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(1) Background: The study investigated whether the ankle–brachial index (ABI) and pulse wave velocity (baPWV) could reflect the severity of small vessel disease (SVD) and large artery atherosclerosis (LAA). (2) Methods: A total of 956 consecutive patients diagnosed with ischemic stroke were prospectively enrolled from July 2016 to December 2017. SVD severity and LAA stenosis grades were evaluated via magnetic resonance imaging and carotid duplex ultrasonography. Correlation coefficients were calculated between the ABI/baPWV and measurement values. Multinomial logistic regression analysis was performed to determine predictive potential. (3) Results: Among the 820 patients included in the final analysis, the stenosis grade of extracranial and intracranial vessels was inversely correlated with the ABI (p < 0.001, respectively) and positively correlated with the baPWV (p < 0.001 and p = 0.004, respectively). Abnormal ABI, not baPWV, independently predicted the presence of moderate (adjusted odds ratio, aOR: 2.18, 95% CI: 1.31–3.63) to severe (aOR: 5.59, 95% CI: 2.21–14.13) extracranial vessel stenosis and intracranial vessel stenosis (aOR: 1.89, 95% CI: 1.15–3.11). Neither the ABI nor baPWV was independently associated with SVD severity. (4) Conclusions: ABI is better than baPWV in screening for and identifying the existence of cerebral large vessel disease, but neither test is a good predictor of cerebral SVD severity. [ABSTRACT FROM AUTHOR]

Super-refractory status epilepticus (SRSE) is a critical condition in which seizures persist despite anesthetic use for 24 h or longer. High mortality has been reported in patients with SRSE, but the cause of death remains unclear. We investigated the factors associated with mortality, including clinical characteristics, SE etiologies and severities, treatments, and responses in patients with SRSE in a 13-year tertiary hospital-based retrospective cohort study comparing these parameters between deceased and surviving patients. SRSE accounted for 14.2% of patients with status epilepticus, and 28.6% of SRSE patients died. Deceased patients were mostly young or middle-aged without known systemic diseases or epilepsy. All deceased patients experienced generalized convulsive status epilepticus and failure of anesthetic tapering-off, significantly higher than survivors. An increased number of second-line anesthetics besides midazolam was observed in the deceased (median, 3, interquartile range 2–3) compared to surviving (1, 1–1; p = 0.0006) patients with prolonged use durations (p = 0.047). For mortality, the cut-off number of second-line anesthetics was 1.5 (AUC = 0.906, p = 0.004). Deceased patients had significantly higher renal and cardiac complications and metabolic acidosis than survivors. In SRSE management, multi-anesthetic use should be carefully controlled to avoid systemic complications and mortality. [ABSTRACT FROM AUTHOR]

We report the synthesis of two carbazole-thiophene-based conjugated microporous polymers (Cz-3Th and Cz-4Th CMPs) with different degrees of planarity for photocatalytic hydrogen evolution from water. Depending upon the building linker's planarity, we found that the porous structure, hydrogen-evolution rate, and photocatalytic stability of the resultant CMPs varied. [ABSTRACT FROM AUTHOR]

Current research on the detection of circulating tumor cells (CTCs) as a diagnostic strategy is still in its early stages. Consequently, there is a need for an efficient platform to capture and accurately detect CTCs with high sensitivity. This study presents the development of a bio-sensing platform that employs a planar-gated graphene field-effect transistor (GFET). This platform is designed for the detection of CTCs associated with nasopharyngeal carcinoma (NPC). In this approach, bilayer graphene is functionalized through a low-damage nitrogen plasma treatment, and then further modified with specific antibodies to enable a label-free detection of CTCs. The real-time electrical signal changes of the sensor were analyzed, demonstrating advantages in terms of rapid sensing and cost-effective on chip fabrication and instrument investment. The results showed that the low-damage nitrogen plasma effectively aminated the graphene surface, with the C–NH 2 bonds accounting for approximately 62.8 % of the nitrogen content. The linear detection range of the sensor from 1 cell/15 μl to 1 cell/1000 μl, with a limit of detection (LoD) of 1 cell/15 μl(∼66/ml). The sensitivity of the sensor was determined to be 0.040 V/decade with a linear regression of 0.93 and with high sensing specificity in mixture cells environments. The CTCs capture density on aminated graphene was calculated to be 238.6 ± 29.8 cells/mm2. We also integrated this sensor chip into a portable system, including the sensing and signal processing unit enabling fast detection and close to point-of-care diagnostic tests. This study provides a promising platform for the rapid and accurate detection of nasopharyngeal carcinoma CTCs for early detection and post-treatment monitoring. Amin-Functionalized Bilayer Graphene Enhancing the CTC Biosensing with Integrated Chip-Level System for Point-of-Care Testing. [Display omitted] [ABSTRACT FROM AUTHOR]

Background: Antiplatelet use on the risk of intracerebral hemorrhage (ICH) in patients with Alzheimer's disease (AD) has not yet been completely elucidated.Objective: This large epidemiologic study aims to estimate the risk of ICH in AD patients treated with antiplatelet therapy (APT).Methods: Using data from Taiwan's National Health Insurance Research Database, ICH risk in APT-treated AD patients with a validated diagnosis (N = 824) was determined. AD without APT and non-AD with and without APT comparison cohorts were selected. To adjust for confounders and competing risk of death, inverse probability of treatment weighting using propensity scores and competing risks regression (CRR) were applied. Cox proportional hazards regression analysis estimated ICH risk in all cohorts comparing with non-AD without APT.Results: Among the 824 AD patients with APT, 79.6% were prescribed aspirin. ICH incidence rates in the AD (with/without APT) and non-AD (with/without APT) cohorts were 2.88/2.70 and 2.24/1.20 per 1,000 person-years, respectively. Overall, AD with (adjusted hazards ratio (aHR), 2.29; 95% CI, 1.19-4.38) and without (aHR, 1.97; 95% CI, 1.08-3.61) APT and non-AD with APT (aHR, 1.80; 95% CI, 1.34-2.42) were at a higher risk and had elevated subdistribution HR obtained from CRR than non-AD without APT controls. However, the risk was comparable between the AD cohorts with and without APT (HR, 1.16; 95% CI, 0.51-2.66).Conclusions: Our study indicated both the APT and non-APT users in AD population yielded higher ICH risks. However, whether APT use potentiate the risk of ICH in AD patients may warrant further evaluation. [ABSTRACT FROM AUTHOR]

The Candecomp/Parafac decomposition (CPD) of the tensor whose maximal dimension is greater than its rank is considered. We derive the upper bound of rank under which computing the CPD is equivalent to solving a structured polynomial system that is determined by the full rank factorization of the matricization of the tensor. Under the generic uniqueness conditions, the CPD solutions of the system are isolated so that these solutions can be achieved by homotopy method. [ABSTRACT FROM AUTHOR]

The numerical rank determination frequently occurs in matrix computation when the conventional exact rank of a hidden matrix is desired to be recovered. This paper presents a Matlab package RankRev that implements two efficient algorithms for computing the numerical rank and numerical subspaces of a matrix along with updating/downdating capabilities for making adjustment to the results when a row or column is inserted/deleted. The package and the underlying algorithms are accurate, reliable, and much more efficient than the singular value decomposition when the matrix is of low rank or low nullity. [ABSTRACT FROM AUTHOR]

This article presents recent efforts in improving the efficiency and scalability of the mixed cell computation step in the context of the Polyhedral Homotopy method. Solving systems of polynomial equations is an important problem in applied mathematics. The Polyhedral Homotopy method is an important numerical method for this task. In this method, a necessary preprocessing step, known as the “mixed cell computation” problem has been the main bottleneck in the parallel efficiency and scalability. This article presents recent remarkable improvements in the parallel scalability of the algorithm that are applicable to a wide range of hardware architectures including multi-core systems, NUMA systems, computer clusters, and GPUs devices. [ABSTRACT FROM AUTHOR]

In a routine phenotype-driven screen, we identified a point mutation in exon 7 of the IL-15 gene in Pedigree 191 (deficient memory (DM)) of N-ethyl-N-nitrosourea mutagenized mice. The DM epidermis expressed an alternatively spliced IL-15 mRNA isoform, IL-15ΔE7, and a wild-type (WT) IL-15 isoform at comparable levels. Mechanical stimulation of DM skin or DM skin graft transplanted onto the WT host resulted in reduced keratinocyte activation and inhibition of neutrophil infiltration into the dermis, demonstrating that DM keratinocytes produced less inflammatory response to external stimulation. Ectopic expression of IL-15ΔE7 in WT skin prevented abrasion-induced epidermal thickening, blocked the accumulation of nuclear antigen Ki67+ cells in the basal and the suprabasal cell layers, increased loricrin expression, and also increased keratinocyte CXCL1 and G-CSF production. IL-15ΔE7 also profoundly blocked neutrophil infiltration in SDS- or immiquimod (IMQ)-treated WT skin. Recombinant IL-15ΔE7 failed to activate STAT-5 and its downstream target bcl-2 expression. Our study points to IL-15ΔE7 as a potential therapeutic agent for treating neutrophilia-associated inflammatory skin disorders. [ABSTRACT FROM AUTHOR]

We solve a problem of Littlewood: there exist seven infinite circular cylinders of unit radius which mutually touch each other. In fact, we exhibit two such sets of cylinders. Our approach is algebraic and uses symbolic and numerical computational techniques. We consider a system of polynomial equations describing the position of the axes of the cylinders in the 3 dimensional space. To have the same number of equations (namely 20) as the number of variables, the angle of the first two cylinders is fixed to 90 degrees, and a small family of direction vectors is left out of consideration. Homotopy continuation method has been applied to solve the system. The number of paths is about 121 billion, it is hopeless to follow them all. However, after checking 80 million paths, two solutions are found. Their validity, i.e., the existence of exact real solutions close to the approximate solutions at hand, was verified with the alphaCertified method as well as by the interval Krawczyk method. [ABSTRACT FROM AUTHOR]

Abstract: Accurate predictions of storm surge and surge deviation are essential for industrial activities in coastal areas. Usually numerical hydrodynamic models or empirical methods are used to estimate the storm surge. This paper proposes an alternative back-propagation neural network (BPN) approach to forecast the storm surge and surge deviation. The prediction of storm surge from a previous typhoon is used as a training set to form predictions for the next event. Wind velocity, wind direction, atmospheric pressure and astronomical tide were selected as inputs in the neural network. The observations obtained during three typhoons from four stations in Taiwan were used to illustrate performance of the BPN model. Comparisons with numerical methods indicate that the storm surge and surge deviation can be efficiently predicted using BPN. [Copyright &y& Elsevier]

Abstract: An application of an artificial neural network (ANN) combined with thermographic analysis for estimating the depth of eroded caves in a seawall is presented in this paper. A model experiment was first conducted in a sandbox using a thermographic device to detect the interior conditions of a structure from its temperature changes measured on the surface. The temperature difference calculated from the air temperature and the measured concrete surface point on a thermographic image was obtained for the neural network. Based on the laboratory data, an optimum ANN model for the estimation of the depth of eroded caves in a seawall was established by using four input factors: the site temperature, humidity, thermographic area, and the temperature difference. The model was verified using data from a seawall in Tainan City, Taiwan. From the results, it was found that the present ANN model efficiently estimates the depth of eroded caves in a seawall. [Copyright &y& Elsevier]

Abstract: It is essential to forecast the variation of storm surge in coastal areas during the typhoon attacks. Conventional investigations of storm surge often used the method of numerical hydrodynamic models or empirical formula. In this paper, the back-propagation neural network (BPN) is applied to predict the short-term typhoon surge and surge deviation in order to overcome the problem of exclusive and nonlinear relationships. The observations obtained during three typhoons of Taichung harbor in Taiwan are verified by the present model. From the comparison with numerical methods, it can be found that the short-term storm surge and surge deviation can be efficiently predicted 1 to 6h ahead using BPN. [Copyright &y& Elsevier]

The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction in response to extra- or intracellular stimuli. Density-based membrane flotation, subcellular fractionation, cell surface biotinylation, and co-immunoprecipitation analyses of bichalcone analog ((E)-1-(4-Hydroxy-3-((4-(4-((E)-3-(pyridin-3-yl)acryloyl)phenyl)piperazin-1-yl)methyl)phenyl)-3-(pyridin-3-yl)prop-2-en-1-one (TSWU-BR4)-treated cancer cells showed dissociation between GRP78 and p85α conferring the recruitment of PTEN to lipid raft membranes associated with p85α. Ectopic expression of GRP78 could overcome induction of lipid raft membrane-associated p85α–unphosphorylated PTEN complex formation and suppression of GRP78−PI3K−Akt−GTP-Rac1-mediated and GRP78-regulated PERK−Nrf2 antioxidant pathway and cancer cell invasion by TSWU-BR4. Using specific inducer, inhibitor, or short hairpin RNA for ASM demonstrated that induction of the lipid raft membrane localization and activation of ASM by TSWU-BR4 is responsible for perturbing homeostasis of cholesterol and ceramide levels in the lipid raft and ER membranes, leading to alteration of GRP78 membrane trafficking and subsequently inducing p85α–unphosphorylated PTEN complex formation, causing disruption of GRP78−PI3K−Akt−GTP-Rac1-mediated signal and ER membrane-associated GRP78-regulated oxidative stress balance, thus inhibiting cancer cell invasion. The involvement of the enrichment of ceramide to lipid raft membranes in inhibition of NF-κB-mediated MMP-2 expression was confirmed through attenuation of NF-κB activation using C2-ceramide, NF-κB specific inhibitors, ectopic expression of NF-κB p65, MMP-2 promoter-driven luciferase, and NF-κB-dependent reporter genes. In conclusion, localization of ASM in the lipid raft membranes by TSWU-BR4 is a key event for initiating formation of ceramide-enriched lipid raft membrane platforms, which causes delocalization of GRP78 from the lipid raft and ER membranes to the cytosol and formation of p85α–unphosphorylated PTEN complexes to attenuate the GRP78-regulated oxidative stress balance and GRP78−p85α−Akt−GTP-Rac1−NF-κB−MMP-2-mediated cancer cell invasion. [ABSTRACT FROM AUTHOR]

A novel mesh-free kernel method is presented for solving function interpolation problems and partial differential equations (PDEs). Despite the simplicity and accuracy of the radial basis function (RBF) method, two main difficulties have been identified: the selection of the scale or shape parameter and the ill-conditioning issue. To address these challenges, an effective condition number (ECN) strategy is proposed for the scale parameter selection, utilizing the ill-conditioning issue to minimize errors. The study demonstrates that this method performs exceptionally well with severely ill-conditioned matrices, making it suitable challenging engineering problems. However, when the problem is severely ill-conditioned, an accurate and efficient method for determining the minimal singular values used in the ECN formulation is required. To tackle this, we utilize an efficient algorithm called minsv, which specifically computes the minimal singular value. The significance of accurately computing the smallest singular value is demonstrated through two interpolation examples, involving non-smooth and smooth test functions with various RBFs and data points. Furthermore, the RBF method is applied to solve a quasicrystal problem, which presents a challenging engineering problem with four unknown parameters, and excellent results are obtained. Finally, we illustrate that using MATLAB's svd function can potentially produce completely incorrect minimal singular values. The codes implemented are available at https://doi.org/10.24433/CO.8716692.v1. [ABSTRACT FROM AUTHOR]

Background: Hypomimia is a clinical feature of Parkinson's disease (PD). Based on the embodied simulation theory, the impairment of facial mimicry may worsen facial emotion recognition; however, the empirical results are inconclusive. Objective: We aimed to explore the worsening of emotion recognition by hypomimia. We further explored the relationship between the hypomimia, emotion recognition, and social functioning. Methods: A total of 114 participants were recruited. The patients with PD and normal controls (NCs) were matched for demographic characteristics. All the participants completed the Mini-Mental State Examination and the Chinese Multi-modalities Emotion Recognition Test. In addition to the above tests, the patients were assessed with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale and Parkinson's Disease Social Functioning Scale (PDSFS). Results: Patients with PD with hypomimia had worse recognition of disgust than NCs (p = 0.018). The severity of hypomimia was predictive of the recognition of disgust (β= –0.275, p = 0.028). Facial emotion recognition was predictive of the PDSFS score of PD patients (β= 0.433, p = 0.001). We also found that recognizing disgust could mediate the relationship between hypomimia and the PDSFS score (β= 0.264, p = 0.045). Conclusion: Patients with hypomimia had the worst disgust facial recognition. Hypomimia may affect the social function of PD patients, which is related to recognizing the expression of disgust. Emotion recognition training may improve the social function of patients with PD. [ABSTRACT FROM AUTHOR]

• ToF-SIMs was conducted in depth profiling analysis for the structural information. • Silane affects the adsorption of 10-MDP by enhancing the hydroxylation of zirconia. • High PO 3 - is the indicator of formation of zirconium phosphate (ZrP) compounds. • Silane-free SE bond presented the highest PO and ZrP related ions at the interface. [Display omitted] The purposes of this study were to investigate whether the presence of silane in universal adhesives affects the functions of 10-methacryloyloxydecyl dihydrogen phosphate (MDP) and adhesion to zirconia. Two silane-containing universal adhesives (Scotchbond Universal (SBU) and Clearfil Universal-Bond (CUB)) and two silane-free adhesives (All-Bond Universal (ABU) and SE-Bond primer (SE)) were individually applied on zirconia disks. Time-of-flight secondary-ion-mass-spectrometry (ToF-SIMS) examined the distributions of MDP- and silane-related ions, as well as evidence of zirconium phosphate (ZrP) compounds, on the surface and interfacial regions using a depth profiling mode. The hydrophilicity and resin wettability of the treated zirconia were examined using a contact angle test. For the shear bond strength (SBS) test, the zirconia disks were air-blasted, treated with the assigned adhesives, and bonded with pre-cured composite cylinders using a resin cement. These resin-zirconia assemblies received a bond test after 24-h storage. Both SBU and CUB exhibited silane-related ions and ZrO 2 (OH)-, but fewer PO- ions in the interfacial regions. CUB had more siloxane-related ions. SE-treated zirconia had abundant PO- ions and particularly high PO 3 -- and ZrP- related ions in the interfacial regions. The silane-free adhesives exhibited a higher affinity to both water and adhesive liquids. SE showed significantly higher SBSs compared to ABU, while SBU and CUB were not statistically different. The silane content may cause hydroxylation of zirconia and affect MDP adsorption. An acidic pH accelerated the condensation of silanol. The bond performance of the MDP-based adhesive could be influenced by the silane content and other components. [ABSTRACT FROM AUTHOR]

Abstract: Recently, considerable efforts have been devoted to evaluation of seismic dynamic response of a circular tunnel. Conventional approaches have considered integral liners embedded in an elastic medium. In this study, we re-examine the problem with piecewise liners embedded in a porous medium. Surrounding saturated porous medium of tunnels is described by Biot''s poroelastic theory, while the liner pieces and the connecting joints are treated as curved beams and characterized by curved beam theories. The scattered wave field in the porous medium is obtained by the wave function expansion method. The differential equations governing the vibration of a curved beam is discretized by the General Differential Quadrature (GDQ) method. The domain decomposition method is used to establish the global discrete dynamic equations for the piecewise tunnel. The surrounding soil and the tunnel are coupled together via the stress and the displacement continuation conditions which are implemented by the boundary collocation method. Numerical results demonstrate that the stiffness difference between the liner piece and the connecting joints has a considerable influence on the internal forces of the liner piece. [Copyright &y& Elsevier]

A dynamic L-cube polynomial is proposed to analyze dynamic three-dimensional pulse images (d3DPIs), as an extension of the previous static L-cube polynomial. In this paper, a weighted least squares (WLS) method is proposed to fit the amplitude C(t) of d3DPI at four physiological key points in addition to the best fit of L-cube polynomials to the measured normal and cold-pressor-test (CPT)-induced taut 3DPIs. Compared with other two fitting functions, C(t) of a dynamic L-cube polynomial can be well matched by the proposed WLS method with the least relative error at four physiological key points in one beat with statistical significance, in addition to the best fit of the measured 3DPIs. Therefore, a dynamic L-cube polynomial can reflect dynamic time characteristics of normal and CPT-induced hypertensive taut 3DPIs, which can be used as an evidence of hypertension diagnosis. [ABSTRACT FROM AUTHOR]

Overlap between quantum states or observables is a fundamental quantity in quantum theory. Equioverlapping measurements arise naturally when considering quantum measurements with equal overlap between measurement operators. This is essentially a kind of symmetric configuration for quantum measurements. The conventional von Neumann measurements and symmetric informationally complete positive operator valued measures (SIC-POVMs) are two extreme cases of equioverlapping measurements. These measurements not only have intuitive physical significance, but also have rich and subtle mathematical structures. However, they remain largely unexplored. In this work, we investigate some general features of equioverlapping measurements with focus on qutrit systems (i.e., three dimensional systems), and partially classify equioverlapping measurements in this case. We further pose the challenge of complete classification and construction of equioverlapping measurements. • Some general features of equioverlapping measurements are revealed. • Equioverlapping measurements in qutrit systems are partially classified and explicitly constructed. • The challenge of complete classification and construction of equioverlapping measurements is proposed. [ABSTRACT FROM AUTHOR]

Background Staple removal from surgical wounds is painful. Only a few articles have provided expert opinions using anesthetic cream for such a problem; however, direct application of the anesthetic cream to a wound may cause infection. A safe alternative can be an anesthetic patch without wound contact. Materials and methods This was a prospective, double-blind, randomized clinical trial. Sixty patients who underwent primary total knee replacement were assigned to an experimental group or control group. One lidocaine patch was applied around the surgical wound for each patient in the experimental group. Alternatively, the adhesive sides of the lidocaine patches were shielded with waterproof films in the control group. A resident peeled off the patch before a single nursing practitioner removed the staples. Pain was assessed with the 10-cm visual analog scale, and a face pain scale-revised was performed. The patients and the nursing practitioner were blind to the management. Results Mean visual analog scale and face pain scale-revised scores were significantly lower in the experimental group. The mean pain score was significantly lower in the experimental group if the application time was >47 min; for patients with application time of 47 min or shorter, the score was comparable with the mean pain scores of the control group ( P = 0.215). Conclusions Removal of the metal skin staples after total knee arthroplasty is associated with moderate-to-severe pain. The lidocaine patch applied topically around the surgical wound could effectively reduce the pain during the procedure, without remarkable complications such as systemic adverse effects or wound contamination. [ABSTRACT FROM AUTHOR]

Introduction: Transurethral surgery of the prostate is currently the gold standard treatment modality for patients with benign prostatic hyperplasia (BPH) with recurrent acute urinary retention. This study aimed to evaluate the outcome and predictors of patients receiving immediate surgery after acute urinary retention (AUR) episodes. Materials and Methods: From January 2016 to January 2017, we retrospectively included 714 patients who received transurethral surgery of prostate due to BPH. Among them, 158 patients received surgeries immediately after an AUR episode. General characteristics data including age, Body mass index (BMI), International prostate symptom score (IPSS score), prostate volume and Prostate-specific antigen (PSA) were reviewed. We also collected surgery-related parameters including surgical types, operation time, and specimen weight. Resection ratio was defined as (resected specimen weight)/(Transurethral ultrasound (TRUS) volume). The catheterization status on discharge, post-operative medication for BPH, and AUR within 3 months after operation were evaluated. Statistical analysis was performed with Statistical product and service solutions (SPSS). Results: The mean age of the patients was 73.5 years, with a BMI of 24 kg/m2. IPSS total score was 25 with a Voiding symptom/Storage symptom score (V/S score) of 14.6 and 10.4, respectively. A total of 74 (46.8%) patients still took medication for BPH for over 1 month after the surgeries, 28 (17.7%) patients were not catheter-free at the time of discharge, and 14 (8.9%) patients had AUR within 3 months after the surgeries. Surgical type did not impact the outcome of surgeries. In patients who received Transurethral resection of the prostate (TURP), the resection ratio is the only predictor for the catheterization status on discharge and post-operative medication for BPH within 3 months after operation. Conclusions: In patients with BPH-related AUR followed by immediate transurethral surgeries, more radical resection is significantly correlated with short-term medication-free and catheter-free status. [ABSTRACT FROM AUTHOR]