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14. Cyclosporine A inhibits TGF-β2-induced myofibroblasts of primary cultured human pterygium fibroblasts

Author

Gum, Sang Il, Kim, Yeoun-Hee, Jung, Jae-Chang, Kim, Im Gyu, Lee, Jun Seok, Lee, Kyoo Won, and Park, Young Jeung

Subjects
Male, 0301 basic medicine, Oligonucleotides, Biophysics, Inflammation, Pterygium, Biochemistry, Transforming Growth Factor beta2, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Laminin, Humans, Medicine, Myofibroblasts, Molecular Biology, Cells, Cultured, Messenger RNA, biology, business.industry, Cell Differentiation, Muscle, Smooth, Cell Biology, Fibroblasts, Actins, eye diseases, Fibronectins, Fibronectin, 030104 developmental biology, Microscopy, Fluorescence, Immunology, Cyclosporine, 030221 ophthalmology & optometry, Cancer research, biology.protein, Female, sense organs, medicine.symptom, business, Myofibroblast, Immunosuppressive Agents, Software, Intracellular, Signal Transduction, Transforming growth factor
Abstract

Cyclosporine A (CsA), an immunomodulatory drug, and is increasingly used to treat moderate dry eye syndrome and ocular surface inflammation. However, any inhibitory effect on differentiation of fibroblasts to myofibroblasts remains unclear. Here, we show that the inhibitory effect of CsA on transforming growth factor-beta2 (TGF-β2)-induced myofibroblasts in primary cultured human pterygium fibroblasts. CsA significantly decreased mRNA and protein expression of myofibroblast-related markers including α-SMA, laminin, and fibronectin. These findings were supported by the results from immunofluorescence staining. Taken together, these results indicate the therapeutic potential of CsA against pterygium progression. Further studies are necessary to elucidate the precise intracellular signal mechanism responsible for CsA-induced downregulation of myofibroblast markers in pterygium fibroblasts.

Published
2017

29. Vision‐related quality of life according to location of visual field loss in patients with glaucoma.

Author

Chun, Yeoun Sook, Sung, Kyung Rim, Park, Chan Kee, Kim, Hwang Ki, Yoo, Chungkwon, Kim, Yong Yeon, Park, Ki Ho, Kim, Chan Yun, Choi, Kyu‐Ryong, Lee, Kyoo Won, Han, Seungbong, and Kim, Chang‐sik

Subjects
VISUAL fields, GLAUCOMA, OPEN-angle glaucoma, QUALITY of life, REGRESSION analysis
Abstract

Purpose: To assess influence of the location of visual field (VF) loss on vision‐related quality of life (VRQOL) in patients with glaucoma. Methods: We included 826 patients with primary open‐angle glaucoma (POAG) enrolled in the prospectively designed Life Quality of Glaucoma Patients Who Underwent Treatment (LIGHT) study organized by the Korean Glaucoma Society. We divided the integrated binocular visual field (IVF) into four regions and evaluated the associations between Rasch‐analysed 25‐item National Eye Institute Visual Function Questionnaire (NEI VFQ‐25) and location of the IVF using univariate and hierarchical multivariable linear regression. Results: Mean deviation (MD) of the IVF at superior centre showed the lowest value among the four regions. Multivariable linear regression analysis revealed significant correlation of the composite score and all subscales of the NEI VFQ‐25 except ocular pain and near activities at each of four IVF regions. Mean deviation at superior centre showed significant correlation with composite score (R2 = 0.181), near activities (R2 = 0.175), and social functioning (R2 = 0.166); MD at superior periphery showed highest correlation with role difficulties (R2 = 0.137); MD at inferior centre showed highest correlation with driving (R2 = 0.145); and MD at inferior periphery showed significant correlation with distance activities (R2 = 0.214) and dependency (R2 = 0.119). Conclusion: Four different regions of the IVF had a similarly important impact on subscales of the NEI VFQ‐25 in glaucoma patients. Preservation of the superior field should be considered as much as that of the inferior field for maintaining a good VRQOL in patients with glaucoma. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Factors influencing vision‐related quality of life according to glaucoma severity.

Author

Chun, Yeoun Sook, Sung, Kyung Rim, Park, Chan Kee, Kim, Hwang Ki, Yoo, Chungkwon, Kim, Yong Yeon, Park, Ki Ho, Kim, Chan Yun, Choi, Kyu‐Ryong, Lee, Kyoo Won, Han, Seungbong, and Kim, Chang sik

Subjects
QUALITY of life, GLAUCOMA
Abstract

Purpose: To identify factors influencing vision‐related quality of life (VRQOL) according to glaucoma severity. Methods: A total of 901 patients with varying stages of glaucoma were recruited from the prospectively designed LIGHT (Life Quality of Glaucoma Patients Who Underwent Treatment) study organized by the Korean Glaucoma Society. Participants completed a basic questionnaire collecting socioeconomic status and clinical information, in addition to the 25‐item National Eye Institute Visual Function Questionnaire (NEI VFQ‐25). Subjects were classified by mean deviation (MD) of integrated binocular visual field (IVF) into mild, moderate and severe damage groups. Factors were evaluated for their influence on VRQOL according to glaucoma severity using univariate and multivariable regression models between Rasch‐analysed NEI VFQ‐25 subscale scores and different variables. Results: The mild, moderate and severe groups contained 720, 111 and 70 patients, respectively; the mean IVF MD in each group was −1.4, −8.5 and −17.9 dB. Significant differences were observed among the three groups with respect to age, IVF MD, visual acuity (VA), education level, income level, number of glaucoma medications prescribed and follow‐up period. The most influential factor associated with VRQOL according to glaucoma severity was VA. The VA of the better eye was much more influential on VRQOL than the VA of the worse eye in the moderate and severe defect groups, and the impact of VA on VRQOL was more prominent in advanced glaucoma. Conclusions: Visual acuity is the most influential factor on VRQOL in patients with glaucoma. Preservation of VA should be strongly prioritized to maintain good VRQOL. [ABSTRACT FROM AUTHOR]

Published
2019
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