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29. Assessment of Validation Method for Bioactive Contents of Fermented Soybean Extracts by Bioconversion and Their Antioxidant Activities

Author

Jung, Tae-Dong, primary, Shin, Gi-Hae, additional, Kim, Jae-Min, additional, Oh, Ji-Won, additional, Choi, Sun-Il, additional, Lee, Jin-Ha, additional, Lee, Sang Jong, additional, Heo, In Young, additional, Park, Seon Ju, additional, Kim, Hyun Tae, additional, Kang, Beom Kyu, additional, and Lee, Ok-Hwan, additional

Published
2016
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32. Changes in Lignan Content and Antioxidant Activity of Fermented Sesame (Sesame indicum L.) by Cultivars

Author

Jung, Tae-Dong, primary, Shin, Gi-Hae, additional, Kim, Jae-Min, additional, Oh, Ji-Won, additional, Choi, Sun-Il, additional, Lee, Jin-Ha, additional, Cho, Myoung-Lae, additional, Lee, Sang Jong, additional, Heo, In Young, additional, Park, Seon Ju, additional, Kim, Sung-Up, additional, Jung, Chan-Sik, additional, and Lee, Ok-Hwan, additional

Published
2016
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34. Can the Oral Glucose Tolerance Test (OGTT) Done at Postpartum (PPT) 1 Week Substitute OGTT at PPT 6 Week in Diagnosing Persistent PPT Glucose Intolerance in the Patients with Gestational Diabetes Mellitus (GDM)?

Author

KIM, YOO LEE, CHO, YONG WOOK, PARK, SEOK WON, and LEE, SANG JONG

Subjects
Research, Diabetes research, Diabetes -- Research
Abstract

Although 75g-OGTT at PPT 6 week is necessary to diagnose persistent PPT glucose intolerance state in GDM patients, it is difficult to do this test because many patients drop out [...]

Published
2000

35. Development and Validation of Analytical Method for Pectolinarin and Pectolinarigenin in Fermented Cirsium setidens Nakai by Bioconversion

Author

Oh, Ji-Won, primary, Lee, Jin-Ha, additional, Cho, Myoung-Lae, additional, Shin, Gi-Hae, additional, Kim, Jae-Min, additional, Choi, Sun-Il, additional, Jung, Tae-Dong, additional, Kim, Young-Hyun, additional, Lee, Sang-Jong, additional, Lee, Bong Jin, additional, Park, Seon Ju, additional, and Lee, Ok-Hwan, additional

Published
2015
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37. Mechanism of Antibacterial Activities of a Rice Hull Smoke Extract (RHSE) Against Multidrug‐Resistant <italic>Salmonella</italic> Typhimurium <italic>In Vitro</italic> and in Mice.

Author

Kim, Sung Phil, Lee, Sang Jong, Nam, Seok Hyun, and Friedman, Mendel

Subjects
*ANTIBACTERIAL agents, *SALMONELLA, *MULTIDRUG resistance in bacteria, *ANTI-infective agents, *BACTERIA
Abstract

Abstract: The present study tested antibacterial activity of a rice hull smoke extract (RHSE) against a multidrug‐resistant strain of Salmonella Typhimurium and examined its mode of suppressive action in vitro and in mice. In vitro studies showed that the minimum inhibitory concentration (MIC) value of RHSE was 1.29% (v/v). The inactivation was confirmed by complete loss of cell viability in the range of 104 to 107 colony forming units of the resistant Salmonella Typhimurium strain. Agarose and sodium dodecyl sulfate–polyacrylamide gel electrophoreses were used to evaluate the integrities of bacterial genomic DNA and total cellular protein profiles. The antibacterial action of RHSE results from a leakage of intracellular macromolecules following rupture of bacterial cells. Scanning electron microscopy of the cells shows that RHSE also induced deleterious morphological changes in the bacterial cell membrane of the pathogens. In vivo antibacterial activity of RHSE at a 1 × MIC concentration was examined in a bacterial gastroenteritis model using Balb/c mice orally infected with the Salmonella Typhimurium. The results show greatly decreased excretion of the bacteria into the feces and suppressed translocation of the bacteria to internal organs (cecum, mesenteric lymph node, spleen, and liver) compared with the infected mice not subjected to the RHSE treatment. Collectively, the present findings indicate that the mechanism of the antibacterial activities both in vitro and in the gastroenteritis environment of the animal model is the result of the direct disruption of cell structure, leading to cell death. RHSE has the potential to serve as a multifunctional food additive that might protect consumers against infections by antibiotic‐resistant microorganisms. Practical Application: The rice hull derived liquid smoke has the potential to complement widely used wood‐derived smoke as an antimicrobial flavor and health‐promoting formulation for application in foods and feeds. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Changes in the Anti-Allergic Activities of Sesame by Bioconversion.

Author

Jung, Tae-Dong, Choi, Sun-Il, Choi, Seung-Hyun, Cho, Bong-Yeon, Sim, Wan-Sup, Xionggao, Han-, Lee, Sang Jong, Park, Seon Ju, Kim, Dan-Bi, Kim, Young-Cheul, Lee, Jin-Ha, and Lee, Ok-Hwan

Abstract

Sesame is an important oilseed crop, which has been used as a traditional health food to ameliorate the prevention of various diseases. We evaluated the changes in the anti-allergic activities of sesame by bioconversion. SDS-PAGE of non-fermented sesame proteins showed major allergen bands, while that of fermented sesame showed only a few protein bands. Additionally, we investigated the effectiveness of fermented sesame by bioconversion in tumor necrosis factor-α (TNF-α)- and interferon-γ (IFN-γ)-induced HaCaT cells. In HaCaT cells, fermented sesame inhibited the mRNA expression of interleukin-6 (IL-6) and interleukin-1 β (IL-1β), thymus and macrophage-derived chemokine (MDC/CCL22), activation-regulated chemokine (TARC/CCL17), and intercellular adhesion molecule-1 (ICAM-1). Moreover, fermented sesame inhibited the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription 1 (STAT1). Fermented sesame exerts anti-allergic effects by suppressing the expression of chemokines and cytokines via blockade of NF-kκB and STAT1 activation. [ABSTRACT FROM AUTHOR]

Published
2018
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