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Background Hypothesis Animals Methods Results Conclusions and Clinical Importance Some studies in humans show that the concurrent use of clopidogrel and omeprazole decreases plasma clopidogrel active metabolite (CAM) concentrations and clopidogrel antiplatelet effects. Whether this drug interaction occurs in cats is unknown.We hypothesized that administration of clopidogrel with omeprazole would decrease plasma CAM concentrations and decrease clopidogrel antiplatelet effects in healthy cats.Ten domestic cats.In this 2‐sequence, 2‐period, 2‐treatment randomized crossover study, healthy cats were randomly assigned to receive clopidogrel only (18.75 mg PO q24h) or clopidogrel with omeprazole (1 mg/kg PO q12h) for 10 days, followed by a 2‐week washout period, and then the opposite treatment for another 10 days. Blood was collected by jugular venipuncture on days 0, 5, and 10. Plasma CAM concentrations were measured using high‐performance liquid chromatography‐tandem mass spectrometry. Platelet function was evaluated using Plateletworks, Multiplate Analyzer, and Platelet Function Analyzer‐100 (PFA‐100).Multiplate Analyzer and PFA‐100 detected no difference in platelet function between days or treatment groups. Plateletworks detected a significant difference (P < .001) in platelet function from day 0 to 5 and day 0 to 10 in both treatment groups but no difference between treatment groups. Plasma CAM concentrations were significantly lower on day 10 (P < .02) in cats receiving both medications versus clopidogrel only.Concurrent omeprazole and clopidogrel administration was associated with altered pharmacokinetics on day 10, but no difference in pharmacodynamics between the 2 treatment groups. The short‐term use of clopidogrel and omeprazole does not seem to alter platelet function significantly. [ABSTRACT FROM AUTHOR]

This essay serves as an introduction to the Questionnaire on Art and Machine Learning. It opens with the testimony of Sam Altman before the US Senate Judiciary Committee on Privacy, Technology and the Law in May 2023, following the launch of ChatGPT a year earlier. ChatGPT is part of a wave of generative AI: AI that not only classifies or analyzes information but also generates it. Media responses to ChatGPT and a range of other text-to-image and text-to-video generators—including Dall-E, Stable Diffusion, MidJourney, Deep AI, and Sora—tend to divide between "Boosterism" and "Doomerism": They either echo Silicon Valley's habitual refrain about the inherent goodness of technological innovation or they describe dystopian scenarios in which human agency is all but eclipsed. "Generative and Adversarial: Art and the Prospects of AI" argues that artists, art historians, critics, and curators offer far more nuanced perspectives on the prospects of AI. Borrowing the language of "generative adversarial networks"—one of several machine-learning models that have revolutionized image production in the past decade—it interrogates AI's aesthetic, political, and ethical possibilities, as well as its historical genealogies. [ABSTRACT FROM AUTHOR]

OVER THE COURSE OF THEIR COLLABORATION, Dutch artists Jeroen de Rijke and Willem de Rooij produced a highly reflective and elliptical body of work tracing the recursive economy of the [...]

WHERE QUESTIONS OF MEDIUM and making are concerned, most art criticism seems patently uninterested in (if not fundamentally incapable of) dealing with issues of production. Why obsess over the stuff [...]

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Karlheinz Brandenburg is a name that would probably ring few bells for visitors to Christian Marclay's midcareer retrospective at the UCLA Hammer Museum, but in critical respects, he stands as [...]