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1,569 results on '"Lee, Ju-Yeon"'

17. Correlates of burnout among healthcare workers during the COVID-19 pandemic in South Korea

Author

Hwang, Soyoon, Kwon, Ki Tae, Lee, So Hee, Kim, Shin-Woo, Chang, Hyun-Ha, Kim, Yoonjung, Bae, Sohyun, Cheong, Hae Suk, Park, Se Yoon, Kim, Bongyoung, Lee, Shinwon, Park, Jiho, Heo, Sang Taek, Oh, Won Sup, Kim, Yeonjae, Park, Kyung-Hwa, Kang, Chang Kyung, Oh, NamHee, Lim, Su Jin, Yun, Seongcheol, Son, Ji Woong, Ryoo, Hyun Wook, Chung, Un Sun, Lee, Ju-Yeon, Park, Hye Yoon, Shin, Ji-Yeon, Bae, Sang-geun, and Lee, Ji-yeon

Published
2023
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29. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods*

Author

De Leoz, Maria Lorna A, Duewer, David L, Fung, Adam, Liu, Lily, Yau, Hoi Kei, Potter, Oscar, Staples, Gregory O, Furuki, Kenichiro, Frenkel, Ruth, Hu, Yunli, Sosic, Zoran, Zhang, Peiqing, Altmann, Friedrich, Grunwald-Grube, Clemens, Shao, Chun, Zaia, Joseph, Evers, Waltraud, Pengelley, Stuart, Suckau, Detlev, Wiechmann, Anja, Resemann, Anja, Jabs, Wolfgang, Beck, Alain, Froehlich, John W, Huang, Chuncui, Li, Yan, Liu, Yaming, Sun, Shiwei, Wang, Yaojun, Seo, Youngsuk, An, Hyun Joo, Reichardt, Niels-Christian, Ruiz, Juan Echevarria, Archer-Hartmann, Stephanie, Azadi, Parastoo, Bell, Len, Lakos, Zsuzsanna, An, Yanming, Cipollo, John F, Pucic-Bakovic, Maja, Štambuk, Jerko, Lauc, Gordan, Li, Xu, Wang, Peng George, Bock, Andreas, Hennig, René, Rapp, Erdmann, Creskey, Marybeth, Cyr, Terry D, Nakano, Miyako, Sugiyama, Taiki, Leung, Pui-King Amy, Link-Lenczowski, Paweł, Jaworek, Jolanta, Yang, Shuang, Zhang, Hui, Kelly, Tim, Klapoetke, Song, Cao, Rui, Kim, Jin Young, Lee, Hyun Kyoung, Lee, Ju Yeon, Yoo, Jong Shin, Kim, Sa-Rang, Suh, Soo-Kyung, de Haan, Noortje, Falck, David, Lageveen-Kammeijer, Guinevere SM, Wuhrer, Manfred, Emery, Robert J, Kozak, Radoslaw P, Liew, Li Phing, Royle, Louise, Urbanowicz, Paulina A, Packer, Nicolle H, Song, Xiaomin, Everest-Dass, Arun, Lattová, Erika, Cajic, Samanta, Alagesan, Kathirvel, Kolarich, Daniel, Kasali, Toyin, Lindo, Viv, Chen, Yuetian, Goswami, Kudrat, Gau, Brian, Amunugama, Ravi, Jones, Richard, Stroop, Corné JM, Kato, Koichi, Yagi, Hirokazu, Kondo, Sachiko, Yuen, CT, Harazono, Akira, Shi, Xiaofeng, Magnelli, Paula E, Kasper, Brian T, Mahal, Lara, Harvey, David J, and O'Flaherty, Roisin

Subjects
Immunization, Antibodies, Monoclonal, Biological Products, Biopharmaceutics, Glycomics, Glycopeptides, Glycosylation, Humans, Laboratories, Polysaccharides, Protein Processing, Post-Translational, Proteomics, mass spectrometry, fluorescence, glycosylation, glycoproteins, glycan, glycopeptide, interlaboratory study, NISTmAb, reference antibody, Biochemistry & Molecular Biology
Abstract

Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.

Published
2020

39. Serum cortisol and neuroticism for post‐traumatic stress disorder over 2 years in patients with physical injuries.

Author

Kim, Jae‐Min, Kang, Hee‐Ju, Kim, Ju‐Wan, Jang, Hyunseok, Kim, Jung‐Chul, Chun, Byung Jo, Lee, Ju‐Yeon, Kim, Sung‐Wan, and Shin, Il‐Seon

Subjects
LOGISTIC regression analysis, PERSONALITY, PERSONALITY studies, PSYCHOSOCIAL factors, TRAUMA centers, POST-traumatic stress disorder, EXTRAVERSION
Abstract

Aim: This study aimed to explore the relationships between serum cortisol levels, personality traits, and the development of Post‐Traumatic Stress Disorder (PTSD) over 2 years among individuals with physical injuries. Methods: Participants were consecutively recruited from a trauma center and followed prospectively for 2 years. At baseline, serum cortisol levels were measured, and personality traits were categorized into five dimensions (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness), using the Big Five Inventory‐10. The diagnosis of PTSD during follow‐up (at 3, 6, 12, and 24 months post‐injury) was determined using the Clinician‐Administered PTSD Scale for DSM‐5. Binary and multinomial logistic regression analyses were conducted to examine the interactions between cortisol levels, personality traits, and PTSD development. Results: Among 923 patients analyzed, 112 (12.1%) were diagnosed with PTSD at some point during the study period, with prevalence rates decreasing from 8.8% at 3 months to 3.7% at 24 months post‐injury. Direct associations between cortisol levels or personality traits and PTSD were not observed. However, a significant interaction between lower cortisol levels and higher Neuroticism in relation to PTSD risk was identified, especially during the early follow‐up periods (3 to 6 months), but this association waned from the 12‐month follow‐up onward. Conclusion: Our findings reveal Neuroticism‐dependent associations between serum cortisol levels and PTSD development, exhibiting temporal variations. These results suggest that PTSD development may be influenced by a complex, time‐sensitive interplay of biological and psychosocial factors, underscoring the importance of considering individual differences in stress reactivity and personality in PTSD research and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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