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Background: Few studies have compared the characteristics of meniscal allograft tears between medial and lateral meniscal allograft transplantation (MAT) using bone fixation. Purpose: To investigate the prevalence, location, and patterns of allograft tears after MAT with the bone fixation technique and compare tear patterns between medial and lateral compartments according to the time elapsed after surgery. Study Design: Cohort study; Level of evidence, 3. Methods: The charts of consecutive patients who underwent primary medial or lateral MAT between December 1996 and June 2019 were retrospectively reviewed. The location, pattern, and postoperative periods during which allograft tears occurred were evaluated by reviewing all series of follow-up magnetic resonance imaging (MRI) scans, which were performed at 6 weeks, 3 months, 6 months, and 1 year postoperatively and every 2 years thereafter with the patient's agreement. Postoperative periods for allograft tears were defined as the time between surgery and the follow-up MRI scan in which the meniscal tear was first confirmed. Allograft tears were compared between the medial and lateral MAT groups. Results: A total of 327 consecutive patients who underwent MAT (55 medial, 272 lateral) with a minimum 2-year follow-up were retrospectively reviewed. The incidences of allograft tears after medial and lateral MATs were 32.7% and 30.9%, respectively. The mean times for tears were 80.1 ± 81.1 months and 48.9 ± 46.3 months in the medial and lateral MAT groups, respectively (P =.130). In both the medial and lateral MAT groups, allograft tears were observed mainly in the posterior horn, with complex tears being the most commonly identified tear type. In medial MATs, root tears were the second most common at 27.8%, with a significantly higher proportion than the lateral MATs (P =.014). On the other hand, in lateral MATs, meniscocapsular separation and radial tears were the second most common at 15.5% each, albeit not significantly more common than in medial MATs (P =.123 and P =.454, respectively). All root tears in medial MATs and meniscocapsular separations in lateral MATs were observed within 1 year postoperatively. Conclusion: Significant differences in allograft tear patterns were identified between the medial and lateral MAT groups. The proportion of root tears in medial MATs was higher than that in lateral MATs; conversely, the proportion of meniscocapsular separation was more common in lateral MATs. Such tear patterns, which may require surgical repair or graft resection, were observed only within 1 year of surgery. Therefore, close observation and regular follow-up in the earlier postoperative period are necessary after medial or lateral MATs. [ABSTRACT FROM AUTHOR]

Background: Graft tears are often observed on magnetic resonance imaging after lateral meniscal allograft transplantation (MAT). Their characteristics, such as the location and configuration, are likely to be different depending on the timing of the injury. However, the clinical relevance of early and late graft tears has not been investigated. Hypothesis: (1) Both early and late graft tears would be associated with the clinical failure of lateral MAT, and (2) an early graft tear (ET) would lead to worse outcomes than a late graft tear (LT) or an intact graft. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 261 patients who had undergone lateral MAT between March 2000 and June 2019 were retrospectively reviewed. The graft tear was investigated using magnetic resonance imaging, which was performed routinely during the first postoperative year and every 2 years thereafter. The patients were classified according to the timing of the graft tear: no graft tear (NT) group, ET (≤1 year after surgery) group, and LT (>1 year after surgery) group. Clinical failure was defined as (1) reoperations including arthroplasty, realignment osteotomy, revision MAT, and meniscectomy (>50% of the graft or to the zone of the meniscocapsular junction) or (2) a Lysholm score of <65. Risk factors for a low survival rate were investigated using Cox regression analysis. A comparison of the Lysholm scores for each group was also performed. Results: There were 24 (9.2%) patients who had clinical failure at a mean follow-up of 7.5 ± 4.3 years. The overall survival rate at 5 years was 92.8% (95% CI, 91.1%-94.5%). A graft tear was noted in 80 patients: 23 patients in the ET group and 57 patients in the LT group. The most common tear pattern was a meniscocapsular tear in the ET group and a complex tear in the LT group. The hazard ratios for clinical failure in the ET and LT groups were 30.7 (95% CI, 9.4-76.4; P <.001) and 4.0 (95% CI, 1.3-12.9; P =.013), respectively. The Lysholm score of the ET group (82.7 ± 14.8) was significantly lower than that of the other 2 groups (NT: 87.6 ± 11.7; LT: 90.7 ± 9.0; P =.024). Conclusion: An ET was a major risk factor for the clinical failure of lateral MAT. An LT was associated with a lower survival rate. An ET was also associated with worse clinical outcomes. [ABSTRACT FROM AUTHOR]

Background: The effect of a concurrent cartilage procedure in lateral meniscal allograft transplantation (MAT) in patients with bipolar cartilage lesions (high-grade lesions on both the femoral and the tibial side) is not well studied. An objective evaluation of graft status after MAT and a concurrent cartilage procedure has not been reported. Purpose: To investigate the effect of concurrent cartilage procedures and lateral MAT on objective and clinical outcomes, including survival, in patients with bipolar cartilage lesions. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 149 patients with high-grade (International Cartilage Regeneration & Joint Preservation Society grade 3 or 4) cartilage lesions were enrolled and assigned to 1 of 3 groups based on the cartilage procedure and cartilage status at the time of MAT. Femoral cartilage procedures (microfracture, n = 18; osteochondral autograft transfer, n = 13) and lateral MAT were performed in 31 patients with bipolar cartilage lesions (cartilage procedure group). Another 70 patients with bipolar lesions underwent only lateral MAT without cartilage procedure (bipolar lesion group). The remaining 48 patients, who had high-grade lesions only on the tibial side and underwent lateral MAT without a cartilage procedure, were selected as a control group (unipolar lesion group). Anatomic survival was objectively assessed by follow-up magnetic resonance imaging and second-look arthroscopy. Clinical survivorship was determined with a Lysholm score <65 or need for additional surgery, such as revision MAT. Results: The mean Lysholm score improved from 67.2 ± 15.9 preoperatively to 86.7 ± 11.1 with a mean follow-up of 78.0 ± 51.2 months (P <.001). The postoperative scores were not significantly different between the 3 groups. The estimated 5-year anatomic survival rate in the cartilage procedure group (86.7%) was higher than that in the bipolar lesion group (65.0%; P =.043) but comparable with that in the unipolar lesion group (90.2%; P =.572). The estimated 5-year clinical survival rates were not significantly different between the groups (P =.187). Conclusion: A concurrent femoral cartilage procedure improved the anatomic survival rate in patients with bipolar chondral lesions who underwent lateral MAT. This finding suggests that the cartilage procedure is an effective treatment choice and may improve the status of an allograft after lateral MAT for patients with bipolar cartilage lesions. [ABSTRACT FROM AUTHOR]

Background: Preoperative body mass index (BMI) is one of the correctable factors before surgery. Few studies have investigated the effect of BMI on the survivorship of lateral meniscal allograft transplantation (MAT). Hypothesis: Patients with a high BMI have inferior survivorship after lateral MAT when compared with those with a normal BMI. Study Design: Cohort study; Level of evidence, 3. Methods: Overall, 306 consecutive patients who underwent lateral MAT were retrospectively reviewed. According to the classification criteria of the World Health Organization, patients were split into 2 groups: normal weight (BMI <25.0) and overweight (BMI ≥25.0). There were 104 patients (34.0%) allocated into the overweight group. Given the demographic heterogeneity between the groups, propensity score matching was performed. Before and after propensity score matching, the anatomic and clinical survival rates of the 2 groups were compared by Kaplan-Meier survival analysis. Anatomic failure was defined as a tear covering >50% of the allograft or unstable peripheral rim on follow-up magnetic resonance imaging and second-look arthroscopy. Clinical failure was defined as a Lysholm score <65 or need for additional surgery, such as revision MAT. Results: For all patients, the mean ± SD follow-up period was 6.9 ± 4.2 years. The mean BMI of the overweight and normal weight groups was 27.8 ± 2.6 and 22.0 ± 1.9, respectively. The mean Lysholm scores at the last follow-up were not significantly different between the groups. However, the anatomic survival rate in the overweight group (77.9%) was significantly lower than that in the normal weight group (90.1%) (P <.001). The clinical survival rate (82.7%) in the overweight group was significantly lower than that in the normal weight group (95.0%) (P <.001). After propensity score matching for patient characteristics, which left 87 patients per group, the anatomic and clinical survival rates were significantly lower in the overweight group. Conclusion: Preoperative high BMI was associated with inferior anatomic and clinical survival rates. The results of the current study suggest that weight loss before lateral MAT may be required in overweight patients for the improvement of anatomic and clinical survival rates. [ABSTRACT FROM AUTHOR]

• Dupuytren's contracture progresses with age and causes deterioration of the hand functions, resulting in hampered daily activities. • The Unité Rhumatologique des Affections dela Main scale is the first patient-reported outcome measure specific to Dupuytren's disease-associated disability. • To use this questionnaire in various countries, adequate translation and cultural adaptation are required to maintain the validity of its contents. • The Korean version of Unité Rhumatologique des Affections dela Main scale was a reliable, valid, and responsive instrument for evaluating disability in patients with Dupuytren's disease. [ABSTRACT FROM AUTHOR]

Dear Editor, The exosome, a kind of extracellular vesicle with a diameter in the range of 50-200 nm, has been extensively investigated in treating various skin issues, such as skin aging mitigation and cutaneous wound healing stimulation, and atopic dermatitis (AD).[[1], [3]] Compared to stem cell therapy, advantageous properties, such as a long half-life, small size, favorable penetration, and low immunogenicity, make exosomes more favorable and beneficial.[4] Although exosomes have been extensively investigated for their application in skin damage repair, the only sources shown to be effective are those derived from mesenchymal stem cells (MSCs).[5] However, exosome isolation from MSCs accompanies multiple drawbacks, such as the time and effort required for MSC culture and expansion, the risk of contamination with red blood cells during the isolation process, neovascularization potential, diminished cell viability, and the extreme invasiveness of removing MSCs from bone marrow.[6] Therefore, finding an alternative cell source for exosome isolation has become imperative for the effective application of exosomes in the repair of dysfunctional skin. The absorbance was then measured at 540 nm using a spectrophotometer (Molecular Devices, San Jose, CA, USA). gl Exosome treatment increased the protein levels of skin permeability barrier biomarkers, compared to the control in HaCaT cells. To investigate the effects of DF exosomes on skin permeability barrier protection, we evaluated the expression levels of skin permeability barrier maintenance biomarkers in keratinocytes treated with 1-chloro-2,4-dinitrobenzene (DNCB). Hence, we evaluated the expression levels of skin permeability barrier maintenance biomarkers in keratinocytes treated with DNCB, a skin irritant, and inducer of dermatitis, including AD. [Extracted from the article]