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205 results on '"Lee, Mei-Yueh"'

8. Better Detection of Peripheral Arterial Disease with Toe-Brachial Index Compared to Ankle-Brachial Index among Taiwanese Patients with Diabetic Kidney Disease.

Author

Chang, Chia-Wei, Sung, Ya-Wen, Huang, Yu-Ting, Chung, Yong-Chuan, and Lee, Mei-Yueh

Subjects
ANKLE brachial index, DIABETIC nephropathies, PERIPHERAL vascular diseases, PEOPLE with diabetes, TYPE 2 diabetes, ARTERIAL calcification
Abstract

Background: Ankle-brachial index (ABI) is a simple method for diagnosing peripheral artery disease (PAD) but has limited reliability in patients with diabetes mellitus (DM) because of medial artery calcification. Our study aims to investigate whether the toe brachial index (TBI) or the cardio-ankle vascular index (CAVI) has a better detection over the ABI for diagnosing PAD in diabetic kidney disease (DKD). Materials and Methods: A cohort of 368 patients (mean age 68.59 ± 13.14 years, 190 males and 178 females) with type 2 DM underwent ABI, TBI, and CAVI measurements at our outpatient clinic. Results: Of all enrolled patients, the TBI is significant in evaluating PAD, especially in patients whose chronic kidney disease (CKD) stage 3a with adjusted odds ratio (AOR) = 6.50, 95% confidence interval (CI) 1.63–25.97, p = 0.0080, stage 3b AOR = 7.47, 95% CI 1.52–36.81, p = 0.0135, and stage 4–5 AOR = 20.13, 95% CI 1.34–94.24, p = 0.0116. CAVI is also significant in CKD stage 1 with AOR = 0.16, 95% CI 0.03–0.77, p = 0.0223, stage 2 with AOR = 0.18, 95% CI 0.04–0.74, p = 0.0180, and stage 3a AOR = 0.31, 95% CI 0.10–0.93, p = 0.0375. Conclusion: TBI has a better yield of detection of PAD compared to ABI among Taiwanese patients with DKD. CAVI may play a role in the early stage of DKD. [ABSTRACT FROM AUTHOR]

Published
2023
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25. A performance guide for major risk factors control in patients with atherosclerotic cardiovascular disease in Taiwan

Author

Li, Yi-Heng, primary, Chen, Jaw-Wen, additional, Lin, Tsung-Hsien, additional, Wang, Yu-Chen, additional, Wu, Chau-Chung, additional, Yeh, Hung-I, additional, Huang, Chin-Chou, additional, Chang, Kuan-Cheng, additional, Wu, Cho-Kai, additional, Chen, Po-Wei, additional, Huang, Chen-Wei, additional, Chen, Zhih-Cherng, additional, Chang, Wei-Ting, additional, Huang, Wei-Chun, additional, Wang, Chih-Yuan, additional, Lee, Mei-Yueh, additional, Chao, A-Ching, additional, Fu, Wei-Ren, additional, Tsai, Li-Kai, additional, Tang, Sung-Chun, additional, Chan, Hsin-Lung, additional, Yang, Yi-Ching, additional, Wu, Yen-Wen, additional, Hwang, Juey-Jen, additional, and Lin, Jiunn-Lee, additional

Published
2020
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28. Electronegative low‐density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade

Author

Chen, Chao‐Hung, primary, Ke, Liang‐Yin, additional, Chan, Hua‐Chen, additional, Chu, Chih‐Sheng, additional, Lee, An‐Sheng, additional, Lin, Kun‐Der, additional, Lee, Mei‐Yueh, additional, Hsiao, Pi‐Jung, additional, Chen, Chu‐Huang, additional, and Shin, Shyi‐Jang, additional

Published
2019
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34. Electronegative low‐density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade.

Author

Chen, Chao‐Hung, Ke, Liang‐Yin, Chan, Hua‐Chen, Chu, Chih‐Sheng, Lee, An‐Sheng, Lin, Kun‐Der, Lee, Mei‐Yueh, Hsiao, Pi‐Jung, Chen, Chu‐Huang, and Shin, Shyi‐Jang

Subjects
MITOGEN-activated protein kinases, METABOLIC syndrome, AORTA, RETINOL-binding proteins, LOW density lipoproteins, PATHOLOGY, RETINOIDS
Abstract

Aims/Introduction: Electronegative low‐density lipoprotein (L5) is the most atherogenic fraction of low‐density lipoprotein and is elevated in people with metabolic syndrome (MetS), whereas the retinol‐binding protein 4 receptor (stimulated by retinoic acid 6 [STRA6]) cascade is disrupted in various organs of patients with obesity‐related diseases. Our objective was to investigate whether L5 from MetS patients capably induces pathogenesis of aorta through disrupting the STRA6 cascade. Material and Methods: We examined the in vivo and in vitro effects of L5 on the STRA6 cascade and aortic atherogenic markers. To investigate the role of this cascade on atherosclerotic formation, crbp1 transfection was carried out in vitro. Results: This study shows that L5 activates atherogenic markers (p38 mitogen‐activated protein kinases, pSmad2 and matrix metallopeptidase 9) and simultaneously suppresses STRA6 signals (STRA6, cellular retinol‐binding protein 1, lecithin‐retinol acyltransferase, retinoic acid receptor‐α and retinoid X receptor‐α) in aortas of L5‐injected mice and L5‐treated human aortic endothelial cell lines and human aortic smooth muscle cell lines. These L5‐induced changes of the STRA6 cascade and atherogenic markers were reversed in aortas of LOX1−/− mice and in LOX1 ribonucleic acid‐silenced human aortic endothelial cell lines and human aortic smooth muscle cell lines. Furthermore, crbp1 gene transfection reversed the disruption of the STRA6 cascade, the phosphorylation of p38 mitogen‐activated protein kinases and Smad2, and the elevation of matrix metallopeptidase 9 in L5‐treated human aortic endothelial cell lines. Conclusions: This study shows that L5 from MetS patients induces atherogenic markers by disrupting STRA6 signaling. Suppression of STRA6 might be one novel pathogenesis of aorta in patients with MetS. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Statin therapy prevents the onset of Parkinson disease in patients with diabetes.

Author

Lin, Kun‐Der, Yang, Chun‐Yuh, Lee, Mei‐Yueh, Ho, Shu‐Chen, Liu, Ching‐Kuan, Shin, Shyi‐Jang, Lin, Kun-Der, Yang, Chun-Yuh, Lee, Mei-Yueh, Ho, Shu-Chen, Liu, Ching-Kuan, and Shin, Shyi-Jang

Abstract

Objective: We studied the association between the statin dosage and the risk of Parkinson disease (PD) in diabetic patients in Taiwan.Methods: One million patients were randomly sampled from a National Health Insurance (NHI) database and followed from 2001 to 2008. Diabetic patients were screened by diagnosis of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes, and statin dosage was determined according to the NHI pharmacy database. PD was diagnosed on the basis of ICD-9-CM codes and anti-Parkinson medication use. Statin users was classified by statin dose-duration-day > 28 and matched with nonusers of statins using a coarsened exact matching method. There were 50,432 patients, and half of them were statin users. We examined the risk of PD between statin users and nonusers of statins and further tested the trends of the relative risk between the statin dosage and PD.Results: The PD incidence rate was lower in statin users than in nonusers of statins. The crude hazard ratio of PD incidence in statin users was 0.65 (95% confidence interval [CI] = 0.57-0.74) in females and 0.60 (95% CI = 0.51-0.69) in males compared with nonusers of statins. After Cox regression analysis, all statins except lovastatin exerted protective effects on PD incidence and had a significant dose-dependent trend.Interpretation: In Taiwanese diabetic patients, the risk of PD is lower in statin users than in nonusers of statins. Statin users, except lovastatin users, are dose-dependently associated with a decreased incidence of PD compared with nonusers of statins. This finding provides a new indication for statin beyond lipid control and cardiovascular events in diabetic patients. Ann Neurol 2016;80:532-540. [ABSTRACT FROM AUTHOR]

Published
2016
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