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12. ADVANCED SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX: EFFICACY OF POSITRON EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY FOR DETERMINING PRIMARY TUMOR RESPONSE DURING INDUCTION CHEMOTHERAPY

Author

Chepeha, Douglas B., Sacco, Assuntina G., Oxford, Lance E, Karamchandani, Rahul, Miller, Tamara H., Teknos, Theodoros N., Bradford, Carol R., Eisbruch, Avraham, Worden, Frank M., Urba, Susan G., Mukherji, Suresh K., Bui, Chuong, Frey, Kirk A., Wolf, Gregory T., and Lee, Julia S.

Published
2009
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20. Chemotherapy alone for organ preservation in advanced laryngeal cancer

Author

Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Vasu Divi and Francis P. Worden contributed equally to this work., Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI ; Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, Department of Biostatistics, University of Michigan Medical School, Ann Arbor, MI, Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI, Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI, Divi, Vasu, Worden, Francis P., Prince, Mark E., Eisbruch, Avraham, Lee, Julia S., Bradford, Carol R., Chepeha, Douglas B., Teknos, Theodoros N., Hogikyan, Norman D., Moyer, Jeffrey S., Tsien, Christina I., Urba, Susan G., Wolf, Gregory T., Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Vasu Divi and Francis P. Worden contributed equally to this work., Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI ; Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, Department of Biostatistics, University of Michigan Medical School, Ann Arbor, MI, Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI, Department of Otolaryngology-Head and Neck Surgery, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI ; Department of Internal Medicine, Division of Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI, Divi, Vasu, Worden, Francis P., Prince, Mark E., Eisbruch, Avraham, Lee, Julia S., Bradford, Carol R., Chepeha, Douglas B., Teknos, Theodoros N., Hogikyan, Norman D., Moyer, Jeffrey S., Tsien, Christina I., Urba, Susan G., and Wolf, Gregory T.

Abstract

Background. For patients with advanced laryngeal cancer, a trial was designed to determine if chemotherapy alone, in patients achieving a complete histologic complete response after a single neoadjuvant cycle, was an effective treatment with less morbidity than concurrent chemoradiotherapy. Methods. Thirty-two patients with advanced laryngeal or hypopharyngeal cancer received 1 cycle of induction chemotherapy, and subsequent treatment was decided based on response. Results. A histologic complete response was achieved in 4 patients and were treated with chemotherapy alone. All 4 patients' cancer relapsed in the neck and required surgery and postoperative radiotherapy (RT). Twenty-five patients were treated with concomitant chemoradiation. Three patients were treated with surgery. Overall survival and disease-specific survival at 3 years were 68% and 78%, respectively. Conclusion. Chemotherapy alone is not feasible for long-term control of regional disease in patients with advanced laryngeal cancer even when they achieve a histologic complete response at the primary site. ?? 2009 Wiley Periodicals, Inc. Head Neck, 2010

Published
2010

21. Lateral oromandibular defect: When is it appropriate to use a bridging reconstruction plate combined with a soft tissue revascularized flap?

Author

Department Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312 ; Dr. Chepeha has reported a financial interest/relationship with KLS Martin. ; Department Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, Department Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, Cancer Center–Biostatistics, University of Michigan, Ann Arbor, Michigan, Department Otolaryngology–Head and Neck Oncology and Reconstructive Surgery, University of Western Ontario, London, Ontario, Canada, Department Otolaryngology–Head and Neck Surgical Oncology, Washington University, St. Louis, Missouri, Chepeha, Douglas B., Teknos, Theodoros N., Fung, Kevin, Shargorodsky, Josef, Sacco, Assuntina G., Nussenbaum, Brian, Jones, Lamont, Eisbruch, Avraham, Bradford, Carol R., Prince, Mark E., Moyer, Jeffrey S., Lee, Julia S., Wolf, Gregory T., Department Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312 ; Dr. Chepeha has reported a financial interest/relationship with KLS Martin. ; Department Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, Department Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, Cancer Center–Biostatistics, University of Michigan, Ann Arbor, Michigan, Department Otolaryngology–Head and Neck Oncology and Reconstructive Surgery, University of Western Ontario, London, Ontario, Canada, Department Otolaryngology–Head and Neck Surgical Oncology, Washington University, St. Louis, Missouri, Chepeha, Douglas B., Teknos, Theodoros N., Fung, Kevin, Shargorodsky, Josef, Sacco, Assuntina G., Nussenbaum, Brian, Jones, Lamont, Eisbruch, Avraham, Bradford, Carol R., Prince, Mark E., Moyer, Jeffrey S., Lee, Julia S., and Wolf, Gregory T.

Abstract

Background A quasi-experimental retrospective study was undertaken to evaluate a new concept of free tissue volume restoration combined with bridging reconstruction plate (compartment approach) to reduce plate-related complication rates. Methods We evaluated 40 patients with large lateral mandible defects and associated complex soft tissue defects reconstructed with a revascularized soft tissue flap and titanium hollow screw reconstruction plates. A case-control comparison was performed based on reconstruction type: restoration of soft tissue defect (conventional approach—group 1) versus over-reconstruction of soft tissue defect (compartment approach—group 2). Results Plate exposure rate was 6 of 16 (38%) in group 1 versus 2 of 24 (8%) in group 2, and the difference was statistically significant ( p = .04). The mean time to exposure was 10 months. Plate fracture rate was 6 of 23 (26.1%) in dentulous patients versus 1 of 17 (5.9%) in edentulous patients. Gastrostomy tube dependence was 6 of 16 (38%) in group 1 versus 6 of 24 (25%) in group 2. Conclusion The “compartment approach” reduces plate exposure rate and gastrostomy tube dependence. Revascularized osseocutaneous reconstruction is still required in dentulous patients. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

Published
2008

22. Prevalence and predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer

Author

Chandarana, Shamir P., primary, Lee, Julia S., additional, Chanowski, Eric J. P., additional, Sacco, Assuntina G., additional, Bradford, Carol R., additional, Wolf, Gregory T., additional, Prince, Mark E., additional, Moyer, Jeffrey S., additional, Eisbruch, Avraham, additional, Worden, Francis P., additional, Giordano, Thomas J., additional, Kumar, Bhavna, additional, Cordell, Katrina G., additional, Carey, Thomas E., additional, and Chepeha, Douglas B., additional

Published
2012
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24. Tobacco Use in Human Papillomavirus–Positive Advanced Oropharynx Cancer Patients Related to Increased Risk of Distant Metastases and Tumor Recurrence

Author

Maxwell, Jessica H., primary, Kumar, Bhavna, additional, Feng, Felix Y., additional, Worden, Francis P., additional, Lee, Julia S., additional, Eisbruch, Avraham, additional, Wolf, Gregory T., additional, Prince, Mark E., additional, Moyer, Jeffrey S., additional, Teknos, Theodoros N., additional, Chepeha, Douglas B., additional, McHugh, Jonathan B., additional, Urba, Susan G., additional, Stoerker, Jay, additional, Walline, Heather M., additional, Kurnit, David M., additional, Cordell, Kitrina G., additional, Davis, Samantha J., additional, Ward, Preston D., additional, Bradford, Carol R., additional, and Carey, Thomas E., additional

Published
2010
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25. Chemotherapy alone for organ preservation in advanced laryngeal cancer

Author

Divi, Vasu, primary, Worden, Francis P., additional, Prince, Mark E., additional, Eisbruch, Avraham, additional, Lee, Julia S., additional, Bradford, Carol R., additional, Chepeha, Douglas B., additional, Teknos, Theodoros N., additional, Hogikyan, Norman D., additional, Moyer, Jeffrey S., additional, Tsien, Christina I., additional, Urba, Susan G., additional, and Wolf, Gregory T., additional

Published
2009
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26. Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion

Author

Worden, Francis P., primary, Moyer, Jeffrey, additional, Lee, Julia S., additional, Taylor, Jeremy M. G., additional, Urba, Susan G., additional, Eisbruch, Avraham, additional, Teknos, Theodoros N., additional, Chepeha, Douglas B., additional, Prince, Mark E., additional, Hogikyan, Norman, additional, Lassig, Amy Anne D., additional, Emerick, Kevin, additional, Mukherji, Suresh, additional, Hadjiski, Lubomir, additional, Tsien, Christina I., additional, Miller, Tamara H., additional, Wallace, Nancy E., additional, Mason, Heidi L., additional, Bradford, Carol R., additional, and Wolf, Gregory T., additional

Published
2009
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27. Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number

Author

Worden, Francis P., primary, Kumar, Bhavna, additional, Lee, Julia S., additional, Wolf, Gregory T., additional, Cordell, Kitrina G., additional, Taylor, Jeremy M.G., additional, Urba, Susan G., additional, Eisbruch, Avraham, additional, Teknos, Theodoros N., additional, Chepeha, Douglas B., additional, Prince, Mark E., additional, Tsien, Christina I., additional, D’Silva, Nisha J., additional, Yang, Kun, additional, Kurnit, David M., additional, Mason, Heidi L., additional, Miller, Tamara H., additional, Wallace, Nancy E., additional, Bradford, Carol R., additional, and Carey, Thomas E., additional

Published
2008
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28. EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer

Author

Kumar, Bhavna, primary, Cordell, Kitrina G., additional, Lee, Julia S., additional, Worden, Francis P., additional, Prince, Mark E., additional, Tran, Huong H., additional, Wolf, Gregory T., additional, Urba, Susan G., additional, Chepeha, Douglas B., additional, Teknos, Theodoros N., additional, Eisbruch, Avraham, additional, Tsien, Christina I., additional, Taylor, Jeremy M.G., additional, D’Silva, Nisha J., additional, Yang, Kun, additional, Kurnit, David M., additional, Bauer, Joshua A., additional, Bradford, Carol R., additional, and Carey, Thomas E., additional

Published
2008
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29. Lateral oromandibular defect: When is it appropriate to use a bridging reconstruction plate combined with a soft tissue revascularized flap?

Author

Chepeha, Douglas B., primary, Teknos, Theodoros N., additional, Fung, Kevin, additional, Shargorodsky, Josef, additional, Sacco, Assuntina G., additional, Nussenbaum, Brian, additional, Jones, Lamont, additional, Eisbruch, Avraham, additional, Bradford, Carol R., additional, Prince, Mark E., additional, Moyer, Jeffrey S., additional, Lee, Julia S., additional, and Wolf, Gregory T., additional

Published
2008
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30. Rap1GAP Promotes Invasion via Induction of Matrix Metalloproteinase 9 Secretion, Which Is Associated with Poor Survival in Low N-Stage Squamous Cell Carcinoma

Author

Mitra, Raj S., primary, Goto, Mitsuo, additional, Lee, Julia S., additional, Maldonado, Diana, additional, Taylor, Jeremy M.G., additional, Pan, Quintin, additional, Carey, Thomas E., additional, Bradford, Carol R., additional, Prince, Mark E., additional, Cordell, Kitrina G., additional, Kirkwood, Keith L., additional, and D'Silva, Nisha J., additional

Published
2008
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31. Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

Author

Kumar, Bhavna, primary, Cordell, Kitrina G., additional, Lee, Julia S., additional, Prince, Mark E., additional, Tran, Huong H., additional, Wolf, Gregory T., additional, Urba, Susan G., additional, Worden, Francis P., additional, Chepeha, Douglas B., additional, Teknos, Theodoros N., additional, Eisbruch, Avraham, additional, Tsien, Christina I., additional, Taylor, Jeremy M.G., additional, D'Silva, Nisha J., additional, Yang, Kun, additional, Kurnit, David M., additional, Bradford, Carol R., additional, and Carey, Thomas E., additional

Published
2007
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35. Some Physical Properties of Weathered Wool1.

Author

Lee, Julia S. and Finkner, Morris D.

Abstract

The deterioration from outdoor weathering of experimental wool fabrics differing in fiber fineness was measured by breaking strength, elongation at break, and crease recovery. With the amount of solar energy held approximately constant for each sampling period of each of the three consecutive sets of exposures, ambient temperature seemed to control the rate of deterioration.Differences in strength and elongation among the fabrics were non-significant. The fine wools recovered from creasing significantly more than the medium wool. [ABSTRACT FROM PUBLISHER]

Published
1967
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36. Wearability of Acala 1517C Cotton.

Author

Lee, Julia S. and Finkner, Morris D.

Abstract

Experimental cotton fabries made from four lots of Acala 1517C cotton fiber selected for strength and fineness were used for constructing 192 gingham dresses. One dress of each fabric was assigned to each of 48 wearers. A schedule for regular wear and care was established. Over a series of 16 wear periods, dresses were withdrawn in replicates of three according to a random sampling plan.The worn fabries were tested at each of the wear periods for qualities pertaining to durability and appearance. Regression equations were calculated and trends of change plotted. Properties of the fabries from the four fiber lots were compared. Fiber fine ness was of greater importance than strength in maintaining desirable wearing qualities of the fabries. [ABSTRACT FROM PUBLISHER]

Published
1966
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37. Efficacy and toxicity of midostaurin with idarubicin and cytarabine induction in <i>FLT3</I>-mutated acute myeloid leukemia.

Author

Lee JS, Wagner CB, Prelewicz S, Kurish HP, Walchack R, Cenin DA, Patel S, Lo M, Schlafer D, Li BKT, Donald Harvey Iii R, Wasef B, Ying J, and Kovacsovics T

Subjects
Humans, Cytarabine adverse effects, Staurosporine pharmacology, Antineoplastic Combined Chemotherapy Protocols adverse effects, fms-Like Tyrosine Kinase 3 genetics, Mutation, Remission Induction, Idarubicin adverse effects, Leukemia, Myeloid, Acute drug therapy, Leukemia, Myeloid, Acute genetics
Published
2023
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38. Thoracodorsal artery scapular tip autogenous transplant: vascularized bone with a long pedicle and flexible soft tissue.

Author

Chepeha DB, Khariwala SS, Chanowski EJ, Zumsteg JW, Malloy KM, Moyer JS, Prince ME, Sacco AG, and Lee JS

Subjects
Adolescent, Adult, Aged, Child, Child, Preschool, Facial Injuries surgery, Facial Neoplasms surgery, Female, Graft Survival, Humans, Male, Middle Aged, Postoperative Complications, Prospective Studies, Treatment Outcome, Young Adult, Plastic Surgery Procedures methods, Scapula transplantation, Surgical Flaps blood supply
Abstract

Objective: To demonstrate that the 3 reconstructive advantages of the thoracodorsal artery scapular tip transplant (Tdast), a long pedicle, independently mobile tissue components, and the 3-dimensional nature of the scapular tip, will improve the quality and success of complex reconstructions by avoiding vein grafting, preventing the need for 2 separate transplants, and facilitating bony inset., Design: Prospective case series., Setting: Tertiary care academic medical center., Patients: Twenty-one patients (male to female ratio, 16:5; mean age, 52 years) underwent reconstruction of the upper, middle, and lower face from 2001 through 2006. Indications for reconstruction were tumor ablation in 11 patients, secondary reconstruction in 4 patients, osteoradionecrosis in 4, and posttraumatic reconstruction in 2. Seventeen patients underwent radiation., Interventions: All patients underwent harvest of an autogenous transplant of scapular tip bone and latissimus dorsi soft tissue based on the thoracodorsal artery. The mean bone length was 5.2 cm (range, 2.5-9.0 cm), and the mean cutaneous surface area was 68 cm² (range, 20-250 cm²)., Main Outcome Measures: Reduction of vein grafting, avoidance of 2 transplants, use of the triangular shape of the scapular tip in reconstruction, complications, and shoulder function., Results: The success rate of transplantation was 100%. The use of this transplant avoided vein grafting in 16 patients and the need for 2 separate transplants in 11 patients, and the 3-dimensional nature of the scapular tip facilitated inset in 13 patients. In 14 patients, more than 1 of these reconstructive advantages was achieved. In 6 patients, all 3 were accomplished. Eleven patients experienced a complication. The major complication rate was 33%, and the minor complication rate was 33%. The mean Constant-Murley test of shoulder function score was 87 of 100 (range, 74-100)., Conclusions: The Tdast is an excellent choice for reconstruction in the head and neck as an alternative to procedures requiring vein grafting and multiple free tissue transplants, or in which the 3-dimensional contour of the scapular tip aids in reconstruction. The complication rate should be assessed in the context of the risk factors of the patient population and the outcome with respect to stable employment, increasing body mass index, and maintenance of shoulder function.

Published
2010
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