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129 results on '"Lee, Sanghoo"'

12. Identification of Single Nucleotide Polymorphisms as Biomarkers for Recurrent Pregnancy Loss in Korean Women

Author

Kim, Hye In, primary, Choi, Eun A, additional, Paik, Eun Chan, additional, Park, Soohyeon, additional, Hwang, Yu Im, additional, Lee, Jae Hoon, additional, Seo, Seok Kyo, additional, Cho, SiHyun, additional, Choi, Young Sik, additional, Lee, Byung Seok, additional, Park, Jimyeong, additional, Lee, Sanghoo, additional, Lee, Kyoung-Ryul, additional, and Yun, Bo Hyon, additional

Published
2022
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15. sj-pdf-1-inq-10.1177_00469580211065684 ��� Supplemental Material for Trend Analysis of the Profiles of 12 Sexually Transmitted Disease Pathogens in the Republic of Korea in 2019

Author

Park, Hye-Jee, Kim, Yun-Tae, Moon, Ju Young, Jin, Choong Eun, Ko, Ki-Han, Lee, Seung-hyun, Min, Okgi, Je, Young Soo, Lee, Mikyeong, Lee, Sanghoo, Kim, Young-Jin, and Lee, Kyoung-Ryul

Subjects
111099 Nursing not elsewhere classified, FOS: Health sciences
Abstract

Supplemental Material, sj-pdf-1-inq-10.1177_00469580211065684 for Trend Analysis of the Profiles of 12 Sexually Transmitted Disease Pathogens in the Republic of Korea in 2019 by Hye-Jee Park, Yun-Tae Kim, Ju Young Moon, Choong Eun Jin, Ki-Han Ko, Seung-hyun Lee, Okgi Min, Mikyeong Lee, Sanghoo Lee, Young-Jin Kim and Kyoung-Ryul Lee in INQUIRY: The Journal of Health Care Organization, Provision, and Financing

Published
2021
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24. Genetic Diversity of Insulin Resistance and Metabolic Syndrome

Author

Lee, Sanghoo, Lee, Kyoung-Ryul, Hong, Gayeon, Kim, Yejin, Lee, Youngkee, Na, Hyeonkyun, Ahn, Jinwoo, and Park, Jimyeong

Subjects
Science / Life Sciences / Biochemistry
Abstract

A key in the etiology of a cluster of metabolic syndrome such as hyperglycemia, dyslipidemia, and obesity is known for insulin resistance, which is becoming a major global public health problem. Extensive studies have revealed many genetic factors for both insulin resistance and the components of metabolic syndrome. Advanced modern genotyping methods including genome-wide association studies and next-generation sequencing have allowed for the identification of both common and rare genetic variants related to these chronic disease-associated traits. Multiple genotype–phenotype studies are also needed to identify new and accurate genetic biomarkers in these conditions. The purpose of this chapter is to present genetic variants related to the pathogenesis of metabolic syndrome and insulin resistance and is to review the relevance between insulin resistance and metabolic syndrome clusters in terms of genetic diversity.

Published
2019

45. 13C NMR spectroscopic analysis on the chiral discrimination of N-acetylphenylalanine, catechin and propranolol induced by cyclic-(1→2)-β-d-glucans (cyclosophoraoses)

Author

Lee, Sanghoo and Jung, Seunho

Subjects
*CYCLIC compounds, *RHIZOBIUM meliloti, *NUCLEAR magnetic resonance spectroscopy
Abstract

Cyclosophoraoses (cyclic-(1→2)-β-d-glucans) produced by Rhizobium meliloti were used as a novel chiral NMR solvating agent. 13C NMR spectroscopic analysis as an enantiodiscriminating tool was carried out where NMR signal splittings were observed on the interactions of cyclosophoraoses with the enantiomers of N-acetylphenylalanine, catechin and propranolol. The 13C chemical shifts of cyclosophoraoses induced by the enantiomeric interactions predominantly occurred at the C-1 and C-2 carbons associated with the -glycosidic linkage. [Copyright &y& Elsevier]

Published
2002
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46. Chiral recognition based on enantioselective interactions of propranolol enantiomers with cyclosophoraoses isolated from <TOGGLE>Rhizobium meliloti</TOGGLE>

Author

Lee, Sanghoo, Choi, Youngjin, Lee, Sangsan, Jeong, Karpjoo, and Jung, Seunho

Abstract

Cyclosophoraoses isolated from Rhizobium meliloti, as an NMR chiral shift agent, were used to discriminate propranolol enantiomers. Continuous variation plot made from the complex of cyclosophoraoses with propranolol showed that the diastereomeric complex had predominantly 1:1 stoichiometry through UV spectroscopic analysis. The chiral recognition of propranolol enantiomers by cyclosophoraoses was investigated through the determination of binding constant based on the 13C NMR chemical shift changes. The averaged Kobs values from the plots were 55.7 M−1 for (R)-(+)-propranolol and 36.6 M−1 for (S)-(–)-propranolol, respectively. Enantioselectivity (α = KR(+)/KS(–)) of 1.52 was then obtained. Computational calculation also revealed that (R)-(+) propranolol was more tightly bound with cyclosophoraose than (S)-(–)-propranolol due to the enhanced van der Waals interaction. Chirality 16:204–210, 2004. © 2004 Wiley-Liss, Inc.

Published
2004
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47. Chiral recognition based on enantioselective interactions of propranolol enantiomers with cyclosophoraoses isolated from Rhizobium meliloti

Author

Lee, Sanghoo, Choi, Youngjin, Lee, Sangsan, Jeong, Karpjoo, and Jung, Seunho

Abstract

Cyclosophoraoses isolated from Rhizobium meliloti, as an NMR chiral shift agent, were used to discriminate propranolol enantiomers. Continuous variation plot made from the complex of cyclosophoraoses with propranolol showed that the diastereomeric complex had predominantly 1:1 stoichiometry through UV spectroscopic analysis. The chiral recognition of propranolol enantiomers by cyclosophoraoses was investigated through the determination of binding constant based on the 13C NMR chemical shift changes. The averaged Kobsvalues from the plots were 55.7 M−1for (R)‐(+)‐propranolol and 36.6 M−1for (S)‐(–)‐propranolol, respectively. Enantioselectivity (α = KR(+)/KS(–)) of 1.52 was then obtained. Computational calculation also revealed that (R)‐(+) propranolol was more tightly bound with cyclosophoraose than (S)‐(–)‐propranolol due to the enhanced van der Waals interaction. Chirality 16:204–210, 2004.© 2004 Wiley‐Liss, Inc.

Published
2004
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49. Trend Analysis of the Profiles of 12 Sexually Transmitted Disease Pathogens in the Republic of Korea in 2019.

Author

Park HJ, Kim YT, Moon JY, Jin CE, Ko KH, Lee SH, Min O, Je YS, Lee M, Lee S, Kim YJ, and Lee KR

Subjects
Aged, Humans, Incidence, Prevalence, Republic of Korea epidemiology, Retrospective Studies, Sexually Transmitted Diseases epidemiology
Abstract

Background: Sexually transmitted diseases (STDs) are common infectious diseases in humans transmitted through unprotected sexual activities. In South Korea, despite the high annual incidence of STDs, detailed examinations of pathogen-specific factors and causes for delays in diagnosis and treatment are still lacking. Furthermore, STD prevalence patterns and important pathogen-specific factors remain unclear. Herein, we retrospectively analyzed the epidemiology of STDs in South Korea in 2019 by analyzing the association of pathogen-specific infection patterns with factors such as sex, age, region, and month., Methods: We obtained the STD test results of 172,973 individuals from the Seoul Clinic Laboratory in 2019, most of whom had multiple infections; hence, 275,296 STD-positive cases were included in this analysis. Through deoxyribonucleic acid (DNA) amplification, they were categorized by pathogen type. Subsequently, they were further classified by month, region, and age while concurrently being stratified according to sex., Results: Among the 12 pathogens detected in this study, Gardnerella vaginalis had the highest prevalence, with 92,490 cases in both sex groups; moreover, many of them were concurrently infected by two or more pathogens. The prevalence of STDs did not differ according to month or region. Conversely, the pathogen-specific prevalence rates significantly differed according to age. Older adults had higher prevalence rates of Chlamydia trachomatis , Trichomonas vaginalis , Candida albicans , and herpes simplex virus type 1 infections than younger adults., Conclusion: These pathogen-specific prevalence patterns provide information that helps to understand population vulnerability according to region and age and helps develop STD prevention and treatment strategies in South Korea.

Published
2021
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50. A Rapid and Simple Liquid-Chromatography-Tandem Mass Spectrometry Method for Measuring 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3 in Human Serum: Comparison with Two Automated Immunoassays.

Author

Lee S, Kim JH, Kim SA, Sun YS, Lee A, Park SJ, Kim YT, Lee KR, and Kim YJ

Subjects
Automation, Humans, Regression Analysis, Reproducibility of Results, 25-Hydroxyvitamin D 2 blood, Calcifediol blood, Chromatography, Liquid methods, Immunoassay methods, Tandem Mass Spectrometry methods
Abstract

Background: Total 25-hydroxyvitamin D (25(OH)D) is well-known to be a reliable biomarker of human vitamin D status, with the recognition of widespread vitamin D insufficiency in general populations. The aims of this study are to validate a fast and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying 25(OH)D 2 and 25(OH)D 3 in serum and to compare two automated immunoassays with the LC-MS/MS method., Methods: Samples were prepared by protein precipitation with ethanol including 25(OH)D 3 -d 6 , followed by a liquid-liquid extraction with hexane. The analytes were separated within a total run time of 3 min. Accuracy was evaluated with standard reference materials (SRM) 972a. Using 150 samples, the LC-MS/MS method was compared with the LIAISON ® assay and ADVIA Centaur ® assay., Results: The LC-MS/MS method had a limit of quantitation of 1 ng/mL for the 25(OH)D 2 and 25(OH)D 3 with linear responses between 1 and 100 ng/mL. Intra- and inter-assay precision were <8.8% and <13.2%, respectively. It also showed a smallest mean difference (+0.9%) for the SRM level 1 to 3, compared to the two immunoassays. Compared to the LC-MS/MS, the mean biases of the RIAISON and ADVIA were +2.4 and +7.9 ng/mL, respectively. Also, the agreement of the LC-MS/MS with the RIAISON was better than that with the ADVIA., Conclusion: This study suggests that the LC-MS/MS method traceable to the SRM can be reliably applied in routine quantification of 25(OH)D 2 and 25(OH)D 3 ., (© 2016 by the Association of Clinical Scientists, Inc.)

Published
2016

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