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1. Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds

Author

Yun, Hyun-Ho, primary, Kim, Seong-Gon, additional, Park, Se-Il, additional, Jo, Woori, additional, Kang, Kyung-Ku, additional, Lee, Eun-Joo, additional, Kim, Dong-Kyu, additional, Jung, Hoe-Su, additional, Son, Ji-Yoon, additional, Park, Jae-Min, additional, Park, Hyun-Sook, additional, Lee, Sunray, additional, Shin, Hong-In, additional, Hong, Il-Hwa, additional, and Jeong, Kyu-Shik, additional

Published
2023
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3. Whitening and moisturizing enhancing effects of three‐dimensional human adipose‐derived mesenchymal stem cell‐conditioned medium‐containing cream.

Author

Kim, Kyung Hye, Lee, Sunray, and Bae, Seunghee

Subjects
*STEM cell culture, *COLD weather conditions, *SKIN care, *HYALURONIC acid
Abstract

Background: High‐functional cosmetic products combined with the concept of "treatment" cosmetics are being introduced to the market. Cosmetic products containing a skin‐derived microbiome, a three‐dimensional (3D) stem cell culture medium, and low‐molecular‐weight collagen are being introduced, and these products are leading the cosmeceutical market. We aimed to confirm the potential of a 3D stem cell culture medium‐containing cream as a skin‐whitening and moisturizing product. Aim: To determine the enhancing effects of a cream containing 3D adipose tissue‐derived mesenchymal stem cell‐conditioned media (3D ADMSC‐CM) on whitening and moisturization. Methods: The inhibitory activities of tyrosinase (TYR) and melanin were confirmed using 3D ADMSC‐CM. Furthermore, hyaluronic acid expression in 3D ADMSC‐CM was verified. The clinical efficacy of the cream containing 3D ADMSC‐CM was established by evaluating its antioxidant properties and effects on skin tone, radiance, freckles, and moisturization. Results: The use of 3D ADMSC‐CM suppressed the inhibitory effects of TYR and melanin by approximately 24% and 33%, respectively, and increased the expression of hyaluronic acid synthase. A significant difference was observed after 4 weeks of using 3D ADMSC‐CM in the skin antioxidant evaluation. After 2 and 4 weeks of use, skin tone and radiance increased and skin freckles decreased significantly. Under extremely cold and dry weather conditions, the use of the cream increased skin moisturization. Conclusions: The 3D ADMSC‐CM cream evaluated in an environment similar to the human body was found to enhance skin whitening and moisturization and can therefore be used in the skin care and cosmetic industries as a biocosmetic product. [ABSTRACT FROM AUTHOR]

Published
2023
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5. In Vitro Tracking of Human Umbilical Vein Endothelial Cells Using Ultra-Sensitive Quantum Dot-Embedded Silica Nanoparticles

Author

Kim, Jaehi, primary, Lee, Sunray, additional, Lee, Yeon Kyung, additional, Seong, Bomi, additional, Kim, Hyung-Mo, additional, Kyeong, San, additional, Kim, Wooyeon, additional, Ham, Kyeongmin, additional, Pham, Xuan-Hung, additional, Hahm, Eunil, additional, Mun, Ji Yeon, additional, Safaa, Mukhtar Anthony, additional, Lee, Yoon-Sik, additional, Jun, Bong-Hyun, additional, and Park, Hyun-Sook, additional

Published
2023
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6. Comparison of guidelines for biological ancillary materials used for the manufacture of gene and cellular therapy products in Asia

Author

Tanaka, Toshimitsu, primary, Yoshimura, Keiji, additional, Chang, Ryan, additional, Choi, Bryan, additional, Gai, Ying, additional, Gupta, Pawan Kumar, additional, Kolkundkar, Udaykumar, additional, Lee, Shing-Mou, additional, Lee, Sunray, additional, Liao, Wenbin, additional, Zhao, Xiang, additional, and Takakura, Koji, additional

Published
2023
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15. Cover Image, Volume 22, Issue 8

Author

Park, Sung Bum, primary, Koh, Byumseok, additional, Jung, Won Hoon, additional, Choi, Kyoung Jin, additional, Na, Yoon Ju, additional, Yoo, Hee Min, additional, Lee, Sunray, additional, Kang, Dukjin, additional, Lee, Dong‐Mok, additional, and Kim, Ki Young, additional

Published
2020
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24. Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives

Author

Nazor, Kristopher L., primary, Altun, Gulsah, additional, Lynch, Candace, additional, Tran, Ha, additional, Harness, Julie V., additional, Slavin, Ileana, additional, Garitaonandia, Ibon, additional, Müller, Franz-Josef, additional, Wang, Yu-Chieh, additional, Boscolo, Francesca S., additional, Fakunle, Eyitayo, additional, Dumevska, Biljana, additional, Lee, Sunray, additional, Park, Hyun Sook, additional, Olee, Tsaiwei, additional, D'Lima, Darryl D., additional, Semechkin, Ruslan, additional, Parast, Mana M., additional, Galat, Vasiliy, additional, Laslett, Andrew L., additional, Schmidt, Uli, additional, Keirstead, Hans S., additional, Loring, Jeanne F., additional, and Laurent, Louise C., additional

Published
2012
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25. Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

Author

Laurent, Louise C., primary, Ulitsky, Igor, additional, Slavin, Ileana, additional, Tran, Ha, additional, Schork, Andrew, additional, Morey, Robert, additional, Lynch, Candace, additional, Harness, Julie V., additional, Lee, Sunray, additional, Barrero, Maria J., additional, Ku, Sherman, additional, Martynova, Marina, additional, Semechkin, Ruslan, additional, Galat, Vasiliy, additional, Gottesfeld, Joel, additional, Belmonte, Juan Carlos Izpisua, additional, Murry, Chuck, additional, Keirstead, Hans S., additional, Park, Hyun-Sook, additional, Schmidt, Uli, additional, Laslett, Andrew L., additional, Muller, Franz-Josef, additional, Nievergelt, Caroline M., additional, Shamir, Ron, additional, and Loring, Jeanne F., additional

Published
2011
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26. P55. Differentiated umbilical cord mesenchymal stem cells as a therapeutic resource

Author

Kim Sun Young, Lee， Sunray, and Hyun-Sook Park

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Cellular differentiation, fungi, Mesenchymal stem cell, Liver failure, Cell Biology, Biology, behavioral disciplines and activities, Umbilical cord, humanities, Cord lining, body regions, Transplantation, medicine.anatomical_structure, Immunology, medicine, Liver function, human activities, Molecular Biology, Developmental Biology
Abstract

In our present study, human umbilical cord mesenchymal stem cells (UCMSCs) were utilized for their immaturity. Expression of differentiated UCMSCs (dif-UCMSCs) makers was confirmed with RT-PCR, immunocytochemical assay. The dif-UCMSCs were transplanted into the chronic damaged mice livers. The secreted ALB in the damaged mice was as increased as non-damaged mice after dif-UCMSCs injection, while the mice with non- dif-UCMSCs were not recovered. Our results suggested that dif-UCMSCs were able to recover liver function of damaged mice. UCMSCs-derived differentiated cell transplantation could be promising alternative way of therapeutic option for liver failure.

Published
2010

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