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2. Effectiveness of an innovative self‐management intervention on the physiology, psychology, and management of patients with pre‐end‐stage renal disease in Taiwan: A randomized, controlled trial.

Author

Wu, Shu F. V., Lee, Mei C., Hsieh, Nan C., Lu, Kuo C., Tseng, Hung L., and Lin, Li J.

Subjects
*TREATMENT of chronic kidney failure, *KIDNEY physiology, *ANALYSIS of covariance, *ANXIETY, *CHI-squared test, *CONCEPTUAL structures, *CONFIDENCE, *STATISTICAL correlation, *CREATININE, *MENTAL depression, *KIDNEY function tests, *RESEARCH funding, *STATISTICAL sampling, *SCALE analysis (Psychology), *HEALTH self-care, *SELF-efficacy, *STATISTICAL hypothesis testing, *T-test (Statistics), *DISEASE management, *QUALITATIVE research, *RANDOMIZED controlled trials, *PRE-tests & post-tests, *BLIND experiment, *EVALUATION of human services programs, *DATA analysis software, *DESCRIPTIVE statistics, *BLOOD urea nitrogen, *INFERENTIAL statistics
Abstract

Abstract: Aim: End‐stage renal disease (ESRD) not only threatens a patient's life expectancy but also burdens the family and society with medical expenses. The mortality and prevalence rates are extremely high in Taiwan. Thus, this articleinvestigated the effectiveness of an innovative self‐management program on the physiology, psychology, and management of patients with pre‐ESRD. Methods: This study was designed as a randomized, controlled trial and was set in the department of nephrology in a regional teaching hospital in Taiwan. In total, 112 patients with pre‐ESRD were assigned randomly to either an experimental (n = 67) or a control (n = 45) group. The baseline data collection included physiological indicators, psychological factors (depression, anxiety), and measures of self‐efficacy and self‐management. Routine hospital care was provided for the control group after the pretest and an innovative self‐management intervention was used in the experimental group for 4 weeks after the pretest. The effectiveness of the intervention was evaluated 3 months later. Results: Improvements in the physiological indicators, such as blood urea nitrogen and creatinine, and the psychological indicators, such as depression, self‐efficacy, and self‐management, reached statistical significance. Conclusion: The innovative self‐management program effectively decreased patients' functional indicators (blood urea nitrogen, creatinine) and level of depression and enhanced their self‐efficacy and self‐management. [ABSTRACT FROM AUTHOR]

Published
2018
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3. POLYSACCHARIDE CONJUGATE VACCINE RESPONSES IN BONE MARROW TRANSPLANT PATIENTS1

Author

GUINAN, EVA C., primary, MOLRINE, DEBORAH C., additional, ANTIN, JOSEPH H., additional, LEE, MEI C., additional, WEINSTEIN, HOWARD J., additional, SALLAN, STEPHEN E., additional, PARSONS, SUSAN K., additional, WHEELER, CATHERINE, additional, GROSS, WENDY, additional, MCGARIGLE, CAROL, additional, BLANDING, PETER, additional, SCHIFFMAN, GERALD, additional, FINBERG, ROBERT W., additional, SIBER, GEORGE R., additional, BOLON, DAVID, additional, WANG, MICHAEL, additional, CARIATI, SOPHIA, additional, and AMBROSINO, DONNA M., additional

Published
1994
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7. IgG1 IgG2 and IgM responses to two Haemophilus influenzaetype b conjugate vaccines in young infants

Author

AMBROSINO, DONNA M., SOOD, SUNIL K., LEE, MEI C., CHEN, DEHAN, COLLARD, HAROLD R., BOLON, DAVID L., JOHNSON, CYNSY, and DAUM, ROBERT S.

Abstract

PRP-meningococcal outer membrane protein complex (PRP-OMPC) and oliogosaccharide linked to variant diphtheria toxin (HbOC) Haemophilus influenzaetype b (HIB) conjugate vaccines have both been licensed for United States infants at 2 months of age. Differences in serologic responses for these vaccines have been noted with PRP-OMPC producing an early response at 2 months of age and HbOC producing a higher response after a third dose at 6 months of age. To further characterize the nature of these distinct responses, we measured the IgG1, IgG2 and IgM anti-HIB concentrations by enzyme-linked immunosorbent assay after administration of both vaccines. PRP-OMPC produced an IgM and IgG1 anti-HIB response following the initial dose at 2 months of age. After two doses of HbOC an increase in IgG1 and IgM were noted and after a third dose at 6 months of age an IgG2 anti-HIB response occurred. In addition 33 study subjects were boosted with PRP-OMPC at age 18 months and compared with 34 subjects who received only a primary dose. The anti-HIB IgG1 and IgG2 concentrations following the booster dose were both significantly higher for the primed group (P= 0.0001 and P= 0.001, respectively). Both HIB conjugate vaccines produce predominantly IgG1 anti-HIB antibody responses. The early response to PRP-OMPC vaccine at 2 months of age may result from adjuvant characteristics of the OMPC.

Published
1992

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