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6. An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer

Author

Kim, Jina, Hwang, Hayoung, Yoon, Heeseok, Lee, Jae-Eon, Oh, Ji Min, An, Hongchan, Ji, Hyun Dong, Lee, Seungmi, Cha, Eunju, Ma, Min Jung, Kim, Dong-Su, Lee, Su-Jeong, Kadayat, Tara Man, Song, Jaeyoung, Lee, Sang Woo, Jeon, Jae-Han, Park, Keun-Gyu, Lee, In-Kyu, Jeon, Yong Hyun, Chin, Jungwook, and Cho, Sung Jin

Published
2020
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8. Correction to “Discovery and Feasibility Study of Medical Fluorophore 33 as a Novel Theranostic Agent”

Author

Son, Kwang Hee, primary, Lee, Da Sol, additional, Park, Geumi, additional, Jeon, So Yeon, additional, Lee, Jae-Eon, additional, Jeon, Hui-Jeon, additional, Lee, Sijoon, additional, Park, Woo-Jin, additional, Shin, Yeonju, additional, Kim, Seong Gon, additional, Lee, Dong-Seok, additional, Han, Ye Ri, additional, Kim, Dong-Su, additional, and Jeon, Yong Hyun, additional

Published
2024
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11. Discovery and Feasibility Study of Medical Fluorophore 33 as a Novel Theranostic Agent

Author

Son, Kwang Hee, primary, Lee, Da Sol, additional, Park, Geumi, additional, Jeon, So Yeon, additional, Lee, Jae-Eon, additional, Jeon, Hui-Jeon, additional, Lee, Sijoon, additional, Park, Woo-Jin, additional, Shin, Yeonju, additional, Kim, Seong Gon, additional, Lee, Dong-Seok, additional, Han, Ye Ri, additional, Kim, Dong-Su, additional, and Jeon, Yong Hyun, additional

Published
2023
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14. Supplementary tables from A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERRγ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer

Author

Singh, Thoudam Debraj, primary, Song, Jaeyoung, primary, Kim, Jina, primary, Chin, Jungwook, primary, Ji, Hyun Dong, primary, Lee, Jae-Eon, primary, Lee, Sang Bong, primary, Yoon, Heeseok, primary, Yu, Ji Hoon, primary, Kim, Sang Kyoon, primary, Yoon, Ghil Suk, primary, Hwang, Hayoung, primary, Lee, Ho Won, primary, Oh, Ji Min, primary, Lee, Sang-Woo, primary, Lee, Jaetae, primary, Choi, Hueng-Sik, primary, Na, Soon-Young, primary, Choi, Won-Il, primary, Park, Young Joo, primary, Song, Young Shin, primary, Kim, Young A., primary, Lee, In-Kyu, primary, Cho, Sung Jin, primary, and Jeon, Yong Hyun, primary

Published
2023
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15. Supplementary Figures from A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERRγ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer

Author

Singh, Thoudam Debraj, primary, Song, Jaeyoung, primary, Kim, Jina, primary, Chin, Jungwook, primary, Ji, Hyun Dong, primary, Lee, Jae-Eon, primary, Lee, Sang Bong, primary, Yoon, Heeseok, primary, Yu, Ji Hoon, primary, Kim, Sang Kyoon, primary, Yoon, Ghil Suk, primary, Hwang, Hayoung, primary, Lee, Ho Won, primary, Oh, Ji Min, primary, Lee, Sang-Woo, primary, Lee, Jaetae, primary, Choi, Hueng-Sik, primary, Na, Soon-Young, primary, Choi, Won-Il, primary, Park, Young Joo, primary, Song, Young Shin, primary, Kim, Young A., primary, Lee, In-Kyu, primary, Cho, Sung Jin, primary, and Jeon, Yong Hyun, primary

Published
2023
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19. An Inverse Agonist of Estrogen-Related Receptor Gamma, GSK5182, Enhances Na + /I − Symporter Function in Radioiodine-Refractory Papillary Thyroid Cancer Cells.

Author

Singh, Thoudam Debraj, Lee, Jae Eon, Son, Kwang Hee, Lee, Bo Ra, Kim, Sang Kyoon, Gulwani, Deepak, Sarangthem, Vijaya, and Jeon, Yong Hyun

Subjects
*THROMBOPOIETIN receptors, *THYROID cancer, *ANAPLASTIC thyroid cancer, *CANCER cells, *MITOGEN-activated protein kinases, *IODINE isotopes
Abstract

Previously, we reported that an inverse agonist of estrogen-related receptor gamma (ERRγ), GSK5182, enhances sodium iodide (Na+/I−) symporter (NIS) function through mitogen-activated protein (MAP) kinase signaling in anaplastic thyroid cancer cells. This finding helped us to further investigate the effects of GSK5182 on NIS function in papillary thyroid cancer (PTC) refractory to radioactive iodine (RAI) therapy. Herein, we report the effects of ERRγ on the regulation of NIS function in RAI-resistant PTC cells using GSK5182. RAI-refractory BCPAP cells were treated with GK5182 for 24 h at various concentrations, and radioiodine avidity was determined with or without potassium perchlorate (KClO4) as an NIS inhibitor. We explored the effects of GSK5182 on ERRγ, the mitogen-activated protein (MAP) kinase pathway, and iodide metabolism-related genes. We examined whether the MAP pathway affected GSK5182-mediated NIS function using U0126, a selective MEK inhibitor. A clonogenic assay was performed to evaluate the cytotoxic effects of I-131. GSK5182 induced an increase in radioiodine avidity in a dose-dependent manner, and the enhanced uptake was completely inhibited by KClO4 in BCPAP cells. We found that ERRγ was downregulated and phosphorylated extracellular signal-regulated kinase (ERK)1/2 was upregulated in BCPAP cells, with an increase in total and membranous NIS and iodide metabolism-related genes. MEK inhibitors reversed the increase in radioiodine avidity induced by GSK5182. Clonogenic examination revealed the lowest survival in cells treated with a combination of GSK5182 and I-131 compared to those treated with either GSK518 or I-131 alone. We demonstrate that an inverse agonist of ERRγ, GSK5182, enhances the function of NIS protein via the modulation of ERRγ and MAP kinase signaling, thereby leading to increased responsiveness to radioiodine in RAI-refractory papillary thyroid cancer cells. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Tunicamycin as a Novel Redifferentiation Agent in Radioiodine Therapy for Anaplastic Thyroid Cancer

Author

Choi, Yoon Ju, primary, Lee, Jae-Eon, additional, Ji, Hyun Dong, additional, Lee, Bo-Ra, additional, Lee, Sang Bong, additional, Kim, Kil Soo, additional, Lee, In-Kyu, additional, Chin, Jungwook, additional, Cho, Sung Jin, additional, Lee, Jaetae, additional, Lee, Sang-Woo, additional, Ha, Jeoung-Hee, additional, and Jeon, Yong Hyun, additional

Published
2021
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24. A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERRγ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer

Author

Singh, Thoudam Debraj, primary, Song, Jaeyoung, additional, Kim, Jina, additional, Chin, Jungwook, additional, Ji, Hyun Dong, additional, Lee, Jae-Eon, additional, Lee, Sang Bong, additional, Yoon, Heeseok, additional, Yu, Ji Hoon, additional, Kim, Sang Kyoon, additional, Yoon, Ghil Suk, additional, Hwang, Hayoung, additional, Lee, Ho Won, additional, Oh, Ji Min, additional, Lee, Sang-Woo, additional, Lee, Jaetae, additional, Choi, Hueng-Sik, additional, Na, Soon-Young, additional, Choi, Won-Il, additional, Park, Young Joo, additional, Song, Young Shin, additional, Kim, Young A., additional, Lee, In-Kyu, additional, Cho, Sung Jin, additional, and Jeon, Yong Hyun, additional

Published
2019
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26. Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer

Author

Kim, Jina, primary, Song, Jaeyoung, additional, Ji, Hyun Dong, additional, Yoo, Eun Kyung, additional, Lee, Jae-Eon, additional, Lee, Sang Bong, additional, Oh, Ji Min, additional, Lee, Seungmi, additional, Hwang, Ji Sun, additional, Yoon, Heeseok, additional, Kim, Dong-Su, additional, Lee, Su-Jeong, additional, Jeong, Minseon, additional, Lee, Sungwoo, additional, Kim, Kyung-Hee, additional, Choi, Hueng-Sik, additional, Lee, Sang Woo, additional, Park, Keun-Gyu, additional, Lee, In-Kyu, additional, Kim, Seong Heon, additional, Hwang, Hayoung, additional, Jeon, Yong Hyun, additional, Chin, Jungwook, additional, and Cho, Sung Jin, additional

Published
2019
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27. Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent

Author

Lee, Sang Bong, primary, Han, Ye Ri, additional, Jeon, Hui-Jeon, additional, Jun, Chul-Ho, additional, Kim, Sang-Kyoon, additional, Chin, Jungwook, additional, Lee, Su-Jeong, additional, Jeong, Minseon, additional, Lee, Jae-Eon, additional, Lee, Chang-Hee, additional, Cho, Sung Jin, additional, Kim, Dong-Su, additional, and Jeon, Yong Hyun, additional

Published
2019
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33. The effects of vitamin D3 on lipogenesis in the liver and adipose tissue of pregnant rats

Author

KANG, EUN-JIN, primary, LEE, JAE-EON, additional, AN, SUNG-MIN, additional, LEE, JAE HO, additional, KWON, HYEOG SOONG, additional, KIM, BYOUNG CHUL, additional, KIM, SEON JONG, additional, KIM, JOO MAN, additional, HWANG, DAE YOUN, additional, JUNG, YOUNG-JIN, additional, YANG, SEUNG YUN, additional, KIM, SEUNG CHUL, additional, and AN, BEUM-SOO, additional

Published
2015
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34. Regulation of steroid hormones in the placenta and serum of women with preeclampsia.

Author

Shin, Ye Young, Jeong, Jea Sic, Park, Mee-Na, Lee, Jae-Eon, An, Sung-Min, Cho, Wan-Seob, Kim, Seung Chul, An, Beum-Soo, and Lee, Kyu-Sup

Subjects
PLACENTA, PREECLAMPSIA, STEROIDS, DEHYDROEPIANDROSTERONE, TESTOSTERONE
Abstract

Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome that results in substantial maternal and fetal morbidity and mortality. The exact cause of PE has not been completely elucidate, although abnormal formation of the placenta has been considered. The placenta connects the developing fetus to the uterine wall, producing a large quantity of steroid hormones to maintain pregnancy. Although steroid hormones, particularly progesterone (P4) and estrogen (E2), in the serum of women with PE have been studied, steroidogenesis in the placenta has not well been established. The present study compared the concentrations of steroid hormones, including pregnenolone (PG), P4, dehydroepiandrosterone (DHEA), testosterone (T) and E2, in the serum and placenta of women with PE. PG, P4, DHEA and E2 concentrations tended to be decreased in PE serum and placentas, and the results were statistically significant for P4 and E2 in the serum. Quantification of genes associated with steroidogenesis in the placenta was performed, and the expression of the P4- and E2-synthesizing enzymes testosterone 17-β-dehydrogenase 3 and 3 β-hydroxysteroid dehydrogenase/δ5 4-isomerase type 1 was reduced. Notably, aromatase, an enzyme required for the production of E2, was upregulated in the PE placenta, suggesting that steroidogenic enzymes may be dynamically regulated and may affect the symptoms of PE. In conclusion, the results of the present study suggested that the levels of steroid hormones, including P4 and E2, in the serum and placenta of women with PE are downregulated, which may be mediated by the regulation of steroidogenic enzyme expression in the PE placenta. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Korea's Contemporary Ceramic Artists and a Renowned Kiln.

Author

Lee Jae-eon

Subjects
KOREAN pottery, CERAMICS, ARTISTS, KOREAN arts, KILNS
Abstract

This article presents information on several noteworthy potters in Korean ceramics history. The author includes artists from various periods of ceramic wares such as ch'ǒngja, paekcha, and punch'ǒng, focusing on the latter. Artists include Shin Sang-ho, Yoon Kwang-jo, and Yi Su-jong. A discussion is also included on the Park Young-sook Kiln.

Published
1999

38. Effect of vitamin D3 on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes.

Author

Hong SH, Lee JE, Kim HS, Jung YJ, Hwang D, Lee JH, Yang SY, Kim SC, Cho SK, and An BS

Abstract

1,25-dihydroxyvitamin D3 (VD3), an active form of Vitamin D, is photosynthesized in the skin of vertebrates in response to solar ultraviolet B radiation (UV-B). VD3 deficiency can cause health problems such as immune disease, metabolic disease, and bone disorders. It has also been demonstrated that VD3 is involved in reproductive functions. Female sex hormones such as estrogen and progesterone are biosynthesized mainly in ovarian granulosa cells as the ovarian follicle develops. The functions of sex hormones include regulation of the estrus cycle and puberty as well as maintenance of pregnancy in females. In this study, we isolated granulosa cells from porcine ovaries and cultured them for experiments. To examine the effects of VD3 on ovarian granulosa cells, the mRNA and protein levels of genes were analyzed by Real-time PCR and Western blotting assay. Production of progesterone from granulosa cells was also measured by ELISA assay. As a result, transcriptional and translational regulation of progesterone biosynthesis-related genes in granulosa cells was significantly altered by VD3. Furthermore, progesterone concentrations in porcine granulosa cell-cultured media decreased in response to VD3. These results show that VD3 was a strong regulator of sex steroid hormone production in porcine granulosa cells, suggesting that vitamin D deficiency may result in inappropriate sexual development of industrial animals and eventually economic loss., (© 2016 the Journal of Biomedical Research. All rights reserved.)

Published
2016
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