, DR, Mazurczak, MA, Lambiase, EA, Vidal, CA, Anac, SY, Rodrigues, GA, Baltz, B, Boccia, R, Wertheim, MS, Holladay, CS, Zenk, D, Fusselman, W, Wade III, JL, Jaslowsk, AJ, Keegan, J, Robinson, MO, Go, RS, Farnen, J, Amin, B, Jurgens, D, Risi, GF, Jr, Beatty, PG, Naqvi, T, Parshad, S, Hansen, VL, Ahmed, M, Steen, PD, Badarinath, S, Dekker, A, Scouros, MA, Young, DE, Graydon Harker, W, Kendall, SD, Citron, ML, Chedid, S, Posada, JG, Jr, Gupta, MK, Rafiyath, S, Buechler-Price, J, Sreenivasappa, S, Chay, CH, Burke, JM, Young, SE, Mahmood, A, Kugler, JW, Gerstner, G, Fuloria, J, Belman, ND, Geller, R, Nieva, J, Whittenberger, BP, Wong, BMY, Cescon, TP, Abesada-Terk, G, Jr, Guarino, MJ, Zweibach, A, Ibrahim, EN, Takahashi, G, Garrison, MA, Mowat, RB, Choi, BS, Oliff, IA, Singh, J, Guter, KA, Ayrons, K, Rowland, KM, Noga, SJ, Rao, SB, Columbie, A, Nualart, MT, Cecchi, GR, Campos, LT, Mohebtash, M, Flores, MR, Rothstein-Rubin, R, O'Connor, BM, Soori, G, Knapp, M, Miranda, FG, Goodgame, BW, Kassem, M, Belani, R, Sharma, S, Ortiz, T, Sonneborn, HL, Markowitz, AB, Wilbur, D, Meiri, E, Koo, VS, Jhangiani, HS, Wong, L, Sanani, S, Lawrence, SJ, Jones, CM, Murray, C, Papageorgiou, C, Gurtler, JS, Ascensao, JL, Venigalla, ML, D'Andrea, M, De Las Casas, C, Haile, DJ, Qazi, FU, Santander, JL, Thomas, MR, Rao, VP, Craig, M, Garg, RJ, Robles, R, Lyons, RM, Stegemoller, RK, Goel, S, Garg, S, Lowry, P, Lynch, C, Lash, B, Repka, T, Baker, J, Goueli, BS, Campbell, TC, Van Echo, DA, Lee, YJ, Reyes, EA, Senecal, FM, Donnelly, G, Byeff, P, Weiss, R, Reid, T, Roeland, E, Goel, A, Prow, DM, Brandt, DS, Kaplan, HG, Payne, JE, Boeckh, MG, Rosen, PJ, Mena, RR, Khan, R, Betts, RF, Sharp, SA, Morrison, VA, Fitz-Patrick, D, Congdon, J, Erickson, N, Abbasi, R, Henderson, S, Mehdi, A, Wos, EJ, Rehmus, E, Beltzer, L, Tamayo, RA, Mahmood, T, Reboli, AC, Moore, A, Brown, JM, Cruz, J, Quick, DP, Potz, JL, Kotz, KW, Hutchins, M, Chowhan, NM, Devabhaktuni, YD, Braly, P, Berenguer, RA, Shambaugh, SC, O'Rourke, TJ, Conkright, WA, Winkler, CF, Addo, FEK, Duic, JP, High, KP, Kutner, ME, Collins, R, Carrizosa, DR, Perry, DJ, Kailath, E, Rosen, N, Sotolongo, R, Shoham, S, Chen, T, Mullane, Kathleen M, Morrison, Vicki A, Camacho, Luis H, Arvin, Ann, McNeil, Shelly A, Durrand, Jessie, Campbell, Bernadette, Su, Shu-Chih, Chan, Ivan S F, Parrino, Janie, Kaplan, Susan S, Popmihajlov, Zoran, and Annunziato, Paula W

Published
2019
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30. A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts

Author

Bravo, Laura, Simões, Joana FF, Cardoso, Victor R, Adisa, Adewale, Aguilera, Maria L, Arnaud, Alexis, Biccard, Bruce, Calvache, Jose, Chernbumroong, Saisakul, Elhadi, Muhammed, Ghosh, Dhruv, Gujjuri, Rohan, Harrison, Ewen, Ho, Michael WS, Kasivisvanathan, Veerappan, Kouli, Omar, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Isik, Arda, Marcus, Hani, Martin, Janet, McLean, Kenneth A, Minaya-Bravo, Ana, Modolo, María Marta, Nepogodiev, Dmitri, Pellino, Gianluca, Picciochi, Maria, Pockney, Peter, van Ramshorst, Gabriëlle, Riad, Aya, Sayyed, Raza, Sund, Malin, Gkoutos, Georgios, Bhangu, Aneel A, Glasbey, James C, Bravo, L, Cardoso, V, Glasbey, J, Chernbumroong, S, Nepogodiev, D, Simoes, JFF, Mclean, KA, Bhangu, AA, Gkoutos, G, Kadir, B, Omar, O, Revell, E, Bahrami-Hessari, M, Ahmed, Waheed-Ul-Rahman, Argus, Leah, Ball, Alasdair, Bhangu, Aneel, Bywater, Edward P, Blanco-Colino, Ruth, Brar, Amanpreet, Chaudhry, Daoud, Dawson, Brett E, Duran, Irani, Elhadi, Muhammed, Glasbey, James C, Gujjuri, Rohan R, Jones, Conor S, Harrison, Ewen M, Kamarajah, Sivesh K, Keatley, James M, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder, Marson, Ella J, Mclean, Kenneth A, Nepogodiev, Dmitri, Norman, Lisa, Ots, Riinu, Outani, Oumaima, Picciochi, Maria, Santos, Irène, Shaw, Catherine, Taylor, Elliott H, Trout, Isobel M, Varghese, Chris, Venn, Mary L, Xu, William, Dajti, Irida, Gjata, Arben, Kacimi, Salah Eddine Oussama, Boccalatte, Luis, Modolo, Maria Marta, Cox, Daniel, Pockney, Peter, Aigner, Felix, Kronberger, Irmgard Elisabeth, Samadov, Elgun, Alderazi, Amer, Padmore, Greg, van Ramshorst, Gabrielle, Lawani, Ismaïl, Cerovac, Anis, Delibegovic, Samir, Baiocchi, Glauco, Gomes, Gustavo Mendonça Ataíde, Lima Buarque, Igor, Gohar, Muhammad, Slavchev, Mihail, Nwegbu, Chukwuemeka, Agarwal, Arnav, Brar, Amanpreet, Martin, Janet, Ng-Kamstra, Joshua, Olivos, Maricarmen, Lou, Wenhui, Ren, Dong-Lin, Calvache, Jose Andres, Perez Rivera, Carlos J-, Danic Hadzibegovic, Ana, Kopjar, Tomislav, Mihanovic, Jakov, Avilés Jiménez, Pablo Mijahil, Gouvas, Nikolaos, Klat, Jaroslav, Novysedlák, René, Amisi, Nicolas, Christensen, Peter, El-Hussuna, Alaa, Batista, Sylvia, Lincango-Naranjo, Eddy, Emile, Sameh, Arévalo Sandoval, Danilo Alfonso, Dhufera, Hailu, Hailu, Samuel, Mengesha, Mengistu G, Kauppila, Joonas H, Arnaud, Alexis P, Demetrashvili, Zaza, Albertsmeier, Markus, Lederhuber, Hans, Löffler, Markus W., Kwesi Acquah, Daniel, Ofori, Bernard, Tabiri, Stephen, Metallidis, Symeon, Tsoulfas, Georgios, Aguilera-Arevalo, Maria-Lorena, Recinos, Gustavo, Mersich, Tamás, Wettstein, Dániel, Ghosh, Dhruva, Kembuan, Gabriele, Brouki Milan, Peiman, Khosravi, Mohammad Hossein, Mozafari, Masoud, Hilmi, Ahmed, Mohan, Helen, Zmora, Oded, Gallo, Gaetano, Pata, Francesco, Pellino, Gianluca, Fujimoto, Yuki, Kuroda, Naoto, Satoi, Sohei, Abou Chaar, Mohamad K., Ayasra, Faris, Fakhradiyev, Ildar, Hamdun, Intisar Hisham Said, Jin-Young, Jang, Jamal, Mohammad, Karout, Lina, Elhadi, Muhammed, Gulla, Aiste, Rasoaherinomenjanahary, Fanjandrainy, Samison, Luc Hervé, Roslani, April Camilla, Durán Sánchez, Iran Irani, Gonzalez, Diana Samantha, Martinez, Laura, Martínez, María José, Nayen, Alejandra, Ramos-De la Medina, Antonio, Nunez, Jade, Outani, Oumaima, Nashidengo, Pueya Rashid, Shrestha, Ashish Lal, Jonker, Pascal, Kruijff, Schelto, Noltes, Milou, Steinkamp, Pieter, Varghese, Chris, Wright, Deborah, Abdur-Rahman, Lukman, Ademuyiwa, Adesoji, Adisa, Adewale, Osinaike, Babatunde, Seyi-Olajide, Justina, Williams, Omolara, Williams, Emmanuel, Pejkova, Sofija, Al Balushi, Zainab, Qureshi, Ahmad Uzair, Sayyed, Raza, Abo Mohsen, Mustafa, Abukhalaf, Sadi A., Cukier, Moises, Gomez-Fernandez, Hugo, Shu Yip, Sebastian, Vasquez Ojeda, Ximena Paola, Sacdalan, Marie Dione, Major, Piotr, Azevedo, José, Cunha, Miguel F., Zarour, Ahmad, Bonci, Eduard-Alexandru, Negoi, Ionut, Efetov, Sergey, Kochetkov, Viktor, Litvin, Andrey, Allen Ingabire, Jc, Bucyibaruta, Georges, Faustin, Ntirenganya, Habumuremyi, Sosthene, Imanishimwe, Alphonsine, Jean de Dieu, Haragirimana, Munyaneza, Emmanuel, Ncogoza, Isaie, Alameer, Ehab, Ndong, Abdourahmane, Radenkovic, Dejan, Chew, Min Hoe, Koh, Frederick, Ngu, James, Panyko, Arpád, Bele, Uros, Košir, Jurij Aleš, Daoud, Hassan, Blanco-Colino, Ruth, Minaya Bravo, Ana Maria, Jayarajah, Umesh, Wickramasinghe, Dakshitha, Adam Essa Adam, Mohammed Elmujtba, Rutegård, Martin, Sund, Malin, Adamina, Michel, Gialamas, Eleftherios, Horisberger, Karoline, Alshaar, Muhammad, Lohsiriwat, Varut, Charles, Shane, Isik, Arda, Leventoğlu, Sezai, Lekuya, Hervé Monka, Lule, Herman, Kopetskyi, Slava, Alsaadi, Hayder, Alshryda, Sattar, Alser, Osaid, Bankhead-Kendall, Brittany, Breen, Kerry, Kaafarani, Haytham, Mashbari, Hassan, Bonilla Cal, Fernando, Al-Naggar, Hamza, Maimbo, Mayaba, Mazingi, Dennis, Abbott, Tom, Adamina, Michel, Akhbari, Melika, Bhanderi, Shivam, Biccard, Bruce, Chakrabortee, Sohini, Costas-Chavarri, Ainhoa, Demetriades, Andreas K, Desai, Anant, Di Saverio, Salomone, Drake, Thomas, Edwards, John, Evans, Jonathan, Fiore, Marco, Ford, Samuel, Fotopoulou, Christina, Fowler, Alexander, Futaba, Kaori, Ganly, Ian, Grace James, Harelimana, Griffiths, Ewen, Hutchinson, Peter, Hyman, Gabriella Yael, Incorvia, Joseph, Jain, Ritu, Jenkinson, Michael, Khan, Tabassum, Knight, Stephen Richard, Kolias, Angelos, Kudsk-Iversen, Søren, Kwan, Tsun Yu, Leung, Elaine, Mayol, Julio, McKay, Siobhan, Meara, John G., Mills, Emily, Moug, Susan, Patel, Akshay, Perinotti, Roberto, Rice, Henry E., Roberts, Keith, Schache, Andrew, Shaw, Richard, Smart, Neil, Stephens, Matthew, Stewart, Grant D., Teasdale, Ella, Vidya, Raghavan, Wright, Naomi, Wuraola, Funmilola, Agastra, Ervis, Thereska, Dariel, Dajti, Irida, Lucchini, Sergio Martin, Laudani, Veronica, Boccalatte, Luis, Chwat, Carina, Pedraza Salazar, Ivana Ines, Pantoja Pachajoa, Diana Alejandra, Duro, Agustin, Calderón Arancibia, José Alfredo, Bright, Tim, Hollington, Paul, Zhou, Xuanyu, Kroon, Hidde M, Farfus, Anthony, Barker, John, Watson, Eleanor, Stevens, Sean, Latif, Haider, Dawson, Amanda Caroline, Chuan, Alwin, Muralidharan, Vijayaragavan, Wong, Enoch, Ackermann, Travis, Pacilli, Maurizio, Hodgson, Russell, Heriot, Alexander, Choong, Peter, Brown, Wendy, Lidder, Surjit, Yeung, Justin, Traeger, Luke, Regalo, Guillermo, Gourlay, Ralph, Pockney, Peter, Badiani, Sarit, Koh, Cherry, Putnis, Soni, Haider, Fayza, Rahman Mitul, Ashrarur, Komen, Niels, Dhondt, Bert, Cappeliez, Serge, Pigeolet, Manon, van Ramshorst, Gabrielle, Schoneveld, Martijn, Stijns, Jasper, Oosterlinck, Wouter, Flamey, Nicolas, Kpangon, Cyrille, Agbadebo, Mouhamed, Tobome, Sèmèvo Romaric, Lawani, Ismaïl, Cerovac, Anis, Vieira Barros, Aldo, Aguiar Júnior, Samuel, Baiocchi, Glauco, Campos, Heloisa Galvão do Amaral, Gross, Jefferson, José Fernandez Coimbra, Felipe, Kowalski, Luiz Paulo, Makdissi, Fabiana, Nakagawa, Suely, Pedreira Duprat Neto, Joao, Vartanian, Jose Guilherme, Yazbek, Guilherme, Zequi, Stenio C, Flumignan, Ronald, Slavchev, Mihail, Jaworska, Natalia, Dell, Angela, Shanthanna, Harsha, Martin, Janet, Behzadi, Abdollah, Nessim, Carolyn, Mozel, Michelle, St-germain, Pascal, Russell, Crispin, Groot, Gary, Safieddine, Najib, Wijeysundera, Duminda, Eskander, Antoine, Chadi, Sami, MacKenzie, Shawn, Heredia, Fernando, Villanueva, Julio, Waissbluth, Sofia, Macchiavello, Roberto, Escudero, Mario I, Fuentes, Tyare, Mimica, Ximena, Olivos, Maricarmen, Bolivar Saenz, Dinimo, Caicedo, Lina, Alzate, Juan Pablo, Luna, Joaquin, Pedraza Alonso, Nestor Fabian, Ortiz Silva, Camilo, Perez Rivera, Carlos J-, Rodriguez, Juliana, Silva-Igua, Liliana, Torres, Martha Luz, Trujillo, Lina María, Nieto Calvache, Albaro José, Balanta-Melo, Julián, Figueroa - Casanova, Rafael, García-Montoya, Oscar-Julián, Marulanda Toro, Carlos Andres, Mendoza Arango, Maria Clara, Diaz Martinez, Eneida, Gutiérrez Perdomo, Valentina, Calvache, Jose Andres, Montenegro, Emileth, Mihanovic, Jakov, Avilés Jiménez, Pablo Mijahil, Gouvas, Nikolaos, Novysedlák, René, Rodriguez-Abreu, Julia, Lincango-Naranjo, Eddy, Abouelnagah, Galal, Shehata, Sameh, Hossam Eldin Fouad Rida, Ahmed, Hassan, Ramy A., Saad, Mahmoud M., Reda Loaloa, Mohamed, Mostafa, Badr, Qassem, Mohamed, Fahmy, Mohamed, Abozied, Hesham, Azzam, Ahmed Y, Ghozy, Sherief, Sallam, Asser, Shehta, Ahmed, Emile, Sameh, Abdelkhalek, Mohamed, Samaka, Rehab, Morsy, Amr, Sherif, Ahmed Elshawadfy, Arévalo Sandoval, Danilo Alfonso, Abebe, Metasebia, Negussie, Abraham, Fisseha, Tigist, Shumbash, Kibruyisfaw, Hailu, Samuel, Yasin, Seid Mohammed, Akililu, Yemisirach Bizuneh, Megersa, Abebe, Tefera, Teshome, Melatework, Atnafu, Bahru, Tsegaye, Bereket, Bezabih, Yoseph Solomon, Sisay, Silamlak, Bekele, Kebebe, Jira, Moa, Mengesha, Mengistu G, Derilo, Habtamu, Degefa, Eyueal, Tadesse, Anteneh, Nidaw, Melkamu, Sarjanoja, Elise, Kauppila, Joonas H, Testelin, Sylvie, Boucher, Sophie, Jouffret, Lionel, Lakkis, Zaher, Zarzavadjian Le Bian, Alban, Harper, Luke, Danguy des Déserts, Marc, André, Benoît, Slim, Karem, Verhaeghe, Romain, Police, Andrea, Girard, Edouard, Chebaro, Alexandre, Subayi Nkembi, Armande, Arnalsteen, Laurent, Ballouhey, Quentin, Mege, Diane, Jeandel, Clement, Duchalais, Emilie, Bouche, Pierre-Alban, Manceau, Gilles, Crétolle, Célia, Hervieux, Erik, Girard, Noémie, Seguin-Givelet, Agathe, Gaujoux, Sebastien, De Simone, Belinda, Boisson, Matthieu, Bergeat, Damien, Arnaud, Alexis P, Fredon, Fabien, Nappi, Francesco, Kassir, Radwan, Scalabre, Aurélien, Migliorelli, Federico, Ezanno, Anne-Cecile, Seeliger, Barbara, Vaysse, Charlotte, Charbonneau, Helene, Misrai, Vincent, Abbo, Olivier, Angeles, Martina Aida, Brunaud, Laurent, Demetrashvili, Zaza, Modabber, Ali, Wolf, Sebastian, Kamphues, Carsten, Höhn, Philipp, Glowka, Tim R., Rokohl, Alexander Christopher, Bork, Ulrich, Fluegen, Georg, Horch, Raymund E., Schmedding, Andrea, Schnitzbauer, Andreas, Eberbach, Helge, Schlager, Daniel, Spelsberg, Fritz, Keppler, Lena, Hecker, Andreas, Wolfer, Susanne, Ronellenfitsch, Ulrich, Nitschke, Christine, Peiper, Christian, Hakami, Ibrahim, Welter, Stefan, Nikolaieva, Karine, Roth, Andreas, Lindert, Judith, Gousias, Konstantinos, Rissmann, Anke, Linz, Valerie Catherine, Rahbari, Nuh, Rassweiler-Seyfried, Marie-Claire, Gut, Anna Eleonora, Gempt, Jens, Reim, Daniel, Wagner, Arthur, Albertsmeier, Markus, Keppler, Alexander M., Stoleriu, Mircea Gabriel, Saier, Tim, Stadler, Josef, Kaiser, Julia Christina, Brunner, Stefan M., Pfister, Karin, Herzberg, Jonas, Nowak, Kai, Reinhard, Tobias, Stavrou, Gregor A., Königsrainer, Alfred, Konrads, Christian, Quante, Markus, Laban, Simon, Pusch von, Silke, Hirschburger, Markus, Doerner, Johannes, Wiegering, Armin, Tampaki, Ekaterini Christina, Gutiérrez Ruiz, Alitza, Rodas, Alejandra, Portilla, Ana Lucía, Recinos, Gustavo, Aguilera-Arevalo, Maria-Lorena, Carrera, Jacqueline, Barrios Duarte, Amalia, Lowey, Megan, Barillas, Sabrina, Vaishnav, Dhaivat, Gorantlu Chowdappa, Raghunandan, Madabhavi, Irappa, Bhat, Dhananjaya, Kumar Venkatappa, Sunil, Thakar, Sumit, Jain, Kavitha, Kumar, Aruna, Nagar, Manoj, Mishra, Tushar, Sekar, Arunkumar, Gupta, Anand, Kaman, Lileswar, Karthigeyan, Madhivanan, Tripathi, Manjul, Rammohan, Ashwin, Othiyil vayoth, Sudheer, Rajanbabu, Anupama, Subbian, Anbukkani, Gupta, Rahul, Raut, Monish, Evelyn. R, Nissi, Kannaiyan, Lavanya, Matai, Dr. Anil, Misra, Sanjeev, Bhende, Vishal, Muthu, Sathish, Ghosh, Indranil, Sharma, Abhishek, Bajaj, Ankur, Rajan, Shiv, Agarwal, Gaurav, Pawar, Pranay, Alexander, Philip, Vijayakumar, M, Hameed, BM Zeeshan, L, Badareesh, Chaudhry, Navneet Kumar, Baliarsing, Lipika, Dharap, Satish, Kulkarni, Amruta, Thyavihally, Yuvaraja, Pramesh, C S, Soni, Rajesh, Dube, Surya Kumar, Sharma, Shilpa, Singh, Harvinder, Bains, Lovenish, Ghodke, Rahul, Kumar, Ashwani, Sodhai, Vivek, Maji, Suvendu, Basu, Somprakas, Mahakalkar, Chandrashekhar, Kannan, Ravi, Mehraj, Asif, N, Ranganath, Phadnis, Ashish, Yadev, I, Kavalakat, Alfie, Mittal, Rohin, Vallam, Karthik Chandra, Akhavizadegan, Hamed, Rezghi Maleki, Esmaeil, Yousefzadeh Kandevani, Naser, Ikele, Hilary, McNestry, Catherine, Fleming, Christina, O’Brien, Stephen, Abd Elwahab, Sami, Davis, Niall, Javadpour, Mohsen, McDonnell, Brendan, O Connor, Clare, Bolger, Jarlath, Clancy, Cillian, Croghan, Stefanie M, Donlon, Noel, Cullinane, Carolyn, Creavin, Ben, Muheilan, Muheilan, Earley, Helen, Kabir, Syed Mohammad Umar, Fahadullah, Muhammad, Ryan, Éanna, Connelly, Tara, Zmora, Oded, Hashimoto, Daisuke, Alqudah, Majdi Ali, Alajalen, Amer, Omari, Rand Y., Ayasra, Faris, Qasem, Abdulrahman, Alawneh, Yazan, Ahmad, Amer, Aladawi, Omar, Alrayes, Bourhan, Haidar, Hanan, Husain, Shatha, Qassem, Faisal, Sumadi, Adnan, Al-Manaseer, Balqees Mahmoud, Alsunna, Zaid, Ra’ed, Hazim, Reyad Bani Hamad, Faten, Abuleil, Amro, Abou Chaar, Mohamad K., Jimaale, Elmi Ahmed Mohamed, Abu-Mehsen, Marah, Olaywah, Noor, Wafi, Omar, Ababneh, Hazim, Abu-Ismail, Luai, Khamees, Almu’atasim, Alkhatib, Ahmad, Bolatbekova, Raikhan, Kulimbet, Mukhtar, Nurgozhin, Talgat, Saliev, Timur, Zhussupov, Baurzhan, Almabayev, Ydyrys, Fakhradiyev, Ildar, Kaidarova, Dilyara, Tamoos, Khalil, Aqeelah, Ahmed, Khalefa mohammed, Alsnosy abdullah, Al maadany, Faraj, Alkadeeki, Ghadah, Gahwagi, Milad, Aldressi, Wafa, Amnaina, Mohamed, Alansari, Arowa hassan abdulrahman, Alkaseek, Akram, Yagoub, Ghozlan, Ben Amer, Anass, Salem, Marwa, Almugaddami, Ayman, Burgan, Dania, Abdelkabir, Mohammed, Alshareef, Khayriyah, Ben jouira, Rayet al islam, Meelad, Ayman, Bouhuwaish, Ahmad, Dwaga, Sumayya Essayah, Khalifa, Houda, Almiqlash, Bushray, Suliaman, Taha, Alawami, Mohammed, Elhajdawe, Fras, Aboazamazem, Hajir, Ellojli, Ibrahim, Msherghi, Ahmed, Saleh, Ismail Ali, Alayan, Mohammed, Roslani, April Camilla, Ndayishyigikiye, Marcel Didier, Munyika, Akutu, Plarre, Philipp, Borowski, David W, Nashidengo, Pueya Rashid, Noltes, Milou, Steinkamp, Pieter, Wells, Cameron, Teague, Rebecca, Elliott, Brodie, Kieser, David, Mohyieldin, Omar, Varghese, Chris, McIntosh, Nick, Haran, Cheyaanthan, Rennie, Sarah, King, Jasmin, Ha, Jeong, McGuinness, Matthew James, Adesanya, Opeoluwa, Olaogun, Julius, Akinmade, Akinola, Bwala, Kefas, Agbonrofo, Peter, Afolabi, Akinwale, Usang, Usang, Ekenze, Sebastian, Olori, Samson, Lawal, Taiwo Akeem, Seyi-Olajide, Justina, Okunlola, Abiodun, Williams, Omolara, Adisa, Adewale, Abdur-Rahman, Lukman, Kache, Stephen, Sale, Danjuma, Anyanwu, Lofty-John, Okereke, Chukwuma, Tolani, Musliu Adetola, Filipce, Venko, Todorovic, Lazar, Pejkova, Sofija, Stavridis, Sotir, Massoud, John George, Alsibai, Sareyah, Sultan, Rizwan, Altaf, Humera Naz, Bhatti, Abu Bakar Hafeez, Waqar, Shahzad Hussain, Aziz, Aliya, Kerawala, Asad Ali, Rai, Lajpat, Anwer, Mariyah, Tariq, Aiman, Ayub, Bushra, Niazi, Sami ullah, Naseem, Muhammad Yasir, Sarwar, Muhammad Zeeshan, Khokhar, Muhammad Imran, Zahid, Imdad Ahmad, Majid, Haroon Javaid, Talat, Nabila, Asif, Muhammad, Chaudhary, Muhammad Hamid, Farooq, Umer, Ahmad, Siddique, Mabood, Waleed, Bukhari, Syed Imran, Tariq, Muhammad, Yaqoob, Eesha, Javed, Saad, Usman Malik, Muhammad, Yaqoob, Hassan Nawaz, Cukier, Moises, Falcon Pacheco, Glenda Marina, Mas Melendez, Robinson, Paucar Urbina, Arazzelly Del Pilar, Rios Chiuyari, Jose, Otiniano Alvarado, Carlos Eduardo, Fuentes Rivera Lau, Lorena, Borda-Luque, Giuliano, Niquen-Jimenez, Milagros, Arias, Claudia, Zegarra, Sergio, Betalleluz Pallardel, Jenner, Ugarte Oscco, Regina Amparo, Mendiola, Gian, Carpio Colmenares, Yahaira Tatiana, Shiraishi Zapata, Carlos, Ortiz, Maria Rosa, Sacdalan, Marie Dione, Major, Piotr, Castro Borges, Filipe, Viveiros, Octavio, Serralheiro, Pedro, Santos-Costa, Paulo, Mendes, Filipa, Rocha Melo, Miguel, Cardoso, Paulo, Soares, Ana, Azevedo, José, Gonçalves Pereira, Rita, Silva, Nelson, Caiado, André, Sacras, Maria Luís, Azevedo, Pedro, Almeida-Reis, Rui, Cunha, Miguel F., Oliveira, João, Nogueiro, Jorge, Sampaio-Alves, Mafalda, Cidade Costa, Luciana, Baía, Catarina, Deus, Ana Cláudia, Branquinho, Rita, Marçal, André, Tojal, André, Makkai-Popa, Silviu Tiberiu, Mironescu, Aurel, Grama, Florin, Toma, Elena Adelina, Negoi, Ionut, Filipescu, Daniela, Bacalbasa, Nicolae, Motas, Natalia, Ionescu, Sebastian, Ginghina, Octav, Costea, Radu, Zarnescu, Narcis Octavian, Drasovean, Radu, Bonci, Eduard-Alexandru, Dimofte, Mihail-Gabriel, Porumb, Vlad, Kirov, Mikhail, Molitvin, Yegor, Litvin, Andrey, Pykhteev, Vadim, Raevskaya, Marianna, Efetov, Sergey, Butyrskii, Aleksandr, Alshahrani, Mushabab, Althumairi, Azah, Alzerwi, Nasser, Al Ameer, Ahmed, Madkhali, Tariq, Abddulrahman, Ghazwani, Salman, Ayoub, Abdu, Iskander, Othman, Ghunaim, Mohammed, Alharthi, Mohammed, Alzaidi, Turki M, Alyami, Mohammad, Al Amri, Abdulrahman, AlFakhri, Abdullah, Alhefdhi, Amal, Chowdhury, Sharfuddin, Nouh, Thamer, Alshehri, Ameen, Alzahrani, Abdulrahman, Alalawi, Dr Yousef, Awad, Selmy, Konate, Ibrahima, Ndong, Abdourahmane, Tendeng, Jacques, Teo, Nan Zun, Koh, Frederick, Košir, Jurij Aleš, Bele, Uros, Aqil, Sabra, Barrena López, Cristina, Sánchez Mozo, Ana, Rodriguez Infante, Antonio, Caja Vivancos, Patricia, Prieto, Mikel, Alberdi San Roman, Igor, Gomez Fernandez, Laura, Muñoz Vives, Josep Maria, Carreras-Castañer, Anna, Díaz-Feijoo, Berta, Sieira-Gil, Ramon, Turrado-Rodriguez, Victor, Sánchez López, Anna, Sánchez-Cabús, Santiago, Jimenez Toscano, Marta, Canals Sin, MªPilar, Laura, Saura García, Martin Sole, Oriol, Palazon Bellver, Pedro, Pérez-Bertólez, Sonia, Prat-Ortells, Jordi, Riba Martínez, Mireia, Rubio-Palau, Josep, Tarrado, Xavier, Nuñez, Jorge, Alonso Mendoza, Veronica, Bescós, Coro, Espin-Basany, Eloy, Espinosa-Bravo, Martin, Gil-Sala, Daniel, González-Suárez, Susana, Montferrer Estruch, Nuria, Porteiro Mariño, Lucia, Rodríguez-Tesouro, Ana, Rojas Portilla, Fabian, Tormos Pérez, M Pilar, Vives, Inmaculada, Garcia De Cortazar, Unai, Tudela, Kiara, Landaluce-Olavarria, Aitor, Estaire Gómez, Mercedes, Almoguera, Jorge, Ugarte-Sierra, Bakarne, Jimenez, Virginia, Bertrand, Marta, Cárdenas Puiggrós, Laura, Delisau-Puig, Olga, Garcia-Adamez, Jorge, Julià Bergkvist, David, Maldonado-Marcos, Eloy, Diego García, Lucia, Roldón Golet, Marta, Soto-Darias, Iván, Rahy-Martín, Aida Cristina, Enjuto, Diego, Ramos-Luengo, Adolfo, Delgado Fernandez, Juan, Lugo Duarte, Carolina, Marquez, Lucila, 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Andrea, Suarez, Raul, Velez Bernal, Jorge Luis, Camargo Gómez, Daniela, kammerer, Christian, Acuna Saravia, Maria Fernanda, Arroyave, Roberto, Barreto Angulo, Jose Maria, Dueñas-Ramirez, Juan Carlos, Escobar Vidarte, Oscar Andres, Gomez, Laura, Gomez, Alejandro, Herrera Castañeda, Enrique, Hinaoui, Marisol, Idrobo Escobar, Anuar Armando, Llanos Lucero, Carlos Antonio, Montoya Casella, Antonio José, Perea Serna, Andrea Carolina, Ríos-Samper, Gabriel, Sandoval, John, Sarmiento Ramirez, Guillermo Alberto, Zuluaga Zuluaga, Mauricio, Figueroa, Juan Sebastian, Gonzalez Mosos, Maria Fernanda, Jaramillo Roncancio, Juan Jose, Mosos, Monica, Ramirez, Juan Sebastian, Idarraga Ramírez, Leidy Natalia, Marin Gonzalez, Ana Maria, Mejia, David Alejandro, Vanegas, Luis Emiro, Aruachan Vesga, Sandra, Diaz Martinez, Eneida, Martinez Estrada, Gustavo Antonio, Giraldo Velasquez, Angela Maria, Tovar, Jesus Hernan, Tovar, German Alirio, Buesaquillo, Christian Ali, Olave Montaño, Victor David, Montenegro, Emileth, Genda, Eben-ezer, Eboma, Fabrice, Grulović, Karlo, Bosak Versic, Ana, Srsen Medancic, Suzana, Brkic, Lucija, Cokarić, Sara, Tomić, Josipa, Brzic, Domagoj, Dijan, Emilio, Grgec Dragicevic, Maja, Konjevoda, Suzana, Morović, Domagoj, Perišić, Gordan, Zuzul, Matea, Anzic, Srdan Ante, Carevic, Iva, Biočina, Bojan, Bobovec, Dino, Bumber, Boris, Duric Vukovic, Katarina, Jelčić, Ivan, Kastelan, Zeljko, Kolak, Juraj, Pasini, Miram, Penezić, Luka, Prstacic, Ratko, Romić, Ivan, Tomic, Mislav, Luksic, Ivica, Avilés Jiménez, Pablo Mijahil, Panayiotou, Yiannis, Stavrinidou, Olga, Yiallourou, Anneza, Michal, Burda, Lukáš, Gawel, Wladyslaw B., Lerch, Milan, Macečková, Nicole, Simetka, Ondrej, Vavra, Petr, Zelenik, Karol, Přibyl, Martin, Klíma, Karel, Pirmorad, Setareh, Hotová, Zuzana, Mladěnka, Aleš, Bozo, Nulvin, Hviid, Louise, Kristensen, Helle Ø, Paulsen, Laerke, Ebbehøj, Anders Lyng, Jönsson, Maria Lovisa, Krarup, Peter-Martin, Otte, Helena, Smith, Henry, Bælum, Jens Kristian, Ellebæk, Signe Bremholm, Batista, Sylvia, Collado Expósito, María Mabel, Crespo, Aldo, D’óleo García, Claudio Samuel, Figueroa, Jatnna, Garcia-Dubus Rodriguez, U, Guzman, Lillian, Lopez, Ariela, Maletta Francisco, Leeany, Munoz, Herisardy, Perez Fernandez, Maricely Ambar, Rodríguez, Ada, Soto, Joel, Ubinas, Raul, Villegas, Aaron, Acra-Tolari, Ricardo, Beltran, Larissa, Betances, Luis Fernand, Díaz Vásquez, Pedro Pablo, Fernandez, Damaris, Figueroa Germosen, Jiomar Manuel, Mejia De la Cruz, Dolores, Ortiz De La Cruz, Fabio, Pelletier, Gabriela, Próspero Enrique, Rodriguez Pumarol, Suero Almanzar, Irina, Lincango-Naranjo, Eddy, Negrete Ocampo, José Ricardo, Sallam, Ibrahim, Sherief, Mohamed, Abdou, Mostafa, Abo Shanab, Ahmed, Abodeeb, Aya, Aboelkhel, Roger, Abosamak, Nour Eldin, Abouelnagah, Yossof, Adel, Dina, Ahmed, Sara, Alberkamy, Abdelrahman, Ali, Ahmed, Ashraf, Olfat, Darwish, Sara, El kharashy, Rasha, Elbadawy, Seifeldin, Elsaka, Alromisaa, Ewedah, Moataz, Ezz, Yara, Gadelrab, Ziyad, Hafez, Nour, Hafez, Youssef, Hassanin, Mohamed, Hussein Aly Salama Aly, Hamza, Ibrahim, Abdelrahman, Mahmoud Abo shabana, Alaa, Mourad, Mohamed, Mubarek, Kamilia, Omar, Samaa, Ragal, Marawan, Romany, John, Salem, Alaa, Samir Abdelaal, Ahmed, Shehata, Sameh, Shehata, Abdelrahman, Shenit, Karim, Yehia, Nermin, Khaled Mohamed Eid, Omar, Ibrahim Elsayed, Omar, Shehata, Mostafa Ahmed, Abd El-Ghani, Wael, Abd Elazeem, Hossam Aldein S., Abdalla, Shimaa, Abdel-Aleem, Mahmoud, Abdelfattah, Mahmoud, Abdelhafez, Mohammed, Abdelkarem, Mohamed M., Abubeih, Hossam, Ahmed, Nagm Eldin Abu Elnga, Ahmed, Ahmed, Ahmed Saad, Sarah, Ali, Abdelrahman Ahmed Abdelrahman, Elmaghraby, Khaled, Elsdfy, Shady, Eltayeb, Almoutaz, Essam, Esraa, Gadelkareem, Rabea, Ghoneim, Ahmed, Hamada Takrouney, Mohammed, Hasan, Ahmad, Hassanin, Mohamed Abdelghafor, Mahran, Wesam, Mahrous, Doha, Ragab, Abdelrahman, Sabry, Aya, Safwat, Hadeer, Saleh, Ahmed, Samir, Ahmed, Sayed, Esraa, Taher, Mohamed Gamal, Yousof, Ebrahim Ahmed, Youssef, Ahmed, Zein Elabedeen, Omar, Ali, Samar, Elbehairy, Gehad, Eleisawy, Mahmoud, Elgendy, Abdelrahman, Elhawary, Rewan, Hamdy, Mahmoud, Hassan, Gehad, Nowar, Mostafa, Sabry, Hesham, Tarek Said-elnaby, Ahmed, Zahed, Mohamed, Zahran, Mohamed, Zoghary, Ahmed Zaki, Atef, Mohamed, Abdelhamid, Mahmoud Hossameldin Saad, El Fiky, Lobna, ElGarhy, Ibrahim, Qassem, Mohamed, Wahba, Abdelrahman, Youssif Omar Fouad, Omar, Abdelsamed, Ahmed, Elsalhy, Mohamed, Eldesouky, Omnia, Wael Mostafa Khalil Bahi, Abdullah, Tawheed, Ahmed, Al-oribi, Saeid, Aly, Nuran Khaled, ElFiky, Mahmoud, Nabil, Ahmed, Samir Farahat, Ahmed, Soliman, Mostafa, Ghaly, Galal, Abbas, Alzhraa Salah, Ibraheem, Maher, Bakry, Abdelrahman, Jammal, Mohamed, M Makram, Abdelrahman, Adel abdelaty, Ahmed, Fayad, Elsayed A., Sallam, Moataz, Shehta, Ahmed, Elfeki, Hossam, Elsaid, Mahmoud, Mostafa, Mohamed, Sakr, Ahmed, Shetiwy, Mohamed, Tawakl, Noura, Yunes, Asmaa, Atallah, Khalid, Shetiwy, Mosab, Abdelmawla, Ahmed, Abdrabou, Ahmed, Abubakr, Asmaa, Al Gohary, Rawda, Elsabagh, Alaa, Elshabrawy, Enas, Hafez, Ahmed, Mikhail, Pola, Mohamed, Mervat, Nada, Ahmed, Omran, Janna, Salem, Osama, Selim, Salma, Shalaby, Ghada, Wahbah, Mahmoud, Zakaria Abdelbary, Eman, Zayan, Ahmad Helmy, Afify, Abdelrahman, Mohamed Ahmed, Mostafa, Abdeldayem, Hesham, Abdelkader Salama, Ibrahim, Ammar, Khaled, Ayoub, Islam, Gad, Emad Hamdy, Hammad, Essam, Macshut, Mahmoud, Sherif, Ahmed Elshawadfy, Shoreem, Hany, Soliman, Hossam Eldeen, Eldaly, Abdullah, Mashaly, Sarah, Abd-Elsalam, Sherief, Abdel-Elsalam, Wafaa, Morsy, Mohamed Sherif, Nasreddin, Mohammed, Sarsik, Sameh, Kams, Liisa, Rätsep, Tõnu, Riips, Karolin, Abebe, Kirubel, Asfaw, Fitsum, Eshete, Mahder, Gedefaw, Yetsedaw, Menjeta, Abeje, Muleta, Mahteme Bekele, Sefera, Sena, Teklu, Daniel, Tirfe, Leake, Worku, Bereket, Eado, Yegeremu, Negussie, Abraham, Woldemariam, Mersha Abebe, Alemu, Megersa, Azmach, Dawit, Mamo, Dr.Mickyas, Menkir, Abel, Woldemariam, Dereje, Wubishet, Estifanos, Supha, Melka, Abebe, Nebyou, Chanie, Abera, Gebre, Hiwot, Laeke, Tsegazeab, Mammo, Tihitena Negussie, Sahlu, Abat, Tiruneh, Abraham Genetu, Zewdneh, Betelhem, Fentaw, Jibril, Tabore, Ketema, Addisalem, Abreha, Tassew, Abdissa, Desalegn, Tesfaw, Mequannet, Asmamaw, Dawit, Bedane, Dereje, Bekele, Ephrem, Getie, Aderaw, Girma, Adissu, Shimelash, Dagim, Ayalew, Tewabe, Kassahun, Berhanu, Mulugeta, Esubalew, Sisay, Silamlak, Ibrahim, Adem, Mekete, Alem, Mohammed, Adnan Abdulkadir, Abdullahi, Yasir Younis, Adem, Ephrem, Siyoum, Eneyew Getachew, Zeleke, Ewunetu, Degefe, Derje Worku, Derilo, Habtamu, Eliyas, Nebiyu, Deressa, Yadani, Melese, Lemi, Muleta, Lemesa, Teshome, Abraham, Tesso, Birhanu, Gebrekirstos, Dr.Gebreagziabher, Pitkänen, Joel, Qian, Cheng, Sinikumpu, Jaakko, Dakpé, Stéphanie, Devauchelle, Bernard, Lavagen, Nolwenn, Bastard, François, Bin, Kim, Moukoko, Didier, Alshawared, Fadi, Beyrne, Carlos Daniel, Lugans, Laurene, Doussot, Alexandre, Onorati, Ilaria, Radu, Dana, André, Benoît, Marion, Herjean, Trilling, Bertrand, Boleslawski, Emmanuel, Noiret, Barbara, Aubry, Estelle, Subayi Nkembi, Armande, Christou, Niki, Usseglio, Julie, Jeandel, Clement, Denis, Waast, Duchalais, Emilie, Regenet, Nicolas, Rigaud, Jerome, Anract, Philippe, Dohan, Anthony, Cazelles, Antoine, Chamouni, Alexandre, Karoui, Mehdi, Mejean, Arnaud, Crétolle, Célia, Thouement, Clermidi, Pauline, Hervieux, Erik, Langlais, Tristan, Leonelli, Lorenzo, Thomin, Anne, Athiel, Yoann, Cathala, Nathalie, Levy-Zauberman, Yael, Macek, Petr, Mombet, Annick, Ollat, Didier, Fabrice, Chartier-Kastler, Emmanuel, Chereau, Nathalie, Melot, Charlotte, Turco, Célia, Chouillard, Elie, Boisson, Matthieu, Frasca, Denis, Livin, Marie, Mahmoud, Fedy, Sulpice, Laurent, Arnaud, Alexis P, Cazemajou, Clément Thierry, Nyangoh Timoh, Krystel, Renault, Annaëlle, Nappi, Francesco, Ezanno, Anne-Cecile, Cherkaoui, Zineb, Vix, Michel, Gornes, Hugo, Berthoumieu, Pierre, Misrai, Vincent, Pierre, Trocard, Angeles, Martina Aida, Del, Mathilde, Vancon, Antoine, Machemedze, Solomon, Muhemi, Roger, Ndizeye, Olivier, O’Connor, Jennifer, Tchoba, Simplice, Modabber, Ali, Schäfer, Benedikt, Wallqvist, Julia, Ziemann, Sebastian, Anthuber, Matthias, Broecheler, Tobias, Goßlau, Yvonne, Maksymiw, Florian, Sommer, Florian, Sommer, Björn, Loch, Florian N, Aghalarov, Ilgar, Braumann, Chris, Höhn, Philipp, Horn, Julian, Egger, Eva, Enderes, Jana, Strieth, Sebastian, Treede, Hendrik, Wittmann, Maria, Marche, Benedikt, Schulz, Sissy-Amelie, Fuchs, Hans, Bork, Ulrich, Meisel, Cornelia, Petzold, Andrea, Fluegen, Georg, Knoefel, Wolfram Trudo, Solodarenko, Oleksandra, Grützmann, Robert, Hackner, Danilo, Faqar-Uz-Zaman, Sara Fatima, Schnitzbauer, Andreas, Fung, Christian, Leiber, Christian, Neidert, Nicolas, Sandkamp, Richard, Schlager, Daniel, Strähle, Jakob, Spelsberg, Fritz, Becker, Johannes, Gonschor, Bernhard, Herbolzheimer, Marit, Keppler, Lena, Hecker, Matthias, Reichert, Martin, Sander, Michael, Schmidt, Götz, Schneck, Emmanuel, Kleeff, Jorg, Lorenz, Kerstin, Ronellenfitsch, Ulrich, Thomssen, Christoph, Dumpies, Christian W., Fischer, Isabel, Gessner, Michael, Klauke, Friederike, Schmidt, Birte, Vinz, Franziska, Sander, Johannes, Betz, Christian Stephan, Bewarder, Julian, Burg, Simon, Klatte, Till Orla, König, Daniela, Köpke, Leon-Gordian, Stangenberg, Martin, Roux, Frederic, Hakami, Ibrahim Abdullah, Mall, Julian W, Graeb, Christian, Huber-Strößner, Kristin, Pempe, Christina, Kelly, Kathrin, Siebert, Julia, Agrawal, Rachit, Gousias, Konstantinos, Qureischie, Homeira, Meyer, Frank, Rissmann, Anke, Turial, Salmai, Al-Nawas, Bilal, Battista, Marco Johannes, Heider, Julia, Mueller, Lena Katharina, Jentschura, Sina- Louisa Patrizia, Kowalewski, Karl-Friedrich, Rassweiler-Seyfried, Marie-Claire, Reissfelder, Christoph, Rotter, Nicole, Scherl, Claudia, Seyfried, Steffen, Fichter, Andreas, Gempt, Jens, Schäffer, Christoph, Wegmann, Helmut, Aghamaliyev, Ughur, Böcker, Wolfgang, von Ehrlich-Treuenstätt, Viktor H., Ladurner, Roland, Schlager, Justin Gabriel, Smolka, Wenko, Glowalla, Claudio, Schneidmueller, Dorien, Henkel, Karl Wilhelm, Stadler, Josef, Hölz, Katharina, Brunner, Stefan M., Prantl, Lukas, Herzberg, Jonas, Kröger, Marie, Niemeier, Andreas, Sras, Yara, Reinhard, Tobias, Löffler, Markus W., Steidle, Christoph, Dayan, Davut, Greve, Jens, Löbig, Niklas, Schochter, Fabienne, Wezel, Felix, Pusch von, Silke, Schmidbauer, Stefan, Boenicke, Lars, Degener, Stephan, Seiberth, Rose, Smit, Marieke, von Rundstedt, Friedrich-Carl, Germer, Christoph-Thomas, Lock, Johan, Lotz, Christopher, Schlesinger, Tobias, Schmid, Benedikt, Treutlein, Agnes, Agyeman-Duah, Nana Kwaku, Appiah, Enoch, Gakpetor, Delali, Minlah Allah, Stephen, Adu-Aryee, Nii Armah, Agboadoh, Nelson, Bediako Bowan, Antoinette, Brown, George Darko, Clegg-Lamptey, Joe-Nat, Fenu, Benjamin Sena, Kumassah, Philemon, Hussey, Romeo, Agbeno, Evans Kofi, Amoako-Boateng, Mabel, Debrah, Samuel, Doku, Dr Kingsley, Mensah, Philip, Nortey, Michael, Opandoh, Isabella Naa Morkor, Yigah, Makafui, Jiagge, Nuna, Acquaye, Jane, Agyemang-Prempeh, Akosua, Amo-Antwi, Kwabena, Amoah, Michael, Amoah, George, Aning, Daniel Gyawu, Annor Mintah, Dominic, Arthur, Joshua, Darko- Asante, Regina, Gaveh, Valerie, Gyamfi, Frank Enoch, Jonathan, Boakye - Yiadom, Konney, Thomas Okpoti, Kyei, Ishmael, Nimako, Boateng, Ofosu-Barko, Ben Blay, Osabutey, Anita, Sagoe, Robert, Yifieyeh, Abiboye, Ansong, George, Abdul-Mumin, Alhassan, Amadu, Munira, Azahares Leal, German, Buunaaim, Alexis, Cheyuo, Ernest, Daboo Salifu, Latif, Issaka, Adamu, Yakubu, Musah, Grypiotis, Ioannis, Papadopoulou, Triada, Korkolis, Dimitrios, Thomakos, Nikolaos, Dellaportas, Dionysios, Dimitra, Papalouka, Hadjizacharias, Theodoros, Konstadoulakis, Manousos, Massaras, Dimitrios, Vezakis, Antonios, Avgerinos, Konstantinos, Kechagias, Aristotelis, Ioannidis, Argyrios, Patelis, Nikolaos, Deskou, Eirini, Stamos, Nikolaos, Tasis, Nikolaos, Danias, Nikolaos, Selmani, Jonida, Kalamatianos, Theodosis, Stranjalis, George, Kondilis, Panagiotis, Kanellopoulou, Vasiliki, Larentzakis, Andreas, Papanikolaou, Vasileios, Potamianos, Spyridon, Triantafyllou, Tania, Panagiotou, Peter, Avramidis, Emmanouil, Bessias, Nikolaos, Tsiantoula, Paraskevi, Charalabopoulos, Alexandros, Kykalos, Stylianos, Kyros, Eleandros, Machairas, Nikolaos, Mastoraki, Aikaterini, Papalampros, Alexandros, Terras, Alexis, Tsourouflis, Gerasimos, Zografos, Constantinos, Antzaka, Christina, Falara, Areti, Perreas, Konstantinos, Rellia, Panagiota, Tasouli, Androniki, Skolarikos, Andreas, Tzelves, Lazaros, Theodorakis, Emmanuel, Karona, Paraskevi, Tzouganakis, Angelos, Chrysos, Emmanuel, Nikolouzakis, Taxiarchis, Tourountzi, Paraskevi, Al, Aggeliki, Kalfountzos, Christos, Arnaoutoglou, Eleni, Christodoulidis, Gregory, Gkolias, Nick, Hajiioannou, Jiannis, Krestinidis, Giorgos, Ntalouka, Maria, Saini, Fani, Skoulakis, Charalampos, Terzoudis, Christos Dimitrios, Zacharoulis, Dimitris, Δακής, Κωνσταντίνος, Filo, Eva, Kontopoulou, Konstantina, Patoulias, Ioannis, Astreidis, Ioannis, Christidis, Panagiotis, Loutzidou, Lydia, Mantevas, Antonis, Tatsis, Dimitris, Tsakiridis, Ioannis, Iordanidou, Eirini, Brolo, Estuardo, Gutiérrez Ruiz, Alitza, De León Lima, María Alejandra, Flores, Mario-Andrés, Morales, Steffanía, Rivera, Pablo, Rodas, Lesly, Santos, Victor, Sosa, Dianne, Barrios Duarte, Amalia, Talé-Rosales, Luis-Fernando, Villeda, Sergio Alejandro, Anicetti, Joshua, Lowey, Megan, Ardebol, Javier, Barillas, Kathia, Barillas, Sabrina, Recinos, Salvador, Hon, Sophie, Liu, Alex Qinyang, Liu, Shirley, Ip, Ho Wai, Mak, Brian, Mok, Chung Ying, Wong, Kiu Fung, Au-Yeung, Kit Ying, Chan, David Yuen Chung, Chiu, Wang Kei, Ho, Jacky Yan Kit, Kung, Janet Wui Cheung, Ling, Samuel Ka Kin, Lok, Hon Ting, Teoh, Jeremy Yuen-Chun, Wong, Randolph, Antal, Zsuzsanna, Bahrehmand, Kiarash, Sztipits, Tamás, Hidi, László, Piros, Laszlo, Rózsa, Balazs, Herczeg, György, Saftics, György, Kulcsicka-Gut, Judit, Sipos, Zsófia, Majmudar, Hardil, Madabhavi, Irappa, G S, Anitha, Kesarla, Venkatesh, Kumar Venkatappa, Sunil, P B, Hareesh, Shivashankar Chikkanayakanahalli, Santhosh, Sunil, Tanvi, Rajagopal, Niranjana, P L, Thirumanikandan, Mishra, Nitu, Wadhwani, Dr Rekha, Dhurwe, Ritika, Pushpalatha, Kameshwarachari, Raj, Sumit, Singh, Pooja, Kumar, Pankaj, Mittal, Yash, Panigrahi, Sibasish, Parija, Sucheta, Patra, Saroj, Sahu, Rabi, Sultania, Mahesh, Tripathy, Sujit, Kansay, Rajeev, Gupta, Sunil Kumar, Kaman, Lileswar, Salunke, Pravin, Singh, Kavindra, Rela, Mohamed, Goudar, Swati, B, Barani kumar P, Murugesan, Anandan, Subbian, Anbukkani, Kumar, Arvind, Chauhan, Tapan singh, Govil, Akhil, Gupta, Shubhra, Sharma, Ashish, Tiwari, Saurabh, Vishwani, Vartika, Evelyn. R, Nissi, Deb, Mainak, Jayaram, Harish, Nagpal, Pooja, Pathak, Prachi, Choudhary, Gautam Ram, Chugh, Ankita, Elhence, Abhay, Madduri, Vijay, Pandey, Himanshu, Saxena, Rahul, Sharma, Naveen, Shekhar, Shashank, Vishnoi, Jeewan Ram, Bhende, Vishal, Chatterjee, Debarshi, Ghosh, Indranil, Naskar, Upasana, Jain, Prateek, Jain, Deepak, Kewlani, Vishal, Priya, Noopur, Parijat, Anand, Anand, Akshay, Bajaj, Ankur, Chaurasia, Akhilanand, Enny, Loreno E., Kumar, Ambrish, Mishra, Brijesh, Pandey, Amita, Rajan, Shiv, Roy, Ashutosh, Sachan, Rekha, Sankhwar, Pushp, Singh, Uma, Singh, Urmila, Srivastava, Chhitij, Verma, Manju Lata, Yadav, Awdhesh, Agarwal, Gaurav, Chanthar, K.m.m.vishvak, Hoysal, Dileep, Mishra, Anjali, Batra, Nitin, Bhatti, Arun, Dhar, Tapasya, Dutta, Rohini, Haque, Parvez David, Jain, Ritu, Luther, Anil, Mahajan, Amit, Pargal, Dr Pinki, Samuel, Abhishek, Singh, Inderjot, Singh Grewal, Sarvpreet, Singhania, Anusha, Alexander, Philip, Thomas, Josy, Krishna, Sunil, Singh, Narinder, Agarwal, Sunny, Balasubramaniam, Srikant, Dharap, Satish, Mhamane, Rameshwar, Nirgude, Anand, Parab, Sandesh, Peswani, Amit, Sahu, Anjana, Samel, Sarika, Shah, Fagun, Abraham, Bejoy, Asari, Ashishkumar, Badhe, Vivek, Badhwar, Sanjiv, Bothara, Vipul, Dalal, Anuj, Date, Avinash, Deshpande, Mandar, Doshi, Anirudha, Gade, Maya, Gajjar, Shreyash, Ghugare, Dr bhavisha, Jain, Divakar, Jenasamant, Saumya Sekhar, Joshi, Vinay, Kalwadia, Neha, Kayal, Akshat, Kulkarni, Yogesh, Mistry, Rajesh, Mulchandani, Manoj, Parab, Dr. Mrunal, Pednekar, Abhinav, Rahmani, Faizan, Rajput, Sunil, Sandlas, Gursev, Sarkar, Hrishikesh, Shetty, Sanket sadanand, Shukla kulkarni, Anshumala, Thete, Raghavendraswami, Wasnik, Shruti, Dhumane, Parag, Sharma, Rahul Deo, Deshmukh, Anuja, Gupta, Stuti, Nayak, Prakash, Thiagarajan, Shivakumar, Tiwari, Virendra Kumar, Voppuru, Saiesh Reddy, Soni, Rajesh, Bajpai, Minu, Farooque, Kamran, Parshad, Rajinder, Sharma, Vijay, Bansal, Kuldeep, Bains, Lovenish, Bhardwaj, Rohit, Mittal, Abhishek, Ponnusamy, Sabarirajan, Ghodke, Rahul, Himani, Kumar, Ashwani, Gadekar, Anup, Panjwani, Taufiq, Maji, Suvendu, Basu, Somprakas, Kandwal, Pankaj, Kumar, Shashank, Poonia, Dharma Ram, Sadhasivam, Saravanan, Mahakalkar, Chandrashekhar, Choudhury, Yousuf, Das, Devishmita, Goala, Subhadra, Singha, S Thoibisana, Singha, Damayanti, Mehraj, Asif, Parray, Fazl, Shah, Raahil, Wani, Rauf, Hegde, Siddhi, Ankadavar, Dr.sushil, Bafna, Darshan, Lad, Parag, Chisthi, Meer, Jothi, Harihara, .C. Mathew, Godwin David, Abel, Livingston, Barla, Ravi Kishore, Benjamin, Santosh, Bliss, Jeremy, Ete, Geley, James, Deeptiman, Jesudason, Mark Ranjan, Karnan, Gomathi, Mark Samuel, Vasanth, Mittal, Rohin, Nathan, Senthil K, Selvaraj, Daniel, Surendran, Suraj, T D, Hariharan, Thangaraj, Santhosh Kumar, Thomas, Varghese, Dilmy, Mohammad Adya Firmansha, Pratama, Dedy, Sugiarto, Adhrie, Surya, Ilham Utama, Tango, Tamara, Hasyim, Andi, Susanti, Ade, Saputra, Teddy, Syarifuddin, Erwin, Islam, Andi Asadul, Anam, Khoirul, Sugianto, Julius Albert, Lestari, Mayang Indah, Amba, Erick Gamaliel, Apriawan, Tedy, Wathoni, Roidah Taqiyya Zahra, Widyastuti, Yunita, Yun Jufan, Akhmad, Etezadpour, Mohammad, Mehrad-Majd, Hassan, Rajaei, Parisa, Mehdizadeh, Mohammad, Soltani, Mina, Pour, Ali Moazami, Azarnia, Gholamreza, Alizadeh, Narges, Mokarami, Hossein, Tehrani, Shahrzad, Alborzi, Majid, Bagheri, Hamed, Eshraghi, Mohsen, Fatemi manesh, Hassan, Hejazi, Seyed fakhreddin, Pezeshki Modarres, Mahdi, Shafiee, Ali, Vafaeimanesh, Jamshid, Hosseini, Elahe, Nikoupour, Hamed, Bastaninejad, Shahin, Firouzifar, Mohammadreza, Motasaddi zarandy, Masoud, Yazdani, Nasrin, Yousefzadeh Kandevani, Naser, Mortazavi, SM Javad, Ahmadi, Sayedali, Khosravi, Mohammad Hossein, Vosoughi, Fardis, Golbakhsh, Mohammadreza, Al-Isawi, Ali, Al-Masood, Mohammed, Gahtan, Yarub, Ahmed, Abdullah, Hilmi, Ahmed, Muhssein, Haidar, McNestry, Catherine, Ekwere, Bosom, Essajee, Murtaza, Chan Chin, Bruno, Edwards Murphy, Amy, Fleming, Christina, Foley, Niamh, Gardiner, Padraig, Hechtl, Daniel, Kayyal, Mohd yasser, Lyons, Maria, O’Brien, Stephen, Ng, Mei Yee, Oduola, Oladayo, Aljohmani, Lylas, Nugent, Timothy, Harris, Johnathon, Kearney, David, Keenan, Robert Anthony, Nolan, Deirdre, Salloum, Croghan, Stefanie M, Donohoe, Emma, Larkin, John, Lynch, Thomas Hugh, Manecksha, Rustom, Nagassima, Katharina, Barry, Mary, Cullinane, Carolyn, Dowdall, Joseph, Hurson, Conor, Kelly, Orlaith, Kennelly, Rory, Kiernan, Aoife, Murphy, Ben, Njeze, Nwabundo, Reynolds, Ian Sean, Winter, Des, Ravi, Akshaya, Ridgway, Paul, Fowler, Amy, McAnena, Peter, Bahadoor, Muhammad Usaama, Kabir, Syed Mohammad Umar, Khalid, Mohamed Hamed, Mujtaba, Syed Nadeem, Sarwar, Muhammad assam, Sugrue, Michael, Varzgalis, Manvydas, Jones-Whiting, Larne, Lim, Seantee, Ryan, Éanna, Sara, Al-Mukhaizeem, Youssef, Crowley, Clare, Flanagan, Michael, Fogarty, Amy, Glynn, Orna, Hill, Rhodri, Khalid, Muhammad Abdullah, Majeed, Zubair, McCullough, Peter, Neary, Peter, Noone, Anthony, O’Kelly, John, Abu abed, Arsan, Haim, Nadav, Hershkovitz, Yehuda, Majadla, Omar, Rabin, Igor, Zmora, Osnat, Demma, Yonatan Avraham, Fishman, Yuri, Farkas, Amicur, Gozal, Yaacov, Greenman, Dmitry, Ostrovsky, Israel Alexander, Pardes, Rivka, Shahar, Tal, Teren, David, Yahud, Reuven, Yellinek, Shlomo, Cianci, Pasquale, Minafra, Marina, Restini, Enrico, Bussolin, Edoardo, De Prizio, Marco, Sulce, Rezart, Poiasina, Elia, Antonacci, Filippo, Arena, Alessandro, Belvedere, Angela, Bernagozzi, Fabio, Boussedra, Safia, Cescon, Matteo, Cipolli, Alessandro, Daddi, Niccolo’, De Crescenzo, Eugenia, De Iaco, Pierandrea, Del Gaudio, Massimo, Della Gatta, Anna Nunzia, Droghetti, Matteo, Giorgini, Federico A., Lanci Lanci, Antonio, Masetti, Michele, Minni, Francesco, Morezzi, Daniele, Perrone, Anna Myriam, Pignatti, Marco, Puglisi, Silvana Bernadetta, Rottoli, Matteo, Schiavina, Riccardo, Serenari, Matteo, Serra, Margherita, Tesei, Marco, Violante, Tommaso, Aspide, Raffaele, Carretta, Alessandro, Conti, Alfredo, De Vita, Carla, Friso, Filippo, La Corte, Emanuele, Rosetti, Vittoria, Sturiale, Carmelo, Donati, Davide Maria, Palmerini, Emanuela, Berselli, Bruno, Bolognesi, Silvia, Farnia, Francesco, Maremonti, Pietro, Razzaboni, Alessandra, La Mendola, Roberta, Arrigoni, Giulia, Baiocchi, Gian Luca, Molfino, Sarah, Panciani, Pier Paolo, Sartori, Enrico, Zanin, Luca, Perrone, Fabrizio, Cappellani, Alessandro, Giaquinta, Alessia, Gioco, Rossella, Veroux, Pierfrancesco, Cianci, Antonio, Lo Giudice, Arturo, Russo, Giorgio Ivan, Sarpietro, Giuseppe, Scandura, Carmen Emanuela, Barca, Ida, Carnevali, Adriano, De Paola, Gilda, Giannaccare, Giuseppe, Sammarco, Giuseppe, D’Andrea, Marcello, Tosatto, Luigino, Mucilli, Felice, Muraglia, Angelo, Giuliani, Domenico Benvenuto, Segalini, Edoardo, Daniele, Alberto, Gelarda, Enrico, Olearo, Elena, Puppo, Andrea, Testa, Valentina, Porta, Andrea, Birindelli, Arianna, Bernabei, Massimiliano, Feo, Carlo V., Virgilio, Edoardo, Bartolini, Ilenia, Bottari, Andrea, Checcucci, Carlotta, De Vincenti, Rosita, Fambrini, Massimiliano, Fortuna, Laura, Gallo, Oreste, Maltinti, Gherardo, Taddei, Antonio, Michelagnoli, Stefano, Maccagnano, Giuseppe, Pesce, Vito, Ercolani, Giorgio, Fappiano, Francesca, Barberis, Andrea, Filauro, Marco, Santoliquido, Matteo, Aprile, Alessandra, Barra, Fabio, De Rosa, Raffaele, Ferrero, Simone, Sparavigna, Marco, Vagge, Aldo, Gambardella, Denise, Tedesco, Manfredo, Spampinato, Marcello Giuseppe, Chiarelli, Marco, Grandi, Samuele, Lenzi, Riccardo, Muscatello, Luca, Germano’, Antonino Francesco, Giani, Alessandro, Bissacco, Daniele, Cassinotti, Elisa, Pignataro, Lorenzo, Torretta, Sara, Armellin, Daniele, Basato, Silvia, Carrano, Francesco Maria, Colombo, Giovanni, De Lucia, Francesca, De Virgilio, Armando, Ferreli, Fabio, La Raja, Carlotta, Milana, Flavio, Rossi, Vanessa, Russo, Elena, Tamburello, Sara, Zerbi, Alessandro, Bona, Davide, Adamoli, Laura, Ansarin, Mohssen, Chu, Francesco, De Berardinis, Rita, Pietrobon, Giacomo, Sedda, Giulia, Caputo, Maria, Cellerino, Paola, Crespi, Michele Achille, Danelli, Piergiorgio, Ferrara, Francesco, Baccellieri, Domenico, Candiani, Massimo, Casiraghi, Arianna, Cipriani, Federica, De Nardi, Paola, Mortini, Pietro, Nocera, Gianluca, Pozzoni, Mirko, Ruffolo, Alessandro Ferdinando, Spina, Alfio, Barberio, Cristina, Beretta, Luigi, Cavenago, Francesca, Fresilli, Stefano, Landoni, Giovanni, Lombardi, Gaetano, Bonomi, Stefano, Guaglio, Marcello, Sala, Laura, Segattini, Silvia, Piccoli, Micaela, Migliore, Marco, Sasia, Diego, Cereda, Marco, Dell’Oro, Cristina, Fogliati, Alessandro, Tamini, Nicolò, Castaldi, Antonio, Bracale, Umberto, Lionetti, Ruggero, Pagano, Gianluca, Peltrini, Roberto, Pirozzi, Nello, D’amico, Maria, Izzo, Francesco, Marra, Ester, Marte, Gianpaolo, Bianco, Francesco, Cappiello, Antonio, Iovino, Claudio, Menna, Maria Paola, Romano, Francesco maria, Rossi, Settimio, Sciaudone, Guido, Ascari, Francesca, Bellora, Paolo, Cerri, Cristina, D’Aloisio, Giordana, Ferrari, Maurizio, Chioffi, Franco, Ciccarino, Pietro, Nezi, Giulia, Bissolotti, Guido, Di Donna, Mariano Catello, Licari, Leo, Salamone, Giuseppe, Toia, Francesca, Annicchiarico, Alfredo, Berretta, Roberto, Capozzi, Vito Andrea, Freyrie, Antonio, Frusca, Tiziana, Arici, Vittorio, Bozzani, Antonio, Filardo, Matteo, de Manzoni Garberini, Andrea, Cauteruccio, Michele, Caristo, Giuseppe, Calabrò, Marcello, Andreani, Lorenzo, Antonio, D’arienzo, Berrettini, Stefano, Colangeli, Simone, Cremonini, Camilla, Dallan, Iacopo, Di Franco, Gregorio, Korasidis, Stylianos, Musetti, Serena, Neri, Carlo Maria, Palmeri, Matteo, Picariello, Miriana, Statuti, Erica, Tartaglia, Dario, Pinotti, Enrico, Basso, Stefano Maria Massimiliano, Ubiali, Paolo, Coiro, Saverio, Mele, Simone, Corbellini, Carlo, Masciandaro, Antonio, Carannante, Filippo, Denaro, Vincenzo, Mazzotta, Erica, Zampogna, Biagio, Cinquepalmi, Matteo, Del Basso, Celeste, Guglielmo, Nicola, Meniconi, Roberto Luca, Sinibaldi, Giovanni, Agnes, Annamaria, Belia, Francesco, Bianchi, Valentina, Cozza, Valerio, Fico, Valeria, Fransvea, Pietro, La Greca, Antonio, Litta, Francesco, Pascale, Marco Maria, Silvia, Tedesco, Benevolo, Maria, Campo, Flaminia, Dona’, Maria Gabriella, Marchesi, Paolo, Mastroianni, Riccardo, Mazzola, Francesco, Moretto, Silvia, Petruzzi, Gerardo, Pichi, Barbara, Tuderti, Gabriele, Bellato, Vittoria, Grande, Michele, Petagna, Lorenzo, Sensi, Bruno, Bruzzaniti, Placido, Ciccarone, Flavia, Cicerchia, Pierfranco Maria, Cirillo, Bruno, D’ambrosio, Giancarlo, De Toma, Giorgio, Familiari, Pietro, Fonsi, Giovanni Battista, Pata, Francesco, Picchetto, Andrea, Salvati, Maurizio, Valentini, Valentino, Zambon, Martina, Zancana, Giuseppa, Zuppi, Emma, Ibrahim, Mohsen, Menna, Cecilia, Rendina, Erino Angelo, Accarino, Giulio, Giancarlo, Accarino, Froiio, Caterina, Copelli, Chiara, Di Maio, Pasquale, Giudice, Marco, Altana, Cristian, Ciccarello, Sandro, Cossu, Maria Laura, Dessole, Francesco, Dettori, Salvatora, Madonia, Massimo, Petrillo, Marco, Piredda, Franco, Rizzo, Davide, Scognamillo, Fabrizio, Soma, Damiano, Tanca, Anna Rita, Marano, Luigi, Pesce, Anna Lisa, Piccioni, Stefania Angela, Resca, Luca, Roviello, Franco, Abrate, Alberto, Clarizia, Guglielmo, Franzini, Marco, Fratto, Antonio, Grechi, Alessandro, Scarnecchia, Elisa, Maiuri, Vincenzo, Dalprà, Francesca, Battistella, Enrico, Romano, Maurizio, Aizza, Giada, de Manzini, Nicolò, Drigo, Davide, Mastronardi, Manuela, Palmisano, Silvia, Bardelli, Laura, Borroni, Giacomo, Livraghi, Lorenzo, Palumbo, Mara, Zullo, Alessandra, Vignotto, Chiara, Caravati, Andrea, De Cristofaro, Carlotta, Giuliani, Tommaso, Guglielmi, Alfredo, Pedrazzani, Corrado, Butturini, Giovanni, Moretto, Gianluigi, Mastriale, Francesco, Olmi, Stefano, Kushikata, Tetsuya, Oyama, Tasuku, Kamiyama, Mizue, Tarao, Kentaroh, Yamada, Takayuki, Shiga, Toshiya, Deguchi, Yoshihiko, Hoshino, Tatsuki, Inoue, Hiroyuki, Ito, Shingo, Takano, Emi, Yamamoto, Masae, Matsuki, Yuka, Matsumoto, Takashi, Sawada, Atsushi, Sato, Kozo, Makino, Jun, Mizota, Toshiyuki, Yonekura, Hiroshi, Ishikawa, Haruka, Kaiho, Yu, Ogawa, Munehiro, Endo, Shunji, Fujiwara, Yoshinori, Kubota, Hisako, Okada, Toshimasa, Hisamatsu, Yoji, Michiura, Taku, Satoshi, Okazaki, Fujita, Tomoyuki, Fukushima, Satsuki, Otsuka, Yuji, Sawada, Ikumi, Miyamoto, Morikazu, Isada, Tetsuro, Bani Amer, Qaed, Fujimoto, Yuki, Kuratani, Norifumi, Takada, Misa, Noro, Shusaku, Kuroda, Naoto, Okamura, Yukiyasu, Uesaka, Katshuhiko, Kuroda, Kento, Abe, Nobutsugu, Ando, Tadao, Hirano, Kouichi, Kobayashi, Yoichi, Motoyasu, Akira, Noguchi, Hikari, Tajima, Atsushi, Toyama, Satoshi, Uchida, Tokujiro, Furukawa, Yuri, Hasumi, Yoko, Iida, Katsuyuki, Ikeda, Tatsuhiko, Kuzuhara, Shigeki, Yamamoto, Naoya, Yamamoto, Mari, Yokota, Toshiya, Yoshioka, Yuki, Kawai, Akira, Nakata, Yoshinori, Sawamura, Shigehito, Kobayashi, Takayuki, Alqudah, Majdi Ali, Alrabadi, Mera, Owais, Qais, Smadi, Aseel, Abunawas, Huthifa, Alhawatmeh, Mohammad, Alwardat, Abdel Rahman Mohannad Ahmad, Dhoon, Slsabela, Jaradat, Enas, Mubaydeen, Teeba, Alzraikat, Sayel H., Omari, Rand Y., Suradi, Haya H., Al Abdallah, Murad, Al Bdour, Zakaria, Al-thaher, Mohammad, Alnajjar, Tareq, AlZaatreh, Mohammad, Ayasra, Faris, Ghayada, Ibrahim, Hasanein, Khaled Moh’d Ahmed, Hassouneh, Anas, Hijazeen, Raid, Khasawneh, Barihan, Semrin, Qusai, Theab, Mohammad, Abazeed, Alaa, Alkurdieh, Moh’d Mujahed, Hammouri, Mohammad, Khader, Sereen, Abu Obead, Hamza, Abudari, Hadeel, Al-azzeh, Nimer, Al-Darabah, Ali, Al-Qannas, Mohammad, Ashour, Subhi, Chabaan, Reem, Fawzi, Ahmad, Haij, Manal, Hassouneh, Esraa, Ibrahim, Zainab, Mohamed, Ishak, Qandeel, Mahmoud, Qassem, Faisal, Shorman, Marwan, Nofal, Sandra, Salameh, Mohammed, Sanjuq, Ghaidaa, Sharabi, Alaa, Sweiti, Alaa, Baninasr, Eman, Abuleil, Amro, Abou Chaar, Mohamad K., Al-latayfeh, Motasem, Al-Shudifat, Abdel-Ellah, Shaikh Ahmad, Abd Almonem, Abu Abed, Laith, Allouzi, Mohammad, Almi’ani, Sari, Alsaiad, Abdulhakim, Daoud, Maher, Dawod, Omar, Fadli, Saba, Jimaale, Elmi Ahmed Mohamed, Qulaghassi, Zaki, Al-howthi, Mohammed, Ababneh, Laila, Ababneh, Roba, Al Khassawneh, Ahmad, Al Sharie, Ahmed, Al-Dabaa, Tawfik, Al-Jarrah, Salsabeel, Alshannaq, Qutaiba, Alsulaiman, Rima, Audat, Ziad, Bdour, Saja, Khatatbeh, Ro’a, Marji, Fares, Abu Ismail, Dima.Y, Abu-Ismail, Luai, Alzoubi, Mai, Alzoubi, Malak, Hussein, Hasan, Rawashdeh, Shireen, Ababneh, Adnan, Abu-Eisheh, Basil, Al Shurman, Hana’, Al-atiyah, Hussam, Aljaiuossi, Anas, Hamdoni, Sara, Kulimbet, Mukhtar, Sakhov, Orazbek, Fakhradiyev, Ildar, Tanabayeva, Shynar, Zhussupov, Baurzhan, Amrayev, Sultan, Kukubassov, Yerlan, Parker, Robert, Mwaria, Claude, Kibunyi, Muthoni, Mailu, Claire, Osea, Lydia, Hirsi, Omar, Dashti, Mustafa, Aldalal, Shuaib, Alozairi, Ous, Al-Shaiji, Tariq, Alhunaidi, Omar, Aljewaied, Ali, Farag, Ahmed, Termos, Salah, Sivins, Armands, Apse, Ingus Arnolds, Kaminskis, Aleksejs, Pāvulāns, Jānis, Itani, Rania, Owiedat, Mustafa, Antonios, Ingrid, Milan Moussa, Rita, Abdel Sater, Ali H., Souleiman, Bassem, Ghiya, Peter, Fakih, Ghinwa, Tamoos, Khalil, Abdulrahman, Taha, Omar Abunaaja, Hayat, Al Gasi, Abd El Jawad, Al maadany, Faraj, Alsaeiti, Sara, Elkhafeefi, Fatimah, Alhouni, Tarek, Alkeelani, Hana, Alkuwafi, Rauoof, Elbargathe, Osama, Elfadli, Mustafa, Elmahgoub, Asma, Alansari, Arowa hassan abdulrahman, Alhaje, Awatif, Haron, Aaya, Alsuwiyah, Suhir, Khel, Samer, Yousef, Rowaida, Abuhlaiga, Ma’aly, Abushahma, Ahmed omar, Aldelensi Alzubi, Alhosen Saleh M, Alnehum, Mohamed alnaser, Alzedam, Ahmad, Matoug, Faisel, Mohammed, Burooj, Sawalem, Mohamed, Kamoka, Elhusain, Salamah, Abdulrauf, Abdeewi, Saedah, Eshnaf, Mabroka, Yahmad, Mohammad, Aljuroushi, Omar, Attia, Hajer, Emran, Ayyah, Samer, Ashraf, Abdullah, Duha milad, Ben esmael, Esraa, Benmasoud, Fatma, Debri, Laila, Younis, Balkees, Elmabrouk, Amna, Hasan, Ameerah Mahdi Abraheem, Suliaman, Taha, Alawami, Mohammed, Alshareea, Entisar, Aribi, Tomather, Lamari, Amani hamid, Mufth, Mohammed, Aburima, Sarah, Al shukri, Asmaa, Alarabi, Rehab, Alelwany, Aisha, Bashir, Rasha, Elhadi, Ahmed, Elkouba, Esraa, Ellojli, Ibrahim, Elmsherghi, Nabiha, Haidar, Arwa, Helal, Hala, Kriem, Eslam, Turshani, Laila, Alayan, Mohammed, Ben Hasan, Hayat, Shaban Ben Hasan, Najat, Shaban Ben Hasan, Rabab, Dambrauskas, Zilvinas, Dekeryte, Inga, Koženiauskaitė, Akvilė, Maleckas, Almantas, Venclauskas, Linas, Zilinskas, Justas, Syminas, Vilius, Aliosin, Oleg, Cizauskaite, Agne, Jurgaitis, Jonas, Mikutaitis, Vytenis, Samalavicius, Narimantas Evaldas, Slepavicius, Algirdas, Vasiliauskas, Bernardas, Dulskas, Audrius, Cekauskas, Albertas, Gulla, Aiste, Zelvys, Arunas, Noël, Audrey, Rajaonarivony, Maheriandrianina Fanambinana Voahary, Andriantsoa, Herimampionona E, Samison, Luc Hervé, Tsiambanizafy, Guillaume Odilon, Solo, Corinne Eulalie, Safiry Andofenohasina, Fanonjomahasoa, Sablon Herinirina, Angelin, Das, Andre, Osman, Mohd Firdauss, Soh, Jien Yen, Zakaria, Zaidi, Chan, Kheng Hooi, Johan, Syamim, Mah, Jin Jiun, Subramaniam, Sentilnathan, Ibrahim, Mohd Razali, Nazimi, Abd Jabar, Bal, Pavin, Fadzli, Ahmad nazran, Jamaris, Suniza, Lee, Yeong Sing, Lim, Jeffery Zk, Moh Pauzi, Siti Farhan, Nair, Ashvin Krishna, Ng, Doris Sin Wen, Ng We Yong, Yuki Julius, Roslani, April Camilla, Saaid, Rahmah, Sethi, Neha, Syed Jafer Hussain Zaidi, Syeda Nureena, Teoh, Li Ying, Munjih, Islah, Sainal, Mohd Yusof, Sarif, Mat Salleh, Chua, Richelle, Ahmad, Abdul 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Gabriela, Morales valencia, Eduardo, Santos, Blanca, Torres Cisneros, Juan Roberto, Bozada-Gutiérrez, Katya, Alvarez, Maria Regina, de la Rosa Abaroa, Marco Antonio, Hernandez, Roberto, Bernardo, Anaya, Ernesto, Arceo-Olaiz, Ricardo, Lopez Flores, Sonia, Esparza Arias, Nereida, Romero Bañuelos, Esmeralda, Salcedo-Hernández, Rosa, Buerba, Gabriela Alejandra, Chan, Carlos, Garay Lechuga, Daniel, Hinojosa, Carlos, Mercado, Miguel Ángel, Peña Gómez Portugal, Emmanuel, Posadas-Trujillo, Oscar Emmanuel, Hernandez Skewes, Karla Yareli, Licona-Meníndez, Roque Delfino, Romero Lechuga, Fernanda, Roque, Oscar, Núñez-González, Roberto Ángel, Alvarez Manilla Orendain, Alfonso, Garcia, Felipe, González León, Juan Antonio, Guzman, Marlin, Herappe, Dorihela, Lerma, Ricardo, Mendoza Pedraza, Fabián Hilario, Noguez Castillo, Monica, Resendiz, Jose Anatolio, Fernandez Rios, Laura Elena, Frigerio, Pamela, Garcia, Iset, Mendoza Frías, Gloria Isela, Anzures Mendoza, Alejandra, Hdez Miguelena, Luis, Zarate 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Blasius, Abdulsalam, Khalifa, Agida, Eyaofun, Ajibola, Hafees, Benard, Adeka, Buba, Amina, Eniola, Sefiu, Isah, Aliyu, Olute, Anne, Osagie, Olabisi, Pius Ogolekwu, Idoko, Ademola, Samuel, Afuwape, Oludolapo, Daodu, Israel, Egbuchulem, Ifeanyichukwu Kelvin, Lawal, Taiwo Akeem, Nwaorgu, Onyekwere, Obadan, Izegaegbe, Odeyemi, Olubunmi, Ogundoyin, Omowonuola, Okere, Oghenekevwe, Oladiran, Ajibola, Olagunju, Naomi, Olawoye, Olayinka, Olusanya, Adeola, Oyelakin, Oyeleye, Ugwu, Ebere, Ademuyiwa, Adesoji, Atoyebi, Oluwole, Bode, Chris, Chibuike George, Ihediwa, Ezenwankwo, Francis, Fatuga, Adedeji, Ladipo-Ajayi, Oluwaseun, Ojewola, Rufus Wale, Okunowo, Adeyemi, Seyi-Olajide, Justina, Ugwu, Aloy Okechukwu, Adebara, Idowu, Adeyemo, Olabisi, Banjo, Oluseyi, Obateru, John, Ojo, Owolabi, Okunlola, Abiodun, Oluwafemi, Fatudimu, Adelaja, Aderinsola, Atobatele, Kazeem, Ayodele, Olabamidele, Bello, Funmi, Omisanjo, Olufunmilade, Aderounmu, Adewale, Adisa, Adewale, Ajekwu, Temitope, Ajekwu, Samuel, Akeem Aderogba, Adeleke, Balogun, Simon, Ojo, Olugbenga, Olasehinde, Olalekan, Olugbami, Adebayo, Wuraola, Funmilola, Mohammed, Tajudeen, Afolabi, Abdulrahman O., Aremu, Isiaka, Ibraheem, Gbadebo, Odeyemi, Peter Olalekan, Olabinjo, Afusat, Raji, Hadijat Olaide, Salawu, Hafeez, Uche-Okonkwo, Kenechukwu, Anipole, Olalekan, Adesina, Oluwaseyi, Enwerem, Kenneth, Isichei, Mercy, Aghadi, Ifeanyi, Kache, Stephen, Lawal, Jamila, Taingson, Matthew, Yusuf, Nuhu, Sale, Danjuma, Takai, Idris Usman, Aji, Sani Ali, Anyanwu, Lofty-John, Bello-Muhammad, Nafisatu, Garzali, Ibrahim Umar, Hasheem, Muhammad Ghazali, Hassan, Sadiq, Ibrahim Usman, Mustapha, Magashi, Mahmoud Kawu, Mukhtar, Ibrahim Aliyu, Nwachukwu, Callistus, Suleiman, Ibrahim, A, Maryam, Mahmood, Farrukh, Salihu, Mohammed, Okereke, Chukwuma, Alegbeleye, Justina Omoikhefe, Awopeju, Abimbola, Fyneface-Ogan, Sotonye, Kasso, Terhemen, Onwuagha, Ijeoma, Salami, Babatunde, Ajagha, Okeoghene, Awaisu, Mudi, Nwabuoku, Stanley Emeka, Oyelowo, Nasir, 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Pereira, André, Pereira-Neves, António, Pina-Vaz, Teresa, Pinheiro, Gabriela, Pinho, Sílvia, Ramos, Pedro, Ramos, Patricia, Vilares Morgado, Rodrigo, Canotilho, Rita, Correia, Ana Margarida, Ferreira Pinto, Ana Paula, Claro, Mariana, Costa Santos, Daniel, Boto, Carlos, Branquinho, Rita, Rodrigues, Sónia, Guidi, Gonçalo, Leal, Clara, Machado, Luís, Marques, Prescillia, Martins, Daniela, Morais, Mariana, Nunes, Sara, Sapage, Rita, Sousa, Rita, Sousa, Diogo, Vaz Pereira, Ricardo, Lima Oliveira, Susana, Abdalla, Samir, Aurif, Fahad, Muzaffar, Nasir, Ahmed, Khalid, Al Dosouky, Mohammed, Al-Tarakji, Mohannad, Almudares, Saif, Elaffandi, Ahmed, Muslim, Muhammad, Qabbani, Amjad, Shah, Amjad, Khan, Mohammad Burhan, Murad, Musab, Costache, Victor, Dumitrescu, Tudor Ștefan, Muntean, George-Ovidiu, Mironescu, Aurel, Bezede, Cosmin, Enciu, Octavian, Baraian, Sergiu Catalin, Niculae, Cristina, Filipescu, Daniela, Goicea, Raluca, Alexe, Vlad, Batog, Olivia, Iliescu, Madalina, Ionescu, Sebastian, 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Rayzah, Musaed, Abd ElGhany, Reda, Al Ameer, Ahmed, Bawa, Dauda, Elzain, Mohammed, Wakill, Fadi, Fahiem-ul-Hassan, Mir, Al Duhileb, Mohammed, Alazzeh, Ghaleb, Alghazal, Thabet, Alkhatib, Abdulrahman, Almatar, Bikheet, Alnaimi, Manal, Alsuwaimel, Munir, Balhareth, Ameera, Abutaleb, Malak, Ageeli, Mohammed, Alhazmi, Barrag, Alkhayrat, Saud, Miftah, Mohammed, Otayfah, Sameer, Sari, AbdulRahman, Alsadiq, Mohammed, Fouad, Mohammed, Iskander, Othman, Al Athath, Samer, Alharthi, Mohammed, Bayazid, Muhannad, Al-Radi, Osman, Altaf, Abdulmalik, Arab, Fatima, Bangash, Mohammed, Basendowah, Mohammed, Farsi, Deema, Farsi, Ali, Habeebullah, Alaa, Malibary, Ziad, Nassif, Mohammed, Nawawi, Anfal, Sabbagh, Abdulrahman J, Sait, Salma, Saleem, Abdulaziz, Trabulsi, Nora, Alghamdi, Abdulaziz, Altalhi, Bassam, Alzaidi, Turki M, Mughal, Samiullah, Samadony, Mustafa, Althobaiti, Awwadh, Hakami, Hadi, Al Jamahir, Mohammed, Al Wadei, Hajr, Al-Qannass, Ali, Al-Qurashi, Qusay, Albakry, Ibrahim, Alkarak, Samer, Alkhanbashi, Omar, Alqannas, Mashhour, Alsakkaf, Mazen, Alzamanan, Mohammed, Mahnashi, Taher, Mohammed, Rawabi, Taha, Youssef, AlAamer, Ohood, Alaglan, Abeer, Alriyees, Lolwah, Alromaihi, Meaad, Alsafi, Maryam, Alsahabi, Jawaher, Alselaim, Nahar, Bin Saad, Khalid, Binjaloud, Ahmed, Dagestani, Hattan, Abaalkhail, Muath, Abukhater, Muhammad, Al Saied, Ghiath, Albarrak, Majed, Alghamdi, Ahmad, Alhogbani, Mofarej, Ali, Aisha Mansoor, Almushawah, Fatema, Alqahtani, Loai, Alqasem, Saad, AlRayih, Mohammed, Alsaleh, Khaled, Alsamari, Alanoud, Alshammari, Abdulaziz, AlSolami, Zeyad, AlSubaie, Fahd, Alsuliman, Yazeed, Alsuwaydani, Saleh, Alzahrani, Saud, Alanoud, Abu-Zaid, Ahmed, Aburahmah, Mohammad, Al Humaid, Lama, Al-Qattan, Mohammad, Alabbasi, Amira, Alahmari, Ahmed, Alaqel, Sara, Alassiri, Ali, Aldaghiri, Khalid, Alhaidari, Ammar, Alhazmi, Alaa, Alhazzaa, Norah, Alhefdhi, Amal, Alhelal, Boshra, Alhuthayl, Meshari, Alkassim, Abdullah, Alkhayal, Wafa, Almalaq, Ali, Almalik, Osama, AlMarshad, 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Alobaysi, Saad, Modahi, Nawaf, AI Nwijy, Khaled, AI Zahrani, Turki, Alahmad, Feras, Alalawi, Dr Yousef, Awaji, Ahmed, Emara, Sherif, Musawa, Nizar, Zakaria, Mahmoud, Althobaiti, Waleed, Paunovic, Ivan, Alajaji, Nouf, Ivanović, Nenad, Kmezić, Stefan, Knezevic, Djordje, Krivokapic, Zoran, Latinčić, Stojan, Markovic, Velimir, Miladinov, Marko, Ninic, Aleksandar, Gregoric, Pavle, Loncar, Zlatibor, Bogdanovic, Ivan, Milisavljević, Filip, Paunovic, Aleksandra, Trivic, Aleksandar, Bumbasirevic, Uros, Lazic, Aleksandar, Djurisic, Igor, Jevric, Marko, Kocic, Milan, Kozomara, Zoran, Markovic, Ivan, Dejanovic, Tatjana, Marinković, Srdjan, Milanovic, Miljan, Lazovic, Mikan, Cuk, Vladica, Milutinović, Vladan, Djan, Vladimir, Trajkovic, Velicko, Lukic, Dejan, Radovanovic, Zoran, Zahorjanski, Sanja, Hing, Jun Xian, Teo, Nan Zun, Arbab, Hana, Dimatatac, Doris Mae, Chew, Min Hoe, Tan, Kiat Tee Benita, Ang, Wei-Wen, Chong, Yew-Lam, Tan, Ming Ngan Aloysius, Wong, Kar Yong, Gális, Branislav, Avsenak, 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Abstract

Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary complications and to support resource allocation and prioritisation during pandemic recovery.

Published
2024
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31. Ultrasound Assessment Of Diaphragmatic Function During Acute Exacerbation Of Chronic Obstructive Pulmonary Disease: A Pilot Study

Author

Lim SY, Lim G, Lee YJ, Cho YJ, Park JS, Yoon HI, Lee JH, and Lee CT

Subjects
ultrasonography, diaphragmatic excursion, diaphragmatic thickening, exacerbation, chronic obstructive pulmonary disease, Diseases of the respiratory system, RC705-779
Abstract

Sung Yoon Lim,1 Gajin Lim,2 Yeon Joo Lee,1 Young Jae Cho,1 Jong Sun Park,1 Ho Il Yoon,1,2 Jae Ho Lee,1,2 Choon-Taek Lee1,3 1Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea; 2Division of Pulmonology Medicine, Department of Internal Medicine, Cheongju Hana Hospital, Cheongju-si, Korea; 3Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaCorrespondence: Choon-Taek LeeDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Seongnam, Seoul, South KoreaTel +82 31 787 7002Fax +82 31 787 4052Email ctlee@snubh.orgPurpose: Impairment of diaphragmatic function is one of the main pathophysiological mechanisms of chronic obstructive pulmonary disease (COPD) and is known to be related to acute exacerbation. Ultrasonography (US) allows for a simple, non-invasive assessment of diaphragm kinetics. The purpose of this study was to investigate the changes in diaphragmatic function during acute exacerbation of COPD, by US.Methods: This single-center, prospective study included patients with acute exacerbation of COPD symptoms. US measurements were performed within 72 hrs after exacerbation and after improvement of symptoms. Diaphragmatic excursion and its thickening fraction (TF) were measured as markers of diaphragmatic function. TF was calculated as (thickness at end inspiration – thickness at end expiration)/thickness at end expiration.Results: Ten patients were enrolled. All patients were male, and the mean age was 79.8 years. The TF of the right diaphragm showed a significant increase from the initial to the follow-up values (80.1 ± 104.9 mm vs. 159.5 ± 224.6 mm, p = 0.011); however, the diaphragmatic excursion did not vary significantly between the initial and follow-up values (22 ± 6 mm vs 23 ±12 mm). The change in excursion between the stable and exacerbation periods was positively correlated with time to the next exacerbation and negatively correlated with the time taken to recover from the exacerbation.Conclusion: These data support the possibility that a defect in diaphragm thickening is related to acute exacerbation of COPD.Keywords: ultrasonography, diaphragmatic excursion, diaphragmatic thickening, exacerbation, chronic obstructive pulmonary disease

Published
2019

33. Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial

Author

Cho EJ, Yu SJ, Kwon SY, Kim JH, Kim DY, Kim W, Lee JS, Lee JW, Lee YJ, Chae HB, and Yoon JH

Subjects
Chronic hepatitis B, Entecavir, Food effect, Efficacy, Therapeutics. Pharmacology, RM1-950
Abstract

Eun Ju Cho,1 Su Jong Yu,1 So Young Kwon,2 Ji-Hoon Kim,3 Do Young Kim,4 Won Kim,5 June Sung Lee,6 Jin Woo Lee,7 Youn Jae Lee,8 Hee Bok Chae,9 Jung-Hwan Yoon1 1Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea; 2Department of Internal Medicine, Konkuk University School of Medicine, KonKuk University Hospital, Seoul, South Korea; 3Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea; 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; 5Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea; 6Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea; 7Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea; 8Department of Gastroenterology, Inje University Busan Paik Hospital, Busan, South Korea; 9Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, South Korea Background: Little clinical data are available about the effect of food on the antiviral efficacy of entecavir for chronic hepatitis B virus (HBV) infection. The present study evaluated whether entecavir administration in the fed state had comparable efficacy to the fasted condition for maintenance of viral suppression in HBV-infected patients with virological response on entecavir therapy.Methods: In this multicenter, randomized, open-label, noninferiority study, patients who were currently receiving entecavir and showed a serum HBV DNA level of

Published
2018

34. Evaluation of pharmacokinetic, pharmacodynamic, efficacy, and safety data of low-dose ticagrelor versus standard dose in East Asians: a systematic review

Author

Lee YJ, Kim HW, Choi JY, Lee BH, and Lee SY

Subjects
Ticagrelor, low dose, East Asians, pharmacokinetic, pharmacodynamic, safety, Therapeutics. Pharmacology, RM1-950
Abstract

Yun Jeong Lee,1 Hyewon Kim,1 Jiyeon Choi,1 Bo Hee Lee,1 Seok-Yong Lee2 1Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Republic of Korea; 2Department of Pharmacy, School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea Abstract: East Asians are prone to higher systemic exposure and increased risk of bleeding compared to other races after administration of antiplatelet agent(s). The aim of this systematic review was to compare and evaluate the appropriateness of a lower dose versus standard dose of ticagrelor in East Asians. A systematic search was conducted in PubMed, EMBASE, and Cochrane databases for studies comparing low versus standard doses of ticagrelor in East Asian populations; a total of seven studies were included in the review. Pharmacokinetic (PK), pharmacodynamic (PD), clinical efficacy, and safety data were collected. PK data demonstrated that the Cmax and area under the curve (AUC) of ticagrelor increased dose-proportionally. PD data indicated that while the low dose of ticagrelor resulted in less antiplatelet activity in three of the five PD studies, in the other studies, there were no differences between low and standard doses. There were two clinical studies included in this review, which showed that the efficacy was similar between the low and standard doses, but both studies were limited by the number of patients included. While there were generally greater incidence of adverse events observed in the standard ticagrelor dose, the magnitude or actual difference between the two doses is difficult to determine due to lack of consistent data. In East Asians, the appropriateness of the low-dose ticagrelor cannot be determined based on the currently available evidence. Additional large-scale and longer duration studies are warranted. Keywords: ticagrelor, P2Y12 receptor antagonist, lower dose, East Asians, Korean, Japanese, Chinese, efficacy, safety

Published
2018

35. Autophagic flux induced by graphene oxide has a neuroprotective effect against human prion protein fragments

Author

Jeong JK, Lee YJ, Jeong SY, Jeong S, Lee GW, and Park SY

Subjects
Graphene oxide, neuroprotection, autophagy, prion protein, mitochondria, Medicine (General), R5-920
Abstract

Jae-Kyo Jeong,1 You-Jin Lee,1 Seung Yol Jeong,2,3 Sooyeon Jeong,2 Geon-Woong Lee,2 Sang-Youel Park1 1Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Iksan, 2Nano Hybrid Technology Research Center, Korea Electrotechnology Research Institute (KERI), Changwon, 3Department of Electrical Functionality Material Engineering, University of Science and Technology (UST), Daejon, Republic of Korea Abstract: Graphene oxide (GO) is a nanomaterial with newly developing biological applications. Autophagy is an intracellular degradation system that has been associated with the progression of neurodegenerative disorders. Although induction of autophagic flux by GO has been reported, the underlying signaling pathway in neurodegenerative disorders and how this is involved in neuroprotection remain obscure. We show that GO itself activates autophagic flux in neuronal cells and confers a neuroprotective effect against prion protein (PrP) (106–126)-mediated neurotoxicity. GO can be detected in SK-N-SH neuronal cells, where it triggers autophagic flux signaling. GO-induced autophagic flux prevented PrP (106–126)-induced neurotoxicity in SK-N-SH cells. Moreover, inactivation of autophagic flux blocked GO-induced neuroprotection against prion-mediated mitochondrial neurotoxicity. This is the first study to demonstrate that GO regulates autophagic flux in neuronal cells, and that activation of autophagic flux signals, induced by GO, plays a neuroprotective role against prion-mediated mitochondrial neurotoxicity. These results suggest that the nanomaterial GO may be used to activate autophagic flux and could be used in neuroprotective strategies for treatment of neurodegenerative disorders, including prion diseases. Keywords: graphene oxide, neuroprotection, autophagy, prion protein, mitochondria

Published
2017

36. Baracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety

Author

Kim DY, Kim JH, Tak WY, Yeon JE, Lee JH, Yoon JH, Lee YJ, Lee BS, Han BH, and Lee HC

Subjects
chronic hepatitis B, generic, ETV from Dong-A ST (Baracle®), Therapeutics. Pharmacology, RM1-950
Abstract

Do Young Kim,1 Ju Hyun Kim,2 Won Young Tak,3 Jong Eun Yeon,4 Joon Hyeok Lee,5 Jung Hwan Yoon,6 Youn Jae Lee,7 Byung Seok Lee,8 Byung Hoon Han,9 Han Chu Lee10 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, 2Department of Gastroenterology, Gachon University Gil Medical Center, Incheon, 3Department of Internal Medicine, Kyungpook National University Hospital, Daegu, 4Department of Internal Medicine, Korea University Guro Hospital, Seoul, 5Department of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 6Department of Internal Medicine, Seoul National University Hospital, Seoul, 7Department of Gastroenterology, Inje University Busan Paik Hospital, Busan, 8Department of Gastroenterology, Chungnam National University Hospital, Daejeon, 9Department of Gastroenterology, Kosin University Gospel Hospital, Busan, 10Department of Internal Medicine, Asan Medical Center, Ulsan University, Seoul, Republic of Korea Background and objective: Entecavir (ETV) is a standard of care for chronic hepatitis B (CHB). In a bioequivalence study, ETV from Dong-A ST (Baracle®) was found to have a pharmacokinetic profile equivalent to ETV from Bristol-Myers Squibb (BMS) (Baraclude®). The present study was conducted to evaluate the antiviral activity and safety of ETV from Dong-A ST in comparison to ETV from BMS in patients with CHB. Methods: In this multicenter, double-blind, active-controlled, stratified-randomized, parallel group, comparative trial, 118 treatment-naïve patients with CHB were randomly assigned to receive either 0.5 mg of ETV from Dong-A ST or ETV from BMS once daily for 48 weeks. The primary efficacy endpoint was virologic improvement (a mean reduction from baseline in serum HBV DNA levels) at 24 weeks. Secondary efficacy endpoints included a mean reduction in serum HBV DNA levels at 48 weeks, proportion of patients with undetectable levels of serum HBV DNA, rates of hepatitis B e antigen (HBeAg) loss and seroconversion, rates of HBsAg loss and seroconversion, and rates of normalization of alanine aminotransferase (ALT) levels. Results: From baseline to week 24, HBV DNA levels (log10) decreased by 4.81 and 4.63 with ETV from Dong-A ST and with ETV from BMS, respectively. The upper limit of two-sided 95% confidence intervals (CI) (equivalent to one-sided 97.5% CIs) for the difference between the treatment groups was 0.208, which was below the noninferiority margin of 1, thus supporting the noninferiority of ETV from Dong-A ST in comparison to ETV from BMS. No statistically significant differences were noted between the treatment groups in all secondary and tertiary efficacy endpoints. Safety profiles were also similar between the two groups. Conclusion: In patients with previously untreated HBeAg-positive or negative HBV infection, the efficacy of ETV from Dong-A ST was noninferior to that of ETV from BMS, and there were no significant differences in efficacy or safety between two groups. Keywords: chronic hepatitis B, generic, ETV from Dong-A ST (Baracle®)

Published
2017

37. Optical inactivation of the anterior cingulate cortex modulate descending pain pathway in a rat model of trigeminal neuropathic pain created via chronic constriction injury of the infraorbital nerve

Author

Moon HC, Heo WI, Kim YJ, Lee D, Won SY, Kim HR, Ha SM, Lee YJ, and Park YS

Subjects
optogenetics, trigeminal neuralgia, anterior cingulate cortex, neuropathic pain, Medicine (General), R5-920
Abstract

Hyeong Cheol Moon,1 Won Ik Heo,2 Yon Ji Kim,3 Daae Lee,4 So Yoon Won,5 Hong Rae Kim,1 Seung Man Ha,1 Youn Joo Lee,6 Young Seok Park1 1Department of Medical Neuroscience and Neurosurgery, College of Medicine, 2Department of Veterinary, College of Veterinary Medicine, 3Department of Biology, College of Natural Sciences, 4Department of Advanced Material Engineering, College of Engineering, 5Biochemistry and Medical Research Center, Chungbuk National University, Cheongju, 6Department of Radiology, Daejoen St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea Purpose: The anterior cingulate cortex (ACC) plays a critical role in the initiation, development, and maintenance of neuropathic pain. Recently, the effects of optical stimulation on pain have been investigated, but the therapeutic effects of optical stimulation on trigeminal neuralgia (TN) have not been clearly shown. Here, we investigated the effects of optical inhibition of the ACC on TN lesions to determine whether the alleviation of pain affects behavior performance and thalamic neuron signaling.Materials and methods: TN lesions were established in animals by generating a chronic constriction injury of the infraorbital nerve, and the animals received injections of AAV-hSyn-eNpHR3.0-EYFP or a vehicle (phosphate-buffered saline [PBS]) in the ACC. The optical fiber was fixed into the ipsilateral ACC after the injection of adeno-associated virus plasmids or vehicle. Behavioral testing, consisting of responses to an air puff and cold allodynia, was performed, and thalamic neuronal activity was monitored following optical stimulation in vivo. Optical stimulation experiments were executed in three steps: during pre-light-off, stimulation-light-on, and post-light-off states. The role of the optical modulation of the ACC in response to pain was shown using a combination of optical stimulation and electrophysiological recordings in vivo.Results: Mechanical thresholds and facial cold allodynia scores were significantly improved in the TN lesion group during optical stimulation compared to those in the control group. Thalamic neuronal activity, consisting of the firing rate (spikes/s) and burst rate (bursts/s), was also decreased during optical stimulation.Conclusion: Reciprocal optical inhibition of the ACC can alleviate pain-associated behavior and decrease abnormal thalamic sensory neuron activity in the trigeminal neuropathic rat model. The descending pain pathway can modulate thalamic neurons from the ACC following optical stimulation. Keywords: optogenetics, trigeminal neuralgia, anterior cingulate cortex, neuropathic pain

Published
2017

38. Longitudinal changes in lung hyperinflation in COPD

Author

Park J, Lee CH, Lee YJ, Park JS, Cho YJ, Lee JH, Lee CT, and Yoon HI

Subjects
Pulmonary disease, chronic obstructive, Lung volume measurements, Forced expiratory volume, Cohort studies, Diseases of the respiratory system, RC705-779
Abstract

Jimyung Park,1 Chang-Hoon Lee,1 Yeon Joo Lee,2 Jong Sun Park,2 Young-Jae Cho,2 Jae Ho Lee,2 Choon-Taek Lee,2 Ho Il Yoon2 On behalf of the Korean Obstructive Lung Disease (KOLD) Study Group 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-Si, South Korea Purpose: COPD is characterized by an accelerated and progressive decline in forced expiratory volume in 1 second (FEV1) and lung hyperinflation. Although lung hyperinflation is the hallmark of COPD, data on the longitudinal changes in lung hyperinflation and any association with the decline in FEV1 are lacking. The aim of this study was to evaluate the longitudinal changes in lung hyperinflation and to investigate its relationship with FEV1 decline. Patients and methods: We conducted a prospective cohort study and studied 176 COPD patients with annual lung volume measurements over a period of 5 years or more. We used a random coefficient model to calculate the annual changes in lung volumes and to evaluate the factors associated with changes in lung hyperinflation. Additionally, the relationship between the change in lung hyperinflation and FEV1 was assessed. Results: Residual volume (RV), inspiratory capacity (IC), and total lung capacity (TLC) declined at a mean rate of 39.5, 49.6, and 63.8 mL/year, respectively. While IC/TLC declined at 0.70%/year, RV/TLC also declined at 0.35%/year. Changes in both IC/TLC and RV/TLC varied significantly. Frequent exacerbations led to an increase in RV/TLC and faster decline in IC/TLC over time. RV/TLC declined in 59.7% and increased in 40.3% of the patients. A significant negative correlation was found between the rates of change in FEV1 and RV/TLC, and the rate of decline in FEV1 was greater in patients with an increase in RV/TLC than in those with a decline in RV/TLC (54.2 vs 10.7 mL/year, P

Published
2017

39. Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator- and apolipoprotein E-conjugated liposomes to the hippocampus

Author

Kuo YC and Lee YJ

Subjects
liposome, nerve growth factor, Alzheimer's disease, blood-brain barrier, serotonin modulator, apolipoprotein E, Medicine (General), R5-920
Abstract

Yung-Chih Kuo, Yin-Jung Lee Department of Chemical Engineering, National Chung Cheng University, Chia-Yi, Taiwan, Republic of China Abstract: β-Amyloid (Aβ)-targeting liposomes (LIP) with surface serotonin modulator (SM) and apolipoprotein E (ApoE) were utilized to facilitate the delivery of nerve growth factor (NGF) across the blood–brain barrier (BBB) for neuroprotection in the hippocampus. The therapeutic efficacy of SM- and ApoE-grafted LIP carrying NGF (NGF-SM-ApoE-LIP) was assessed by an in vitro Alzheimer’s disease (AD) model of degenerated SK-N-MC cells and an in vivo AD model of Aβ-insulted Wistar rats. The experimental evidences revealed that the modified SM and ApoE on the surface of LIP increased the permeation of NGF across the BBB without serious damage to structural integrity of tight junction. When compared with free NGF, NGF-SM-ApoE-LIP upregulated the expression of phosphorylated neurotrophic tyrosine kinase receptor type 1 on cholinergic neurons and significantly improved their survival. In addition, NGF-SM-ApoE-LIP could reduce the secretion of acetylcholinesterase and malondialdehyde and rescue hippocampal neurons from apoptosis in rat brains. The synergistic effect of SM and ApoE is promising in the induction of NGF to inhibit the neurotoxicity of Aβ and NGF-SM-ApoE-LIP can be a potent antiapoptotic pharmacotherapy for clinical care of patients with AD. Keywords: Alzheimer’s disease, blood–brain barrier, serotonin modulator, apolipoprotein E, nerve growth factor, liposome

Published
2016

40. Entity matching across stereo cameras for tracking construction workers

Author

Lee, YJ, Park, MW, and Brilakis, I

Abstract

While GPS and RFID are dominantly used for tracking construction equipment and materials, 3D vision-based tracking that employs stereo-vision system has been also proposed as an alternative to efficiently track construction resources operating in a congested site. The 3D vision-based tracking requires an entity to be tracked in both cameras of the stereovision system so that two of 2D pixel coordinates are generated for each entity. Its 3D coordinate can be calculated by triangulating two projection rays that go through the 2D pixel coordinates. In order to track multiple entities of the same type simultaneously, the triangulation requires an additional process to match entities across the two camera views. This paper proposes an efficient method of entity matching for tracking construction workers. The method is mainly based on epipolar geometry which represents the geometric relation between two camera views. Two additional strategies - distance ratio thresholding and frame grouping - are introduced to reject false matchings and to ultimately increase precision of the 3D tracking. Experiment results demonstrate its suitability for automated entity matching for 3D vision-based tracking of construction workers.

Published
2023
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42. Toll-like receptor 3-induced immune response by poly(D,L-lactide-co-glycolide) nanoparticles for dendritic cell-based cancer immunotherapy

Author

Han HD, Byeon YS, Kang TH, Jung ID, Lee JW, Shin BC, Lee YJ, Sood AK, and Park YM

Subjects
dendritic cell, immunotherapy, nanoparticles, cancer, Medicine (General), R5-920
Abstract

Hee Dong Han,1,* Yeongseon Byeon,1,* Tae Heung Kang,1 In Duk Jung,1 Jeong-Won Lee,2 Byung Cheol Shin,3 Young Joo Lee,4 Anil K Sood,5–7 Yeong-Min Park1 1Department of Immunology, School of Medicine, Konkuk University, Chungwondaero, Chungju-Si, Chungcheongbuk-Do, 2Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 3Bio/Drug Discovery Division, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, 4Department of Bioscience and Biotechnology, Sejong University, Kwang-Jin-Gu, Seoul, South Korea; 5Department of Gynecologic Oncology and Reproductive Medicine, 6Department of Cancer Biology, 7Center for RNA Interference and Non-coding RNA, The University of Texas MD Anderson Cancer Center, TX, USA *These authors contributed equally to this work Abstract: Dendritic cells (DCs) are potent professional antigen-presenting cells that are capable of initiating a primary immune response and activating T cells, and they play a pivotal role in the immune responses of the host to cancer. Prior to antigen presentation, efficient antigen and adjuvant uptake by DCs is necessary to induce their maturation and cytokine generation. Nanoparticles (NPs) are capable of intracellular delivery of both antigen and adjuvant to DCs. Here, we developed an advanced poly(D,L-lactide-co-glycolide) (PLGA)-NP encapsulating both ovalbumin (OVA) as a model antigen and polyinosinic-polycytidylic acid sodium salt (Toll-like receptor 3 ligand) as an adjuvant to increase intracellular delivery and promote DC maturation. The PLGA-NPs were taken up by DCs, and their uptake greatly facilitated major histocompatibility class I antigen presentation in vitro. Moreover, vaccination with PLGA-NP-treated DCs led to the generation of ovalbumin-specific CD8+ T cells, and the resulting antitumor efficacy was significantly increased in EG.7 and TC-1 tumor-bearing mice compared to control mice (P

Published
2016

44. A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

Author

Chung H, Lee H, Han H, An H, Lim KS, Lee YJ, Cho JY, Yoon SH, Jang IJ, and Yu KS

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Hyewon Chung,1,* Howard Lee,1,2,* HyeKyung Han,1 Hyungmi An,1 Kyoung Soo Lim,1,3 YongJin Lee,4 Joo-Youn Cho,1 Seo Hyun Yoon,1 In-Jin Jang,1 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 3Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea; 4Medical and Regulatory Affairs Team, Samyang Biopharmaceuticals Corporation, Seoul, Republic of Korea *These authors contributed equally to this work Purpose: SYP-1018 is a lyophilized polymeric nanoparticle formulation of voriconazole that is under development for intravenous dosing. This study compared the pharmacokinetic and tolerability profiles of SYP-1018 with those of Vfend®, the marketed formulation of voriconazole. The effect of CYP2C19 polymorphism on the voriconazole pharmacokinetics was also evaluated. Methods: An open-label, two-treatment, two-period, two-sequence crossover study was conducted in 52 healthy male volunteers, who randomly received a single intravenous infusion of either of the two voriconazole formulations at 200 mg. Blood samples were collected up to 24 hours after drug administration for pharmacokinetic analysis. The plasma concentrations of voriconazole were determined using liquid chromatography with tandem mass spectrometry, and the pharmacokinetic parameters were estimated using a noncompartmental method. CYP2C19 genotype was identified in 51 subjects. Results: The geometric mean ratio (90% confidence interval) of SYP-1018 to Vfend® was 0.99 (0.93–1.04) for the maximum plasma concentrations (Cmax) and 0.97 (0.92–1.01) for the area under the concentration–time curve (AUC) from dosing to the last quantifiable concentration (AUClast). Nineteen homozygous extensive metabolizers (EMs, *1/*1), 19 intermediate metabolizers (IMs, *1/*2 or *1/*3), and ten poor metabolizers (PMs, *2/*2, *2/*3, or *3/*3) were identified, and the pharmacokinetic comparability between SYP-1018 and Vfend® was also noted when analyzed separately by genotype. The systemic exposure to voriconazole was greatest in the PM group, followed by the IM, and then the EM groups. Furthermore, the intrasubject variability for Cmax and AUClast was greater in IMs and PMs than in EMs. No serious adverse event occurred, and both treatments were well tolerated. Conclusion: SYP-1018 had comparable pharmacokinetic and tolerability profiles to Vfend® after a single intravenous infusion. CYP2C19 genotype affected not only the pharmacokinetics of voriconazole, but its intrasubject variability. SYP-1018 can be further developed as a clinically effective alternative to Vfend®. Keywords: voriconazole, pharmacokinetics, pharmacogenetics, CYP2C19

Published
2015

45. Erratum to: Measurement of exclusive Υ photoproduction from protons in pPb collisions at √sNN=5.02TeV

Author

Sirunyan, AM, Tumasyan, A, Adam, W, Ambrogi, F, Asilar, E, Bergauer, T, Brandstetter, J, Brondolin, E, Dragicevic, M, Ero, J, Del Valle, AE, Flechl, M, Friedl, M, Fruhwirth, R, Ghete, VM, Grossmann, J, Hrubec, J, Jeitler, M, Konig, A, Krammer, N, Kratschmer, I, Liko, D, Madlener, T, Mikulec, I, Pree, E, Rad, N, Rohringer, H, Schieck, J, Schofbeck, R, Spanring, M, Spitzbart, D, Taurok, A, Waltenberger, W, Wittmann, J, Wulz, CE, Zarucki, M, Chekhovsky, V, Mossolov, V, Gonzalez, JS, De Wolf, EA, Di Croce, D, Janssen, X, Lauwers, J, Pieters, M, Van De Klundert, M, Van Haevermaet, H, Van Mechelen, P, Van Remortel, N, Abu Zeid, S, Blekman, F, D'Hondt, J, De Bruyn, I, De Clercq, J, Deroover, K, Flouris, G, Lontkovskyi, D, Lowette, S, Marchesini, I, Moortgat, S, Moreels, L, Python, Q, Skovpen, K, Tavernier, S, Van Doninck, W, Van Mulders, P, Van Parijs, I, Beghin, D, Bilin, B, Brun, H, Clerbaux, B, De Lentdecker, G, Delannoy, H, Dorney, B, Fasanella, G, Favart, L, Goldouzian, R, Grebenyuk, A, Kalsi, AK, Lenzi, T, Luetic, J, Seva, T, Starling, E, Vander Velde, C, Vanlaer, P, Vannerom, D, Yonamine, R, Cornelis, T, Dobur, D, Fagot, A, Gul, M, Khvastunov, I, Poyraz, D, Roskas, C, Trocino, D, Tytgat, M, Verbeke, W, Vermassen, B, Vit, M, Zaganidis, N, Bakhshiansohi, H, Bondu, O, Brochet, S, Bruno, G, Caputo, C, Caudron, A, David, P, De Visscher, S, Delaere, C, Delcourt, M, Francois, B, Giammanco, A, Krintiras, G, Lemaitre, V, Magitteri, A, Mertens, A, Musich, M, Piotrzkowski, K, Quertenmont, L, Saggio, A, Marono, MV, Wertz, S, Zobec, J, Alda, WL, Alves, FL, Alves, GA, Brito, L, Silva, GC, Hensel, C, Moraes, A, Pol, ME, Teles, PR, Das Chagas, EBB, Carvalho, W, Chinellato, J, Coelho, E, Da Costa, EM, Da Silveira, GG, Damiao, DD, De Souza, SF, Malbouisson, H, Jaime, MM, De Almeida, MM, Herrera, CM, Mundim, L, Nogima, H, Rosas, LJS, Santoro, A, Sznajder, A, Thiel, M, Manganote, EJT, De Araujo, FTD, Pereira, AV, Ahuja, S, Bernardes, CA, Calligaris, L, Tomei, TRFP, Gregores, EM, Mercadante, PG, Novaes, SF, Padula, SS, Abad, DR, Vargas, JCR, Aleksandrov, A, Hadjiiska, R, Iaydjiev, P, Marinov, A, Misheva, M, Rodozov, M, Shopova, M, Sultanov, G, Dimitrov, A, Litov, L, Pavlov, B, Petkov, P, Fang, W, Gao, X, Yuan, L, Ahmad, M, Bian, JG, Chen, GM, Chen, HS, Chen, M, Chen, Y, Jiang, CH, Leggat, D, Liao, H, Liu, Z, Romeo, F, Shaheen, SM, Spiezia, A, Tao, J, Wang, C, Wang, Z, Yazgan, E, Zhang, H, Zhao, J, Ban, Y, Chen, G, Li, J, Li, Q, Liu, S, Mao, Y, Qian, SJ, Wang, D, Xu, Z, Wang, Y, Avila, C, Cabrera, A, Montoya, CAC, Sierra, LFC, Florez, C, Hernandez, CFG, Delgado, MAS, Courbon, B, Godinovic, N, Lelas, D, Puljak, I, Cipriano, PMR, Sculac, T, Antunovic, Z, Kovac, M, Brigljevic, V, Ferencek, D, Kadija, K, Mesic, B, Starodumov, A, Susa, T, Ather, MW, Attikis, A, Mavromanolakis, G, Mousa, J, Nicolaou, C, Ptochos, F, Razis, PA, Rykaczewski, H, Finger, M, Jarrin, EC, Khalil, S, Mahmoud, MA, Mohammed, Y, Bhowmik, S, Dewanjee, RK, Kadastik, M, Perrini, L, Raidal, M, 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Subjects
Erratum
Abstract

Erratum to: Eur. Phys. J. C (2019) 79:277 https://doi.org/10.1140/epjc/s10052-019-6774-8 In this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected.

Published
2022

46. Measurement of the inclusive t(t)over-bar production cross section in proton-proton collisions at √s = 5.02 TeV

Author

Tumasyan, A, Adam, W, Andrejkovic, JW, Bergauer, T, Chatterjee, S, Dragicevic, M, Del Valle, AE, Fruhwirth, R, Krammer, N, Lechner, L, Liko, D, Mikulec, I, Paulitsch, P, Pitters, FM, Schieck, J, Schofbeck, R, Spanring, M, Templ, S, Waltenberger, W, Wulz, CE, Chekhovsky, V, Litomin, A, Makarenko, V, Darwish, MR, De Wolf, EA, Janssen, T, Kello, T, Lelek, A, Sfar, HR, Van Mechelen, P, Van Putte, S, Van Remortel, N, Blekman, F, Bols, ES, D'Hondt, J, Delcourt, M, El Faham, H, Lowette, S, Moortgat, S, Morton, A, Muller, D, Sahasransu, AR, Tavernier, S, Van Doninck, W, Van Mulders, P, Stylianou, N, Beghin, D, Bilin, B, Clerbaux, B, De Lentdecker, G, Favart, L, Grebenyuk, A, Kalsi, AK, Lee, K, Mahdavikhorrami, M, Makarenko, I, Moureaux, L, Petre, L, Popov, A, Postiau, N, Starling, E, Thomas, L, Vanden Bemden, M, Vander Velde, C, Vanlaer, P, Vannerom, D, Wezenbeek, L, Gao, X, Cornelis, T, Dobur, D, Knolle, J, Lambrecht, L, Mestdach, G, Niedziela, M, Roskas, C, Samalan, A, Skovpen, K, Tytgat, M, Verbeke, W, Vermassen, B, Vit, M, Bethani, A, Bruno, G, Bury, F, Caputo, C, David, P, Delaere, C, Donertas, IS, Giammanco, A, Jaffel, K, Jain, S, Lemaitre, V, Mondal, K, Prisciandaro, J, Taliercio, A, Teklishyn, M, Tran, TT, Vischia, P, Wertz, S, Alves, GA, Hensel, C, Moraes, A, Alda, WL, Pereira, MAG, Ferreira, MB, Malbouisson, HB, Carvalho, W, Chinellato, J, Da Costa, EM, Da Silveira, GG, Damiao, DD, De Souza, SF, Figueiredo, DM, Herrera, CM, Amarilo, KM, Mundim, L, Nogima, H, Teles, PR, Santoro, A, Do Amaral, SMS, Sznajder, A, Thiel, M, De Araujo, FTD, Pereira, AV, Bernardes, CA, Calligaris, L, Tomei, TRFP, Gregores, EM, Lemos, DS, Mercadante, PG, Novaes, SF, Padula, SS, Aleksandrov, A, Antchev, G, Hadjiiska, R, Iaydjiev, P, Misheva, M, Rodozov, M, Shopova, M, Sultanov, G, Dimitrov, A, Ivanov, T, Litov, L, Pavlov, B, Petkov, P, Petrov, A, Cheng, T, Guo, Q, Javaid, T, Mittal, M, Wang, H, Yuan, L, Ahmad, M, Bauer, G, Dozen, C, Hu, Z, Martins, J, Wang, Y, Yi, K, Chapon, E, Chen, GM, Chen, HS, Chen, M, Iemmi, F, Kapoor, A, Leggat, D, Liao, H, Liu, ZA, Milosevic, V, Monti, F, Sharma, R, Tao, J, Thomas-Wilsker, J, Wang, J, Zhang, H, Zhang, S, Zhao, J, Agapitos, A, An, Y, Ban, Y, Chen, C, Levin, A, Li, Q, Lyu, X, Mao, Y, Qian, SJ, Wang, D, Wang, Q, Xiao, J, Lu, M, You, Z, Okawa, H, Lin, Z, Xiao, M, Avila, C, Cabrera, A, Florez, C, Fraga, J, Guisao, JM, Ramirez, F, Alvarez, JDR, Gonzalez, CAS, Giljanovic, D, Godinovic, N, Lelas, D, Puljak, I, Antunovic, Z, Kovac, M, Sculac, T, Brigljevic, V, Ferencek, D, Majumder, D, Roguljic, M, Starodumov, A, Susa, T, Attikis, A, Christoforou, K, Erodotou, E, Ioannou, A, Kole, G, Kolosova, M, Konstantinou, S, Mousa, J, Nicolaou, C, Ptochos, F, Razis, PA, Rykaczewski, H, Saka, H, Finger, M, Kveton, A, Ayala, E, Jarrin, EC, Abdalla, H, Salama, E, Lotfy, A, Mahmoud, MA, Bhowmik, S, Dewanjee, RK, Ehataht, K, Kadastik, M, Nandan, S, Nielsen, C, Pata, J, Raidal, M, Tani, L, Veelken, C, Eerola, P, Forthomme, L, Kirschenmann, H, Osterberg, K, Voutilainen, M, Bharthuar, S, Brucken, E, Garcia, F, Havukainen, J, Kim, MS, Kinnunen, R, Lampen, T, Lassila-Perini, K, Lehti, S, Linden, T, Lotti, M, Martikainen, L, Myllymaki, M, Ott, J, Siikonen, H, Tuominen, E, Tuominiemi, J, Luukka, P, Petrow, H, Tuuva, T, Amendola, C, Besancon, M, Couderc, F, Dejardin, M, Denegri, D, Faure, JL, Ferri, F, Ganjour, S, Givernaud, A, Gras, P, de Monchenault, GH, Jarry, P, Lenzi, B, Locci, E, Malcles, J, Rander, J, Rosowsky, A, Sahin, MO, Savoy-Navarro, A, Titov, M, Yu, GB, Mijuskovic, J, Ahuja, S, Beaudette, F, Bonanomi, M, Perraguin, AB, Busson, P, Cappati, A, Charlot, C, Davignon, O, Diab, B, Falmagne, G, Ghosh, S, de Cassagnac, RG, Hakimi, A, Kucher, I, Motta, J, Nguyen, M, Ochando, C, Paganini, P, Rembser, J, Salerno, R, Sauvan, JB, Sirois, Y, Tarabini, A, Zabi, A, Zghiche, A, Agram, JL, Andrea, J, Apparu, D, Bloch, D, Bourgatte, G, Brom, JM, Chabert, EC, Collard, C, Darej, D, Fontaine, JC, Goerlach, U, Grimault, C, Le Bihan, AC, Nibigira, E, Van Hove, P, Asilar, E, Beauceron, S, Bernet, C, Boudoul, G, Camen, C, Carle, A, Chanon, N, Contardo, D, Depasse, P, El Mamouni, H, Fay, J, Gascon, S, Gouzevitch, M, Ille, B, Laktineh, IB, Lattaud, H, Lesauvage, A, Lethuillier, M, Mirabito, L, Perries, S, Shchablo, K, Sordini, V, Torterotot, L, Touquet, G, Vander Donckt, M, Viret, S, Lomidze, I, Toriashvili, T, Tsamalaidze, Z, Mestvirishvili, A, Feld, L, Klein, K, Lipinski, M, Meuser, D, Pauls, A, Rauch, MP, Rowert, N, Schulz, J, Teroerde, M, Dodonova, A, Eliseev, D, Erdmann, M, Fackeldey, P, Fischer, B, Hebbeker, T, Hoepfner, K, Ivone, F, Keller, H, Mastrolorenzo, L, Merschmeyer, M, Meyer, A, Mocellin, G, Mondal, S, Mukherjee, S, Noll, D, Novak, A, Pook, T, Pozdnyakov, A, Rath, Y, Reithler, H, Roemer, J, Schmidt, A, Schuler, SC, Sharma, A, Vigilante, L, Wiedenbeck, S, Zaleski, S, Borras, K, Kasem, A, Coubez, X, Dziwok, C, Flugge, G, Ahmad, WH, Hlushchenko, O, Kress, T, Nowack, A, Pistone, C, Pooth, O, Roy, D, Sert, H, Stahl, A, Ziemons, T, Petersen, HA, Martin, MA, Asmuss, P, Babounikau, I, Baxter, S, Behnke, O, Martinez, AB, Bhattacharya, S, Bin Anuar, AA, Botta, V, Brunner, D, Campbell, A, Cardini, A, Cheng, C, Colombina, F, Rodriguez, SC, Silva, GC, Danilov, V, Didukh, L, Eckerlin, G, Eckstein, D, Banos, LIE, Filatov, O, Gallo, E, Geiser, A, Giraldi, A, Grohsjean, A, Guthoff, M, Jafari, A, Jomhari, NZ, Jung, H, Kasemann, M, Kaveh, H, Kleinwort, C, Krucker, D, Lange, W, Lidrych, J, Lipka, K, Lohmann, W, Mankel, R, Melzer-Pellmann, IA, Morentin, MM, Metwally, J, Meyer, AB, Meyer, M, Mnich, J, Mussgiller, A, Otarid, Y, Adan, DP, Pitzl, D, Raspereza, A, Lopes, BR, Rubenach, J, Saggio, A, Saibel, A, Savitskyi, M, Scham, M, Scheurer, V, Schutze, P, Schwanenberger, C, Singh, A, Ricardo, RES, Stafford, D, Tonon, N, Turkot, O, Van de Klundert, M, Walsh, R, Walter, D, Wen, Y, Wichmann, K, Wiens, L, Wissing, C, Wuchterl, S, Bakhshiansohi, H, Aggleton, R, Albrecht, S, Bein, S, Benato, L, Benecke, A, Connor, P, De Leo, K, Eich, M, Feindt, F, Frohlich, A, Garbers, C, Garutti, E, Gunnellini, P, Haller, J, Hinzmann, A, Kasieczka, G, Klanner, R, Kogler, R, Kramer, T, Kutzner, V, Lange, J, Lange, T, Lobanov, A, Malara, A, Nigamova, A, Rodriguez, KJP, Rieger, O, Schleper, P, Schroder, M, Schwandt, J, Schwarz, D, Sonneveld, J, Stadie, H, Steinbruck, G, Tews, A, Vormwald, B, Zoi, I, Bechtel, J, Berger, T, Butz, E, Caspart, R, Chwalek, T, De Boer, W, Dierlamm, A, Droll, A, El Morabit, K, Faltermann, N, Giffels, M, Gosewisch, JO, Gottmann, A, Hartmann, F, Heidecker, C, Husemann, U, Keicher, P, Koppenhofer, R, Maier, S, Metzler, M, Mitra, S, Muller, T, Neukum, M, Nurnberg, A, Quast, G, Rabbertz, K, Rauser, J, Savoiu, D, Schnepf, M, Seith, D, Shvetsov, I, Simonis, HJ, Ulrich, R, Van der Linden, J, Von Cube, RF, Wassmer, M, Weber, M, Wieland, S, Wolf, R, Wozniewski, S, Wunsch, S, Anagnostou, G, Daskalakis, G, Geralis, T, Kyriakis, A, Loukas, D, Stakia, A, Diamantopoulou, M, Karasavvas, D, Karathanasis, G, 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Subjects
Hadron-Hadron Scattering, Top Physics
Abstract

The top quark pair production cross section is measured in proton-proton collisions at a center-of-mass energy of 5.02 TeV. The data were collected in a special LHC low-energy and low-intensity run in 2017, and correspond to an integrated luminosity of 302 pb(-1). The measurement is performed using events with one electron and one muon of opposite charge, and at least two jets. The measured cross section is 60.7 +/- 5.0 (stat) +/- 2.8 (syst) +/- 1.1 (lumi) pb. A combination with the result in the single lepton + jets channel, based on data collected in 2015 at the same center-of-mass energy and corresponding to an integrated luminosity of 27.4 pb(-1), is then performed. The resulting measured value is 63.0 +/- 4.1 (stat) +/- 3.0 (syst+lumi) pb, in agreement with the standard model prediction of 66.8(-3.1)(+2.9) pb.

Published
2022

48. Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery:a systematic review and international external validation cohort study

Author

Kouli, O, Murray, V, Bhatia, S, Cambridge, WA, Kawka, M, Shafi, S, Knight, SR, Kamarajah, SK, McLean, KA, Glasbey, JC, Khaw, RA, Ahmed, W, Akhbari, M, Baker, D, Borakati, A, Mills, E, Thavayogan, R, Yasin, I, Raubenheimer, K, Ridley, W, Sarrami, M, Zhang, G, Egoroff, N, Pockney, P, Richards, T, Bhangu, A, Creagh-Brown, B, Edwards, M, Harrison, EM, Lee, M, Nepogodiev, D, Pinkney, T, Pearse, R, Smart, N, Vohra, R, Sohrabi, C, Jamieson, A, Nguyen, M, Rahman, A, English, C, Tincknell, L, Kakodkar, P, Kwek, I, Punjabi, N, Burns, J, Varghese, S, Erotocritou, M, McGuckin, S, Vayalapra, S, Dominguez, E, Moneim, J, Salehi, M, Tan, HL, Yoong, A, Zhu, L, Seale, B, Nowinka, Z, Patel, N, Chrisp, B, Harris, J, Maleyko, I, Muneeb, F, Gough, M, James, CE, Skan, O, Chowdhury, A, Rebuffa, N, Khan, H, Down, B, Fatimah Hussain, Q, Adams, M, Bailey, A, Cullen, G, Fu, YXJ, McClement, B, Taylor, A, Aitken, S, Bachelet, B, Brousse de Gersigny, J, Chang, C, Khehra, B, Lahoud, N, Lee Solano, M, Louca, M, 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Subjects
Adult, Cohort Studies, Postoperative Complications, Health Information Management, Medicine (miscellaneous), COVID-19, Humans, Decision Sciences (miscellaneous), Health Informatics, Prospective Studies, Prognosis, Pandemics
Abstract

Background Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications. Methods We did a systematic review and international external validation cohort study. The systematic review was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE and Embase on March 1, 2020, for articles published in English that reported on risk prediction models for postoperative pulmonary complications following abdominal surgery. External validation of existing models was done within a prospective international cohort study of adult patients (≥18 years) undergoing major abdominal surgery. Data were collected between Jan 1, 2019, and April 30, 2019, in the UK, Ireland, and Australia. Discriminative ability and prognostic accuracy summary statistics were compared between models for the 30-day postoperative pulmonary complication rate as defined by the Standardised Endpoints in Perioperative Medicine Core Outcome Measures in Perioperative and Anaesthetic Care (StEP-COMPAC). Model performance was compared using the area under the receiver operating characteristic curve (AUROCC). Findings In total, we identified 2903 records from our literature search; of which, 2514 (86·6%) unique records were screened, 121 (4·8%) of 2514 full texts were assessed for eligibility, and 29 unique prognostic models were identified. Nine (31·0%) of 29 models had score development reported only, 19 (65·5%) had undergone internal validation, and only four (13·8%) had been externally validated. Data to validate six eligible models were collected in the international external validation cohort study. Data from 11 591 patients were available, with an overall postoperative pulmonary complication rate of 7·8% (n=903). None of the six models showed good discrimination (defined as AUROCC ≥0·70) for identifying postoperative pulmonary complications, with the Assess Respiratory Risk in Surgical Patients in Catalonia score showing the best discrimination (AUROCC 0·700 [95% CI 0·683–0·717]). Interpretation In the pre-COVID-19 pandemic data, variability in the risk of pulmonary complications (StEP-COMPAC definition) following major abdominal surgery was poorly described by existing prognostication tools. To improve surgical safety during the COVID-19 pandemic recovery and beyond, novel risk stratification tools are required. Funding British Journal of Surgery Society.

Published
2022

49. Use of novel oral anticoagulants for the treatment of venous thromboembolism and its considerations in Asian patients

Author

Lee YJ

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Yun-Jeong Lee College of Pharmacy, Dankook University, Cheonan, Republic of Korea Abstract: Parenteral anticoagulation followed by warfarin has been conventionally used for the treatment of venous thromboembolism (VTE). However, there are numerous troublesome characteristics of warfarin that prompted the development of novel oral anticoagulants (NOACs) for the treatment of VTE. Asians are reported to be at an increased risk of bleeding with warfarin, and while the reported incidence of VTE in Asians is lower than in Caucasians, the annual rate of VTE in Asia is rising along with the need for better oral anticoagulant options. Recently, several Phase III clinical trials with NOACs for the treatment and prevention of VTE recurrence have been published. For the treatment of VTE, the four NOACs – dabigatran, rivaroxaban, apixaban, and edoxaban – each showed comparable efficacy outcomes while resulting in better safety outcomes when compared with conventional treatment. In these trials, Asian patients had comparable efficacy and safety outcomes as other races, except in the edoxaban trial, in which the Asian subgroup had better safety profiles than other races, although further confirmation is necessary. For secondary prevention, dabigatran was compared with conventional treatment and showed similar efficacy and safety outcomes. When NOACs were compared with placebo for secondary prevention of VTE, they showed superior efficacy and increased bleeding except for apixaban, which showed comparable major bleeding and composite of major and clinically relevant nonmajor bleeding rates as placebo. No significant differences in the outcomes based on race were observed in the Asian subgroups for secondary prevention. Therefore, NOACs can be used with similar efficacy and at least similar or superior safety compared with conventional treatment in the treatment of VTE, and at no increased risk in Asian patients. Keywords: dabigatran, rivaroxaban, apixaban, edoxaban, secondary prevention, Asia

Published
2014

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