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140 results on '"Lee, Simon M. Y."'

9. The first chromosome-level genome for a marine mammal as a resource to study ecology and evolution

Author

Fan, Guangyi, Zhang, Yaolei, Liu, Xiaochuan, Wang, Jiahao, Sun, Zeguo, Sun, Shuai, Zhang, He, Chen, Jianwei, Lv, Meiqi, Han, Kai, Tan, Xiaoxuan, Hu, Jie, Guan, Rui, Fu, Yuanyuan, Liu, Shanshan, Chen, Xi, Xu, Qiwu, Qin, Yating, Liu, Longqi, Bai, Jie, Wang, Ou, Tang, Jingbo, Lu, Haorong, Shang, Zhouchun, Wang, Bo, Hu, Guohai, Zhao, Xia, Zou, Yan, Chen, Ao, Gong, Meihua, Zhang, Wenwei, Lee, Simon M.-Y., Li, Songhai, Liu, Junnian, Li, Zhen, Lu, Yishan, Sabir, Jamal S. M., Sabir, Mumdooh J., Khan, Muhummadh, Hajrah, Nahid H., Yin, Ye, Kristiansen, Karsten, Yang, Huanming, Wang, Jian, Xu, Xun, Liu, Xin, Fan, Guangyi, Zhang, Yaolei, Liu, Xiaochuan, Wang, Jiahao, Sun, Zeguo, Sun, Shuai, Zhang, He, Chen, Jianwei, Lv, Meiqi, Han, Kai, Tan, Xiaoxuan, Hu, Jie, Guan, Rui, Fu, Yuanyuan, Liu, Shanshan, Chen, Xi, Xu, Qiwu, Qin, Yating, Liu, Longqi, Bai, Jie, Wang, Ou, Tang, Jingbo, Lu, Haorong, Shang, Zhouchun, Wang, Bo, Hu, Guohai, Zhao, Xia, Zou, Yan, Chen, Ao, Gong, Meihua, Zhang, Wenwei, Lee, Simon M.-Y., Li, Songhai, Liu, Junnian, Li, Zhen, Lu, Yishan, Sabir, Jamal S. M., Sabir, Mumdooh J., Khan, Muhummadh, Hajrah, Nahid H., Yin, Ye, Kristiansen, Karsten, Yang, Huanming, Wang, Jian, Xu, Xun, and Liu, Xin

Published
2019

10. The first chromosome‐level genome for a marine mammal as a resource to study ecology and evolution

Author

Fan, Guangyi, primary, Zhang, Yaolei, additional, Liu, Xiaochuan, additional, Wang, Jiahao, additional, Sun, Zeguo, additional, Sun, Shuai, additional, Zhang, He, additional, Chen, Jianwei, additional, Lv, Meiqi, additional, Han, Kai, additional, Tan, Xiaoxuan, additional, Hu, Jie, additional, Guan, Rui, additional, Fu, Yuanyuan, additional, Liu, Shanshan, additional, Chen, Xi, additional, Xu, Qiwu, additional, Qin, Yating, additional, Liu, Longqi, additional, Bai, Jie, additional, Wang, Ou, additional, Tang, Jingbo, additional, Lu, Haorong, additional, Shang, Zhouchun, additional, Wang, Bo, additional, Hu, Guohai, additional, Zhao, Xia, additional, Zou, Yan, additional, Chen, Ao, additional, Gong, Meihua, additional, Zhang, Wenwei, additional, Lee, Simon M.‐Y., additional, Li, Songhai, additional, Liu, Junnian, additional, Li, Zhen, additional, Lu, Yishan, additional, Sabir, Jamal S. M., additional, Sabir, Mumdooh J., additional, Khan, Muhummadh, additional, Hajrah, Nahid H., additional, Yin, Ye, additional, Kristiansen, Karsten, additional, Yang, Huanming, additional, Wang, Jian, additional, Xu, Xun, additional, and Liu, Xin, additional

Published
2019
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18. Universal target‐enrichment baits for anthozoan (Cnidaria) phylogenomics: New approaches to long‐standing problems

Author

Quattrini, Andrea M., primary, Faircloth, Brant C., additional, Dueñas, Luisa F., additional, Bridge, Tom C. L., additional, Brugler, Mercer R., additional, Calixto‐Botía, Iván F., additional, DeLeo, Danielle M., additional, Forêt, Sylvain, additional, Herrera, Santiago, additional, Lee, Simon M. Y., additional, Miller, David J., additional, Prada, Carlos, additional, Rádis‐Baptista, Gandhi, additional, Ramírez‐Portilla, Catalina, additional, Sánchez, Juan A., additional, Rodríguez, Estefanía, additional, and McFadden, Catherine S., additional

Published
2017
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19. Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia

Author

Law, Henry C. H., primary, Szeto, Samuel S. W., additional, Quan, Quan, additional, Zhao, Yun, additional, Zhang, Zaijun, additional, Krakovska, Olga, additional, Lui, Leong Ting, additional, Zheng, Chengyou, additional, Lee, Simon M.-Y., additional, Siu, K. W. Michael, additional, Wang, Yuqiang, additional, and Chu, Ivan K., additional

Published
2017
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24. Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[n]uril (n= 7, 8)

Author

Yin, Hang, Huang, Qiaoxian, Zhao, Wenwen, Bardelang, David, Siri, Didier, Chen, Xiuping, Lee, Simon M. Y., and Wang, Ruibing

Abstract

This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host–guest chemistry and its potential applications in pharmaceutical chemistry.

Published
2024
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25. Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

Author

Zhang, Zaijun, primary, Zhang, Gaoxiao, additional, Sun, Yewei, additional, Szeto, Samuel S. W., additional, Law, Henry C. H., additional, Quan, Quan, additional, Li, Guohui, additional, Yu, Pei, additional, Sho, Eiketsu, additional, Siu, Michael K. W., additional, Lee, Simon M. Y., additional, Chu, Ivan K., additional, and Wang, Yuqiang, additional

Published
2016
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26. Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods

Author

Zhou, Xuelin, primary, Choi, Pou Seng, additional, Yang, Jia-Ming, additional, Or, Penelope M. Y., additional, Hoi, Pui Man, additional, Lee, Simon M. Y., additional, Leung, George P. H., additional, Ngai, Sai Ming, additional, Kong, Siu Kai, additional, Ho, Ho Pui, additional, Wong, Melody Y. M., additional, Chan, Shun Wan, additional, Yeung, John H. K., additional, and Kwan, Yiu Wa, additional

Published
2016
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29. Universal target‐enrichment baits for anthozoan (Cnidaria) phylogenomics: New approaches to long‐standing problems.

Author

Quattrini, Andrea M., Faircloth, Brant C., Dueñas, Luisa F., Bridge, Tom C. L., Brugler, Mercer R., Calixto‐Botía, Iván F., DeLeo, Danielle M., Forêt, Sylvain, Herrera, Santiago, Lee, Simon M. Y., Miller, David J., Prada, Carlos, Rádis‐Baptista, Gandhi, Ramírez‐Portilla, Catalina, Sánchez, Juan A., Rodríguez, Estefanía, and McFadden, Catherine S.

Subjects
ANTHOZOA, PHYLOGENY, NUCLEOTIDE sequencing, GENETIC markers, ALCYONIUM
Abstract

Abstract: Anthozoans (e.g., corals, anemones) are an ecologically important and diverse group of marine metazoans that occur from shallow to deep waters worldwide. However, our understanding of the evolutionary relationships among the ~7,500 species within this class is hindered by the lack of phylogenetically informative markers that can be reliably sequenced across a diversity of taxa. We designed and tested 16,306 RNA baits to capture 720 ultraconserved element loci and 1,071 exon loci. Library preparation and target enrichment were performed on 33 taxa from all orders within the class Anthozoa. Following Illumina sequencing and Trinity assembly, we recovered 1,774 of 1,791 targeted loci. The mean number of loci recovered from each species was 638 ± 222, with more loci recovered from octocorals (783 ± 138 loci) than hexacorals (475 ± 187 loci). Parsimony informative sites ranged from 26 to 49% for alignments at differing hierarchical taxonomic levels (e.g., Anthozoa, Octocorallia, Hexacorallia). The per cent of variable sites within each of three genera (Acropora, Alcyonium, and Sinularia) for which multiple species were sequenced ranged from 4.7% to 30%. Maximum‐likelihood analyses recovered highly resolved trees with topologies matching those supported by other studies, including the monophyly of the order Scleractinia. Our results demonstrate the utility of this target‐enrichment approach to resolve phylogenetic relationships from relatively old to recent divergences. Redesigning the baits with improved affinities to capture loci within each subclass will provide a valuable toolset to address systematic questions, further our understanding of the timing of diversifications and help resolve long‐standing controversial relationships in the class Anthozoa. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Constraining the Teratogenicity of Pesticide Pollution by a Synthetic Nanoreceptor.

Author

Yang, Xue, Li, Shengke, Wang, Ziyi, Lee, Simon M. Y., Wang, Lian‐Hui, and Wang, Ruibing

Subjects
TERATOGENICITY testing, PESTICIDE pollution, CUCURBITURIL, PHENOL oxidase, ZEBRA danio
Abstract

The teratogenicity of the pesticide nereistoxin (NTX) and its derivative thiocyclam (THI) towards aquatic life was dramatically constrained by a synthetic nanoreceptor, cucurbit[7]uril, through selective encapsulation of the pesticides ( KCB[7]-NTX of 3.24(±0.31)×106 m−1 and KCB[7]-THI of 7.46(±0.10)×105 m−1), as evidenced by the rate of hatchability, morphology development, and tyrosinase activity of zebrafish larvae incubated with the pesticides (3-300 μ m) in the absence and in the presence of 300 μ m cucurbit[7]uril, demonstrating the significant potential of the nanoreceptor in managing ecological pollution of these pesticides. [ABSTRACT FROM AUTHOR]

Published
2018
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35. A versatile reversed phase-strong cation exchange-reversed phase (RP–SCX–RP) multidimensional liquid chromatography platform for qualitative and quantitative shotgun proteomics

Author

Law, Henry C. H., primary, Kong, Ricky P. W., additional, Szeto, Samuel S. W., additional, Zhao, Yun, additional, Zhang, Zaijun, additional, Wang, Yuqiang, additional, Li, Guohui, additional, Quan, Quan, additional, Lee, Simon M. Y., additional, Lam, Herman C., additional, and Chu, Ivan K., additional

Published
2015
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37. Sailuotong Prevents Hydrogen Peroxide (H2O2)-Induced Injury in EA.hy926 Cells.

Author

Sai Wang Seto, Chang, Dennis, Wai Man Ko, Xian Zhou, Hosen Kiat, Bensoussan, Alan, Lee, Simon M. Y., Hoi, Maggie P. M., Steiner, Genevieve Z., and Jianxun Liu

Subjects
THERAPEUTIC use of ginseng, VASCULAR dementia, CELLULAR mechanics, HYDROGEN peroxide, OXIDATIVE stress, CELL death, THERAPEUTICS
Abstract

Sailuotong (SLT) is a standardised three-herb formulation consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus designed for the management of vascular dementia. While the latest clinical trials have demonstrated beneficial effects of SLT in vascular dementia, the underlying cellular mechanisms have not been fully explored. The aim of this study was to assess the ability and mechanisms of SLT to act against hydrogen peroxide (H2O2)-induced oxidative damage in cultured human vascular endothelial cells (EAhy926). SLT (1-50 µg/mL) significantly suppressed the H2O2-induced cell death and abolished the H2O2-induced reactive oxygen species (ROS) generation in a concentration-dependent manner. Similarly, H2O2 (0.5 mM; 24 h) caused a ~2-fold increase in lactate dehydrogenase (LDH) release from the EA.hy926 cells which were significantly suppressed by SLT (1-50 µg/mL) in a concentration-dependent manner. Incubation of SLT (50 µg/mL) increased superoxide dismutase (SOD) activity and suppressed the H2O2-enhanced Bax/Bcl-2 ratio and cleaved caspase-3 expression. In conclusion, our results suggest that SLT protects EA.hy916 cells against H2O2-mediated injury via direct reduction of intracellular ROS generation and an increase in SOD activity. These protective effects are closely associated with the inhibition of the apoptotic death cascade via the suppression of caspase-3 activation and reduction of Bax/Bcl-2 ratio, thereby indicating a potential mechanism of action for the clinical effects observed. [ABSTRACT FROM AUTHOR]

Published
2017
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39. Transcriptome Analysis in Venom Gland of the Predatory Giant Ant Dinoponera quadriceps: Insights into the Polypeptide Toxin Arsenal of Hymenopterans

Author

Torres, Alba F. C., primary, Huang, Chen, additional, Chong, Cheong-Meng, additional, Leung, Siu Wai, additional, Prieto-da-Silva, Álvaro R. B., additional, Havt, Alexandre, additional, Quinet, Yves P., additional, Martins, Alice M. C., additional, Lee, Simon M. Y., additional, and Rádis-Baptista, Gandhi, additional

Published
2014
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46. Transcriptome Analysis in Venom Gland of the Predatory Giant Ant Dinoponera quadriceps: Insights into the Polypeptide Toxin Arsenal of Hymenopterans.

Author

Torres, Alba F. C., Huang, Chen, Chong, Cheong-Meng, Leung, Siu Wai, Prieto-da-Silva, Álvaro R. B., Havt, Alexandre, Quinet, Yves P., Martins, Alice M. C., Lee, Simon M. Y., and Rádis-Baptista, Gandhi

Subjects
VENOM glands, MYRMECOPHAGA, PREDATION, POLYPEPTIDES, HYMENOPTERA, PATHOLOGICAL physiology
Abstract

Background: Dinoponera quadriceps is a predatory giant ant that inhabits the Neotropical region and subdues its prey (insects) with stings that deliver a toxic cocktail of molecules. Human accidents occasionally occur and cause local pain and systemic symptoms. A comprehensive study of the D. quadriceps venom gland transcriptome is required to advance our knowledge about the toxin repertoire of the giant ant venom and to understand the physiopathological basis of Hymenoptera envenomation. Results: We conducted a transcriptome analysis of a cDNA library from the D. quadriceps venom gland with Sanger sequencing in combination with whole-transcriptome shotgun deep sequencing. From the cDNA library, a total of 420 independent clones were analyzed. Although the proportion of dinoponeratoxin isoform precursors was high, the first giant ant venom inhibitor cysteine-knot (ICK) toxin was found. The deep next generation sequencing yielded a total of 2,514,767 raw reads that were assembled into 18,546 contigs. A BLAST search of the assembled contigs against non-redundant and Swiss-Prot databases showed that 6,463 contigs corresponded to BLASTx hits and indicated an interesting diversity of transcripts related to venom gene expression. The majority of these venom-related sequences code for a major polypeptide core, which comprises venom allergens, lethal-like proteins and esterases, and a minor peptide framework composed of inter-specific structurally conserved cysteine-rich toxins. Both the cDNA library and deep sequencing yielded large proportions of contigs that showed no similarities with known sequences. Conclusions: To our knowledge, this is the first report of the venom gland transcriptome of the New World giant ant D. quadriceps. The glandular venom system was dissected, and the toxin arsenal was revealed; this process brought to light novel sequences that included an ICK-folded toxins, allergen proteins, esterases (phospholipases and carboxylesterases), and lethal-like toxins. These findings contribute to the understanding of the ecology, behavior and venomics of hymenopterans. [ABSTRACT FROM AUTHOR]

Published
2014
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47. Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase.

Author

Wei Cui, Zaijun Zhang, Wenming Li, Shinghung Mak, Shengquan Hu, Huan Zhang, Shuai Yuan, Jianhui Rong, Choi, Tony Chunglit, Lee, Simon M. Y., Yifan Han, and Vitorica, Javier

Subjects
NITRIC-oxide synthases, VASCULAR endothelial growth factor receptors, CANCER treatment, APOPTOSIS, NEUROTOXICOLOGY, DOPAMINERGIC neurons
Abstract

SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR- 2) for cancer therapy. In this study, we have found for the first time that SU5416 unexpectedly prevented 1-methyl-4- phenylpyridinium ion (MPP+ )-induced neuronal apoptosis in cerebellar granule neurons, and decreased 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP)-induced loss of dopaminergic neurons and impairment of swimming behavior in zebrafish in a concentration-dependent manner. However, VEGFR-2 kinase inhibitor II, another specific VEGFR-2 inhibitor, failed to reverse neurotoxicity at the concentration exhibiting anti-angiogenic activity, strongly suggesting that the neuroprotective effect of SU5416 is independent from its anti-angiogenic action. SU5416 potently reversed MPP+ -increased intracellular nitric oxide level with an efficacy similar to 7-nitroindazole, a specific neuronal nitric oxide synthase (nNOS) inhibitor. Western blotting analysis showed that SU5416 reduced the elevation of nNOS protein expression induced by MPP+ . Furthermore, SU5416 directly inhibited the enzyme activity of rat cerebellum nNOS with an IC50 value of 22.7 µM. In addition, knock-down of nNOS expression using short hairpin RNA (shRNA) abolished the neuroprotective effects of SU5416 against MPP+ -induced neuronal loss. Our results strongly demonstrate that SU5416 might exert its unexpected neuroprotective effects by concurrently reducing nNOS protein expression and directly inhibiting nNOS enzyme activity. In view of the capability of SU5416 to cross the blood-brain barrier and the safety for human use, our findings further indicate that SU5416 might be a novel drug candidate for neurodegenerative disorders, particularly those associated with NO-mediated neurotoxicity. [ABSTRACT FROM AUTHOR]

Published
2012
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49. New Perspective on the Dual Functions of Indirubins in Cancer Therapy and Neuroprotection

Author

Wang, Ying, Hoi, Pui Man, Chan, Judy Yuet-Wa, and Lee, Simon M.-Y.

Abstract

Indirubin is an active ingredient mainly used to treat leukemia in China and is reported to be a leading inhibitor of cyclindependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) by competing with ATP binding sites. New findings have indicated that its comprehensive structure may contribute to its polypharmacological activities particularly in cancer and neurodegenerative disease therapy, as both of these diseases are usually accompanied by a common molecular link related to abnormal phosphorylation of CDKs and GSK-3. In the elderly, cancer and neurodegenerative disease are tightly associated common diseases and sometimes unavoidably coexist. In this review, the underlying mechanisms of the dual actions of indirubin and its structurally-related compounds in cancer and neurodegenerative disease therapy are presented.

Published
2014

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