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7,867 results on '"Lee, Nam"'

1. Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression

Author

Javed, Zaineb, Shin, Dong Hui, Pan, Weihua, White, Sierra R, Elhaw, Amal Taher, Kim, Yeon Soo, Kamlapurkar, Shriya, Cheng, Ya-Yun, Benson, J Cory, Abdelnaby, Ahmed Emam, Phaëton, Rébécca, Wang, Hong-Gang, Yang, Shengyu, Sullivan, Mara L G, St.Croix, Claudette M, Watkins, Simon C, Mullett, Steven J, Gelhaus, Stacy L, Lee, Nam, Coffman, Lan G, Aird, Katherine M, Trebak, Mohamed, Mythreye, Karthikeyan, Walter, Vonn, and Hempel, Nadine

Published
2024
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17. Calabi-Yau threefolds with non-Gorenstein involutions

Author

Lee, Nam-Hoon

Subjects
Mathematics - Algebraic Geometry, Mathematics - Differential Geometry
Abstract

The concept of non-Gorenstein involutions on Calabi-Yau threefolds is a higher dimensional generalization of non-symplectic involutions on $K3$ surfaces. We present some elementary facts about Calabi-Yau threefolds with non-Gorenstein involutions. We give a classification of the Calabi-Yau threefolds of Picard rank one with non-Gorenstein involutions whose fixed locus is not zero-dimensional., Comment: 13 pages, 3 tables

Published
2021

24. An example of non-K\'ahler Calabi-Yau fourfold

Author

Lee, Nam-Hoon

Subjects
Mathematics - Algebraic Geometry, 14J32, 32Q25, 14J35, 32J18, 14D06
Abstract

We show that there exists a non-K\"ahler Calabi-Yau fourfold, constructing an example by smoothing a normal crossing variety., Comment: 11 pages. Some typos are corrected with addition of some references

Published
2021

26. Genetics and Otitis Media

Author

Lee, Nam K., Santos-Cortez, Regie Lyn P., Goycoolea, Marcos V., editor, Selaimen da Costa, Sady, editor, de Souza, Chris, editor, and Paparella, Michael M., editor

Published
2023
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29. The FRET-based structural dynamics challenge -- community contributions to consistent and open science practices

Author

Lerner, Eitan, Ambrose, Benjamin, Barth, Anders, Birkedal, Victoria, Blanchard, Scott C., Borner, Richard, Cordes, Thorben, Craggs, Timothy D., Ha, Taekjip, Haran, Gilad, Hugel, Thorsten, Ingargiola, Antonino, Kapanidis, Achillefs, Lamb, Don C., Laurence, Ted, Lee, Nam ki, Lemke, Edward A., Margeat, Emmanuel, Michaelis, Jens, Michalet, Xavier, Nettels, Daniel, Peulen, Thomas-Otavio, Schuler, Benjamin, Seidel, Claus A. M., So-leimaninejad, Hamid, and Weiss, Shimon

Subjects
Quantitative Biology - Biomolecules, Physics - Biological Physics
Abstract

Single-molecule F\"{o}rster resonance energy transfer (smFRET) has become a mainstream technique for probing biomolecular structural dynamics. The rapid and wide adoption of the technique by an ever-increasing number of groups has generated many improvements and variations in the technique itself, in methods for sample preparation and characterization, in analysis of the data from such experiments, and in analysis codes and algorithms. Recently, several labs that employ smFRET have joined forces to try to bring the smFRET community together in adopting a consensus on how to perform experiments and analyze results for achieving quantitative structural information. These recent efforts include multi-lab blind-tests to assess the accuracy and precision of smFRET between different labs using different procedures, the formal assembly of the FRET community and development of smFRET procedures to be considered for entries in the wwPDB. Here we delve into the different approaches and viewpoints in the field. This position paper describes the current "state-of-the field", points to unresolved methodological issues for quantitative structural studies, provides a set of 'soft recommendations' about which an emerging consensus exists, and a list of resources that are openly available. To make further progress, we strongly encourage 'open science' practices. We hope that this position paper will provide a roadmap for newcomers to the field, as well as a reference for seasoned practitioners.

Published
2020
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33. FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.

Author

Lerner, Eitan, Barth, Anders, Hendrix, Jelle, Ambrose, Benjamin, Birkedal, Victoria, Blanchard, Scott C, Börner, Richard, Sung Chung, Hoi, Cordes, Thorben, Craggs, Timothy D, Deniz, Ashok A, Diao, Jiajie, Fei, Jingyi, Gonzalez, Ruben L, Gopich, Irina V, Ha, Taekjip, Hanke, Christian A, Haran, Gilad, Hatzakis, Nikos S, Hohng, Sungchul, Hong, Seok-Cheol, Hugel, Thorsten, Ingargiola, Antonino, Joo, Chirlmin, Kapanidis, Achillefs N, Kim, Harold D, Laurence, Ted, Lee, Nam Ki, Lee, Tae-Hee, Lemke, Edward A, Margeat, Emmanuel, Michaelis, Jens, Michalet, Xavier, Myong, Sua, Nettels, Daniel, Peulen, Thomas-Otavio, Ploetz, Evelyn, Razvag, Yair, Robb, Nicole C, Schuler, Benjamin, Soleimaninejad, Hamid, Tang, Chun, Vafabakhsh, Reza, Lamb, Don C, Seidel, Claus Am, and Weiss, Shimon

Subjects
Fluorescence Resonance Energy Transfer, Molecular Biology, Single Molecule Imaging, FRET, biochemistry, biomolecules, chemical biology, community, conformation, dynamics, molecular biophysics, single-molecule, structural biology, Bioengineering, Generic health relevance, Biochemistry and Cell Biology
Abstract

Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-increasing number of groups has generated significant progress in sample preparation, measurement procedures, data analysis, algorithms and documentation. Several labs that employ smFRET approaches have joined forces to inform the smFRET community about streamlining how to perform experiments and analyze results for obtaining quantitative information on biomolecular structure and dynamics. The recent efforts include blind tests to assess the accuracy and the precision of smFRET experiments among different labs using various procedures. These multi-lab studies have led to the development of smFRET procedures and documentation, which are important when submitting entries into the archiving system for integrative structure models, PDB-Dev. This position paper describes the current 'state of the art' from different perspectives, points to unresolved methodological issues for quantitative structural studies, provides a set of 'soft recommendations' about which an emerging consensus exists, and lists openly available resources for newcomers and seasoned practitioners. To make further progress, we strongly encourage 'open science' practices.

Published
2021

45. ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen

Author

Su, Yang, Zhang, Xin, Bidlingmaier, Scott, Behrens, Christopher R, Lee, Nam-Kyung, and Liu, Bin

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Orphan Drug, Biotechnology, Rare Diseases, Lung, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Aetiology, Alkaline Phosphatase, Animals, Antigens, Surface, Antineoplastic Agents, Immunological, CHO Cells, Cell Line, Tumor, Cricetulus, Epitopes, Female, GPI-Linked Proteins, Humans, Immunoconjugates, Immunoglobulin G, Male, Mesothelioma, Malignant, Mice, Inbred NOD, Molecular Targeted Therapy, Xenograft Model Antitumor Assays, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Identification of tumor-specific cell surface antigens has proven challenging, as the vast majority of tumor-associated antigens are also expressed in normal tissues. In mesothelioma, we identified a highly specific tumor cell surface antigen that can be targeted for therapy development. Mesothelioma is caused by malignant transformation of the mesothelium, is incurable, and can be categorized into three histologic subtypes: epithelioid, biphasic, and sarcomatoid. To identity novel mesothelioma cell surface antigens with broad subtype coverage and high tissue specificity, we have previously selected phage antibody display libraries on live mesothelioma cells and tissues following counterselection on normal cells and identified a panel of human antibodies that bind all subtypes of mesothelioma, but not normal mesothelium. One of the antibodies, M25, showed high specificity against an antigen we identify here as ALPPL2. IHC on normal human tissues found that ALPPL2 is expressed only on placental trophoblasts, but not on any other normal tissues. This significant tissue specificity and broad tumor type coverage suggest that ALPPL2 could be an excellent cell surface target for therapeutic development against mesothelioma. To evaluate therapeutic potential of ALPPL2 targeting, an ALPPL2-targeted antibody-drug conjugate was developed and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid and sarcomatoid mesothelioma. Thus, ALPPL2 belongs to a rare class of cell surface antigens classified as truly tumor specific and is well suited for therapy development against ALPPL2-expressing tumors. SIGNIFICANCE: These findings identify ALPP2 as a true tumor-specific cell surface antigen whose tissue specificity enables the development of novel therapies.

Published
2020

46. $d$-semistable Calabi--Yau threefolds of Type III

Author

Lee, Nam-Hoon

Subjects
Mathematics - Algebraic Geometry
Abstract

We develop some methods to construct normal crossing varieties whose dual complexes are two-dimensional, which are smoothable to Calabi--Yau threefolds. We calculate topological invariants of smoothed Calabi--Yau threefolds and show that several of them are new examples., Comment: 25 pages

Published
2018

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