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1. Gynecological Cancer

Author

Mayr, Nina A., Lee, Larissa J., Small, William, Jr, Yashar, Catheryn M., Grosu, Anca-Ligia, editor, Nieder, Carsten, editor, and Nicolay, Nils Henrik, editor

Published
2023
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3. Does Prophylactic Paraortic Lymph Node Irradiation Improve Outcomes in Women With Stage IIIC1 Endometrial Carcinoma?

Author

Yoon, Jennifer, Fitzgerald, Halle, Wang, Yaqun, Wang, Qingyang, Vergalasova, Irina, Elshaikh, Mohamed A., Dimitrova, Irina, Damast, Shari, Li, Jessie Y., Fields, Emma C., Beriwal, Sushil, Keller, Andrew, Kidd, Elizabeth A., Usoz, Melissa, Jolly, Shruti, Jaworski, Elizabeth, Leung, Eric W., Donovan, Elysia, Taunk, Neil K., Chino, Junzo, Natesan, Divya, Russo, Andrea L., Lea, Jayanthi S., Albuquerque, Kevin V., Lee, Larissa J., and Hathout, Lara

Published
2022
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7. A Multi-Institutional Analysis of Adjuvant Chemotherapy and Radiation Sequence in Women With Stage IIIC Endometrial Cancer

Author

Hathout, Lara, Wang, Yaqun, Wang, Qingyang, Vergalasova, Irina, Elshaikh, Mohamed A., Dimitrova, Irina, Damast, Shari, Li, Jessie Y., Fields, Emma C., Beriwal, Sushil, Keller, Andrew, Kidd, Elizabeth A., Usoz, Melissa, Jolly, Shruti, Jaworski, Elizabeth, Leung, Eric W., Donovan, Elysia, Taunk, Neil K., Chino, Junzo, Natesan, Divya, Russo, Andrea L., Lea, Jayanthi S., Albuquerque, Kevin V., and Lee, Larissa J.

Published
2021
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9. Executive summary of the American Radium Society® Appropriate Use Criteria for management of uterine carcinosarcoma

Author

Elshaikh, Mohamed A., Modh, Ankit, Jhingran, Anuja, Biagioli, Matthew C., Coleman, Robert L., Gaffney, David K., Harkenrider, Matthew M., Heskett, Karen, Jolly, Shruti, Kidd, Elizabeth, Lee, Larissa J., Li, Linna, Portelance, Lorraine, Sherertz, Tracy, Venkatessan, Aradhana M., Wahl, Andrew O., Yashar, Catheryn M., and Small, William, Jr

Published
2020
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11. An analysis of appropriate delivery of postoperative radiation therapy for endometrial cancer using the RAND/UCLA Appropriateness Method: Executive summary

Author

Jones, Ellen, Beriwal, Sushil, Beyer, David, Chino, Junzo, Jhingran, Anuja, Lee, Larissa, Michalski, Jeff, Mundt, Arno J, Patton, Caroline, Petersen, Ivy, Portelance, Lorraine, Schwarz, Julie K, and McCloskey, Susan

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Uterine Cancer, Oncology and carcinogenesis
Abstract

PurposeTo summarize the results of American Society for Radiation Oncology (ASTRO)'s analysis of appropriate delivery of postoperative radiation therapy (RT) for endometrial cancer using the RAND/University of California, Los Angeles (UCLA) Appropriateness Method, outline areas of convergence and divergence with the 2014 ASTRO endometrial Guideline, and highlight where this analysis provides new information or perspective.Methods and materialsThe RAND/UCLA Appropriateness Method was used to combine available evidence with expert opinion. A comprehensive literature review was conducted and a multidisciplinary panel rated the appropriateness of RT options for different clinical scenarios. Treatments were categorized by the median rating as Appropriate, Uncertain, or Inappropriate.ResultsThe ASTRO endometrial Guideline and this analysis using the RAND/UCLA Appropriateness Method did not recommend adjuvant RT for early-stage, low-risk endometrioid cancers and largely agree regarding use of vaginal brachytherapy for low-intermediate and high-intermediate risk patients. For more advanced endometrioid cancer, chemotherapy with RT is supported by both documents. The Guideline and the RAND/UCLA analysis diverged regarding use of pelvic radiation. For stages II and III, this analysis rated external beam RT plus vaginal brachytherapy Appropriate, whereas the Guideline preferred external beam alone. In addition, this analysis offers insight on the role of histology, extent of nodal dissection, and para-aortic nodal irradiation; the use of intensity modulated RT; and management of stage IVA.ConclusionsThis analysis based on the RAND/UCLA Method shows significant agreement with the 2014 endometrial Guideline. Areas of divergence, often in scenarios with low-level evidence, included use of external beam RT plus vaginal brachytherapy in stages II and III and external beam RT alone in early-stage patients. Furthermore, the analysis explores other important questions regarding management of this disease site.

Published
2016

18. The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905.

Author

Lee, Larissa J, Ratner, Elena, Uduman, Mohamed, Winter, Kathryn, Boeke, Marta, Greven, Kathryn M, King, Stephanie, Burke, Thomas W, Underhill, Kelly, Kim, Harold, Boulware, Raleigh J, Yu, Herbert, Parkash, Vinita, Lu, Lingeng, Gaffney, David, Dicker, Adam P, and Weidhaas, Joanne

Subjects
Humans, Endometrial Neoplasms, Lymphatic Metastasis, Genetic Predisposition to Disease, ras Proteins, Proto-Oncogene Proteins, MicroRNAs, Risk Factors, Case-Control Studies, Gene Expression Regulation, Neoplastic, Mutation, Alleles, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Proto-Oncogene Proteins p21(ras), Gene Expression Regulation, Neoplastic, and over, General Science & Technology
Abstract

ObjectiveTo explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk, as well as the association of microRNA (miRNA) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials.Methods/materialsThe association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls. miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics, and survival outcomes were evaluated by variant allele type.ResultsThe KRAS-variant was not significantly associated with overall endometrial cancer risk (14% controls and 17% type 1 cancers), although was enriched in type 2 endometrial cancers (24%, p = 0.2). In the combined analysis of RTOG 9708/9905, miRNA expression differed by age, presence of lymphovascular invasion and KRAS-variant status. Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100% and 77% (HR 0.3, p = 0.24), respectively, favoring the variant.ConclusionsThe KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers. In addition, tumor miRNA expression appears to be associated with patient age, lymphovascular invasion and the KRAS-variant, supporting the hypothesis that altered tumor biology can be measured by miRNA expression, and that the KRAS-variant likely impacts endometrial tumor biology.

Published
2014

29. The Impact of Racial Disparities on Outcome in Patients With Stage IIIC Endometrial Carcinoma

Author

Patrich, Tomas, primary, Wang, Yaqun, additional, Elshaikh, Mohamed A., additional, Zhu, Simeng, additional, Damast, Shari, additional, Li, Jessie Y., additional, Fields, Emma C., additional, Beriwal, Sushil, additional, Keller, Andrew, additional, Kidd, Elizabeth A., additional, Usoz, Melissa, additional, Jolly, Shruti, additional, Jaworski, Elizabeth, additional, Leung, Eric W., additional, Taunk, Neil K., additional, Chino, Junzo, additional, Russo, Andrea L., additional, Lea, Jayanthi S., additional, Lee, Larissa J., additional, Albuquerque, Kevin V., additional, and Hathout, Lara, additional

Published
2023
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36. Comparison and Consensus Guidelines for Delineation of Clinical Target Volume for CT- and MR-Based Brachytherapy in Locally Advanced Cervical Cancer

Author

Viswanathan, Akila N., Erickson, Beth, Gaffney, David K., Beriwal, Sushil, Bhatia, Sudershan K., Lee Burnett, Omer, III, D'Souza, David P., Patil, Nikhilesh, Haddock, Michael G., Jhingran, Anuja, Jones, Ellen L., Kunos, Charles A., Lee, Larissa J., Lin, Lilie L., Mayr, Nina A., Petersen, Ivy, Petric, Primoz, Portelance, Lorraine, Small, William, Jr., Strauss, Jonathan B., Townamchai, Kanokpis, Wolfson, Aaron H., Yashar, Catheryn M., and Bosch, Walter

Published
2014
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47. Increased juvenile native fish abundance following a major flood in an Arizona river.

Author

Jenney, Christopher J., Nemec, Zach C., Lee, Larissa N., and Bonar, Scott A.

Subjects
NATIVE fishes, FLOODS, FISH communities, INTRODUCED species, CARP, HABITATS, RARE fishes, FLOOD control
Abstract

Spring floods trigger spawning in many native fishes of the desert Southwest (USA), but less is known about fish community response when native fishes are rare. Here, we document change to native and nonnative fish captures and instream habitat features following a decade-high flooding event (2019) in the Verde River (AZ) where native fish captures were rare in the years pre-flood. Using prepositioned areal electrofishing devices (PAEDs), we sampled the fish community at 90 sampling units pre-flood (2017) and resampled those same units post-flood (2019) to compare and identify changes to catch and habitat features. Relative abundance of native fishes increased from 0.6% pre-flood (0.01 fish/PAED) to 53.0% post-flood (1.66 fish/PAED) and was largely attributable to the presence of juvenile Roundtail Chub Gila robusta (≤ 70 mm total length (TL)) and juvenile Sonora Sucker Catostomus insignis (≤ 100 mm TL). Juvenile Desert Sucker Catostomus clarkii experienced a lesser increase. One adult native fish was captured in 2017 and adult native fishes were absent from 2019 sampling. The catch of adult/subadult Common Carp Cyprinus carpio (> 100 mm TL) declined; however, this could be related to reservoir management and not the flood. The abundance of all size-classes of Black Bass Micropterus spp., Red Shiner Cyprinella lutrensis and other nonnative fishes did not change. The majority (97%) of juvenile native fishes were captured at the uppermost sampling reach. A 54% reduction to canopy cover across all sampling reaches and an increase of fine sediments at the most downstream reach demonstrates how floods can restructure the river environment. This case-study adds evidence that protection of spring floods is vital to the persistence and recolonization of fishes native to the desert Southwest, especially where they are rare. The continued presence of nonnative species may preclude juvenile native fishes from recruiting to adults. [ABSTRACT FROM AUTHOR]

Published
2022
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