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450 results on '"Lee, Suk‐Hee"'

7. UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

Author

Moore, Carlene, Cevikbas, Ferda, Pasolli, H Amalia, Chen, Yong, Kong, Wei, Kempkes, Cordula, Parekh, Puja, Lee, Suk Hee, Kontchou, Nelly-Ange, Yeh, Iwei, Jokerst, Nan Marie, Fuchs, Elaine, Steinhoff, Martin, and Liedtke, Wolfgang B

Subjects
Climate-Related Exposures and Conditions, Chronic Pain, Pain Research, 1.1 Normal biological development and functioning, Underpinning research, Skin, Analysis of Variance, Animals, Cells, Cultured, Endothelin-1, Epithelial Cells, Immunohistochemistry, Mice, Mice, Transgenic, Microscopy, Electron, Pain, Signal Transduction, Sunburn, TRPV Cation Channels, Ultraviolet Rays, calcium-permeable channels, epithelial-neuronal cross-talk, photodermatitis, phototransduction, epithelial–neuronal cross-talk
Abstract

At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells and known to function in sensory transduction, a property shared with other transient receptor potential channels. We show that following UVB exposure mice with induced Trpv4 deletions, specifically in keratinocytes, are less sensitive to noxious thermal and mechanical stimuli than control animals. Exploring the mechanism, we find that epidermal TRPV4 orchestrates UVB-evoked skin tissue damage and increased expression of the proalgesic/algogenic mediator endothelin-1. In culture, UVB causes a direct, TRPV4-dependent Ca(2+) response in keratinocytes. In mice, topical treatment with a TRPV4-selective inhibitor decreases UVB-evoked pain behavior, epidermal tissue damage, and endothelin-1 expression. In humans, sunburn enhances epidermal expression of TRPV4 and endothelin-1, underscoring the potential of keratinocyte-derived TRPV4 as a therapeutic target for UVB-induced sunburn, in particular pain.

Published
2013

11. Supplementary Figures 1 - 4 from Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy

Author

Williamson, Elizabeth A., primary, Damiani, Leah, primary, Leitao, Andrei, primary, Hu, Chelin, primary, Hathaway, Helen, primary, Oprea, Tudor, primary, Sklar, Larry, primary, Shaheen, Montaser, primary, Bauman, Julie, primary, Wang, Wei, primary, Nickoloff, Jac A., primary, Lee, Suk-Hee, primary, and Hromas, Robert, primary

Published
2023
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12. Supplementary Tables 1-10, Figures 1-6, Methods from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

Author

Kurek, Kyle C., primary, Del Mare, Sara, primary, Salah, Zaidoun, primary, Abdeen, Suhaib, primary, Sadiq, Hussain, primary, Lee, Suk-hee, primary, Gaudio, Eugenio, primary, Zanesi, Nicola, primary, Jones, Kevin B., primary, DeYoung, Barry, primary, Amir, Gail, primary, Gebhardt, Mark, primary, Warman, Matthew, primary, Stein, Gary S., primary, Stein, Janet L., primary, Lian, Jane B., primary, and Aqeilan, Rami I., primary

Published
2023
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13. Data from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

Author

Kurek, Kyle C., primary, Del Mare, Sara, primary, Salah, Zaidoun, primary, Abdeen, Suhaib, primary, Sadiq, Hussain, primary, Lee, Suk-hee, primary, Gaudio, Eugenio, primary, Zanesi, Nicola, primary, Jones, Kevin B., primary, DeYoung, Barry, primary, Amir, Gail, primary, Gebhardt, Mark, primary, Warman, Matthew, primary, Stein, Gary S., primary, Stein, Janet L., primary, Lian, Jane B., primary, and Aqeilan, Rami I., primary

Published
2023
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21. PARP1 is required for chromosomal translocations

Author

Wray, Justin, Williamson, Elizabeth A., Singh, Sudha B., Wu, Yuehan, Cogle, Christopher R., Weinstock, David M., Zhang, Yu, Lee, Suk-Hee, Zhou, Daohong, Shao, Lijian, Hauer-Jensen, Martin, Pathak, Rupak, Klimek, Virginia, Nickoloff, Jac A., and Hromas, Robert

Published
2013
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22. Machine learning application for classification of Alzheimer's disease stages using 18F-flortaucipir positron emission tomography.

Author

Park, Sang Won, Yeo, Na Young, Lee, Jinsu, Lee, Suk-Hee, Byun, Junghyun, Park, Dong Young, Yum, Sujin, Kim, Jung-Kyeom, Byeon, Gihwan, Kim, Yeshin, and Jang, Jae-Won

Subjects
POSITRON emission tomography, ENTORHINAL cortex, ALZHEIMER'S disease, BOOSTING algorithms, MACHINE learning, RECEIVER operating characteristic curves, DISEASE progression
Abstract

Background: The progression of Alzheimer's dementia (AD) can be classified into three stages: cognitive unimpairment (CU), mild cognitive impairment (MCI), and AD. The purpose of this study was to implement a machine learning (ML) framework for AD stage classification using the standard uptake value ratio (SUVR) extracted from 18F-flortaucipir positron emission tomography (PET) images. We demonstrate the utility of tau SUVR for AD stage classification. We used clinical variables (age, sex, education, mini-mental state examination scores) and SUVR extracted from PET images scanned at baseline. Four types of ML frameworks, such as logistic regression, support vector machine (SVM), extreme gradient boosting, and multilayer perceptron (MLP), were used and explained by Shapley Additive Explanations (SHAP) to classify the AD stage. Results: Of a total of 199 participants, 74, 69, and 56 patients were in the CU, MCI, and AD groups, respectively; their mean age was 71.5 years, and 106 (53.3%) were men. In the classification between CU and AD, the effect of clinical and tau SUVR was high in all classification tasks and all models had a mean area under the receiver operating characteristic curve (AUC) > 0.96. In the classification between MCI and AD, the independent effect of tau SUVR in SVM had an AUC of 0.88 (p < 0.05), which was the highest compared to other models. In the classification between MCI and CU, the AUC of each classification model was higher with tau SUVR variables than with clinical variables independently, which yielded an AUC of 0.75(p < 0.05) in MLP, which was the highest. As an explanation by SHAP for the classification between MCI and CU, and AD and CU, the amygdala and entorhinal cortex greatly affected the classification results. In the classification between MCI and AD, the para-hippocampal and temporal cortex affected model performance. Especially entorhinal cortex and amygdala showed a higher effect on model performance than all clinical variables in the classification between MCI and CU. Conclusions: The independent effect of tau deposition indicates that it is an effective biomarker in classifying CU and MCI into clinical stages using MLP. It is also very effective in classifying AD stages using SVM with clinical information that can be easily obtained at clinical screening. [ABSTRACT FROM AUTHOR]

Published
2023
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24. A Look into a Mother’s Fetal and Infant Care

Author

Kim Cholong, Kwon， Mee Ryang, and Lee， Suk Hee

Subjects
Fetus, medicine.medical_specialty, business.industry, Obstetrics, Infant Care, Medicine, business
Published
2020

27. Impact of the COVID-19 on Emergency Department Workload and Emergency Care Workers’ Psychosocial Stress in a Local Pandemic Area

Author

Yeo, In-Hwan, Kim, Yun-Jeong, Kim, Jong-Kun, Lee, Dong-Eun, Choe, Jae-Young, Kim, Chang-Ho, Park, Jung-Bae, Seo, Kang-Suk, Park, Sin-Yul, Lee, Suk-Hee, Cho, Jae-Kyung, and Lee, Sang-Hun

Subjects
emergency department, healthcare workers, depression, COVID-19, post-traumatic stress disorder, anxiety, humanities
Abstract

Background and Objectives: Due to the unexpected spread of coronavirus disease 2019 (COVID-19), there was a serious crisis of emergency medical system collapse. Healthcare workers working in the emergency department were faced with psychosocial stress and workload changes. Materials and Methods: This was a cross-sectional survey of healthcare workers in the emergency department in Daegu and Gyeongbuk, Korea, from November 16 to 25, 2020. In the survey, we assessed the general characteristics of the respondents, changes in the working conditions before and after the COVID-19 pandemic, and resulting post-traumatic stress disorder, depression and anxiety statuses using 49 questions. Results: A total of 529 responses were collected, and 520 responses were included for the final analyses. Changes in working conditions and other factors due to COVID-19 varied by emergency department level, region and disease group. Working hours, intensity, role changes, depression and anxiety scores were higher in the higher level emergency department. Isolation ward insufficiency and the risk of infection felt by healthcare workers tended to increase in the lower level emergency department. Treatment and transfer delay were higher in the fever and respiratory disease groups (M = 3.58, SD = 1.18, M = 4.08, SD = 0.95), respectively. In all the disease groups, both treatment and transfer were delayed more in Gyeongbuk than in Daegu. Conclusions: Different goals should be pursued by the levels and region of the emergency department to overcome the effects of the COVID-19 pandemic and promote optimal care.

Published
2021
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28. Impact of the COVID-19 Pandemic on Emergency Department Workload and Emergency Care Workers’ Psychosocial Stress in the Outbreak Area

Author

Yeo, In-Hwan, primary, Kim, Yun-Jeong, additional, Kim, Jong-Kun, additional, Lee, Dong-Eun, additional, Choe, Jae-Young, additional, Kim, Chang-Ho, additional, Park, Jung-Bae, additional, Seo, Kang-Suk, additional, Park, Sin-Yul, additional, Lee, Suk-Hee, additional, Cho, Jae-Kyung, additional, and Lee, Sang-Hun, additional

Published
2021
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50. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2

Author

Young, Daniel W., Hassan, Mohammad Q., Pratap, Jitesh, Galindo, Mario, Zaidi, Sayyed K., Lee, Suk-hee, Yang, Xiaoqing, Xie, Ronglin, Javed, Amjad, Underwood, Jean M., Furcinitti, Paul, Imbalzano, Anthony N., Penman, Sheldon, Nickerson, Jeffrey A., Montecino, Martin A., Lian, Jane B., Stein, Janet L., van Wijnen, Andre J., and Stein, Gary S.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Daniel W. Young [1, 5, 6]; Mohammad Q. Hassan [1, 6]; Jitesh Pratap [1]; Mario Galindo [1, 5]; Sayyed K. Zaidi [1]; Suk-hee Lee [1]; Xiaoqing Yang [1]; Ronglin [...]

Published
2007
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